Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK

Redox Biology

Volumn 1, Issue 1, 2013, Pages 552-565

  Wu, Defeng ^a   Cederbaum, Arthur I ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Autophagy; CYP2E1; Cytotoxicity; JNK; Mitochondria dysfunction; P38 MAPK; ROS

Indexed keywords

3 METHYLADENINE; ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ALCOHOL; ARACHIDONIC ACID; BUTHIONINE SULFOXIMINE; CARBON TETRACHLORIDE; CARCINOGEN; CYTOCHROME P450 2E1; LIPID; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; POLYUNSATURATED FATTY ACID; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; 3-METHYLADENINE; ADENINE; ATG7 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL STRAIN HEPG2; CELL VIABILITY; CYTOTOXICITY; DIABETES MELLITUS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER INJURY; MITOCHONDRIAL MEMBRANE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; WILD TYPE; ANALOGS AND DERIVATIVES; DRUG EFFECTS; GENETICS; HEPG2 CELL LINE; METABOLISM; MITOCHONDRION; SIGNAL TRANSDUCTION;

ADENINE; ARACHIDONIC ACID; AUTOPHAGY; BUTHIONINE SULFOXIMINE; CARBON TETRACHLORIDE; CYTOCHROME P-450 CYP2E1; HEP G2 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA; OXIDATIVE STRESS; SIROLIMUS; UBIQUITIN-ACTIVATING ENZYMES;

EID: 84888035697     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2013.10.008     Document Type: Article

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