Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

Nature

Volumn 385, Issue 6619, 1997, Pages 787-793

  Booth, David R ^a   Sunde, Margaret ^b   Bellotti, Vittorio ^a,d   Robinson, Carol V ^b   Hutchinson, Winston L ^a   Fraser, Paul E ^c   Hawkins, Philip N ^a   Dobson, Christopher M ^b   Radford, Sheena E ^b,d,e   Blake, Colin C F ^b   Pepys, Mark B ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF PAVIA   (Italy)

^e UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; DEUTERIUM; LYSOZYME;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL CELL; ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN STABILITY; THERMOSTABILITY;

AMYLOID; AMYLOIDOSIS; CIRCULAR DICHROISM; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; HEAT; HUMANS; LIVER DISEASES; MODELS, MOLECULAR; MURAMIDASE; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS;

EID: 0031056829     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/385787a0     Document Type: Article

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