Inhibition of dengue virus and west Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 3, 2012, Pages 1213-1221

  Tiew, Kok Chuan ^a   Dou, Dengfeng ^a   Teramoto, Tadahisa ^b   Lai, Huiguo ^b   Alliston, Kevin R ^a   Lushington, Gerald H ^c   Padmanabhan, R ^b   Groutas, William C ^a  

^a WICHITA STATE UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF KANSAS   (United States)

Author keywords

Click chemistry; Dengue virus; Inhibitor; Protease; West Nile virus

Indexed keywords

2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL] N (PROP 2 YNYL)ACETAMIDE; 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL] N [3 [[1 (3 PHENYLPROPYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY]PHENYL]ACETAMIDE; 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL] N [3 [[1 (PHENYLTHIOMETHYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY]PHENYL]ACETAMIDE; 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL] N [[1 (2 PHENOXYETHYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]ACETAMIDE; 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL] N [[1 (3 PHENYLPROPYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]ACETAMIDE; 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL] N [[1 (PHENYLTHIOMETHYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]ACETAMIDE; 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL] N [[1 PHENETHYL 1H 1,2,3 TRIAZOL 4 YL]METHYL]ACETAMIDE; 2 [4 [[2 (3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL)ACETAMIDO]METHYL] 1H 1,2,3 TRIAZOL 1 YL]ACETIC ACID; BENZ[D]ISOTHIAZOL 3(2H) ONE DERIVATIVE; DENGUE VIRUS PROTEASE; ENZYME INHIBITOR; METHYL 4 [[4 [[2 (3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL)ACETAMIDO]METHYL] 1H 1,2,3 TRIAZOL 1 YL]METHYL]BENZOIC ACID; METHYL 4 [[4 [[3 [2 (3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL)ACETAMIDO]PHENOXY]METHYL] 1H 1,2,3 TRIAZOL 1 YL]METHYL]BENZOIC ACID; N [(1 BENZYL 1H 1,2,3 TRIAZOL 4 YL)METHY] 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL]ACETAMIDE; N [3 [(1 BENZYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY]PHENYL] 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL]ACETAMIDE; N [3 [[1 (3 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY]PHENYL] 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL]ACETAMIDE; N [3 [[1 (4 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY]PHENYL] 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL]ACETAMIDE; N [3 [[1 (4 METHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY]PHENYL] 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL]ACETAMIDE; N [[1 (2 OXO 2 PHENYLETHYL) 1H 1,2,3 TRIAZOL 4 YL]METHY] 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL]ACETAMIDE; N [[1 (3 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHY] 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL]ACETAMIDE; N [[1 (4 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHY] 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL]ACETAMIDE; N [[1 (4 METHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHY] 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL]ACETAMIDE; N [[1 [2 OXO 2 (2 PHENOXYPHENYLAMINO)ETHYL] 1H 1,2,3 TRIAZOL 4 YL]METHY] 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL]ACETAMIDE; N [[1 [2 OXO 2 (3 PHENOXYPHENYLAMINO)ETHYL] 1H 1,2,3 TRIAZOL 4 YL]METHY] 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL]ACETAMIDE; N [[1 [2 OXO 2 (4 PHENOXYPHENYLAMINO)ETHYL] 1H 1,2,3 TRIAZOL 4 YL]METHY] 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL]ACETAMIDE; N [[1 [2 OXO 2 (PHENYLAMINO)ETHYL] 1H 1,2,3 TRIAZOL 4 YL]METHY] 2 [3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL]ACETAMIDE; TERT BUTYL 2 [4 [[2 (3 OXOBENZO[D]ISOTHIAZOL 2(3H) YL)ACETAMIDO]METHYL] 1H 1,2,3 TRIAZOL 1 YL]ACETIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS ENZYME; WEST NILE VIRUS PROTEASE;

ARTICLE; CHEMICAL REACTION; CLICK CHEMISTRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENGUE VIRUS; DRUG BINDING; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME PURIFICATION; ENZYME SUBSTRATE COMPLEX; HYDROPHOBICITY; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR LIBRARY; MOLECULAR WEIGHT; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; WEST NILE FLAVIVIRUS;

ANTIVIRAL AGENTS; CLICK CHEMISTRY; DENGUE; DENGUE VIRUS; HUMANS; MODELS, MOLECULAR; PEPTIDE HYDROLASES; PROTEASE INHIBITORS; THIAZOLES; WEST NILE FEVER; WEST NILE VIRUS;

DENGUE VIRUS; WEST NILE VIRUS;

EID: 84856213045     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.12.047     Document Type: Article

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