Autophagy in health and disease. 2. Regulation of lipid metabolism and storage by autophagy: Pathophysiological implications

American Journal of Physiology - Cell Physiology

Volumn 298, Issue 5, 2010, Pages

  Czaja, Mark J ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Adipocyte; Fatty liver disease; Hepatocyte; Macroautophagy; Metabolic syndrome

Indexed keywords

FAT DROPLET; LIPID;

ADIPOCYTE; AGING; AUTOPHAGY; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; FATTY LIVER; HUMAN; LIPID METABOLISM; LIPID STORAGE; LIPOLYSIS; LIVER; LIVER CELL; LYSOSOME; METABOLIC SYNDROME X; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW;

ADIPOCYTES; AGING; ANIMALS; AUTOPHAGY; HEPATOCYTES; HUMANS; LIPID METABOLISM; LIVER; METABOLIC SYNDROME X;

EID: 77951464621     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00527.2009     Document Type: Review

References (37)

1. Baerga R, Zhang Y, Chen PH, Goldman S, Jin S. Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice. Autophagy 5: 1118-1130, 2009.
2. Cecconi F, Levine B. The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell 15: 344-357, 2008.
3. Cheng J, Ohsaki Y, Tauchi-Sato K, Fujita A, Fujimoto T. Cholesterol depletion induces autophagy. Biochem Biophys Res Commun 351: 246-252, 2006.
4. Craig WY, Cooper AD. Effects of chylomicron remnants and β-VLDL on the class and composition of newly secreted lipoproteins by HepG2 cells. J Lipid Res 29: 299-308, 1988.
5. Cuervo AM, Bergamini E, Brunk UT, Droge W, Ffrench M, Terman A. Autophagy and aging: the importance of maintaining "clean" cells. Autophagy 1: 131-140, 2005.
6. Cuervo AM, Knecht E, Terlecky SR, Dice JF. Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation. Am J Physiol Cell Physiol 269: C1200-C1208, 1995. (Pubitemid 3005885)
7. Debeer LJ, Thomas J, De Schepper PJ, Mannaerts GP. Lysosomal triacylglycerol lipase and lipolysis in isolated rat hepatocytes. J Biol Chem 254: 8841-8846, 1979. (Pubitemid 10239423)
8. Ding WX, Chen X, Ni HM, Stolz DB, Lu B, Clemens DL, Yin XM. Autophagy is activated as a pro-survival mechanism to protect against ethanol-induced hepatotoxicity (Abstract). Hepatology 50: 1153A, 2009.
9. Donati A, Cavallini G, Paradiso C, Vittorini S, Pollera M, Gori Z, Bergamini E. Age-related changes in the autophagic proteolysis of rat isolated liver cells: effects of antiaging dietary restrictions. J Gerontol A Biol Sci Med Sci 56: B375-B383, 2001. (Pubitemid 32816727)
10. Duee PH, Pegorier JP, el Manoubi L, Herbin C, Kohl C, Girard J. Hepatic triglyceride hydrolysis and development of ketogenesis in rabbits. Am J Physiol Endocrinol Metab 249: E478-E484, 1985.
11. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 365: 1415-1428, 2005.
12. Farre JC, Manjithaya R, Mathewson RD, Subramani S. PpAtg30 tags peroxisomes for turnover by selective autophagy. Dev Cell 14: 365-376, 2008.
13. Finn PF, Dice JF. Proteolytic and lipolytic responses to starvation. Nutrition 22: 830-844, 2006.
14. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287: 356-359, 2002. (Pubitemid 34251969)
15. Fujita K, Nozaki Y, Wada K, Yoneda M, Fujimoto Y, Fujitake M, Endo H, Takahashi H, Inamori M, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A. Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis. Hepatology 50: 772-780, 2009.
16. Gibbons GF, Islam K, Pease RJ. Mobilisation of triacylglycerol stores. Biochim Biophys Acta 1483: 37-57, 2000.
17. Glazer HP, Osipov RM, Clements RT, Sellke FW, Bianchi C. Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling. Cell Cycle 8: 1738-1746, 2009.
18. Inami Y, Yamashina S, Izumi K, Fukada H, Kon K, Ikejima K, Wantanabe S. Lipid accumulation inhibits induction of autophagy in the mouse liver (Abstract). Hepatology 50: 1168A, 2009.
19. Jia K, Levine B. Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy 3: 597-599, 2007. (Pubitemid 350060057)
20. Kaushik S, Massey AC, Cuervo AM. Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy. EMBO J 25: 3921-3933, 2006. (Pubitemid 44338735)
21. Martin S, Parton RG. Lipid droplets: a unified view of a dynamic organelle. Nat Rev Mol Cell Biol 7: 373-378, 2006.
22. Massey AC, Zhang C, Cuervo AM. Chaperone-mediated autophagy in aging and disease. Curr Top Dev Biol 73: 205-235, 2006.
23. Murphy DJ. The biogenesis and functions of lipid bodies in animals, plants and microorganisms. Prog Lipid Res 40: 325-438, 2001.
24. Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 293: E444-E452, 2007. (Pubitemid 47205086)
25. Ohsaki Y, Cheng J, Fujita A, Tokumoto T, Fujimoto T. Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B. Mol Biol Cell 17: 2674-2683, 2006. (Pubitemid 43825504)
26. Pan M, Maitin V, Parathath S, Andreo U, Lin SX, St Germain C, Yao Z, Maxfield FR, Williams KJ, Fisher EA. Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control. Proc Natl Acad Sci USA 105: 5862-5867, 2008. (Pubitemid 351758463)
27. Postic C, Magnuson MA. DNA excision in liver by an albumin-Cre transgene occurs progressively with age. Genesis 26: 149-150, 2000. (Pubitemid 30158104)
28. Shibata M, Yoshimura K, Furuya N, Koike M, Ueno T, Komatsu M, Arai H, Tanaka K, Kominami E, Uchiyama Y. The MAP1-LC3 conjugation system is involved in lipid droplet formation. Biochem Biophys Res Commun 382: 419-423, 2009.
29. Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo AM, Czaja MJ. Autophagy regulates lipid metabolism. Nature 458: 1131-1135, 2009.
30. Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK, Tang Y, Pessin JE, Schwartz GJ, Czaja MJ. Autophagy regulates adipose mass and differentiation in mice. J Clin Invest 119: 3329-3339, 2009.
31. Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, Bergmann O, Blomqvist L, Hoffstedt J, Naslund E, Britton T, Concha H, Hassan M, Ryden M, Frisen J, Arner P. Dynamics of fat cell turnover in humans. Nature 453: 783-787, 2008. (Pubitemid 351793777)
32. Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell 104: 531543, 2001.
33. Tolkovsky AM. New gene on the block: Atg32-A specific receptor for selective mitophagy in S. cerevisiae. Autophagy 104: 1077-1078, 2009.
34. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerback S, Nuutila P. Functional brown adipose tissue in healthy adults. N Engl J Med 360: 1518-1525, 2009.
35. Wang Y, Singh R, Massey AC, Kane SS, Kaushik S, Grant T, Xiang Y, Cuervo AM, Czaja MJ. Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus. J Biol Chem 283: 4766-4777, 2008.
36. Wu X, Sakata N, Dixon J, Ginsberg HN. Exogenous VLDL stimulates apolipoprotein B secretion from HepG2 cells by both pre- and post-translational mechanisms. J Lipid Res 35: 1200-1210, 1994. (Pubitemid 24209394)
37. Zechner R, Madeo F. Cell biology: another way to get rid of fat. Nature 458: 1118-1119, 2009.