Chemistry and Implications of Antinutritional Factors in Dry Beans and Pulses

Dry Beans and Pulses Production, Processing and Nutrition

Volumn , Issue , 2012, Pages 359-377

  Sathe, Shridhar K ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

Author keywords

Allergy; Antinutritional factors; Dry beans; Enzyme inhibitors; Health benefits; Phenolic compounds; Phytate; Proteins; Saponins

Indexed keywords

EID: 84887243262     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118448298.ch15     Document Type: Chapter

References (113)

1. Alonso R, Orúe E, Marzo F. 1998. Effects of extrusion and conventional processing methods on protein an antinutritional factor contents in pea seeds. Food Chem 63: 505-12.
2. Aparicio-Fernández X, Reynoso Camacho R, Castaño-Tostado E, García-Gasca T, de Mejía EG, Guzmán-Maldonado SH, Elizondo G, Yousef GG, Lila MA, Loarca-Pine G. 2008. Antiradical capacity and induction of apoptosis on HeLa cells by a Phaseolus vulgaris extract. Plant Food Hum Nutr 63: 35-40.
3. Augustin JM, Kuzina V, Andersen SB, Bak S. 2011. Molecular activities, biosynthesis and evolution of triterpenoid saponins. Phytochem 72: 435-57.
4. Ballabio C, Magni C, Restani P, Mottini M, Fiocchi A, Tedeschi G, Duranti M. 2010. IgE-mediated crossreactivity among leguminous seed proteins in peanut allergic children. Plant Foods Human Nutr 65: 396-402.
5. Ballhorn DJ, Kautz S, Heil M, Hegeman AD. 2009. Cyanogenesis of wild lima bean (Phaseolus lunatus L.) is an efficient direct defence in nature. PLoS One 4(5): e5450. doi:10.1371/journal.pone.0005450.
6. Barrett ML, Udani JK. 2011. A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris): A review of clinical studies on weight loss and glycemic control. Nutr J 10: 24.
7. Benninger CW, Hosfield GL. 2003. Antioxidant activity of extracts, condensed tannin fractions, and pure flavonoids from Phaseolus vulgaris L. seed coat color genotypes. J Agric Food Chem 51: 7879-83.
8. Bernal J, Mendiola JA, Ibáñez E, Cifuentes A. 2011. Advanced analysis of neutraceuticals. J Pharm Biomed Analysis 55: 758-74.
9. Berridge MJ. 1993. Inositol trisphosphate and calcium signalling. Nature 361: 315-25.
10. Berridge MJ. 2005. Unlocking the secrets of cell signaling. Ann Rev Physiol 67: 1-21.
11. Berridge MJ. 2011. Calcium signaling and Alzheimer's disease. Neurochem Res 36: 1149-56.
12. Berridge MJ, Irvine RF. 1984. Inositol triphosphate, a novel 2nd messenger in cellular signal transduction. Nature 312: 315-21.
13. Bhat R, Karim AA. 2009. Exploring the nutritional potential of wild and underutilized legumes. Comp Rev Food Sci Food Safety 8: 305-31.
14. Birt D, Hendrich S, Wang Q. 2001. Dietary agents in cancer prevention: Flavonoids and isoflavonoids. Pharmacol Therapeutics 90: 157-77.
15. Botta B, Menendez P, Zappia G, de Lima RA, Torge R, Monache GD. 2009. Prenylated isoflavonoids: Botanical distribution, structures, biological activities and biotechnological studies, an update (1995-2006). Curr Med Chem 16: 3414-68.
16. Bradacs G, Heilmann J, Weckerle CS. 2011. Medicinal plant use in Vanuatu: A comprehensive ethnobotanical study of three islands. J Ethnopharmacol 137: 434-48.
17. Brieteneder H, Mills ENC. 2005. Plant food allergens-Structural and functional aspects of allergenicity. Biotechnol Adv 23: 395-99.
