Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation

Gut

Volumn 39, Issue 2, 1996, Pages 284-290

  Pender, S L F ^a   Lionetti, P ^a   Murch, S H ^a   Wathan, N ^a   MacDonald, T T ^a,b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Lamina propria; Matrix; Proteinase; T cell

Indexed keywords

ALPHA 2 MACROGLOBULIN; DEXAMETHASONE; POKEWEED MITOGEN; PROTEINASE; PROTEOGLYCAN;

ARTICLE; CONCENTRATION RESPONSE; EXTRACELLULAR MATRIX; FETUS; HUMAN; HUMAN TISSUE; INTESTINE INJURY; LAMINA PROPRIA; PRIORITY JOURNAL; PROTEIN DEGRADATION; T LYMPHOCYTE ACTIVATION;

EID: 0029814859     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.39.2.284     Document Type: Article

References (53)

1. Malizia G, Trejdosiewicz LK, Wood GM, Howdle PD, Janossy G, Losowsky MS. The microenvironment of coeliac disease: T cell phenotypes and expression of the T2 'T blast' antigen by small bowel lymphocytes. Clin Exp Immunol 1985; 60: 437-46.
2. Halstensen TS, Brandtzaeg P. Activated T lymphocytes in the celiac lesion: non-proliferative activation (CD25) of CD4+ α/β cells in the lamina propira but proliferation (Ki-67) of α/β and γδ cells in the epithelium. Eur J Immunol 1993; 23: 505-10.
3. Lundin KEA, Scott H, Hansen T, Paulsen G, Halstensen TS, Fausa O, et al. Gliadin-specific, HLA-DQ (α1*0501,β1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 1993; 178: 187-95.
4. Nilssen E, Lundin KEA, Krajci P, Scott H, Sollid L, Brandtzaeg P. Gluten-specific HIA-DQ restricted T cells from coeliac mucosa produce cytokines with a Th1 or TH0 profile dominated by interferon-γ. Scand Immunol 1994; 40: 711.
5. Kontakou M, Sturgess R, Premioslo R, Limb G, Nelufer J, Ciclitira P. Detection of interferon-gamma mRNA in the mucosa of patients with coeliac disease by in situ hybridisation. Gut 1994; 35: 1398-405.
6. Breese EJ, Farthing MJG, Kumar P, MacDonald TT. Interleukin-2 and interferon-gamma producing cells in the lamina propria in coeliac disease. Dig Dis Sci 1994; 39: 2243.
7. Choy M-Y, Richman PI, Walker-Smith JA, MacDonald TT. Differential expression of CD25 (Inetrleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis. Gut 1990; 31: 1365-70.
8. Mullin GE, Lazenby AJ, Harris ML, Bayless TM, James SP. Increased intcrleukin-2 mRNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis. Gastroenterology 1992; 102: 1620-7.
9. Fais S, Capobianchi MR, Pallone F, Di Marco P, Boirivant M, Dianzani F, et al. Spontaneous release of interferongamma by intestinal lamina propria lymphocytes in Crohn's disease: Kinetics of in vitro response to interferon-gamma inducers. Gut 1991; 32: 403-7.
10. Breese EM, Braegger CP, Corrigan CP, Walker-Smith JA, MacDonald TT. Lymphokine secreting cells in the intestinal mucosa in inflammatory bowel disease. Immunology 1993; 78: 127-31.
11. Stronkhorst A, Tytgat GNJ, VanDeventer SJH. CD4 antibody treatment in Crohn's disease. Scand J Immunol 1992; 27 (suppl 194): 61-5.
12. Guy-Grand D, Vassalli P. Gut injury in mouse graft-versus-host disease. Study of its occurrence and mechanisms. J Clin Invest 1986; 77: 1584-95.
13. hi CD4+ T cells. Immunity 1994; 1: 553-62.
14. Rudolphi A, Boll G, Poulsen SS, Claesson MH, Reimann J. Gut homing CD4+ T cell receptor αβ+ T cells in the pathogenesis of murine inflammatory bowel disease. Eur J Immunol 1994; 24: 2803-12.
