-
1
-
-
0035847075
-
Transgenic monkeys produced by retroviral gene transfer into mature oocytes
-
Chan A.W., Chong K.Y., Martinovich C., Simerly C., Schatten G. Transgenic monkeys produced by retroviral gene transfer into mature oocytes. Science 2001, 291:309-312.
-
(2001)
Science
, vol.291
, pp. 309-312
-
-
Chan, A.W.1
Chong, K.Y.2
Martinovich, C.3
Simerly, C.4
Schatten, G.5
-
2
-
-
18544410106
-
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
-
Davies S.W., Turmaine M., Cozens B.A., DiFiglia M., Sharp A.H., Ross C.A., Scherzinger E., Wanker E.E., Mangiarini L., Bates G.P. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 1997, 90:537-548.
-
(1997)
Cell
, vol.90
, pp. 537-548
-
-
Davies, S.W.1
Turmaine, M.2
Cozens, B.A.3
DiFiglia, M.4
Sharp, A.H.5
Ross, C.A.6
Scherzinger, E.7
Wanker, E.E.8
Mangiarini, L.9
Bates, G.P.10
-
3
-
-
77953666105
-
Genetic animal models of Parkinson's disease
-
Dawson T.M., Ko H.S., Dawson V.L. Genetic animal models of Parkinson's disease. Neuron 2010, 66:646-661.
-
(2010)
Neuron
, vol.66
, pp. 646-661
-
-
Dawson, T.M.1
Ko, H.S.2
Dawson, V.L.3
-
4
-
-
0030752709
-
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
-
DiFiglia M., Sapp E., Chase K.O., Davies S.W., Bates G.P., Vonsattel J.P., Aronin N. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 1997, 277:1990-1993.
-
(1997)
Science
, vol.277
, pp. 1990-1993
-
-
DiFiglia, M.1
Sapp, E.2
Chase, K.O.3
Davies, S.W.4
Bates, G.P.5
Vonsattel, J.P.6
Aronin, N.7
-
5
-
-
46749157501
-
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
-
Gray M., Shirasaki D.I., Cepeda C., Andre V.M., Wilburn B., Lu X.H., Tao J., Yamazaki I., Li S.H., Sun Y.E., Li X.J., Levine M.S., Yang X.W. Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. J. Neurosci. 2008, 28:6182-6195.
-
(2008)
J. Neurosci.
, vol.28
, pp. 6182-6195
-
-
Gray, M.1
Shirasaki, D.I.2
Cepeda, C.3
Andre, V.M.4
Wilburn, B.5
Lu, X.H.6
Tao, J.7
Yamazaki, I.8
Li, S.H.9
Sun, Y.E.10
Li, X.J.11
Levine, M.S.12
Yang, X.W.13
-
6
-
-
0027490598
-
Molecular genetics of Huntington's disease
-
Gusella J.F., MacDonald M.E., Ambrose C.M., Duyao M.P. Molecular genetics of Huntington's disease. Arch. Neurol. 1993, 50:1157-1163.
-
(1993)
Arch. Neurol.
, vol.50
, pp. 1157-1163
-
-
Gusella, J.F.1
MacDonald, M.E.2
Ambrose, C.M.3
Duyao, M.P.4
-
7
-
-
0033119123
-
Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology
-
Gutekunst C.A., Li S.H., Yi H., Mulroy J.S., Kuemmerle S., Jones R., Rye D., Ferrante R.J., Hersch S.M., Li X.J. Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology. J. Neurosci. 1999, 19:2522-2534.
-
(1999)
J. Neurosci.
, vol.19
, pp. 2522-2534
-
-
Gutekunst, C.A.1
Li, S.H.2
Yi, H.3
Mulroy, J.S.4
Kuemmerle, S.5
Jones, R.6
Rye, D.7
Ferrante, R.J.8
Hersch, S.M.9
Li, X.J.10
-
8
-
-
0041656292
-
The hunt for huntingtin function: interaction partners tell many different stories
-
Harjes P., Wanker E.E. The hunt for huntingtin function: interaction partners tell many different stories. Trends Biochem. Sci. 2003, 28:425-433.
