Carbon isotope effect study on orotidine 5′-monophosphate decarboxylase: Support for an anionic intermediate

Biochemistry

Volumn 47, Issue 2, 2008, Pages 798-803

  Van Vleet, Jeremy L ^a   Reinhardt, Laurie A ^a   Miller, Brian G ^b,c   Sievers, Annette ^b,d   Cleland, W Wallace ^a  

^a UNIVERSITY OF WISCONSIN   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c FLORIDA STATE UNIVERSITY   (United States)

^d BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON ISOTOPE EFFECT; ENZYMATIC PROFICIENCY; MONOPHOSPHATE DECARBOXYLASE; NONENZYMATIC REACTION;

ISOTOPES; REACTION RATES; SUBSTRATES; TRANSITION METALS;

ENZYMES;

2' DEOXYOROTIDINE 5' MONOPHOSPHATE; 5 FLUOROOROTIDINE 5' MONOPHOSPHATE; ANION; CARBENE; CARBON 13; FLUORINE; OROTIDINE; OROTIDINE 5' PHOSPHATE; OROTIDINE 5' PHOSPHATE DECARBOXYLASE; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ARTICLE; COVALENT BOND; DECARBOXYLATION; ENERGY; ENZYME MECHANISM; ENZYME SUBSTRATE; PRIORITY JOURNAL; PROTON TRANSPORT; WILD TYPE;

BINDING SITES; CARBON ISOTOPES; KINETICS; MUTANT PROTEINS; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE; PROTEIN CONFORMATION;

EID: 38849119713     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701664n     Document Type: Article

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