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Volumn 17, Issue 11, 2013, Pages 1345-1356

Contributions of HIV-1 Nef to immune dysregulation in HIV-infected patients: A therapeutic target?

Author keywords

Dendritic cells; HIV; Immune dysregulation; Nef; Small molecule inhibitors

Indexed keywords

HIV 1 NEF; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; NANOBODY; NEF PROTEIN; UNCLASSIFIED DRUG;

EID: 84886903090     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2013.830712     Document Type: Review
Times cited : (11)

References (121)
  • 1
    • 84883054324 scopus 로고    scopus 로고
    • Overview of the current state of the epidemic
    • Hankins C. Overview of the current state of the epidemic. Curr HIV AIDS Rep 2013;10(2):113-23
    • (2013) Curr HIV AIDS Rep , vol.10 , Issue.2 , pp. 113-123
    • Hankins, C.1
  • 2
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators
    • Palella FJ Jr, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998;338(13):853-60
    • (1998) N Engl J Med , vol.338 , Issue.13 , pp. 853-860
    • Palella Jr., F.J.1    Delaney, K.M.2    Moorman, A.C.3
  • 3
    • 84856450070 scopus 로고    scopus 로고
    • Targets for inhibition of HIV replication: Entry enzyme action release and maturation
    • Sierra-Aragon S, Walter H. Targets for inhibition of HIV replication: entry, enzyme action, release and maturation. Intervirology 2012;55(2):84-97
    • (2012) Intervirology , vol.55 , Issue.2 , pp. 84-97
    • Sierra-Aragon, S.1    Walter, H.2
  • 4
    • 84855343477 scopus 로고    scopus 로고
    • Projected life expectancy of people with HIV according to timing of diagnosis
    • Nakagawa F, Lodwick RK, Smith CJ, et al. Projected life expectancy of people with HIV according to timing of diagnosis. AIDS 2012;26(3):335-43
    • (2012) AIDS , vol.26 , Issue.3 , pp. 335-343
    • Nakagawa, F.1    Lodwick, R.K.2    Smith, C.J.3
  • 5
    • 79953117041 scopus 로고    scopus 로고
    • Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation
    • Allers K, Hutter G, Hofmann J, et al. Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation. Blood 2011;117(10):2791-9
    • (2011) Blood , vol.117 , Issue.10 , pp. 2791-2799
    • Allers, K.1    Hutter, G.2    Hofmann, J.3
  • 6
    • 84875985311 scopus 로고    scopus 로고
    • Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study
    • Saez-Cirion A, Bacchus C, Hocqueloux L, et al. Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. PLoS Pathog 2013;9(3):e1003211
    • (2013) PLoS Pathog , vol.9 , Issue.3
    • Saez-Cirion, A.1    Bacchus, C.2    Hocqueloux, L.3
  • 7
    • 84877342048 scopus 로고    scopus 로고
    • Talk of HIV cure goes viral
    • Holmes D. Talk of HIV cure goes viral. Lancet Infect Dis 2013;13(4):298-9
    • (2013) Lancet Infect Dis , vol.13 , Issue.4 , pp. 298-299
    • Holmes, D.1
  • 8
    • 3543125970 scopus 로고    scopus 로고
    • A long-term latent reservoir for HIV-1: Discovery and clinical implications
    • Siliciano JD, Siliciano RF. A long-term latent reservoir for HIV-1: discovery and clinical implications. J Antimicrob Chemother 2004;54(1):6-9
    • (2004) J Antimicrob Chemother , vol.54 , Issue.1 , pp. 6-9
    • Siliciano, J.D.1    Siliciano, R.F.2
  • 9
    • 84862119215 scopus 로고    scopus 로고
    • HIV-1 antiretroviral resistance: Scientific principles and clinical applications
    • Tang MW, Shafer RW. HIV-1 antiretroviral resistance: scientific principles and clinical applications. Drugs 2012;72(9):e1-25
    • (2012) Drugs , vol.72 , Issue.9
    • Tang, M.W.1    Shafer, R.W.2
  • 10
    • 79957617692 scopus 로고    scopus 로고
    • Immune reconstitution under antiretroviral therapy: The new challenge in HIV-1 infection
    • Corbeau P, Reynes J. Immune reconstitution under antiretroviral therapy: the new challenge in HIV-1 infection. Blood 2011;117(21):5582-90
    • (2011) Blood , vol.117 , Issue.21 , pp. 5582-5590
    • Corbeau, P.1    Reynes, J.2
  • 11
    • 34247537169 scopus 로고    scopus 로고
    • Class of antiretroviral drugs and the risk of myocardial infarction
    • Friis-Moller N, Reiss P, Sabin CA, et al. Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med 2007;356(17):1723-35
    • (2007) N Engl J Med , vol.356 , Issue.17 , pp. 1723-1735
    • Friis-Moller, N.1    Reiss, P.2    Sabin, C.A.3
  • 13
    • 76049109697 scopus 로고    scopus 로고
    • Drug-induced lipotoxicity: Lipodystrophy associated with HIV-1 infection and antiretroviral treatment
    • Villarroya F, Domingo P, Giralt M. Drug-induced lipotoxicity: lipodystrophy associated with HIV-1 infection and antiretroviral treatment. Biochim Biophys Acta 2010;1801(3):392-9
    • (2010) Biochim Biophys Acta , vol.1801 , Issue.3 , pp. 392-399
    • Villarroya, F.1    Domingo, P.2    Giralt, M.3
  • 14
    • 84862642887 scopus 로고    scopus 로고
    • Dysregulation of glucose metabolism in HIV patients: Epidemiology mechanisms and management
    • Gutierrez AD, Balasubramanyam A. Dysregulation of glucose metabolism in HIV patients: epidemiology, mechanisms, and management. Endocrine 2012;41(1):1-10
    • (2012) Endocrine , vol.41 , Issue.1 , pp. 1-10
    • Gutierrez, A.D.1    Balasubramanyam, A.2
  • 15
    • 0023790222 scopus 로고
    • Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR
    • Ahmad N, Venkatesan S. Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR. Science 1988;241(4872):1481-5
    • (1988) Science , vol.241 , Issue.4872 , pp. 1481-1485
    • Ahmad, N.1    Venkatesan, S.2
  • 16
    • 0028835788 scopus 로고
    • Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
