SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 24, 2011, Pages 7318-7337

Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases

(3) Nitsche, Christoph a Steuer, Christian a Klein, Christian D a

a UNIVERSITY OF HEIDELBERG (Germany)

Author keywords

Aldol condensation; Dengue virus; Flavivirin; Nitrile; NS2B NS3 protease; West Nile virus

Indexed keywords

2 ARYL 2 CYANOACRYLAMIDE DERIVATIVE; 2 CYANO 3 (2,4 DICHLOROPHENYL)ACRYLAMIDE; 2 CYANO 3 (3 HYDROXYPHENYL)ACRYLAMIDE; 2 CYANO 3 (3 METHOXYPHENYL)ACRYLAMIDE; 2 CYANO 3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDE; 2 CYANO 3 (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 2 CYANO 3 (4 FLUOROPHENYL)ACRYLAMIDE; 2 CYANO 3 (4 HYDROXYPHENYL) N (TETRAHYDROFURAN 2 YLMETHYL)ACRYLAMIDE; 2 CYANO 3 (4 HYDROXYPHENYL)ACRYLAMIDE; 2 CYANO 3 (4 ISOPROPYLPHENYL) N (PYRIDIN 2 YLMETHYL)ACRYLAMIDE; 2 CYANO 3 (4 ISOPROPYLPHENYL) N (TETRAHYDROFURAN 2 YLMETHYL)ACRYLAMIDE; 2 CYANO 3 (4 ISOPROPYLPHENYL)ACRYLAMIDE; 2 CYANO 3 (4 METHOXYPHENYL)ACRYLAMIDE; 2 CYANO 3 (4 METHYLPHENYL)ACRYLAMIDE; 2 CYANO 3 [4 (HYDROXYMETHYL)PHENYL]ACRYLAMIDE; 2 CYANO 3 PHENYLACRYLAMIDE; 2 CYANO N CYCLOPROPYL 3 (4 HYDROXYPHENYL)ACRYLAMIDE; 2 CYANO N CYCLOPROPYL 3 (4 ISOPROPYLPHENYL)ACRYLAMIDE; 3 (4 BROMOPHENYL) 2 CYANO N CYCLOPROPYLACRYLAMIDE; 3 (4 BROMOPHENYL) 2 CYANOACRYLAMIDE; 3 (4 HYDROXYPHENYL) 2 (MORPHOLIN 4 YLCARBONYL)ACRYLONITRILE; 3 (HYDROXYPHENYL) 2 [(4 METHYLPIPERAZIN 1 YL)CARBONYL]ACRYLONITRILE; AMIDE; APROTININ; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 2B; NONSTRUCTURAL PROTEIN 3; SERINE PROTEINASE INHIBITOR; THROMBIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIVIRAL SUSCEPTIBILITY; ARTICLE; COVALENT BOND; DENGUE VIRUS; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; WEST NILE FLAVIVIRUS;

ACRYLAMIDES; ANTIVIRAL AGENTS; DENGUE; DENGUE VIRUS; HUMANS; PEPTIDE HYDROLASES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; WEST NILE FEVER; WEST NILE VIRUS;

DENGUE VIRUS; WEST NILE VIRUS;

EID: 82255192015 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2011.10.061 Document Type: Article

Times cited : (96)

References (23)

1
- 10944252079
- J.S. Mackenzie, D.J. Gubler, and L.R. Petersen Nat. Med. 10 2004 S98
- (2004) Nat. Med. , vol.10 , pp. 98
- MacKenzie, J.S.¹ Gubler, D.J.² Petersen, L.R.³

2
- 53249121029
- J. Lescar, D.H. Luo, T. Xu, A. Sampath, S.P. Lim, B. Canard, and S.G. Vasudevan Antivir. Res. 80 2008 94
- (2008) Antivir. Res. , vol.80 , pp. 94
- Lescar, J.¹ Luo, D.H.² Xu, T.³ Sampath, A.⁴ Lim, S.P.⁵ Canard, B.⁶ Vasudevan, S.G.⁷

