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Volumn 9, Issue 7, 2011, Pages 474-489

The Nef-infectivity enigma: Mechanisms of enhanced lentiviral infection

Author keywords

Cholesterol; Envelope protein; HIV; Infectivity; Mutation analysis; Nef; Proteasome; Viral replication

Indexed keywords

CD4 ANTIGEN; CELL PROTEIN; LIPIDOME; NEF PROTEIN; VIRUS PROTEIN;

EID: 84856453839     PISSN: 1570162X     EISSN: 18734251     Source Type: Journal    
DOI: 10.2174/157016211798842099     Document Type: Review
Times cited : (21)

References (130)
  • 1
    • 84890312070 scopus 로고    scopus 로고
    • Joint United Nations Programme on HIV/AIDS (UNAIDS)
    • [cited 2011 11th June], Available from
    • Joint United Nations Programme on HIV/AIDS (UNAIDS). Global report: UNAIDS report on the global AIDS epidemic 2010. 2010 [cited 2011 11th June]; Available from: http://www.unaids.org/documents /20101123_GlobalReport_em.pdf
    • (2010) Global report: UNAIDS report on the global AIDS epidemic 2010
  • 2
    • 79953117041 scopus 로고    scopus 로고
    • Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation
    • Allers K, Hutter G, Hofmann J, et al. Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation. Blood 2011; 117: 2791-9.
    • (2011) Blood , vol.117 , pp. 2791-2799
    • Allers, K.1    Hutter, G.2    Hofmann, J.3
  • 3
    • 73549107210 scopus 로고    scopus 로고
    • Novel approaches to inhibiting HIV-1 replication
    • Adamson CS and Freed EO. Novel approaches to inhibiting HIV-1 replication. Antiviral Res 2010; 85: 119-41.
    • (2010) Antiviral Res , vol.85 , pp. 119-141
    • Adamson, C.S.1    Freed, E.O.2
  • 4
    • 61949425674 scopus 로고    scopus 로고
    • Strategies for inhibiting function of HIV-1 accessory proteins: A necessary route to AIDS therapy?
    • Richter SN, Frasson I and Palu G. Strategies for inhibiting function of HIV-1 accessory proteins: a necessary route to AIDS therapy? Curr Med Chem 2009; 16: 267-86.
    • (2009) Curr Med Chem , vol.16 , pp. 267-286
    • Richter, S.N.1    Frasson, I.2    Palu, G.3
  • 5
    • 44649139364 scopus 로고    scopus 로고
    • HIV-1 accessory proteins--ensuring viral survival in a hostile environment
    • Malim MH and Emerman M. HIV-1 accessory proteins--ensuring viral survival in a hostile environment. Cell Host Microbe 2008; 3: 388-98.
    • (2008) Cell Host Microbe , vol.3 , pp. 388-398
    • Malim, M.H.1    Emerman, M.2
  • 6
    • 0025743306 scopus 로고
    • Importance of the nef gene for maintenance of high virus loads and for development of AIDS
    • Kestler HW, 3rd, Ringler DJ, Mori K, et al. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 1991; 65: 651-62.
    • (1991) Cell , vol.65 , pp. 651-662
    • Kestler III, H.W.1    Ringler, D.J.2    Mori, K.3
  • 7
    • 0028804160 scopus 로고
    • Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients
    • Deacon NJ, Tsykin A, Solomon A, et al. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 1995; 270: 988-91.
    • (1995) Science , vol.270 , pp. 988-991
    • Deacon, N.J.1    Tsykin, A.2    Solomon, A.3
  • 8
    • 0028835788 scopus 로고
    • Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
    • Kirchhoff F, Greenough TC, Brettler DB, et al. Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med 1995; 332: 228-32.
    • (1995) N Engl J Med , vol.332 , pp. 228-232
    • Kirchhoff, F.1    Greenough, T.C.2    Brettler, D.B.3
  • 9
    • 0031979771 scopus 로고    scopus 로고
    • Grossly defective nef gene sequences in a human immunodeficiency virus type 1-seropositive long-term nonprogressor
    • Salvi R, Garbuglia AR, Di CA, et al. Grossly defective nef gene sequences in a human immunodeficiency virus type 1-seropositive long-term nonprogressor. J Virol 1998; 72: 3646-57.
    • (1998) J Virol , vol.72 , pp. 3646-3657
    • Salvi, R.1    Garbuglia, A.R.2    Di, C.A.3
  • 10
    • 36048974619 scopus 로고    scopus 로고
    • Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo
    • Gorry PR, McPhee DA, Verity E, et al. Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo. Retrovirology 2007; 4: 66.
    • (2007) Retrovirology , vol.4 , pp. 66
    • Gorry, P.R.1    McPhee, D.A.2    Verity, E.3
  • 11
    • 79955426303 scopus 로고    scopus 로고
    • The Sydney Blood Bank Cohort: Implications for viral fitness as a cause of elite control
    • Zaunders J, Dyer WB and Churchill M. The Sydney Blood Bank Cohort: implications for viral fitness as a cause of elite control. Curr Opin HIV AIDS 2011; 6: 151-6.
    • (2011) Curr Opin HIV AIDS , vol.6 , pp. 151-156
