Role of cytochromes P450 in chemical toxicity and oxidative stress: Studies with CYP2E1

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 569, Issue 1-2, 2005, Pages 101-110

  Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Acetaminophen; Carcinogens; CYP2E1; Cytochromes P450; Gene knockout mice; MAPK; Metabolic activation; Oxidative stress ERK; Reactive oxygen species

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2E1; MITOGEN ACTIVATED PROTEIN KINASE 1; PARACETAMOL;

ALCOHOL OXIDATION; APOPTOSIS; CARCINOGENESIS; CELL DEATH; CONCENTRATION (PARAMETERS); CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; KNOCKOUT MOUSE; LIVER TOXICITY; NONHUMAN; NULL CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; REACTOR CASCADE; REVIEW; SIGNAL TRANSDUCTION;

ACETAMINOPHEN; ANIMALS; APOPTOSIS; CYTOCHROME P-450 CYP2E1; DRUG TOXICITY; HEPATITIS, TOXIC; HUMANS; METABOLIC DETOXICATION, DRUG; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; XENOBIOTICS;

EID: 10444229539     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2004.04.021     Document Type: Review

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