HIV-1 Nef protein visits B-cells via macrophage nanotubes: A mechanism for AIDS-related lymphoma pathogenesis?

Current HIV Research

Volumn 8, Issue 8, 2010, Pages 638-640

  Lamers, Susanna L ^a,b   Fogel, Gary B ^c   Huysentruyt, Leanne C ^d   McGrath, Michael S ^d,e  

^a POLYTECHNIC UNIVERSITY   (United States)

^b BIOINFOEXPERTS LLC   (United States)

^c NATURAL SELECTION INC   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e The West Coast AIDS and Cancer Specimen Resource   (United States)

Author keywords

AIDS related lymphoma; HIV 1; HIV 1 nef protein; Macrophages

Indexed keywords

IMMUNOGLOBULIN RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 4; NANOTUBE; NEF PROTEIN;

AIDS RELATED COMPLEX; ARTICLE; B LYMPHOCYTE; CAUSE OF DEATH; CELL ACTIVATION; CELL PROLIFERATION; DISEASE ASSOCIATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPHOMA; MACROPHAGE; MACROPHAGE ACTIVATION; NONHUMAN; PATHOGENESIS; PROTEIN TRANSPORT; PROTEIN VARIANT;

B-LYMPHOCYTES; HIV INFECTIONS; HIV-1; HUMANS; LYMPHOMA, AIDS-RELATED; MACROPHAGES; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 78650907444     PISSN: 1570162X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016210794088209     Document Type: Article

References (31)

1. Xu W, Santini PA, Sullivan JS, et al. HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long range intercellular conduits. Nat Immunol 2009; 10(9): 1008-17.
2. Moir S, Fauci AS. Nef, macrophages and B cells: a highway for evasion. Immunol Cell Biol 2010; 88(1): 1-2.
3. Rudnicka D, Schwartz O. Intrusive HIV-1-infected cells. Nat Immunol 2009; 10(9): 933-4.
4. Swingler S, Zhou J, Swingler C, et al. Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS. Cell Host Microbe 2008; 4(1): 63-76.
5. Huysentruyt LC, McGrath MS. The role of macrophages in the development and progression of AIDS-related non-Hodgkin lymphoma. J Leukoc Biol 2009; 87(4): 627-32.
6. McGrath MS. T-cells and macrophages in HIV disease. Clin Rev Allergy Immunol 1997; 14(4): 359-66.
7. Herbein G, Varin A. The macrophage in HIV-1 infection: from activation to deactivation. Retrovirology 2010 Apr 9; 7: 33.
8. Cassol E, Cassetta L, Alfano M, Poli G. Macrophage polarization and HIV-1 infection. J Leukocyte Biol 2010; 87(4): 599-608.
9. Mantovani A, Sica A, Allavena P, Garlanda C, Locati M. Tumorassociated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation. Hum Immunol 2009; 70(5): 325-30.
10. Sica A, Larghi P, Mancino A, et al. Macrophage polarization in tumour progression. Semin Cancer Biol 2008; 18(5): 349-55.
11. Umemura N, Saio M, Suwa T, et al. Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1-and M2-type characteristics. J Leukoc Biol 2008; 83(5): 1136-44.
12. Herbein G, Varin A. The macrophage in HIV-1 infection: from activation to deactivation? Retrovirology 2010; 7: 33.
13. Carl S, Greenough TC, Krumbiegel M, et al. Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS. J Virol 2001; 75(8): 3657-65.
14. Klotman ME, Kim S, Buchbinder A, DeRossi A, Baltimore D, Wong Staal F. Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. Proc Natl Acad Sci USA 1991; 88(11): 5011-5.
15. Choi HJ, Smithgall TE. HIV-1 Nef promotes survival of TF-1 macrophages by inducing Bcl-XL expression in an extracellular signal regulated kinase-dependent manner. J Biol Chem 2004; 279(49): 51688-96.
16. Lehmann MH, Walter S, Ylisastigui L, et al. Extracellular HIV-1 Nef increases migration of monocytes. Exp Cell Res 2006; 312(18): 3659-68.
17. Swingler S, Mann A, Jacque J, et al. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages. Nat Med 1999; 5(9): 985-6.
18. Peterlin BM, Trono D. Hide, shield and strike back: how HIV-infected cells avoid immune eradication. Nat Rev Immunol 2003; 3(2): 97-107.
19. Chaudhry A, Verghese DA, Das SR, et al. HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathway. J Immunol 2009; 183(4): 2415-24.
20. Lee CH, Saksela K, Mirza UA, Chait BT, Kuriyan J. Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell 1996; 85: 931-42.
21. Bentham M, Mazaleyrat S, Harris M. Role of myristoylation and N-terminal basic residues in membrane association of the human immunodeficiency virus type 1 Nef protein. J Gen Virol 2006; 87(3): 563-71.
22. Giese SI, Woerz I, Homann S, Tibroni N, Geyer M, Fackler OT. Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef. Virology 2006; 355(2): 175-91.
23. Coates K, Boulton V, Cooke S, Mann D, Harris M. Analysis of the interactions between Nef and cellular proteins. Res Virol 1997; 148(1): 68-70.
24. Fackler OT, Kienzle N, Kremmer E, et al. Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization. Eur J Biochem 1997; 247(3): 843-51.
25. Kaminchik J, Margalit R, Yaish S, et al. Cellular distribution of HIV type 1 Nef protein: identification of domains in Nef required for association with membrane and detergent-insoluble cellular matrix. AIDS Res Hum Retroviruses 1994; 10(8): 1003-10.
26. Niederman TM, Hastings WR, Ratner L. Myristoylation-enhanced binding of the HIV-1 Nef protein to T cell skeletal matrix. Virology 1993; 197(1): 420-5.
27. Salemi M, Lamers SL, Huysentruyt LC, et al. Distinct patterns of HIV-1 evolution within metastatic tissues in patients with non-Hodgkins lymphoma. PLoS One 2009; 4(12): e8153.
28. Lamers S, Salemi M, Fogel G, McGrath M. HIV dynamics, signatures and structures associated with the development of AIDS-related lymphoma. International AIDS Conference 2010; Vienna, Austria, July 18-23, 2010(Abstract # 16160).
29. Lamers S, Fogel G, Huysentruyt L, Poon A, McGrath M. The HIV nef protein within ARL is genetically and structurally distinct from those in the brain of patients with HAD. 12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies 2010.
30. Lamers SL, Salemi M, McGrath MS, Fogel GB. Prediction of R5, X4, and R5X4 HIV-1 coreceptor usage with evolved neural networks. IEEE/ACM Trans Comput Biol Bioinform 2008; 5(2): 291-300.
31. Yeung ML, Bennasser Y, Watashi K, Le SY, Houzet L, Jeang KT. Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybrid. Nucleic Acids Res 2009; 37(19): 6575-86.