Design and evaluation of substrate-based octapeptide and non substrate-based tetrapeptide inhibitors of dengue virus NS2B-NS3 proteases

Biochemical and Biophysical Research Communications

Volumn 434, Issue 4, 2013, Pages 767-772

  Prusis, Peteris ^a   Junaid, Muhammad ^a   Petrovska, Ramona ^a   Yahorava, Sviatlana ^a   Yahorau, Aleh ^a   Katzenmeier, Gerd ^b   Lapins, Maris ^a   Wikberg, Jarl E S ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

D optimal design; Dengue virus; Non substrate based; NS2B NS3 protease; Substrate based; Tetrapeptide inhibitor

Indexed keywords

NONSTRUCTURAL PROTEIN 2B; NONSTRUCTURAL PROTEIN 3; OCTAPEPTIDE; PROTEINASE INHIBITOR; TETRAPEPTIDE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CRYSTAL STRUCTURE; DENGUE VIRUS; DENGUE VIRUS 1; DENGUE VIRUS 2; DENGUE VIRUS 3; DENGUE VIRUS 4; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; MICHAELIS CONSTANT; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

DENGUE VIRUS;

EID: 84878175594     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.03.139     Document Type: Article

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