On the Role of Aggregation Prone Regions in Protein Evolution, Stability, and Enzymatic Catalysis: Insights from Diverse Analyses

PLoS Computational Biology

Volumn 9, Issue 10, 2013, Pages

  Buck, Patrick M ^a   Kumar, Sandeep ^a   Singh, Satish K ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT PROTEINS;

AGGREGATION PROPENSITY; CATALYTIC RESIDUE; COMPREHENSIVE ANALYSIS; ENZYMATIC CATALYSIS; EVOLUTION STABILITY; MONOMERIC PROTEINS; NON-REDUNDANT; PROTEIN EVOLUTION; REDUNDANT DATASETS; SEQUENCE IDENTITY;

AMINO ACIDS;

RECOMBINANT PROTEIN;

AGGREGATION PRONE REGION; AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; GENETIC CONSERVATION; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN DEFECT; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; SOLUBILITY; STRUCTURE ACTIVITY RELATION;

DATABASES, PROTEIN; EVOLUTION, MOLECULAR; MODELS, MOLECULAR; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PROTEINS; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84887315193     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003291     Document Type: Article

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