Insights into the potential aggregation liabilities of the b12 Fab fragment via elevated temperature molecular dynamics

Protein Engineering, Design and Selection

Volumn 26, Issue 3, 2013, Pages 195-206

  Buck, Patrick M ^a   Kumar, Sandeep ^a   Singh, Satish K ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

aggregation prone regions; biotherapeutics; monoclonal antibodies

Indexed keywords

ASSOCIATION REACTIONS; DEFORMATION; MOLECULAR DYNAMICS; SOLVENTS;

AGGREGATION-PRONE REGION; ANTIBODY THERAPEUTICS; ANTIGEN BINDING; BETA-STRAND; BIOTHERAPEUTICS; DYNAMICS SIMULATION; ELEVATED TEMPERATURE; FORMULATION DEVELOPMENT; SOLVENT EXPOSURE; STABILITY STUDY;

MONOCLONAL ANTIBODIES;

CYANOCOBALAMIN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G1 ANTIBODY;

AMINO ACID SEQUENCE; ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; HEAT STRESS; HIGH TEMPERATURE; HUMAN; MOLECULAR DYNAMICS; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN STABILITY; STRUCTURE ANALYSIS; TEMPERATURE MEASUREMENT; TEMPERATURE STRESS;

EID: 84874269499     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzs099     Document Type: Article

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