18. Campbell PM, Reiner D, Moore AE, Lee R, Epstein MM, Higgins TJV. 2011. Comparison of the α-amylase inhibitor-1 from common bean (Phaseolus vulgaris) varieties and transgenic expression in other legumes-post-translational modifications and immunogenicity. J Agric Food Chem 59: 6047-54.
19. Chung SY, Champagne ET. 2007. Effects of phytic acid on peanut allergens and allergenic properties of extract. J Agric Food Chem 55: 9054-58.
20. Cook NC, Samman S. 1996. Flavonoids-Chemistry, metabolism, cardioprotective effects and dietary sources. J Nutr Biochem 7: 66-76.
21. Cornforth DP. 2002. Potential use of phytate as an antioxidant in cooked meats. In: Reddy NR, Sathe SK, editors. Food Phytates. Boca Raton, FL: CRC Press. p 199-209.
22. D'Addabbo T, Carbonara T, Leonetti P, Radicci V, Tava A, Avato P. 2011. Control of plant parasitic nematodes with active saponins and biomass from Medicago sativa. Phytochem Res 10: 503-19.
23. Deshpande SS. 1992. Food legumes in human nutrition: A personal perspective. Rev Food Sci Nutr 32: 333-63.
24. Deshpande SS, Campbell CG. 1992. Genotype variation in BOAA, condensed tannins, phenolics and enzyme inhibitors of grass pea (Lathyrus sativus). Can J Plant Sci 72: 1037-47.
25. Deshpande SS, Nielsen SS. 1987. In vitro digestibility of dry bean (Phaseolus vulgaris L.) proteins: The role of heat stable protease inhibitors. J Food Sci 52: 1330-34.
26. Deshpande SS, Sathe SK. 1991. Toxicants in plants. In: Sharma RP, Salunkhe DK, editors. Mycotoxins and Phytoalexins. Boca Raton, FL: CRC Press, Inc. p 671-730.
27. Deshpande SS, Sathe SK, Salunkhe DK, Cornforth DP. 1982. Effects of dehulling on phytic acid, polyphenols and enzyme inhibitors of dry bean (Phaseolus vulgaris L.). J Food Sci 47: 1846-50.
28. Dixon RA, Ferreira D. 2002. Genistein. Phytochem 60: 205-11.
29. Dixon RA, Sumner LW. 2003. Legume natural products: Understanding and manipulating complex pathways for human and animal health. Plant Physiol 131: 878-85.
30. Dunwell JM, Culham A, Carter CE, Sosa-Aguirre CR, Goodenough PW. 2001. Evolution of functional diversity in the cupin superfamily. Trends Biochem Sci 26: 740-46.
31. Duranti M, Gius C. 1997. Legume seeds: Protein content and nutritional value. Field Crops Res 53: 31-45.
32. Foskett JK, White C, Cheung KH, Mak DOD. 2007. Inositol triphosphate receptor Ca2+ release channels. Physiol Rev 87: 593-658.
33. Gimeno PM, Brito FF, Iglesias AM, Vega M, Martinez PB. 2007. Allergic reaction caused by a new hidden food, broad bean flour. Allergy 62: 1340-41.
34. Gomes VM, Okorkov LA, Rose TL, Fernandes KVS, Xavier-Filho J. 1998. Legume vicilins (7S storage globulins) inhibit yeast growth and glucose stimulated acidification of the medium by yeast cells. Biochim Biophys Acta 1379: 207-16.
35. Guillamón E, Pedrosa MC, Burbano C, Cuadrado C, Sánchez MC, Muzquiz M. 2008. The trypsin inhibitors present in seed of different grain legume species and cultivar. Food Chem 107: 68-74.
36. Gurfinkel DM, Rao AV. 2002. Determination of saponins in legumes by direct densitometry. J Agric Food Chem 50: 426-30.