-
(2003)
Trends Biochem. Sci.
, vol.28
, pp. 425-433
-
-
Harjes, P.1
Wanker, E.E.2
-
9
-
-
77952526316
-
An ovine transgenic Huntington's disease model
-
Jacobsen J.C., Bawden C.S., Rudiger S.R., McLaughlan C.J., Reid S.J., Waldvogel H.J., MacDonald M.E., Gusella J.F., Walker S.K., Kelly J.M., Webb G.C., Faull R.L., Rees M.I., Snell R.G. An ovine transgenic Huntington's disease model. Hum. Mol. Genet. 2010, 19:1873-1882.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 1873-1882
-
-
Jacobsen, J.C.1
Bawden, C.S.2
Rudiger, S.R.3
McLaughlan, C.J.4
Reid, S.J.5
Waldvogel, H.J.6
MacDonald, M.E.7
Gusella, J.F.8
Walker, S.K.9
Kelly, J.M.10
Webb, G.C.11
Faull, R.L.12
Rees, M.I.13
Snell, R.G.14
-
10
-
-
0347418928
-
Production of cloned pigs by using somatic cells as donors
-
Lai L., Prather R.S. Production of cloned pigs by using somatic cells as donors. Cloning Stem Cells 2003, 5:233-241.
-
(2003)
Cloning Stem Cells
, vol.5
, pp. 233-241
-
-
Lai, L.1
Prather, R.S.2
-
11
-
-
0031945025
-
Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats
-
Li S.H., Li X.J. Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats. Hum. Mol. Genet. 1998, 7:777-782.
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 777-782
-
-
Li, S.H.1
Li, X.J.2
-
12
-
-
1242338856
-
Huntingtin-protein interactions and the pathogenesis of Huntington's disease
-
Li S.H., Li X.J. Huntingtin-protein interactions and the pathogenesis of Huntington's disease. Trends Genet. 2004, 20:146-154.
-
(2004)
Trends Genet.
, vol.20
, pp. 146-154
-
-
Li, S.H.1
Li, X.J.2
-
13
-
-
0035862896
-
Neurological abnormalities in a knock-in mouse model of Huntington's disease
-
Lin C.H., Tallaksen-Greene S., Chien W.M., Cearley J.A., Jackson W.S., Crouse A.B., Ren S., Li X.J., Albin R.L., Detloff P.J. Neurological abnormalities in a knock-in mouse model of Huntington's disease. Hum. Mol. Genet. 2001, 10:137-144.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 137-144
-
-
Lin, C.H.1
Tallaksen-Greene, S.2
Chien, W.M.3
Cearley, J.A.4
Jackson, W.S.5
Crouse, A.B.6
Ren, S.7
Li, X.J.8
Albin, R.L.9
Detloff, P.J.10
-
14
-
-
34247612367
-
The use of pigs in neuroscience: modeling brain disorders
-
Lind N.M., Moustgaard A., Jelsing J., Vajta G., Cumming P., Hansen A.K. The use of pigs in neuroscience: modeling brain disorders. Neurosci. Biobehav. Rev. 2007, 31:728-751.
-
(2007)
Neurosci. Biobehav. Rev.
, vol.31
, pp. 728-751
-
-
Lind, N.M.1
Moustgaard, A.2
Jelsing, J.3
Vajta, G.4
Cumming, P.5
Hansen, A.K.6
-
15
-
-
0034306571
-
Identification and characterization of the miniature pig Huntington's disease gene homolog: evidence for conservation and polymorphism in the CAG triplet repeat
-
Matsuyama N., Hadano S., Onoe K., Osuga H., Showguchi-Miyata J., Gondo Y., Ikeda J.E. Identification and characterization of the miniature pig Huntington's disease gene homolog: evidence for conservation and polymorphism in the CAG triplet repeat. Genomics 2000, 69:72-85.