    • Kirchhoff F, Greenough TC, Brettler DB, et al. Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med 1995;332(4):228-32
    • (1995) N Engl J Med , vol.332 , Issue.4 , pp. 228-232
    • Kirchhoff, F.1    Greenough, T.C.2    Brettler, D.B.3
  • 17
    • 0025743306 scopus 로고
    • Importance of the nef gene for maintenance of high virus loads and for development of AIDS
    • Kestler HW III, Ringler DJ, Mori K, et al. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 1991;65(4):651-62
    • (1991) Cell , vol.65 , Issue.4 , pp. 651-662
    • Kestler III, H.W.1    Ringler, D.J.2    Mori, K.3
  • 18
    • 0026667917 scopus 로고
    • Long-term symptomless HIV-1 infection in recipients of blood products from a single donor
    • Learmont J, Tindall B, Evans L, et al. Long-term symptomless HIV-1 infection in recipients of blood products from a single donor. Lancet 1992;340(8824):863-7
    • (1992) Lancet , vol.340 , Issue.8824 , pp. 863-867
    • Learmont, J.1    Tindall, B.2    Evans, L.3
  • 19
    • 0028804160 scopus 로고
    • Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients
    • Deacon NJ, Tsykin A, Solomon A, et al. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 1995;270(5238):988-91
    • (1995) Science , vol.270 , Issue.5238 , pp. 988-991
    • Deacon, N.J.1    Tsykin, A.2    Solomon, A.3
  • 20
    • 59849114234 scopus 로고    scopus 로고
    • Mechanisms of HIV non-progression; Robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection
    • Dyer WB, Zaunders JJ, Yuan FF, et al. Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection. Retrovirology 2008;5:112
    • (2008) Retrovirology , vol.5 , pp. 112
    • Dyer, W.B.1    Zaunders, J.J.2    Yuan, F.F.3
  • 21
    • 0033519616 scopus 로고    scopus 로고
    • Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort
    • Learmont JC, Geczy AF, Mills J, et al. Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort. N Engl J Med 1999;340(22):1715-22
    • (1999) N Engl J Med , vol.340 , Issue.22 , pp. 1715-1722
    • Learmont, J.C.1    Geczy, A.F.2    Mills, J.3
  • 22
    • 79955426303 scopus 로고    scopus 로고
    • The Sydney Blood Bank Cohort: Implications for viral fitness as a cause of elite control
    • Zaunders J, Dyer WB, Churchill M. The Sydney Blood Bank Cohort: implications for viral fitness as a cause of elite control. Curr Opin HIV AIDS 2011;6(3):151-6
    • (2011) Curr Opin HIV AIDS , vol.6 , Issue.3 , pp. 151-156
    • Zaunders, J.1    Dyer, W.B.2    Churchill, M.3
  • 23
    • 36048974619 scopus 로고    scopus 로고
    • Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo
    • Gorry PR, McPhee DA, Verity E, et al. Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo. Retrovirology 2007;4:66
    • (2007) Retrovirology , vol.4 , pp. 66
    • Gorry, P.R.1    McPhee, D.A.2    Verity, E.3
  • 24
    • 84871914433 scopus 로고    scopus 로고
    • Attenuation of multiple Nef functions in HIV-1 elite controllers
    • Mwimanzi P, Markle TJ, Martin E, et al. Attenuation of multiple Nef functions in HIV-1 elite controllers. Retrovirology 2013;10:1
    • (2013) Retrovirology , vol.10 , pp. 1
    • Mwimanzi, P.1    Markle, T.J.2    Martin, E.3
  • 25
    • 0032538278 scopus 로고    scopus 로고
    • Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice
    • Hanna Z, Kay DG, Rebai N, et al. Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 1998;95(2):163-75
    • (1998) Cell , vol.95 , Issue.2 , pp. 163-175
    • Hanna, Z.1    Kay, D.G.2    Rebai, N.3
  • 26
    • 0032855131 scopus 로고    scopus 로고
    • Human immunodeficiency virus nef gene expression affects generation and function of human T cells, but not dendritic cells
    • Verhasselt B, Naessens E, Verhofstede C, et al. Human immunodeficiency virus nef gene expression affects generation and function of human T cells, but not dendritic cells. Blood 1999;94(8):2809-18
    • (1999) Blood , vol.94 , Issue.8 , pp. 2809-2818
    • Verhasselt, B.1    Naessens, E.2    Verhofstede, C.3
  • 27
    • 0141993006 scopus 로고    scopus 로고
    • Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development
    • Stove V, Naessens E, Stove C, et al. Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development. Blood 2003;102(8):2925-32
    • (2003) Blood , vol.102 , Issue.8 , pp. 2925-2932
    • Stove, V.1    Naessens, E.2    Stove, C.3
  • 28
    • 33644926146 scopus 로고    scopus 로고
    • Modelling thymic HIV-1 Nef effects
    • Stove V, Verhasselt B. Modelling thymic HIV-1 Nef effects. Curr HIV Res 2006;4(1):57-64
    • (2006) Curr HIV Res , vol.4 , Issue.1 , pp. 57-64
    • Stove, V.1    Verhasselt, B.2
  • 29
    • 84899434252 scopus 로고    scopus 로고
    • Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis: Role of the AKT signaling pathway
    • [Epub ahead of print]
    • Zhu X, Guo Y, Yao S, et al. Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis: role of the AKT signaling pathway. Oncogene 2013; [Epub ahead of print]
    • (2013) Oncogene
    • Zhu, X.1    Guo, Y.2    Yao, S.3
  • 30
    • 47749133802 scopus 로고    scopus 로고
    • HIV Nef: Role in pathogenesis and viral fitness
    • Arien KK, Verhasselt B. HIV Nef: role in pathogenesis and viral fitness. Curr HIV Res 2008;6(3):200-8
    • (2008) Curr HIV Res , vol.6 , Issue.3 , pp. 200-208
    • Arien, K.K.1    Verhasselt, B.2
  • 31
    • 74849088296 scopus 로고    scopus 로고
    • Implications of Nef: Host cell interactions in viral persistence and progression to AIDS
    • Arhel NJ, Kirchhoff F. Implications of Nef: host cell interactions in viral persistence and progression to AIDS. Curr Top Microbiol Immunol 2009;339:147-75
