Potential aggregation-prone regions in complementarity-determining regions of antibodies and their contribution towards antigen recognition: A computational analysis

Pharmaceutical Research

Volumn 27, Issue 8, 2010, Pages 1512-1529

  Wang, Xiaoling ^a   Singh, Satish K ^a   Kumar, Sandeep ^a  

^a PFIZER INC   (United States)

Author keywords

biotherapeutics; drug development; fab antigen interface; monoclonal antibody; structure

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; ANTIGEN ANTIBODY COMPLEX; COMPLEMENTARITY DETERMINING REGION; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY; PROTEIN BINDING;

AGGREGATION PRONE REGION; ANTIBODY COMBINING SITE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BETA SHEET; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; CRYSTAL STRUCTURE; IMMUNOGLOBULIN STRUCTURE; PRIORITY JOURNAL; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; COMPUTER SIMULATION; DRUG DESIGN; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY COMPLEX; COMPLEMENTARITY DETERMINING REGIONS; COMPUTER SIMULATION; DRUG DESIGN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; SEQUENCE ALIGNMENT;

EID: 77955467854     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0143-5     Document Type: Article

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