-
(2000)
Genomics
, vol.69
, pp. 72-85
-
-
Matsuyama, N.1
Hadano, S.2
Onoe, K.3
Osuga, H.4
Showguchi-Miyata, J.5
Gondo, Y.6
Ikeda, J.E.7
-
16
-
-
0034329742
-
Apoptosis in neurodegenerative disorders
-
Mattson M.P. Apoptosis in neurodegenerative disorders. Nat. Rev. Mol. Cell Biol. 2000, 1:120-129.
-
(2000)
Nat. Rev. Mol. Cell Biol.
, vol.1
, pp. 120-129
-
-
Mattson, M.P.1
-
17
-
-
0037107191
-
Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice
-
Menalled L.B., Sison J.D., Wu Y., Olivieri M., Li X.J., Li H., Zeitlin S., Chesselet M.F. Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice. J. Neurosci. 2002, 22:8266-8276.
-
(2002)
J. Neurosci.
, vol.22
, pp. 8266-8276
-
-
Menalled, L.B.1
Sison, J.D.2
Wu, Y.3
Olivieri, M.4
Li, X.J.5
Li, H.6
Zeitlin, S.7
Chesselet, M.F.8
-
18
-
-
78049265461
-
Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector
-
Niu Y., Yu Y., Bernat A., Yang S., He X., Guo X., Chen D., Chen Y., Ji S., Si W., Lv Y., Tan T., Wei Q., Wang H., Shi L., Guan J., Zhu X., Afanassieff M., Savatier P., Zhang K., Zhou Q., Ji W. Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector. Proc. Natl. Acad. Sci. USA 2010, 107:17663-17667.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 17663-17667
-
-
Niu, Y.1
Yu, Y.2
Bernat, A.3
Yang, S.4
He, X.5
Guo, X.6
Chen, D.7
Chen, Y.8
Ji, S.9
Si, W.10
Lv, Y.11
Tan, T.12
Wei, Q.13
Wang, H.14
Shi, L.15
Guan, J.16
Zhu, X.17
Afanassieff, M.18
Savatier, P.19
Zhang, K.20
Zhou, Q.21
Ji, W.22
more..
-
20
-
-
0028283985
-
Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases
-
Perutz M.F., Johnson T., Suzuki M., Finch J.T. Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases. Proc. Natl. Acad. Sci. USA 1994, 91:5355-5358.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 5355-5358
-
-
Perutz, M.F.1
Johnson, T.2
Suzuki, M.3
Finch, J.T.4
-
21
-
-
5444231258
-
Huntingtin processing in pathogenesis of Huntington disease
-
Qin Z.H., Gu Z.L. Huntingtin processing in pathogenesis of Huntington disease. Acta Pharmacol. Sin. 2004, 25:1243-1249.
-
(2004)
Acta Pharmacol. Sin.
, vol.25
, pp. 1243-1249
-
-
Qin, Z.H.1
Gu, Z.L.2
-
22
-
-
52949154301
-
Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs
-
Rogers C.S., Stoltz D.A., Meyerholz D.K., Ostedgaard L.S., Rokhlina T., Taft P.J., Rogan M.P., Pezzulo A.A., Karp P.H., Itani O.A., Kabel A.C., Wohlford-Lenane C.L., Davis G.J., Hanfland R.A., Smith T.L., Samuel M., Wax D., Murphy C.N., Rieke A., Whitworth K., Uc A., Starner T.D., Brogden K.A., Shilyansky J., McCray P.B., Zabner J., Prather R.S., Welsh M.J. Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science 2008, 321:1837-1841.
-
(2008)
Science
, vol.321
, pp. 1837-1841
-
-
Rogers, C.S.1
Stoltz, D.A.2
Meyerholz, D.K.3
Ostedgaard, L.S.4
Rokhlina, T.5
Taft, P.J.6
Rogan, M.P.7
Pezzulo, A.A.8
Karp, P.H.9
Itani, O.A.10
Kabel, A.C.11
Wohlford-Lenane, C.L.12
Davis, G.J.13
Hanfland, R.A.14
Smith, T.L.15
Samuel, M.16
Wax, D.17
Murphy, C.N.18
Rieke, A.19
Whitworth, K.20
Uc, A.21
Starner, T.D.22
Brogden, K.A.23
Shilyansky, J.24
McCray, P.B.25
Zabner, J.26
Prather, R.S.27
Welsh, M.J.28
more..