15. MacDonald TT. Inflammatory bowel disease in knock-out mice. Current Biology 1994; 4: 261-3.
16. MacDonald TT, Spencer J. Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. J Exp Med 1988; 167: 1341-9.
17. Lionetti P, Breese EJ, Spencer J, Braegger CP, Murch SH, Taylor J, et al. Activation of Vβ3+ T cells and tissue damage in human small intestine induced by the bacterial superantigen, Staphylococcus aureus enterotoxin B. Eur J Immunol 1993; 23: 664-8.
18. Lionetti P, Breese EJ, Braegger CP, Murch SH, Taylor J, MacDonald TT. T cell activation can induce either mucosal destruction or adaptation in cultured human fetal small intestine. Gastroenterology 1993; 105: 373-81.
19. Schuppan D, Riecken EO. Molecules of the extracellular matrix: potential role of collagens and glycoproteins in intestinal adaptation. Digestion 1990; 46: 2-11.
20. Beaulieu J-F, Vachon PH, Chartrand S. Immunolocalization of extracellular matrix components during organogenesis in the human small intestine. Anat Embryol 1991; 181: 363-9.
21. Kjellen L, Lindahl U. Proteoglycans: structures and interactions. Ann Rev Biochem 1991; 60: 443-75.
22. Ruoslahti E, Yamaguchi Y. Proteoglycans as modulators of growth factor activities. Cell 1991; 64: 867-9.
23. Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B. CD44 is the principal cell surface receptor for hyaluronate. Cell 1990; 61: 1303-13.
24. Lindahl U, Hook M. Glycosaminoglycans and their binding to biological macromolecules. Ann Rev Biochem 1978; 47: 385-417.
25. Ruoslahti E. Proteoglycans in cell regulation. J Biol Chem 1989; 264: 13369-72.
26. Autrup H, Barrett LA, Jackson FE, Jesudason ML, Stoner G, Phelps P, et al. Explant culture of human colon. Gustroenterology 1978; 74: 1248-57.
27. Lander AD. Targeting the glycosaminoglycan-binding sites on proteins. Chemistry and Biology 1994; 1: 73-8.
28. Murch SH, MacDonald TT, Walker-Smith JA, Levin M, Lionetti P, Klein NJ. Disruption of sulphated glycosaminoglycans in intestinal inflammation. Lancet 1993; 341: 711-4.
29. Klein NJ, Shennan GI, Heyderman RS, Levin M. Alteration in glycosaminoglycan metabolism and surface charge on human umbilical vein endothelial cells induced by cytokines, endotoxin and neutrophils. J Cell Sci 1992; 102: 821-32.
30. Isaacson PG, Wright DH. Immunocytochemistry of lympho reticular tumours. In: Polak JM, Van Noorden S, eds. Immunocytochemistry: practical applications in pathology and biology. Bristol: John Wright, 1983: 249-61.
31. Thomas R, Schuermann G, Lionetti P, Pender SLF, MacDonald TT. T cell receptor Vβ expression in human intestine: regional variation in post-natal intestine and biased usage in fetal gut. Gut 1996; 38: 190-5.
32. Spencer J, MacDonald TT. Ontogeny of the mucosal immune response. In: Jewell DP, ed. Springer seminars in immunopathology-human intestinal immunology. Basel: Springer, 1990; 12: 129-37.
33. Monk TJ, Spencer J, Cerf-Bensussan N, MacDonald TT. Activation of mucosal T-cells in situ with anti-CD3 antibody: phenotype of the activated T cells and their distribution within the mucosal micro-environment. Clin Exp Immunol 1988; 74: 216-22.
34. MacDonald TT, Weinel A, Spencer J. HLA-DR expression in human fetal intestinal epithelium. Gut 1988; 29: 1342-8.
