Structural Characterization of the Molecular Events during a Slow Substrate-Product Transition in Orotidine 5′-Monophosphate Decarboxylase

Journal of Molecular Biology

Volumn 387, Issue 5, 2009, Pages 1199-1210

  Fujihashi, Masahiro ^a,b   Wei, Lianhu ^c   Kotra, Lakshmi P ^c,d,e   Pai, Emil F ^b,f  

^a KYOTO UNIVERSITY   (Japan)

^b MaRS Centre   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^f UNIVERSITY OF TORONTO   (Canada)

Author keywords

covalent inhibition; ODCase; OMPDC; orotidine monophosphate decarboxylase; time resolved crystallography

Indexed keywords

BARBITURIC ACID; NUCLEOPHILE; OROTIDINE 5' PHOSPHATE DECARBOXYLASE;

ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; COVALENT BOND; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DECARBOXYLATION; ENZYME STRUCTURE; MUTANT; PRIORITY JOURNAL; PROTEIN STRUCTURE; SUBSTITUTION REACTION;

METHANOTHERMOBACTER THERMAUTOTROPHICUS;

EID: 63649145250     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.02.037     Document Type: Article

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