    • (2009) Curr Top Microbiol Immunol , vol.339 , pp. 147-175
    • Arhel, N.J.1    Kirchhoff, F.2
  • 32
    • 84856499935 scopus 로고    scopus 로고
    • One protein to rule them all: Modulation of cell surface receptors and molecules by HIV Nef
    • Landi A, Iannucci V, Nuffel AV, et al. One protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef. Curr HIV Res 2011;9(7):496-504
    • (2011) Curr HIV Res , vol.9 , Issue.7 , pp. 496-504
    • Landi, A.1    Iannucci, V.2    Nuffel, A.V.3
  • 33
    • 0025733252 scopus 로고
    • Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
    • Garcia JV, Miller AD. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature 1991;350(6318):508-11
    • (1991) Nature , vol.350 , Issue.6318 , pp. 508-511
    • Garcia, J.V.1    Miller, A.D.2
  • 34
    • 2342503325 scopus 로고    scopus 로고
    • Role of CD4 receptor down-regulation during HIV-1 infection
    • Levesque K, Finzi A, Binette J, Cohen EA. Role of CD4 receptor down-regulation during HIV-1 infection. Curr HIV Res 2004;2(1):51-9
    • (2004) Curr HIV Res , vol.2 , Issue.1 , pp. 51-59
    • Levesque, K.1    Finzi, A.2    Binette, J.3    Cohen, E.A.4
  • 35
    • 0029875421 scopus 로고    scopus 로고
    • Endocytosis of major histocompatibility complex class i molecules is induced by the HIV-1 Nef protein
    • Schwartz O, Marechal V, Le Gall S, et al. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat Med 1996;2(3):338-42
    • (1996) Nat Med , vol.2 , Issue.3 , pp. 338-342
    • Schwartz, O.1    Marechal, V.2    Le Gall, S.3
  • 36
    • 0033151621 scopus 로고    scopus 로고
    • The selective downregulation of class i major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
    • Cohen GB, Gandhi RT, Davis DM, et al. The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity 1999;10(6):661-71
    • (1999) Immunity , vol.10 , Issue.6 , pp. 661-671
    • Cohen, G.B.1    Gandhi, R.T.2    Davis, D.M.3
  • 37
    • 0035834141 scopus 로고    scopus 로고
    • HIV-1 Nef impairs MHC class II antigen presentation and surface expression
    • Stumptner-Cuvelette P, Morchoisne S, Dugast M, et al. HIV-1 Nef impairs MHC class II antigen presentation and surface expression. Proc Natl Acad Sci USA 2001;98(21):12144-9
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.21 , pp. 12144-12149
    • Stumptner-Cuvelette, P.1    Morchoisne, S.2    Dugast, M.3
  • 38
    • 84856453839 scopus 로고    scopus 로고
    • The Nef-infectivity enigma: Mechanisms of enhanced lentiviral infection
    • Vermeire J, Vanbillemont G, Witkowski W, Verhasselt B. The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection. Curr HIV Res 2011;9(7):474-89
    • (2011) Curr HIV Res , vol.9 , Issue.7 , pp. 474-489
    • Vermeire, J.1    Vanbillemont, G.2    Witkowski, W.3    Verhasselt, B.4
  • 39
    • 84855916547 scopus 로고    scopus 로고
    • Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release
    • Shelton MN, Huang MB, Ali SA, et al. Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release. J Virol 2012;86(1):406-19
    • (2012) J Virol , vol.86 , Issue.1 , pp. 406-419
    • Shelton, M.N.1    Huang, M.B.2    Ali, S.A.3
  • 40
    • 71849085384 scopus 로고    scopus 로고
    • HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells
    • Lenassi M, Cagney G, Liao M, et al. HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells. Traffic 2010;11(1):110-22
    • (2010) Traffic , vol.11 , Issue.1 , pp. 110-122
    • Lenassi, M.1    Cagney, G.2    Liao, M.3
  • 41
    • 69949128211 scopus 로고    scopus 로고
    • Massive secretion by T cells is caused by HIV Nef in infected cells and by Nef transfer to bystander cells
    • Muratori C, Cavallin LE, Kratzel K, et al. Massive secretion by T cells is caused by HIV Nef in infected cells and by Nef transfer to bystander cells. Cell Host Microbe 2009;6(3):218-30
    • (2009) Cell Host Microbe , vol.6 , Issue.3 , pp. 218-230
    • Muratori, C.1    Cavallin, L.E.2    Kratzel, K.3
  • 42
    • 84874238349 scopus 로고    scopus 로고
    • HIV Nef paxillin and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases
    • Lee JH, Wittki S, Brau T, et al. HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases. Mol Cell 2013;49(4):668-79
    • (2013) Mol Cell , vol.49 , Issue.4 , pp. 668-679
    • Lee, J.H.1    Wittki, S.2    Brau, T.3
  • 43
    • 84880065053 scopus 로고    scopus 로고
    • Exosomes derived from HIV-1 infected cells contain TAR RNA
    • Narayanan A, Iordanskiy S, Das R, et al. Exosomes derived from HIV-1 infected cells contain TAR RNA. J Biol Chem 2013;288(27):20014-33
    • (2013) J Biol Chem , vol.288 , Issue.27 , pp. 20014-20033
    • Narayanan, A.1    Iordanskiy, S.2    Das, R.3
  • 44
    • 34247129671 scopus 로고    scopus 로고
    • Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor
    • Chaudhuri R, Lindwasser OW, Smith WJ, et al. Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. J Virol 2007;81(8):3877-90
    • (2007) J Virol , vol.81 , Issue.8 , pp. 3877-3890
    • Chaudhuri, R.1    Lindwasser, O.W.2    Smith, W.J.3
  • 45
    • 23844471509 scopus 로고    scopus 로고
    • Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta
    • Stove V, Van de Walle I, Naessens E, et al. Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta. J Virol 2005;79(17):11422-33
    • (2005) J Virol , vol.79 , Issue.17 , pp. 11422-11433
    • Stove, V.1    Van De Walle, I.2    Naessens, E.3
  • 46
    • 0028878783 scopus 로고
    • Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4