35. Przemioslo RT, Lundin KEA, Sollid LM, Nelufer J, Ciclitira PJ. Histological changes in small bowel mucosa induced by gliadin sensitive T lymphocytes can be blocked by anti-interferon-γ antibody. Gut 1995; 36: 874-9.
36. Mowat AM. Antibodies to IFN-γ prevent immunologically mediated intestinal damage in murine graft-versus-host reaction. Immunology 1989; 68: 18-23.
37. Garside P, Bunce C, Tomlinson RC, Nichols BL, Mowat AM. Analysis of enteropathy induced by tumour necrosis factor α. Cytokine 1993; 5: 24-8.
38. Murphy G, Reynolds JJ. Extracellular matrix degradation. In: Royce P, Steinmann B, eds. Connective tissue and its heritable disorders. New York: Wiley-Liss, 1993: 287-316.
39. Sottrup-Jensen L. α-Macroglobulins: Structure, shape, and mechanism of proteinase complex formation. J Biol Chem 1989; 264: 11539-42.
40. 2-macroglobulin with proteases. Characteristics and specificity of the reaction, and a hypothesis concerning molecular mechanism. Biochem J 1973; 133: 709-24.
41. Sottrup-Jensen L, Birkedal-Hansen H. Human fibroblast collagenase-α2-macroglobulin interactions. Localization of the cleavage sites in the bait regions of five mammalian α-macroglobulins. J Biol Chem 1989; 264: 393-401.
42. Feldman SR, Rosenberg MR, Key NA, Michalopoulos G, Pizzo SV. Binding of α2-macroglobulins to hepatocytes: mechanism of in vivo clearance. Biochem Biophv Res Commun 1985; 128: 795-802.
43. Kaplan J, Nielsen ML. Analysis of macrophage surface receptors. J Biol Chem 1979; 254: 7329-35.
44. Straight DL, Jakoi L, McKee PA, Snyderman R. Binding of α2-macroglobulin-thrombin complexes and methylamine-treated α2-macroglobulin to human blood monocytes. Biochemistry 1988; 27: 2885-90.
45. Mannhalter JW, Borth W, Eibl MM. Modulation of antigen-induced T cell proliferation by α2M-trypsin complexes, J Immunol 1986; 136: 2792-9.
46. Borth W. α2-macroglobulin, a multifunctional binding protein with targeting characteristics. FASEB J 1992; 6: 3345-53.
47. Dayter JM, Beutler B, Cerami A. Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. J Exp Med 1985; 162: 2163-8.
48. Meikle MC, Atkinson SJ, Ward RV, Murphy G, Reynolds JJ. Gingival fibroblasts degrade type I collagen films when stimulated with tumor necrosis factor and interleukin 1: Evidence that breakdown is mediated by metallo-proteinases. J Periodontal Res 1989; 24: 207-13.
49. Arya SK, Wong-Staal F, Gallo RC. Dexamethasone-mediated inhibition of human T cell growth factor and γ-interferon messenger RNA. J Immunol 1984; 133: 273-6.
50. Reed JC, Abidi AH, Alpers JD, Hoover RG, Robb RJ, Nowell PC. Effect of cyclosporin A and dexamethasone on Interleukm 2 receptor gene expression. J Immunol 1986; 137: 150-4.
51. MacDonald TT, Lionetti P, Cheng S. T cell-mediated mucosal transformation. In: Rieken EO, Zeitz M, Stallmach A, Heise W, eds. Malignancy and chronic inflammation in the gastrointestinal tract-new concepts. Dordrecht: Kluwer Academic, 1995: 87-92.
52. McGuire-Goldring MKB, Murphy G, Gowen M, Meats JE, Ebsworth NM, Poll C, et al. Effects of retinol and dexamethasone on cytokine-mediated control of metallo-proteinases and their inhibitors by human articular chondrocytes and synovial cells in culture. Biochim Biophys Acta 1983; 763: 129-39.
53. Clark SD, Kobayashi DK, Welgus HG. Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human tibroblasts. J Clin Invest 1987; 80: 1280-8.