Conformational changes in orotidine 5′-monophosphate decarboxylase: A structure-based explanation for how the 5′-phosphate group activates the enzyme

Biochemistry

Volumn 51, Issue 43, 2012, Pages 8665-8678

  Desai, Bijoy J ^a   Wood, B McKay ^a   Fedorov, Alexander A ^b   Fedorov, Elena V ^b   Goryanova, Bogdana ^c   Amyes, Tina L ^c   Richard, John P ^c   Almo, Steven C ^b   Gerlt, John A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CARBOXYLATE GROUPS; CONFORMATIONAL CHANGE; DATA SUPPORT; DE NOVO DESIGN; DECARBOXYLASES; ENZYMATIC CATALYSIS; HYDROGEN BONDING INTERACTIONS; HYDROPHOBIC CLUSTERS; INTRINSIC BINDING; METHANOTHERMOBACTER THERMAUTOTROPHICUS; MONOPHOSPHATES; PHOSPHATE GROUP; REACTION COORDINATES; STRUCTURAL ORIGIN; STRUCTURE-BASED;

BINDING ENERGY; CARBOXYLATION; ENZYMES; HYDROGEN BONDS; SUBSTRATES;

INTERFACES (MATERIALS);

FUNCTIONAL GROUP; OROTIDINE 5' PHOSPHATE DECARBOXYLASE; SOLVENT;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; HYDROPHOBICITY; METHANOTHERMOBACTER THERMAUTOTROPHICUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; METHANOBACTERIACEAE; MODELS, MOLECULAR; MUTATION; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE; PHOSPHATES; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS;

METHANOTHERMOBACTER THERMAUTOTROPHICUS;

EID: 84868089459     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301188k     Document Type: Article

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