    • Saksela K, Cheng G, Baltimore D. Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4. EMBO J 1995;14(3):484-91
    • (1995) EMBO J , vol.14 , Issue.3 , pp. 484-491
    • Saksela, K.1    Cheng, G.2    Baltimore, D.3
  • 47
    • 0028485232 scopus 로고
    • HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization
    • Baur AS, Sawai ET, Dazin P, et al. HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity 1994;1(5):373-84
    • (1994) Immunity , vol.1 , Issue.5 , pp. 373-384
    • Baur, A.S.1    Sawai, E.T.2    Dazin, P.3
  • 48
    • 68549123450 scopus 로고    scopus 로고
    • HIV-1 Nef interferes with host cell motility by deregulation of Cofilin
    • Stolp B, Reichman-Fried M, Abraham L, et al. HIV-1 Nef interferes with host cell motility by deregulation of Cofilin. Cell Host Microbe 2009;6(2):174-86
    • (2009) Cell Host Microbe , vol.6 , Issue.2 , pp. 174-186
    • Stolp, B.1    Reichman-Fried, M.2    Abraham, L.3
  • 49
    • 84860201476 scopus 로고    scopus 로고
    • Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function
    • Meuwissen PJ, Stolp B, Iannucci V, et al. Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function. Retrovirology 2012;9:34
    • (2012) Retrovirology , vol.9 , pp. 34
    • Meuwissen, P.J.1    Stolp, B.2    Iannucci, V.3
  • 50
    • 24744438912 scopus 로고    scopus 로고
    • HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation
    • Muthumani K, Choo AY, Hwang DS, et al. HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation. Blood 2005;106(6):2059-68
    • (2005) Blood , vol.106 , Issue.6 , pp. 2059-2068
    • Muthumani, K.1    Choo, A.Y.2    Hwang, D.S.3
  • 51
    • 0035848864 scopus 로고    scopus 로고
    • HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell
    • Geleziunas R, Xu W, Takeda K, et al. HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell. Nature 2001;410(6830):834-8
    • (2001) Nature , vol.410 , Issue.6830 , pp. 834-838
    • Geleziunas, R.1    Xu, W.2    Takeda, K.3
  • 52
    • 0035173735 scopus 로고    scopus 로고
    • HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals
    • Wolf D, Witte V, Laffert B, et al. HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals. Nat Med 2001;7(11):1217-24
    • (2001) Nat Med , vol.7 , Issue.11 , pp. 1217-1224
    • Wolf, D.1    Witte, V.2    Laffert, B.3
  • 53
    • 33645288761 scopus 로고    scopus 로고
    • Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells
    • Qiao X, He B, Chiu A, et al. Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells. Nat Immunol 2006;7(3):302-10
    • (2006) Nat Immunol , vol.7 , Issue.3 , pp. 302-310
    • Qiao, X.1    He, B.2    Chiu, A.3
  • 54
    • 69049119032 scopus 로고    scopus 로고
    • HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits
    • Xu W, Santini PA, Sullivan JS, et al. HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits. Nat Immunol 2009;10(9):1008-17
    • (2009) Nat Immunol , vol.10 , Issue.9 , pp. 1008-1017
    • Xu, W.1    Santini, P.A.2    Sullivan, J.S.3
  • 55
    • 46949095793 scopus 로고    scopus 로고
    • Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS
    • Swingler S, Zhou J, Swingler C, et al. Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS. Cell Host Microbe 2008;4(1):63-76
    • (2008) Cell Host Microbe , vol.4 , Issue.1 , pp. 63-76
    • Swingler, S.1    Zhou, J.2    Swingler, C.3
  • 56
    • 0038342442 scopus 로고    scopus 로고
    • HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection
    • Swingler S, Brichacek B, Jacque JM, et al. HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection. Nature 2003;424(6945):213-19
    • (2003) Nature , vol.424 , Issue.6945 , pp. 213-219
    • Swingler, S.1    Brichacek, B.2    Jacque, J.M.3
  • 57
    • 0345096572 scopus 로고    scopus 로고
    • The functional consequences of delivery of HIV-1 Nef to dendritic cells using an adenoviral vector
    • Maccormac LP, Jacque JM, Chain B. The functional consequences of delivery of HIV-1 Nef to dendritic cells using an adenoviral vector. Vaccine 2004;22(3-4):528-35
    • (2004) Vaccine , vol.22 , Issue.3-4 , pp. 528-535
    • MacCormac, L.P.1    Jacque, J.M.2    Chain, B.3
  • 58
    • 0036351906 scopus 로고    scopus 로고
    • HIV-1 Nef induces dendritic cell differentiation: A possible mechanism of uninfected CD4(+) T cell activation
    • Quaranta MG, Tritarelli E, Giordani L, Viora M. HIV-1 Nef induces dendritic cell differentiation: a possible mechanism of uninfected CD4(+) T cell activation. Exp Cell Res 2002;275(2):243-54
    • (2002) Exp Cell Res , vol.275 , Issue.2 , pp. 243-254
    • Quaranta, M.G.1    Tritarelli, E.2    Giordani, L.3    Viora, M.4
  • 59
    • 25444510358 scopus 로고    scopus 로고
    • The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs
    • Chaudhry A, Das SR, Hussain A, et al. The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs. J Immunol 2005;175(7):4566-74
    • (2005) J Immunol , vol.175 , Issue.7 , pp. 4566-4574
    • Chaudhry, A.1    Das, S.R.2    Hussain, A.3
  • 60
    • 79960391235 scopus 로고    scopus 로고
    • HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements
    • Leonard JA, Filzen T, Carter CC, et al. HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements. J Virol 2011;85(14):6867-81
    • (2011) J Virol , vol.85 , Issue.14 , pp. 6867-6881
    • Leonard, J.A.1    Filzen, T.2    Carter, C.C.3
  • 61
    • 53849093455 scopus 로고    scopus 로고
    • Cell biology of HIV-1 infection of macrophages
    • Carter CA, Ehrlich LS. Cell biology of HIV-1 infection of macrophages. Annu Rev Microbiol 2008;62:425-43