37. Holzhauser T, Wackermann O, Ballmer-Weber B, Bindslev-Jensen C, Scibilia J, Perono Groffo L, Utsumi S, Poulsen LK, Vieths S. 2009. Soybean (Glycine max) allergy in Europe: Gly m 5 (β-conglycinin) and Gly m 6 (glycinin) are potential diagnostic markers for severe allergic reactions to soy. J Allergy Clin Immunol 123: 452-8.
38. Jackman KA, Woodman OL, Sobey CG. 2007. Isoflavones, equol and cardiovascular disease: Pharmacological and therapeutic insights. Curr Medicinal Chem 14: 2824-30.
39. Jenab M, Thompson LU. 2002. Role of phytic acid in cancer and other diseases. In: Reddy NR, Sathe SK, editors. Food Phytates. Boca Raton, FL: CRC Press. p 225-58.
40. Jeng TLJ, Shih YJ, Lai CC, Wu MT, Sung JM. 2010. Anti-oxidative characterization of NaN3-induced common bean mutants. Food Chem 119: 1006-11.
41. Karadeniz A, Erdogan N, Genç H, Emre I. 2010. ODAP levels in Lathyrus species distributed on Burdur-Isparta provinces in Turkey. Gen Res Crop Evol 57: 1121-26.
42. Khattab RY, Arntfield SD. 2009. Nutritional quality of legume seeds as affected by some physical treatments 2. Antinutritional factors. LWT-Food Sci Technol 42: 1113-18.
43. Khokhar S, Chauhan BM. 1986. Antinutritional factors in moth bean: Varietal differences and effects of methods of domestic processing and cooking. J Food Sci 51: 591-594.
44. Kon S, Sanshuck DW. 1981. Phytate content and its effect of cooking quality of beans. J Food Process Preserv 5: 169-78.
45. Krishnan HB, Kim WS, Jang S, Kerley MS. 2009. All three subunits of soybean β conglycinin are potential food allergens. J Agric Food Chem 57: 938-43.
46. Kuhnle GGC, Ward HA, Vogiatzoglou A, Luben RN, Mulligan A, Wareham NJ, Forouhi N, Khaw KT. 2011. Association between dietary phyto-estrogens and bone density in men and menopausal women. Brit J Nutr 106: 1063-9.
47. Kumar V, Sinha AK, Makkar HPS, Becker K. 2010. Dietary roles of phytate and phytase in human nutrition: A review. Food Chem 120: 945-59.
48. Lee SH, Jin N, Paik DJ, Kim DY, Chung IM, Park Y. 2011. Consumption of legumes improves certain bone markers in ovariectomized rats. Nutr Res 31: 397-403.
49. Leterme P. 2002. Recommendations by health organizations for pulse consumption. Brit J Nutr 88 (Suppl 3): S239-42.
50. Li M, Wang HX, Ng TB. 2011. An antifungal peptide with proliferative activity toward tumor cells from red kidney beans. Prot Peptide Letts 18: 594-600.
51. Liener IE. 1979. Significance for humans of biologically active factors in soybeans and other food legumes. J Oil Chem Soc 56: 121-29.
52. Liener IE. 1981. Factors affecting nutritional quality of soy products. J Oil Chem Soc 58: 406-15.
53. Liener IE. 1982. Toxic constituents in legumes. In: Arora SK, editor. Chemistry and Biochemistry of Legumes. New Delhi, India: Oxford & IBH Publishing Co. p 217-57.
54. Lin PY, Lai HM. 2006. Bioactive compounds in legumes and their germinated products. J Agric Food Chem 54: 3807-14.
55. Linderoth A, Biernat M, Prykhodko O, Kornilovska I, Pusztai A, Pierzynowski SG, Björn WR. 2005. Induced growth and maturation of the gastrointestinal tract after Phaseolus vulgaris lectin exposure in suckling rats. J Ped Gastroenterol Nutr 41: 195-203.
56. López-Torrejón G, Salcedo G, Martín-Esteban M, Díaz-Perales A, Pascual CY, Sanchez Monge R. 2003. Len c1, a major allergen and vicilin from lentil seeds: Protein isolation and cDNA cloning. J Allergy Clin Immunol 112: 1208-15.
