Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 32, 2005, Pages 11402-11407

  Slow, Elizabeth J ^a   Graham, Rona K ^a   Osmand, Alexander P ^b   Devon, Rebecca S ^a   Lu, Ge ^a   Deng, Yu ^a   Pearson, Jacqui ^a   Vaid, Kuljeet ^a   Bissada, Nagat ^a   Wetzel, Ronald ^b   Leavitt, Blair R ^a   Hayden, Michael R ^a,c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF TENNESSEE GRADUATE SCHOOL OF MEDICINE   (United States)

^c Centre for Molecular Medicine and Therapeutics   (Canada)

Author keywords

Aggregates; Excitotoxicity; Fragment; Huntington disease; Mouse models

Indexed keywords

GENOMIC DNA; HUNTINGTIN; POLYGLUTAMINE; QUINOLINIC ACID;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOINFORMATICS; DEGENERATIVE DISEASE; HUNTINGTON CHOREA; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; YEAST ARTIFICIAL CHROMOSOME;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIORAL SYMPTOMS; BRAIN; CHROMOSOMES, ARTIFICIAL, YEAST; COMPUTATIONAL BIOLOGY; DISEASE MODELS, ANIMAL; DNA PRIMERS; HUMANS; HUNTINGTON DISEASE; INCLUSION BODIES; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); ROTAROD PERFORMANCE TEST; SEQUENCE ANALYSIS, DNA;

EID: 23844472610     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0503634102     Document Type: Article

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