    • (2008) Annu Rev Microbiol , vol.62 , pp. 425-443
    • Carter, C.A.1    Ehrlich, L.S.2
  • 62
    • 0347951393 scopus 로고    scopus 로고
    • The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection
    • Crowe S, Zhu T, Muller WA. The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection. J Leukoc Biol 2003;74(5):635-41
    • (2003) J Leukoc Biol , vol.74 , Issue.5 , pp. 635-641
    • Crowe, S.1    Zhu, T.2    Muller, W.A.3
  • 63
    • 22744434226 scopus 로고    scopus 로고
    • Cell death mechanisms in HIV-associated dementia: The involvement of syncytia
    • Nardacci R, Antinori A, Kroemer G, Piacentini M. Cell death mechanisms in HIV-associated dementia: the involvement of syncytia. Cell Death Differ 2005;12(Suppl 1):855-8
    • (2005) Cell Death Differ , vol.12 , Issue.SUPPL. 1 , pp. 855-858
    • Nardacci, R.1    Antinori, A.2    Kroemer, G.3    Piacentini, M.4
  • 64
    • 77953647799 scopus 로고    scopus 로고
    • HIV-1 Nef triggers macrophage fusion in a p61Hck-and protease-dependent manner
    • Verollet C, Zhang YM, Le Cabec V, et al. HIV-1 Nef triggers macrophage fusion in a p61Hck-and protease-dependent manner. J Immunol 2010;184(12):7030-9
    • (2010) J Immunol , vol.184 , Issue.12 , pp. 7030-7039
    • Verollet, C.1    Zhang, Y.M.2    Le Cabec, V.3
  • 65
    • 34547801169 scopus 로고    scopus 로고
    • Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with Nef-deleted virus
    • Churchill MJ, Chiavaroli L, Wesselingh SL, Gorry PR. Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with Nef-deleted virus. Retrovirology 2007;4:43
    • (2007) Retrovirology , vol.4 , pp. 43
    • Churchill, M.J.1    Chiavaroli, L.2    Wesselingh, S.L.3    Gorry, P.R.4
  • 66
    • 84855615229 scopus 로고    scopus 로고
    • HIV-mediated up-regulation of invariant chain (CD74) correlates with generalized immune activation in HIV+ subjects
    • Ghiglione Y, Rodriguez AM, De Candia C, et al. HIV-mediated up-regulation of invariant chain (CD74) correlates with generalized immune activation in HIV+ subjects. Virus Res 2012;163(1):380-4
    • (2012) Virus Res , vol.163 , Issue.1 , pp. 380-384
    • Ghiglione, Y.1    Rodriguez, A.M.2    De Candia, C.3
  • 67
    • 78650907444 scopus 로고    scopus 로고
    • HIV-1 nef protein visits B-cells via macrophage nanotubes: A mechanism for AIDS-related lymphoma pathogenesis?
    • Lamers SL, Fogel GB, Huysentruyt LC, McGrath MS. HIV-1 nef protein visits B-cells via macrophage nanotubes: a mechanism for AIDS-related lymphoma pathogenesis? Curr HIV Res 2010;8(8):638-40
    • (2010) Curr HIV Res , vol.8 , Issue.8 , pp. 638-640
    • Lamers, S.L.1    Fogel, G.B.2    Huysentruyt, L.C.3    McGrath, M.S.4
  • 68
    • 0025735629 scopus 로고
    • The dendritic cell system and its role in immunogenicity
    • Steinman RM. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991;9:271-96
    • (1991) Annu Rev Immunol , vol.9 , pp. 271-296
    • Steinman, R.M.1
  • 69
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392(6673):245-52
    • (1998) Nature , vol.392 , Issue.6673 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 70
    • 36048945481 scopus 로고    scopus 로고
    • The interaction of HIV with dendritic cells: Outcomes and pathways
    • Piguet V, Steinman RM. The interaction of HIV with dendritic cells: outcomes and pathways. Trends Immunol 2007;28(11):503-10
    • (2007) Trends Immunol , vol.28 , Issue.11 , pp. 503-510
    • Piguet, V.1    Steinman, R.M.2
  • 72
    • 67649253072 scopus 로고    scopus 로고
    • HIV interactions with monocytes and dendritic cells: Viral latency and reservoirs
    • Coleman CM, Wu L. HIV interactions with monocytes and dendritic cells: viral latency and reservoirs. Retrovirology 2009;6:51
    • (2009) Retrovirology , vol.6 , pp. 51
    • Coleman, C.M.1    Wu, L.2
  • 73
    • 0038407687 scopus 로고    scopus 로고
    • DC-SIGN: A novel HIV receptor on DCs that mediates HIV-1 transmission
    • Geijtenbeek TB, van Kooyk Y. DC-SIGN: a novel HIV receptor on DCs that mediates HIV-1 transmission. Curr Top Microbiol Immunol 2003;276:31-54
    • (2003) Curr Top Microbiol Immunol , vol.276 , pp. 31-54
    • Geijtenbeek, T.B.1    Van Kooyk, Y.2
  • 74
    • 0036172314 scopus 로고    scopus 로고
    • DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection
    • Kwon DS, Gregorio G, Bitton N, et al. DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity 2002;16(1):135-44
    • (2002) Immunity , vol.16 , Issue.1 , pp. 135-144
    • Kwon, D.S.1    Gregorio, G.2    Bitton, N.3
  • 75
    • 0036169006 scopus 로고    scopus 로고
    • HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread
    • Sol-Foulon N, Moris A, Nobile C, et al. HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread. Immunity 2002;16(1):145-55
    • (2002) Immunity , vol.16 , Issue.1 , pp. 145-155
    • Sol-Foulon, N.1    Moris, A.2    Nobile, C.3
  • 76
    • 0029874948 scopus 로고    scopus 로고
    • Replication of HIV-1 in dendritic cell-derived syncytia at the mucosal surface of the adenoid
    • Frankel SS, Wenig BM, Burke AP, et al. Replication of HIV-1 in dendritic cell-derived syncytia at the mucosal surface of the adenoid. Science 1996;272(5258):115-17
    • (1996) Science , vol.272 , Issue.5258 , pp. 115-117
    • Frankel, S.S.1    Wenig, B.M.2    Burke, A.P.3
  • 77
    • 84858256290 scopus 로고    scopus 로고
    • DC-SIGN antagonists a potential new class of anti-infectives
    • Anderluh M, Jug G, Svajger U, Obermajer N. DC-SIGN antagonists, a potential new class of anti-infectives. Curr Med Chem 2012;19(7):992-1007