3
- 27744581672
- Z. Yin, S.J. Patel, W.-L. Wang, G. Wang, W.-L. Chan, K.R.R. Rao, J. Alam, D.A. Jeyaraj, X. Ngew, V. Patel, D. Beer, S.P. Lim, S.G. Vasudevan, and T.H. Keller Bioorg. Med. Chem. Lett. 16 2006 36
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 36
- Yin, Z.¹ Patel, S.J.² Wang, W.-L.³ Wang, G.⁴ Chan, W.-L.⁵ Rao, K.R.R.⁶ Alam, J.⁷ Jeyaraj, D.A.⁸ Ngew, X.⁹ Patel, V.¹⁰ Beer, D.¹¹ Lim, S.P.¹² Vasudevan, S.G.¹³ Keller, T.H.¹⁴

4
- 33745025763
- P. Erbel, N. Schiering, A. D'Arcy, M. Renatus, M. Kroemer, S.P. Lim, Z. Yin, T.H. Keller, S.G. Vasudevan, and U. Hommel Nat. Struct. Mol. Biol. 13 2006 372
- (2006) Nat. Struct. Mol. Biol. , vol.13 , pp. 372
- Erbel, P.¹ Schiering, N.² D'Arcy, A.³ Renatus, M.⁴ Kroemer, M.⁵ Lim, S.P.⁶ Yin, Z.⁷ Keller, T.H.⁸ Vasudevan, S.G.⁹ Hommel, U.¹⁰

5
- 80052859422
- A. Schüller, Z. Yin, C.S. Brian Chia, D.N.P. Doan, H.-K. Kim, L. Shang, T.P. Loh, J. Hill, and S.G. Vasudevan Antivir. Res. 92 2011 96
- (2011) Antivir. Res. , vol.92 , pp. 96
- Schüller, A.¹ Yin, Z.² Brian Chia, C.S.³ Doan, D.N.P.⁴ Kim, H.-K.⁵ Shang, L.⁶ Loh, T.P.⁷ Hill, J.⁸ Vasudevan, S.G.⁹

6
- 2642551603
- J. Adams, and M. Kauffman Cancer Invest. 22 2004 304
- (2004) Cancer Invest. , vol.22 , pp. 304
- Adams, J.¹ Kauffman, M.²

7
- 77952544197
- K. Peese Drug Discov. Today 15 2010 406
- (2010) Drug Discov. Today , vol.15 , pp. 406
- Peese, K.¹

8
- 70350061698
- D.R. Nelson Hepatology 50 2009 997
- (2009) Hepatology , vol.50 , pp. 997
- Nelson, D.R.¹

9
- 0037777695
- E.B. Villhauer, J.A. Brinkman, G.B. Naderi, B.F. Burkey, B.E. Dunning, K. Prasad, B.L. Mangold, M.E. Russell, and T.E. Hughes J. Med. Chem. 46 2003 2774
- (2003) J. Med. Chem. , vol.46 , pp. 2774
- Villhauer, E.B.¹ Brinkman, J.A.² Naderi, G.B.³ Burkey, B.F.⁴ Dunning, B.E.⁵ Prasad, K.⁶ Mangold, B.L.⁷ Russell, M.E.⁸ Hughes, T.E.⁹

10
- 46749153785
- Z.H. Pei Curr. Opin. Drug Discovery Dev. 11 2008 512
- (2008) Curr. Opin. Drug Discovery Dev. , vol.11 , pp. 512
- Pei, Z.H.¹

11
- 79959530775
- C. Steuer, C. Gege, W. Fischl, K.H. Heinonen, R. Bartenschlager, and C.D. Klein Bioorg. Med. Chem. 19 2011 4067
- (2011) Bioorg. Med. Chem. , vol.19 , pp. 4067
- Steuer, C.¹ Gege, C.² Fischl, W.³ Heinonen, K.H.⁴ Bartenschlager, R.⁵ Klein, C.D.⁶

12
- 0028068793
- Y. Tanaka, S. Niwa, H. Nishioka, T. Yamanaka, M. Torizuka, K. Yoshinaga, N. Kobayashi, Y. Ikeda, and H. Arai J. Med. Chem. 37 1994 2071
- (1994) J. Med. Chem. , vol.37 , pp. 2071
- Tanaka, Y.¹ Niwa, S.² Nishioka, H.³ Yamanaka, T.⁴ Torizuka, M.⁵ Yoshinaga, K.⁶ Kobayashi, N.⁷ Ikeda, Y.⁸ Arai, H.⁹

