Circe effect versus enzyme preorganization: What can be learned from the structure of the most proficient enzyme?

ChemBioChem

Volumn 2, Issue 2, 2001, Pages 109-111

  Warshel, Arieh ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Electrostatic interactions; Enzyme catalysis; Lyases; Molecular modeling; Orotidine 5 phosphate decarboxylase

Indexed keywords

OROTIDINE 5' PHOSPHATE DECARBOXYLASE;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ELECTROCHEMISTRY; KINETICS; PROTEIN CONFORMATION;

BINDING SITES; ELECTROCHEMISTRY; KINETICS; MODELS, MOLECULAR; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE; PROTEIN CONFORMATION;

EID: 0035793649     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/1439-7633(20010202)2:2<109::AID-CBIC109>3.0.CO;2-9     Document Type: Article

References (3)

1. W. P. Jencks, Catalysis in Chemistry and Enzymohgy, Dover Publisher, New York, 1987.
2. A. Warshel, Computer Modeling of Chemical Reactions in Enzymes and Solutions, Wiley, New York, 1991.
3. A. Warshel, J. Florián, Proc. Natl. Acad. Sci. USA 1998, 95, 5950.