    • (2012) Curr Med Chem , vol.19 , Issue.7 , pp. 992-1007
    • Anderluh, M.1    Jug, G.2    Svajger, U.3    Obermajer, N.4
  • 78
    • 84871678979 scopus 로고    scopus 로고
    • Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides
    • Izquierdo-Useros N, Lorizate M, Puertas MC, et al. Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides. PLoS Biol 2012;10(12):e1001448
    • (2012) PLoS Biol , vol.10 , Issue.12
    • Izquierdo-Useros, N.1    Lorizate, M.2    Puertas, M.C.3
  • 79
    • 34547816196 scopus 로고    scopus 로고
    • HIV-1 Nef impairs the dynamic of DC/NK crosstalk: Different outcome of CD56(dim) and CD56 (bright) NK cell subsets
    • Quaranta MG, Napolitano A, Sanchez M, et al. HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56(dim) and CD56 (bright) NK cell subsets. FASEB J 2007;21(10):2323-34
    • (2007) FASEB J , vol.21 , Issue.10 , pp. 2323-2334
    • Quaranta, M.G.1    Napolitano, A.2    Sanchez, M.3
  • 80
    • 0038025223 scopus 로고    scopus 로고
    • Recruitment of HIV and its receptors to dendritic cell-T cell junctions
    • McDonald D, Wu L, Bohks SM, et al. Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science 2003;300(5623):1295-7
    • (2003) Science , vol.300 , Issue.5623 , pp. 1295-1297
    • McDonald, D.1    Wu, L.2    Bohks, S.M.3
  • 81
    • 66149137185 scopus 로고    scopus 로고
    • Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses
    • Rudnicka D, Feldmann J, Porrot F, et al. Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses. J Virol 2009;83(12):6234-46
    • (2009) J Virol , vol.83 , Issue.12 , pp. 6234-6246
    • Rudnicka, D.1    Feldmann, J.2    Porrot, F.3
  • 82
    • 0033962413 scopus 로고    scopus 로고
    • The decreased replicative capacity of simian immunodeficiency virus SIVmac239Delta(nef) is manifest in cultures of immature dendritic cells and T cells
    • Messmer D, Ignatius R, Santisteban C, et al. The decreased replicative capacity of simian immunodeficiency virus SIVmac239Delta(nef) is manifest in cultures of immature dendritic cells and T cells. J Virol 2000;74(5):2406-13
    • (2000) J Virol , vol.74 , Issue.5 , pp. 2406-2413
    • Messmer, D.1    Ignatius, R.2    Santisteban, C.3
  • 83
    • 0027043276 scopus 로고
    • Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene
    • Daniel MD, Kirchhoff F, Czajak SC, et al. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 1992;258(5090):1938-41
    • (1992) Science , vol.258 , Issue.5090 , pp. 1938-1941
    • Daniel, M.D.1    Kirchhoff, F.2    Czajak, S.C.3
  • 84
    • 0032947945 scopus 로고    scopus 로고
    • Immunization with a live, attenuated simian immunodeficiency virus vaccine leads to restriction of viral diversity in Rhesus macaques not protected from pathogenic challenge
    • Sodora DL, Sheridan KE, Marx PA, Connor RI. Immunization with a live, attenuated simian immunodeficiency virus vaccine leads to restriction of viral diversity in Rhesus macaques not protected from pathogenic challenge. J Virol 1999;73(5):4443-6
    • (1999) J Virol , vol.73 , Issue.5 , pp. 4443-4446
    • Sodora, D.L.1    Sheridan, K.E.2    Marx, P.A.3    Connor, R.I.4
  • 85
    • 0035919709 scopus 로고    scopus 로고
    • Nef is required for efficient HIV-1 replication in cocultures of dendritic cells and lymphocytes
    • Petit C, Buseyne F, Boccaccio C, et al. Nef is required for efficient HIV-1 replication in cocultures of dendritic cells and lymphocytes. Virology 2001;286(1):225-36
    • (2001) Virology , vol.286 , Issue.1 , pp. 225-236
    • Petit, C.1    Buseyne, F.2    Boccaccio, C.3
  • 86
    • 84875522520 scopus 로고    scopus 로고
    • Comparative proteomic analysis of HIV-1 particles reveals a role for Ezrin and EHD4 in the Nef-dependent increase of virus infectivity
    • Bregnard C, Zamborlini A, Leduc M, et al. Comparative proteomic analysis of HIV-1 particles reveals a role for Ezrin and EHD4 in the Nef-dependent increase of virus infectivity. J Virol 2013;87(7):3729-40
    • (2013) J Virol , vol.87 , Issue.7 , pp. 3729-3740
    • Bregnard, C.1    Zamborlini, A.2    Leduc, M.3
  • 87
    • 80052671541 scopus 로고    scopus 로고
    • Nef does not inhibit F-actin remodelling and HIV-1 cell-cell transmission at the T lymphocyte virological synapse
    • Haller C, Tibroni N, Rudolph JM, et al. Nef does not inhibit F-actin remodelling and HIV-1 cell-cell transmission at the T lymphocyte virological synapse. Eur J Cell Biol 2011;90(11):913-21
    • (2011) Eur J Cell Biol , vol.90 , Issue.11 , pp. 913-921
    • Haller, C.1    Tibroni, N.2    Rudolph, J.M.3
  • 88
    • 1642540589 scopus 로고    scopus 로고
    • HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse
    • Jolly C, Kashefi K, Hollinshead M, Sattentau QJ. HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse. J Exp Med 2004;199(2):283-93
    • (2004) J Exp Med , vol.199 , Issue.2 , pp. 283-293
    • Jolly, C.1    Kashefi, K.2    Hollinshead, M.3    Sattentau, Q.J.4
  • 89
    • 79955664789 scopus 로고    scopus 로고
    • How HIV takes advantage of the cytoskeleton in entry and replication
    • Stolp B, Fackler OT. How HIV takes advantage of the cytoskeleton in entry and replication. Viruses 2011;3(4):293-311
    • (2011) Viruses , vol.3 , Issue.4 , pp. 293-311
    • Stolp, B.1    Fackler, O.T.2
  • 90
    • 27844473354 scopus 로고    scopus 로고
    • A dynamic view of the immunological synapse
    • Dustin ML. A dynamic view of the immunological synapse. Semin Immunol 2005;17(6):400-10
    • (2005) Semin Immunol , vol.17 , Issue.6 , pp. 400-410
