Thiazolidinone-peptide hybrids as dengue virus protease inhibitors with antiviral activity in cell culture

Journal of Medicinal Chemistry

Volumn 56, Issue 21, 2013, Pages 8389-8403

  Nitsche, Christoph ^a   Schreier, Verena N ^a   Behnam, Mira A M ^a   Kumar, Anil ^a   Bartenschlager, Ralf ^a   Klein, Christian D ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIVIRUS AGENT; OXYGEN; PEPTIDE; PROTEINASE INHIBITOR; RHODANINE; SULFUR; THIOHYDANTOIN DERIVATIVE;

AMINO ACID SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DENGUE VIRUS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; KNOEVENAGEL CONDENSATION; MEMBRANE PERMEABILITY; MOLECULAR MODEL; PEPTIDE SYNTHESIS; PROTEINASE INHIBITION; SOLID PHASE SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; CELL CULTURE TECHNIQUES; DENGUE VIRUS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDES; PROTEASE INHIBITORS; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES; TUMOR CELLS, CULTURED; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84887869847     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400828u     Document Type: Article

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