57. Lott JNA, Ockenden I, Raboy V, Batten GD. 2000. Phytic acid and phosphorous in crop seeds and fruits: A global estimate. Seed Sci Res 10: 11-33.
58. Lule SU, Xia W. 2005. Food phenolics, pros and cons: A review. Food Res Intl 21: 367-88.
59. Madhujith T, Naczk M, Shahidi F. 2004. Antioxidant activity of common beans (Phaseolus vulgaris L.). J Food Lipids 11: 220-33.
60. Mandic A, Hansson J, Linder S, Shoshan MC. 2003. Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J Biol Chem 278: 9100-06.
61. Marathe S, Rajalakshmi V, Jamdar SN, Sharma A. 2011. Comparative study on antioxidant activity of different varieties of commonly consumed legumes in India. Food Chem Toxicol 49: 2005-12.
62. Mazur W. 1998. Phytoestrogen content in foods. Baillière's Clin Endocrinol Metab 12: 729-42.
63. Mills ENC, Mackie AR. 2008. The impact of processing on allergenicity of food. Curr Opin Allergy Clin Immunol 8: 249-53.
64. Misra A, Kumar R, Mishra V, Chaudhari BP, Raisuddin S, Das M, Dwivedi PD. 2011. Potential allergens of green gram (Vigna radiata L. Millsp) identified as members of cupin superfamily and seed albumin. Clin Exp Allergy 41: 1157-68.
65. Naoumkina MA, Modolo LV, Huhman DV, Urbanczyk-Wochniak E, Tang Y, Sumner LW, Dixon RA. 2010. Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago trucatula. Plant Cell 22: 850-66.
66. NRC [National Research Council]. 1979. Tropical Legumes: Resources for the Future. Washington, DC: National Academy of Sciences. 332 p.
67. Oomah BD, Luc G, Leprelle C, Drover JCG, Harrison JE, Olson M. 2011. Phenolics, phytic acid, and phytase in Canadian-grown low-tannin faba bean (Vicia faba L.) genotypes. J Agric Food Chem 59: 3763-71.
68. Ososki AL, Kennelly EJ. 2003. Phytoestrogens: A review of the present state of research. Phytotherapy Research 17: 845-69.
69. Pase MP, Grima N, Sarris J. 2011. The effects of dietary and nutrient interventions on arterial stiffness: A systematic review. Amer J Clin Nutr 93: 446-54.
70. Prasad S, Phromnoi K, Yadav VR, Chturvedi MM, Aggrawal BB. 2010. Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer. Planta Med 76: 1044-63.
71. Price KR, Johnson IT, Fenwick GR. 1987. The chemistry and biological significance of saponins in food and feeding stuffs. CRC Crit Rev Food Sci Nutr 26: 27-135.
72. Rayas-Duarte P, Bergeron D, Nielsen SS. 1992. Screening of heat stable trypsin inihibitors in dry beans and their partial purification from Great Northern beans (Phaseolus vulgaris L.) using anhydrotrypsinsepharose affinity chromatography. J Agric Food Chem 40: 32-42.
73. Reddy NR, Pierson MD, Sathe SK, Salunkhe DK. 1985. Dry bean tannins: A review of nutritional implications. J Am Oil Chem Soc 62: 541-9.
74. Reddy NR, Sathe SK, Salunkhe DK. 1982. Phytate in legumes and cereals. Adv Food Res 28: 1-91.
75. Rochfort S, Ezernieks V, Neumann N, Panozzo J. 2011. Pulses for human health: Changes in isoflavone and saponin content with preparation and cooking. Aust J Chem 64: 790-7.
76. Rochfort S, Panozzo J. 2007. Phytochemicals for health, the role of pulses. J Agric Food Chem 55: 7981-94.
77. Rougé P, Culerrier R, Granier C, Rancé F, Barre A. 2010. Characterization of IgE-binding epitopes of peanut (Arachis hypogaea) PNA lectin allergen cross-reacting with other structurally related legume lectins. Mol Immunol 47: 2359-66.