    • Dustin, M.L.1
  • 91
    • 70349705617 scopus 로고    scopus 로고
    • The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses
    • Arhel N, Lehmann M, Clauss K, et al. The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses. J Clin Invest 2009;119(10):2965-75
    • (2009) J Clin Invest , vol.119 , Issue.10 , pp. 2965-2975
    • Arhel, N.1    Lehmann, M.2    Clauss, K.3
  • 92
    • 33745070227 scopus 로고    scopus 로고
    • Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1
    • Schindler M, Munch J, Kutsch O, et al. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell 2006;125(6):1055-67
    • (2006) Cell , vol.125 , Issue.6 , pp. 1055-1067
    • Schindler, M.1    Munch, J.2    Kutsch, O.3
  • 93
    • 33646552033 scopus 로고    scopus 로고
    • Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse
    • Thoulouze MI, Sol-Foulon N, Blanchet F, et al. Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse. Immunity 2006;24(5):547-61
    • (2006) Immunity , vol.24 , Issue.5 , pp. 547-561
    • Thoulouze, M.I.1    Sol-Foulon, N.2    Blanchet, F.3
  • 94
    • 84856077084 scopus 로고    scopus 로고
    • HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling
    • Pan X, Rudolph JM, Abraham L, et al. HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling. Blood 2012;119(3):786-97
    • (2012) Blood , vol.119 , Issue.3 , pp. 786-797
    • Pan, X.1    Rudolph, J.M.2    Abraham, L.3
  • 95
    • 84875060311 scopus 로고    scopus 로고
    • Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells
    • Chen Y, Hwang SL, Chan VS, et al. Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells. PLoS Pathog 2013;9(1):e1003100
    • (2013) PLoS Pathog , vol.9 , Issue.1
    • Chen, Y.1    Hwang, S.L.2    Chan, V.S.3
  • 96
    • 0037217830 scopus 로고    scopus 로고
    • Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals
    • Barron MA, Blyveis N, Palmer BE, et al. Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals. J Infect Dis 2003;187(1):26-37
    • (2003) J Infect Dis , vol.187 , Issue.1 , pp. 26-37
    • Barron, M.A.1    Blyveis, N.2    Palmer, B.E.3
  • 97
    • 34249774578 scopus 로고    scopus 로고
    • Parallel loss of myeloid and plasmacytoid dendritic cells from blood and lymphoid tissue in simian AIDS
    • Brown KN, Trichel A, Barratt-Boyes SM. Parallel loss of myeloid and plasmacytoid dendritic cells from blood and lymphoid tissue in simian AIDS. J Immunol 2007;178(11):6958-67
    • (2007) J Immunol , vol.178 , Issue.11 , pp. 6958-6967
    • Brown, K.N.1    Trichel, A.2    Barratt-Boyes, S.M.3
  • 98
    • 0034894379 scopus 로고    scopus 로고
    • Structure-function relationships in HIV-1 Nef
    • Geyer M, Fackler OT, Peterlin BM. Structure-function relationships in HIV-1 Nef. EMBO Rep 2001;2(7):580-5
    • (2001) EMBO Rep , vol.2 , Issue.7 , pp. 580-585
    • Geyer, M.1    Fackler, O.T.2    Peterlin, B.M.3
  • 99
    • 37249004920 scopus 로고    scopus 로고
    • Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
    • Wells JA, McClendon CL. Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 2007;450(7172):1001-9
    • (2007) Nature , vol.450 , Issue.7172 , pp. 1001-1009
    • Wells, J.A.1    McClendon, C.L.2
  • 101
    • 4644370686 scopus 로고    scopus 로고
    • Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lck
    • Olszewski A, Sato K, Aron ZD, et al. Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lck. Proc Natl Acad Sci USA 2004;101(39):14079-84
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.39 , pp. 14079-14084
    • Olszewski, A.1    Sato, K.2    Aron, Z.D.3
  • 102
    • 0035123886 scopus 로고    scopus 로고
    • Activation of NFAT-dependent gene expression by Nef: Conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta
    • Manninen A, Huotari P, Hiipakka M, et al. Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta. J Virol 2001;75(6):3034-7
    • (2001) J Virol , vol.75 , Issue.6 , pp. 3034-3037
    • Manninen, A.1    Huotari, P.2    Hiipakka, M.3
  • 103
    • 0035919704 scopus 로고    scopus 로고
    • Inhibition of cellular functions of HIV-1 Nef by artificial SH3 domains
    • Hiipakka M, Huotari P, Manninen A, et al. Inhibition of cellular functions of HIV-1 Nef by artificial SH3 domains. Virology 2001;286(1):152-9
    • (2001) Virology , vol.286 , Issue.1 , pp. 152-159
    • Hiipakka, M.1    Huotari, P.2    Manninen, A.3
  • 104
    • 37649000332 scopus 로고    scopus 로고
    • Protein-protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein
    • Betzi S, Restouin A, Opi S, et al. Protein-protein interaction inhibition (2P2I) combining high throughput and virtual screening: application to the HIV-1 Nef protein. Proc Natl Acad Sci USA 2007;104(49):19256-61
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.49 , pp. 19256-19261
    • Betzi, S.1    Restouin, A.2    Opi, S.3
  • 105
    • 73449135109 scopus 로고    scopus 로고
    • Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds
    • Emert-Sedlak L, Kodama T, Lerner EC, et al. Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds. ACS Chem Biol 2009;4(11):939-47
    • (2009) ACS Chem Biol , vol.4 , Issue.11 , pp. 939-947
    • Emert-Sedlak, L.1    Kodama, T.2    Lerner, E.C.3
  • 106
    • 84857680190 scopus 로고    scopus 로고
    • Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner
    • Narute PS, Smithgall TE. Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner. PLoS ONE 2012;7(2):e32561
    • (2012) PLoS ONE , vol.7 , Issue.2
    • Narute, P.S.1    Smithgall, T.E.2
  • 107
    • 81055125791 scopus 로고    scopus 로고