-
23
-
-
66449106662
-
Generation of transgenic non-human primates with germline transmission
-
Sasaki E., Suemizu H., Shimada A., Hanazawa K., Oiwa R., Kamioka M., Tomioka I., Sotomaru Y., Hirakawa R., Eto T., Shiozawa S., Maeda T., Ito M., Ito R., Kito C., Yagihashi C., Kawai K., Miyoshi H., Tanioka Y., Tamaoki N., Habu S., Okano H., Nomura T. Generation of transgenic non-human primates with germline transmission. Nature 2009, 459:523-527.
-
(2009)
Nature
, vol.459
, pp. 523-527
-
-
Sasaki, E.1
Suemizu, H.2
Shimada, A.3
Hanazawa, K.4
Oiwa, R.5
Kamioka, M.6
Tomioka, I.7
Sotomaru, Y.8
Hirakawa, R.9
Eto, T.10
Shiozawa, S.11
Maeda, T.12
Ito, M.13
Ito, R.14
Kito, C.15
Yagihashi, C.16
Kawai, K.17
Miyoshi, H.18
Tanioka, Y.19
Tamaoki, N.20
Habu, S.21
Okano, H.22
Nomura, T.23
more..
-
24
-
-
0033054555
-
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin
-
Schilling G., Becher M.W., Sharp A.H., Jinnah H.A., Duan K., Kotzuk J.A., Slunt H.H., Ratovitski T., Cooper J.K., Jenkins N.A., Copeland N.G., Price D.L., Ross C.A., Borchelt D.R. Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum. Mol. Genet. 1999, 8:397-407.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 397-407
-
-
Schilling, G.1
Becher, M.W.2
Sharp, A.H.3
Jinnah, H.A.4
Duan, K.5
Kotzuk, J.A.6
Slunt, H.H.7
Ratovitski, T.8
Cooper, J.K.9
Jenkins, N.A.10
Copeland, N.G.11
Price, D.L.12
Ross, C.A.13
Borchelt, D.R.14
-
25
-
-
10744227174
-
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
-
Slow E.J., van Raamsdonk J., Rogers D., Coleman S.H., Graham R.K., Deng Y., Oh R., Bissada N., Hossain S.M., Yang Y.Z., Li X.J., Simpson E.M., Gutekunst C.A., Leavitt B.R., Hayden M.R. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum. Mol. Genet. 2003, 12:1555-1567.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 1555-1567
-
-
Slow, E.J.1
van Raamsdonk, J.2
Rogers, D.3
Coleman, S.H.4
Graham, R.K.5
Deng, Y.6
Oh, R.7
Bissada, N.8
Hossain, S.M.9
Yang, Y.Z.10
Li, X.J.11
Simpson, E.M.12
Gutekunst, C.A.13
Leavitt, B.R.14
Hayden, M.R.15
-
26
-
-
0035543870
-
Production of transgenic miniature pigs by pronuclear microinjection
-
Uchida M., Shimatsu Y., Onoe K., Matsuyama N., Niki R., Ikeda J.E., Imai H. Production of transgenic miniature pigs by pronuclear microinjection. Transgenic Res. 2001, 10:577-582.
-
(2001)
Transgenic Res.