78. Rougé P, Culerrier R, Thibau F, Didier A, Barre A. 2011. A case of severe anaphylaxis to kidney bean: phaseolin (vicilin) and PHA (lectin) identified as putative allergens. Allergy 66: 301-02.
79. Roy F, Boye JI, Simpson BK. 2010. Bioactive proteins and peptides in pulse crops: Pea, chickpea, and lentil. Food Res Intl 43: 432-42.
80. Rozan P, Kuo Y-H, Lambein F. 2000. Free amino acids present in commercially available seedlings sold for human consumption. A potential hazard for consumers. J Agric Food Chem 48: 716-23.
81. Salgado P, Freire JB, Ferreira RB, Seabra M, Teixeira AR, Toullec R, Lallès JP. 2002. Legume proteins of the vicilin family are more immunogenic than those of the legumin family in weaned piglets. Food Agric Immunol 14: 51-63.
82. Sanchez-Monge R, Lopez-Torrejón G, Pascual CY, Varela J, Martin-Esteban M, Salcedo G. 2004. Vicilin and convicilin are potential major allergens from pea. Clin Exp Allergy 34: 1747-53.
83. Sarwar M, Attitalla IH, Abdollahi M. 2011. A review on the recent advances in pharmacological studies on medicinal plants: Animal studies are done but clinical studies needs completing. Asian J Anim Vet Adv 6: 867-83.
84. Sathe SK, Reddy NR. 2002. Introduction. In: Reddy NR, Sathe SK, editors. Food Phytates. Boca Raton, FL: CRC Press. p 1-5.
85. Sathe SK, Salunkhe DK. 1981. Studies on trypsin and chymotrypsin inhibitory activities, hemagglutinating activity, and sugars in the Great Northern beans (Phaseolus vulgaris L.). J Food Sci 46: 626-29.
86. Sell M, Steinhart H, Paschke A. 2005. Influence of maturation on the alteration of allergenicity of green pea (Pisum sativum L.). J Agric Food Chem 53: 1717-22.
87. Serrano J, Puupponen-Pimiä R, Dauer A, Aura A-M, Saura-Calixto F. 2009. Review: Tannins: Current knowledge of food sources, intake, bioavailability and biological effects. Mol Nutr Food Res 53: S310-29.
88. Shi J, Arunasalam K, Yeung D, Kakuda Y, Mittal G, Jiang YM. 2004. Saponins from edible legumes: Chemistry, processing, and health benefits. J Med Food 7: 67-78.
89. Shimelis EA, Rakshit SK. 2007. Effect of processing on antinutrients and in vitro protein digestibility of kidney bean (Phaseolus vulgaris L.) varieties grown in East Africa. Food Chem 103: 163-72.
90. Shimelis EA, Rakshit SK. 2008. Influence of natural and controlled fermentations on α-galactosides, antinutrients and protein digestibility of beans (Phaseolus vulgaris L.). Intl J Food Sci Technol 43: 658-65.
91. Sirtori CR, Arnoldi A, Johnson SK. 2005. Phytoestrogens: End of a tale? Ann Medicine 37: 423-38.
92. Sreerama YN, Sashikala VB, Pratape VM, Singh V. 2012. Nutrients and antinutrients in cowpea and horse gram flours in comparison to chickpea flour: Evaluation of their flour functionality. Food Chem 131: 462-68.
93. Suzuki T, Nishioka T, Ishizuka S, Hara H. 2010. A novel mechanism underlying phytate-mediated biological action-phytate hydrolysates induce intracellular calcium signaling intracellular calcium signaling by a Gαq protein-coupled receptor and phospholipase C-dependent mechanism in colorectal cancer. Mol Nutr Food Res 54: 947-55.