    • The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement
    • Chutiwitoonchai N, Hiyoshi M, Mwimanzi P, et al. The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement. PLoS ONE 2011;6(11):e27696
    • (2011) PLoS ONE , vol.6 , Issue.11
    • Chutiwitoonchai, N.1    Hiyoshi, M.2    Mwimanzi, P.3
  • 108
    • 77958041295 scopus 로고    scopus 로고
    • Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action
    • Dikeakos JD, Atkins KM, Thomas L, et al. Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action. Mol Biol Cell 2010;21(19):3279-92
    • (2010) Mol Biol Cell , vol.21 , Issue.19 , pp. 3279-3292
    • Dikeakos, J.D.1    Atkins, K.M.2    Thomas, L.3
  • 109
    • 70149085247 scopus 로고    scopus 로고
    • Dysregulated activation of a Src tyrosine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms
    • Hassan R, Suzu S, Hiyoshi M, et al. Dysregulated activation of a Src tyrosine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms. J Cell Physiol 2009;221(2):458-68
    • (2009) J Cell Physiol , vol.221 , Issue.2 , pp. 458-468
    • Hassan, R.1    Suzu, S.2    Hiyoshi, M.3
  • 110
    • 0038183834 scopus 로고    scopus 로고
    • Synthetic inhibitors of proline-rich ligand-mediated protein-protein interaction: Potent analogs of UCS15A
    • Oneyama C, Agatsuma T, Kanda Y, et al. Synthetic inhibitors of proline-rich ligand-mediated protein-protein interaction: potent analogs of UCS15A. Chem Biol 2003;10(5):443-51
    • (2003) Chem Biol , vol.10 , Issue.5 , pp. 443-451
    • Oneyama, C.1    Agatsuma, T.2    Kanda, Y.3
  • 111
    • 84878935042 scopus 로고    scopus 로고
    • Nanobodies: Natural single-domain antibodies
    • Muyldermans S. Nanobodies: natural single-domain antibodies. Annu Rev Biochem 2013;82:775-97
    • (2013) Annu Rev Biochem , vol.82 , pp. 775-797
    • Muyldermans, S.1
  • 112
    • 79953707336 scopus 로고    scopus 로고
    • Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody
    • Bouchet J, Basmaciogullari SE, Chrobak P, et al. Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody. Blood 2011;117(13):3559-68
    • (2011) Blood , vol.117 , Issue.13 , pp. 3559-3568
    • Bouchet, J.1    Basmaciogullari, S.E.2    Chrobak, P.3
  • 113
    • 84861318507 scopus 로고    scopus 로고
    • Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions
    • Bouchet J, Herate C, Guenzel CA, et al. Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions. J Virol 2012;86(9):4856-67
    • (2012) J Virol , vol.86 , Issue.9 , pp. 4856-4867
    • Bouchet, J.1    Herate, C.2    Guenzel, C.A.3
  • 114
    • 79956336664 scopus 로고    scopus 로고
    • Molecular design functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef
    • Breuer S, Schievink SI, Schulte A, et al. Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. PLoS One 2011;6(5):e20033
    • (2011) PLoS One , vol.6 , Issue.5
    • Breuer, S.1    Schievink, S.I.2    Schulte, A.3
  • 115
    • 0029133326 scopus 로고
    • The role of myristoylation in the interactions between human immunodeficiency virus type i Nef and cellular proteins
    • Harris M. The role of myristoylation in the interactions between human immunodeficiency virus type I Nef and cellular proteins. Biochem Soc Trans 1995;23(3):557-61
    • (1995) Biochem Soc Trans , vol.23 , Issue.3 , pp. 557-561
    • Harris, M.1
  • 116
    • 84856425445 scopus 로고    scopus 로고
    • Nef surfaces: Where to interfere with function
    • Lulf S, Horenkamp FA, Breuer S, Geyer M. Nef surfaces: where to interfere with function. Curr HIV Res 2011;9(7):543-51
    • (2011) Curr HIV Res , vol.9 , Issue.7 , pp. 543-551
    • Lulf, S.1    Horenkamp, F.A.2    Breuer, S.3    Geyer, M.4
  • 117
    • 84872898071 scopus 로고    scopus 로고
    • Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity
    • Emert-Sedlak LA, Narute P, Shu ST, et al. Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity. Chem Biol 2013;20(1):82-91
    • (2013) Chem Biol , vol.20 , Issue.1 , pp. 82-91
    • Emert-Sedlak, L.A.1    Narute, P.2    Shu, S.T.3
  • 118
    • 0034843329 scopus 로고    scopus 로고
    • The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck
    • Hanna Z, Weng X, Kay DG, et al. The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck. J Virol 2001;75(19):9378-92
    • (2001) J Virol , vol.75 , Issue.19 , pp. 9378-9392
    • Hanna, Z.1    Weng, X.2    Kay, D.G.3
  • 119
    • 84861491693 scopus 로고    scopus 로고
    • Src kinase inhibitors: Promising cancer therapeutics?
    • Creedon H, Brunton VG. Src kinase inhibitors: promising cancer therapeutics? Crit Rev Oncog 2012;17(2):145-59
    • (2012) Crit Rev Oncog , vol.17 , Issue.2 , pp. 145-159
    • Creedon, H.1    Brunton, V.G.2
  • 120
    • 84871369699 scopus 로고    scopus 로고
    • The role of Src kinase in macrophage-mediated inflammatory responses
    • Byeon SE, Yi YS, Oh J, et al. The role of Src kinase in macrophage-mediated inflammatory responses. Mediators Inflamm 2012;2012:512926
    • (2012) Mediators Inflamm , vol.2012 , pp. 512926
    • Byeon, S.E.1    Yi, Y.S.2    Oh, J.3
  • 121
    • 36048985664 scopus 로고    scopus 로고
    • Replication-dependent pathogenicity of attenuated nef-deleted HIV-1 in vivo
    • Gorry PR, Churchill M, Learmont J, et al. Replication-dependent pathogenicity of attenuated nef-deleted HIV-1 in vivo. J Acquir Immune Defic Syndr 2007;46(4):390-4
    • (2007) J Acquir Immune Defic Syndr , vol.46 , Issue.4 , pp. 390-394
    • Gorry, P.R.1    Churchill, M.2    Learmont, J.3


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