13
- 0028803516
- J.R. Li, E. Wilk, and S. Wilk Arch. Biochem. Biophys. 323 1995 148
- (1995) Arch. Biochem. Biophys. , vol.323 , pp. 148
- Li, J.R.¹ Wilk, E.² Wilk, S.³

14
- 0033533402
- T.E. Hughes, M.D. Mone, M.E. Russell, S.C. Weldon, and E.B. Villhauer Biochemistry 38 1999 11597
- (1999) Biochemistry , vol.38 , pp. 11597
- Hughes, T.E.¹ Mone, M.D.² Russell, M.E.³ Weldon, S.C.⁴ Villhauer, E.B.⁵

15
- 70349308429
- K. Wang, K. Nguyen, Y. Huang, and A. Dömling J. Comb. Chem. 11 2009 920
- (2009) J. Comb. Chem. , vol.11 , pp. 920
- Wang, K.¹ Nguyen, K.² Huang, Y.³ Dömling, A.⁴

16
- 84859216007
- CCDC-#848916 (3b) and #848917 (14) contain the supplementary crystallographic data for this article. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/ data-request/cif.

17
- 45649085054
- H. Xu, X.H. Yu, L.Y. Sun, J. Liu, W. Fan, Y.J. Shen, and W. Wang Tetrahedron Lett. 49 2008 4687
- (2008) Tetrahedron Lett. , vol.49 , pp. 4687
- Xu, H.¹ Yu, X.H.² Sun, L.Y.³ Liu, J.⁴ Fan, W.⁵ Shen, Y.J.⁶ Wang, W.⁷

18
- 20844435969
- H. Zhang, Q. Cai, and D.W. Ma J. Org. Chem. 70 2005 5164
- (2005) J. Org. Chem. , vol.70 , pp. 5164
- Zhang, H.¹ Cai, Q.² Ma, D.W.³

19
- 74049147097
- C. Steuer, K.H. Heinonen, L. Kattner, and C.D. Klein J. Biomol. Screen. 14 2009 1102
- (2009) J. Biomol. Screen. , vol.14 , pp. 1102
- Steuer, C.¹ Heinonen, K.H.² Kattner, L.³ Klein, C.D.⁴

20
- 78751620005
- S.M. Tomlinson, and S.J. Watowich Antivir. Res. 89 2011 127
- (2011) Antivir. Res. , vol.89 , pp. 127
- Tomlinson, S.M.¹ Watowich, S.J.²

21
- 70349782289
- C. Bodenreider, D. Beer, T.H. Keller, S. Sonntag, D.Y. Wen, L.J. Yap, Y.H. Yau, S.G. Shochat, D.Z. Huang, T. Zhou, A. Caflisch, X.C. Su, K. Ozawa, G. Otting, S.G. Vasudevan, J. Lescar, and S.P. Lim Anal. Biochem. 395 2009 195
- (2009) Anal. Biochem. , vol.395 , pp. 195
- Bodenreider, C.¹ Beer, D.² Keller, T.H.³ Sonntag, S.⁴ Wen, D.Y.⁵ Yap, L.J.⁶ Yau, Y.H.⁷ Shochat, S.G.⁸ Huang, D.Z.⁹ Zhou, T.¹⁰ Caflisch, A.¹¹ Su, X.C.¹² Ozawa, K.¹³ Otting, G.¹⁴ Vasudevan, S.G.¹⁵ Lescar, J.¹⁶ Lim, S.P.¹⁷

22
- 77950560159
- i/MW (kDa) according to
- i/MW (kDa) according to: E.J. Perola Med. Chem. 53 2010 2986
- (2010) Med. Chem. , vol.53 , pp. 2986
- Perola, E.J.¹

23
- 79959498239
- Diamond, S. L.; Thrombin 1536 HTS, PubChem Bio-Assay ID 1046. < http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=1046&loc=ea-ras >.
- Thrombin 1536 HTS, PubChem Bio-Assay ID 1046
- Diamond, S.L.¹

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.