Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: Influence of the chemical structure on retention and enantioselectivity

Journal of Pharmaceutical and Biomedical Analysis

Volumn 45, Issue 2, 2007, Pages 211-218

  Temporini, Caterina ^a   Calleri, Enrica ^a   Fracchiolla, Giuseppe ^b   Carbonara, Giuseppe ^b   Loiodice, Fulvio ^b   Lavecchia, Antonio ^c   Tortorella, Paolo ^b   Brusotti, Gloria ^a   Massolini, Gabriella ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF BARI   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Chiral HPLC; Enantiomeric discrimination; Molecular modelling; Monolithic PGA column

Indexed keywords

2 ARYLALKYL 2 ARYLOXYACETIC ACID; 2 ARYLOXYALKYL 2 ARYLOXYACETIC ACID; ACETIC ACID DERIVATIVE; ALKYL GROUP; PENICILLIN AMIDASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CHIRALITY; ENANTIOMER; ENANTIOSELECTIVITY; MOLECULAR MODEL; PRIORITY JOURNAL; RACEMIC MIXTURE; SYNTHESIS;

ACETIC ACID; BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTATIONAL BIOLOGY; ENZYMES, IMMOBILIZED; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PENICILLIN AMIDASE; PHOSPHATES; PROTEIN BINDING; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM;

EID: 34848905680     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.06.005     Document Type: Article

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