Mechanism of the orotidine 5′-monophosphate decarboxylase-catalyzed reaction: Effect of solvent viscosity on kinetic constants

Biochemistry

Volumn 48, Issue 24, 2009, Pages 5510-5517

  Wood, B McKay ^a   Chan, Kui K ^a   Amyes, Tina L ^b   Richard, John P ^b   Gerlt, John A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIONIC INTERMEDIATES; CATALYZED REACTIONS; DECARBOXYLASE; KINETIC CONSTANT; KINETIC EFFECT; KINETIC ISOTOPE EFFECTS; METHANOTHERMOBACTER THERMAUTOTROPHICUS; MONOPHOSPHATE; RATE ACCELERATION; REACTION COORDINATES; REACTIVE SUBSTRATES; SACCHAROMYCES CEREVISIAE; SOLVENT VISCOSITY; STRUCTURAL BASIS; SUBSTRATE BINDING;

CARBOXYLATION; CATALYSTS; DISSOCIATION; RATE CONSTANTS; SOLVENTS; SUBSTRATES;

VISCOSITY;

OROTIDINE 5' PHOSPHATE DECARBOXYLASE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DECARBOXYLATION; ENZYME SUBSTRATE COMPLEX; METHANOBACTERIUM THERMOAUTOTROPHICUM; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; VISCOSITY;

BACTERIAL PROTEINS; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; KINETICS; METHANOBACTERIACEAE; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP; VISCOSITY;

METHANOTHERMOBACTER THERMAUTOTROPHICUS; SACCHAROMYCES CEREVISIAE;

EID: 67649173263     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9006226     Document Type: Article

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