, vol.10
, pp. 577-582
-
-
Uchida, M.1
Shimatsu, Y.2
Onoe, K.3
Matsuyama, N.4
Niki, R.5
Ikeda, J.E.6
Imai, H.7
-
28
-
-
49649117786
-
Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease
-
Wang C.E., Tydlacka S., Orr A.L., Yang S.H., Graham R.K., Hayden M.R., Li S., Chan A.W., Li X.J. Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Hum. Mol. Genet. 2008, 17:2738-2751.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 2738-2751
-
-
Wang, C.E.1
Tydlacka, S.2
Orr, A.L.3
Yang, S.H.4
Graham, R.K.5
Hayden, M.R.6
Li, S.7
Chan, A.W.8
Li, X.J.9
-
29
-
-
0034163497
-
Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice
-
Wheeler V.C., White J.K., Gutekunst C.A., Vrbanac V., Weaver M., Li X.J., Li S.H., Yi H., Vonsattel J.P., Gusella J.F., Hersch S., Auerbach W., Joyner A.L., MacDonald M.E. Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice. Hum. Mol. Genet. 2000, 9:503-513.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 503-513
-
-
Wheeler, V.C.1
White, J.K.2
Gutekunst, C.A.3
Vrbanac, V.4
Weaver, M.5
Li, X.J.6
Li, S.H.7
Yi, H.8
Vonsattel, J.P.9
Gusella, J.F.10
Hersch, S.11
Auerbach, W.12
Joyner, A.L.13
MacDonald, M.E.14
-
30
-
-
33847684865
-
The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes
-
Woodman B., Butler R., Landles C., Lupton M.K., Tse J., Hockly E., Moffitt H., Sathasivam K., Bates G.P. The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes. Brain Res. Bull. 2007, 72:83-97.
-
(2007)
Brain Res. Bull.
, vol.72
, pp. 83-97
-
-
Woodman, B.1
Butler, R.2
Landles, C.3
Lupton, M.K.4
Tse, J.5
Hockly, E.6
Moffitt, H.7
Sathasivam, K.8
Bates, G.P.9
-
31
-
-
77957732707
-
Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs
-
Yang D., Wang C.E., Zhao B., Li W., Ouyang Z., Liu Z., Yang H., Fan P., O'Neill A., Gu W., Yi H., Li S., Lai L., Li X.J. Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs. Hum. Mol. Genet. 2010, 19:3983-3994.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 3983-3994
-
-
Yang, D.1
Wang, C.E.2
Zhao, B.3
Li, W.4
Ouyang, Z.5
Liu, Z.6
Yang, H.7
Fan, P.8
O'Neill, A.9
Gu, W.10
Yi, H.11
Li, S.12
Lai, L.13
Li, X.J.14
-
32
-
-
45149105779
-
Towards a transgenic model of Huntington's disease in a non-human primate
-
Yang S.H., Cheng P.H., Banta H., Piotrowska-Nitsche K., Yang J.J., Cheng E.C., Snyder B., Larkin K., Liu J., Orkin J., Fang Z.H., Smith Y., Bachevalier J., Zola S.M., Li S.H., Li X.J., Chan A.W. Towards a transgenic model of Huntington's disease in a non-human primate. Nature 2008, 453:921-924.
-
(2008)
Nature
, vol.453
, pp. 921-924
-
-
Yang, S.H.1
Cheng, P.H.2
Banta, H.3
Piotrowska-Nitsche, K.4
Yang, J.J.5
Cheng, E.C.6
Snyder, B.7
Larkin, K.8
Liu, J.9
Orkin, J.10
Fang, Z.H.11
Smith, Y.12
Bachevalier, J.13
Zola, S.M.14
Li, S.H.15
Li, X.J.16
Chan, A.W.17
-
33
-
-
0034641936
-
Apoptosis in the nervous system
-
Yuan J., Yankner B.A. Apoptosis in the nervous system. Nature 2000, 407:802-809.
-
(2000)
Nature
, vol.407
, pp. 802-809
-
-
Yuan, J.1
Yankner, B.A.2
-
34
-
-
0141891952
-
Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity
-
Zhou H., Cao F., Wang Z., Yu Z.X., Nguyen H.P., Evans J., Li S.H., Li X.J. Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity. J. Cell Biol. 2003, 163:109-118.
-
(2003)
J. Cell Biol.
, vol.163
, pp. 109-118
-
-
Zhou, H.1
Cao, F.2
Wang, Z.3
Yu, Z.X.4
Nguyen, H.P.5
Evans, J.6
Li, S.H.7
Li, X.J.8
|