Privileged scaffolds or promiscuous binders: A comparative study on rhodanines and related heterocycles in medicinal chemistry

Journal of Medicinal Chemistry

Volumn 55, Issue 2, 2012, Pages 743-753

  Mendgen, Thomas ^a   Steuer, Christian ^a   Klein, Christian D ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; BACTERIAL ENZYME; EXOCYCLIC DOUBLE BOND; GLUTATHIONE; HYDANTOIN DERIVATIVE; METHIONYL AMINOPEPTIDASE; RHODANINE; SERINE PROTEINASE; THIOHYDANTOIN DERIVATIVE; THROMBIN; TRANSFERASE;

ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; CRYSTAL STRUCTURE; DENGUE VIRUS; DRUG SCREENING; DRUG SELECTIVITY; ELECTROPHILICITY; ENZYME INHIBITION; HYDROGEN BOND; MOLECULAR INTERACTION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HYDANTOINS; HYDROGEN BONDING; LIGANDS; METALLOPROTEASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; RHODANINE; SERINE PROTEASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES; TRANSFERASES;

EID: 84856383832     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201243p     Document Type: Article

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