The effective molarity of the substrate phosphoryl group in the transition state for yeast OMP decarboxylase

Bioorganic Chemistry

Volumn 33, Issue 1, 2005, Pages 45-52

  Sievers, Annette ^a   Wolfenden, Richard ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Binding discrimination; Connectivity effect; Effective molarity; ODCase; OMP; OMP decarboxylase; Orotidine; Transition state

Indexed keywords

ALANINE; ASPARTIC ACID; CARBON DIOXIDE; CARBOXYLYASE; OUTER MEMBRANE PROTEIN; PHOSPHATE;

ARTICLE; BINDING AFFINITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; YEAST;

ALANINE; ASPARTIC ACID; BINDING, COMPETITIVE; DECARBOXYLATION; MOLECULAR STRUCTURE; MUTATION; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE; PHOSPHATES; SACCHAROMYCES CEREVISIAE; SUBSTRATE SPECIFICITY; TIME FACTORS; URIDINE;

EID: 12844285698     PISSN: 00452068     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bioorg.2004.08.005     Document Type: Article

References (23)

1. D.E. Koshland Jr. Proc. Natl. Acad. Sci. USA 44 1958 98 104
2. A. Kaji, and S.P. Colowick J. Biol. Chem. 240 1965 4454 4462
3. W.P. Jencks Proc. Natl. Acad. Sci. USA 78 1981 4046 4050
4. A. Radzicka, and R. Wolfenden Science 267 1995 90 93
5. T.C. Appleby, C. Kinsland, T.P. Begley, and S.E. Ealick Proc. Natl. Acad. Sci. USA 97 2000 2005 2010
6. B.G. Miller, A.M. Hassell, R. Wolfenden, M.V. Milburn, and S.A. Short Proc. Natl. Acad. Sci. USA 97 2000 2011 2016
7. N. Wu, Y. Mo, J. Gao, and E.F. Pai Proc. Natl. Acad. Sci. USA 97 2000 2017 2022
8. P. Harris, J.-C. Navarro Poulsen, K.F. Jensen, and S. Larsen Biochemistry 39 2000 4217 4224
9. B.G. Miller, M.J. Snider, S.A. Short, and R. Wolfenden Biochemistry 39 2000 8113 8118
10. P.W. Landesman, Design, synthesis and evaluation of potential inhibitors of pyrimidine biosynthesis: a mechanistic approach, Ph.D. thesis, S.U.N.Y at Buffalo, 1982
11. A.M. Michelson, W. Drell, and H.K. Mitchell Proc. Natl. Am. Chem. Soc. USA 37 1951 396 399
12. F.E. Hruska J. Am. Chem. Soc. 93 1971 1795 1797
13. B.G. Miller, J.A. Smiley, S.A. Short, and R. Wolfenden J. Biol. Chem. 274 1999 23841 23843
14. M.E. Jones, P.R. Kavipurapu, and T.W. Traut Methods Enzymol. 51 1978 155 157
15. D.J.T. Porter, and S.A. Short Biochemistry 39 2000 11788 11800
16. H.L. Levine, R.S. Brody, and F.H. Westheimer Biochemistry 19 1980 365 369
17. B.G. Miller, M.J. Snider, R. Wolfenden, and S.A. Short J. Biol. Chem. 276 2001 15174 15176
18. B.G. Miller, G.L. Butterfoss, S.A. Short, and R. Wolfenden Biochemistry 40 2001 6227 6232
19. T.L. Amyes, A.C. O'Donnoghue, and J.P. Richard J. Am. Chem. Soc. 123 2001 11325 11326
20. W.M. Kati, S.A. Acheson, and R. Wolfenden Biochemistry 31 1992 7356 7366
21. R. Wolfenden Mol. Cell. Biochem. 3 1973 207 211
22. B.G. Miller, and R. Wolfenden Annu. Rev. Biochem. 71 2002 847 885
23. W.M. Kati, and R. Wolfenden Acc. Chem. Res. 23 1991 209 215