The distribution of ligand-binding pockets around protein-protein interfaces suggests a general mechanism for pocket formation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 10, 2012, Pages 3784-3789

  Gao, Mu ^a   Skolnick, Jeffrey ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Packing; Promiscuous interaction; Protein structural evolution

Indexed keywords

AMINO ACID; SOLVENT;

ARTICLE; CONTROLLED STUDY; HUMAN; LIGAND BINDING; MOLECULAR LIBRARY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STRUCTURE; RANDOMIZED CONTROLLED TRIAL; SURFACE PROPERTY;

ALGORITHMS; ANIMALS; COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; DIMERIZATION; HUMANS; LIGANDS; MODELS, MOLECULAR; MODELS, STATISTICAL; MOLECULAR CONFORMATION; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEINS;

EID: 84857983099     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1117768109     Document Type: Article

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