94. Szkudelska, K, Nogowski, L. 2007. Genistein-A dietary compound inducing hormonal and metabolic changes. J Steroid Biochem Mol Biol 105: 37-45.
95. Thompson LU. 1993. Potential health benefits and problems associated with antinutrients in food. Food Res Intl 26: 131-9.
96. Udedibie ABI, Carlini CR. 1998. Questions and answers to edibility problem of the Canavalis ensiformis seeds - A review. Anim Feed Sci Technol 74: 95-106.
97. Urbano G, Lopez-Jurado PA, Vidal-Valverde ET, Porres J. 2000. The role of phytic acid in legumes: Antinutrient or beneficial function? J Physiol Biochem 56: 283-94.
98. Valluru R, Ven den Ende W. 2011. Myo-inositol and beyond - Emerging networks under stress. Plant Sci 181: 387-400.
99. Valdes ST, Medeiros CCM, Michelluti DJ, Tramonte VLCG. 2011. Association of genotype and preparation methods on the antioxidant activity, and antinutrients in common beans (Phaseolus vulgaris L.). LWT-Food Sci Technol 44: 2104-11.
100. Vadivel V, Biesalski HK. 2011. Contribution of phenolic compounds to the antioxidantpotential and type II diabetes related enzyme inhibition properties of Pongamia pinnata L. Pierre seeds. Proc Biochem 46: 1973-80.
101. Vadivel V, Stuetz W, Scherbaum V, Biesalski HK. 2011. Total free phenolic content and health relevant functionality of Indian wild legume grains: Effects of indigenous processing methods. J Food Comp Anal 24: 935-43.
102. Vereda A, Andreae DA, Lin J, Schreffler WG, Ibañez MD, Cuesta-Herranz J, Bardina L, Sampson HA. 2010. Identification of IgE sequential epitopes of lentil (Len c1) by means of peptide microarray immunoassay. J Allergy Clin Immunol 126: 596-601.
103. Vetter J. 2000. Plant cyanogenic glycosides. Toxicon 38: 11-36.
104. Virk-Baker MK, Nagy TR, Barnes S. 2010. Role of phytoestrogens in cancer therapy. Plant Med 76: 1132-42.
105. Visioli F. 2011. Nutritional support in the pharmacological treatment of metabolic syndrome. Euro J Pharmacol 668(Suppl. 1): S43-9.
106. Vucenik I, Stains J. 2010. Cancer preventive and therapeutic properties of IP(6): Efficacy and mechanisms. Periodicum Biol 112: 451-8.
107. Wahl O, Oswald M, Tretzel L, Herres E, Arend J, Efferth T. 2011. Inhibition of tumor angiogenesis by antibodies, synthetic small molecules and natural products. Curr Med Chem 18: 3136-55.
108. Wang N, Hatcher DW, Toews R, Gawalko EJ. 2009. Influence of cooking and dehulling on nutritional composition of several varieties of lentils (Lens culinaris). LWT-Food Sci Technol 42: 842-48.
109. Wang N, Hatcher DW, Tyler RT, Toews R, Gawalko EJ. 2010. Effect of cooking on the composition of beans (Phaseolus vulgaris L.) and chickpeas (Cicer arietinum L.). Food Res Intl 43: 589-94.
110. Wang S, Rao P. 2010. A leguminous trypsin-chymotrypsin inhibitor Limenin with antifungal activity from Phaseolus limensis. Euro Food Res Technol 231: 331-38.
111. Wiryawan KG, Dingle JG. 1999. Review: Recent research on improving the quality of grain legumes for chicken growth. Anim Feed Sci Technol 76: 185-93.
112. Xu B, Chang SKC. 2011. Reduction of antiproliferative capacities, cell-based antioxidant capacities and phytochemical contents of common beans and soybeans upon thermal processing. Food Chem 129: 974-81.
113. Xu BJ, Chang SKC. 2009. Phytochemical profiles and health-promoting effects of cool-season food legumes as influenced by thermal processing. J Agric Food Chem 57: 10718-31.