    • Zaunders, J.1    Dyer, W.B.2    Churchill, M.3
  • 12
    • 0032905068 scopus 로고    scopus 로고
    • Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques
    • Baba TW, Liska V, Khimani AH, et al. Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques. Nat Med 1999; 5: 194-203.
    • (1999) Nat Med , vol.5 , pp. 194-203
    • Baba, T.W.1    Liska, V.2    Khimani, A.H.3
  • 13
    • 0032538278 scopus 로고    scopus 로고
    • Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice
    • Hanna Z, Kay DG, Rebai N, et al. Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 1998; 95: 163-75.
    • (1998) Cell , vol.95 , pp. 163-175
    • Hanna, Z.1    Kay, D.G.2    Rebai, N.3
  • 15
    • 47749133802 scopus 로고    scopus 로고
    • HIV Nef: Role in pathogenesis and viral fitness
    • Arien KK and Verhasselt B. HIV Nef: role in pathogenesis and viral fitness. Curr HIV Res 2008; 6: 200-8.
    • (2008) Curr HIV Res , vol.6 , pp. 200-208
    • Arien, K.K.1    Verhasselt, B.2
  • 16
    • 74849088296 scopus 로고    scopus 로고
    • Implications of Nef: Host cell interactions in viral persistence and progression to AIDS
    • Arhel NJ and Kirchhoff F. Implications of Nef: host cell interactions in viral persistence and progression to AIDS. Curr Top Microbiol Immunol 2009; 339: 147-75.
    • (2009) Curr Top Microbiol Immunol , vol.339 , pp. 147-175
    • Arhel, N.J.1    Kirchhoff, F.2
  • 17
    • 0023790222 scopus 로고
    • Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR
    • Ahmad N and Venkatesan S. Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR. Science 1988; 241: 1481-85.
    • (1988) Science , vol.241 , pp. 1481-1485
    • Ahmad, N.1    Venkatesan, S.2
  • 18
    • 0024331985 scopus 로고
    • Nef protein of human immunodeficiency virus type 1: Evidence against its role as a transcriptional inhibitor
    • Hammes SR, Dixon EP, Malim MH, et al. Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor. Proc Natl Acad Sci USA 1989; 86: 9549-53.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 9549-9553
    • Hammes, S.R.1    Dixon, E.P.2    Malim, M.H.3
  • 19
    • 0024316873 scopus 로고
    • Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1
    • Kim S, Ikeuchi K, Byrn R, et al. Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1989; 86: 9544-48.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 9544-9548
    • Kim, S.1    Ikeuchi, K.2    Byrn, R.3
  • 20
    • 0028006247 scopus 로고
    • The human immunodeficiency virus-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages
    • Miller MD, Warmerdam MT, Gaston I, et al. The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J Exp Med 1994; 179: 101-13.
    • (1994) J Exp Med , vol.179 , pp. 101-113
    • Miller, M.D.1    Warmerdam, M.T.2    Gaston, I.3
  • 21
    • 0027952787 scopus 로고
    • The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes
    • Spina CA, Kwoh TJ, Chowers MY, et al. The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J Exp Med 1994; 179: 115-23.
    • (1994) J Exp Med , vol.179 , pp. 115-123
    • Spina, C.A.1    Kwoh, T.J.2    Chowers, M.Y.3
  • 22
    • 0034948709 scopus 로고    scopus 로고
    • Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators
    • Simmons A, Aluvihare V and McMichael A. Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators. Immunity 2001; 14: 763-77.
    • (2001) Immunity , vol.14 , pp. 763-777
    • Simmons, A.1    Aluvihare, V.2    McMichael, A.3
  • 23
    • 0034602776 scopus 로고    scopus 로고
    • The Nef protein of HIV-1 associates with rafts and primes T cells for activation
    • Wang JK, Kiyokawa E, Verdin E and Trono D. The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc Natl Acad Sci USA 2000; 97: 394-99.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 394-399
    • Wang, J.K.1    Kiyokawa, E.2    Verdin, E.3    Trono, D.4
  • 24
    • 58849132949 scopus 로고    scopus 로고
    • Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B
    • Witte V, Laffert B, Gintschel P, et al. Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B. J Immunol 2008; 181: 8425-32.
    • (2008) J Immunol , vol.181 , pp. 8425-8432
    • Witte, V.1    Laffert, B.2    Gintschel, P.3
  • 25
    • 0033578016 scopus 로고    scopus 로고
    • Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein
    • Ross TM, Oran AE and Cullen BR. Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein. Curr Biol 1999; 9: 613-21.
    • (1999) Curr Biol , vol.9 , pp. 613-621
    • Ross, T.M.1    Oran, A.E.2    Cullen, B.R.3
  • 26
    • 80052671541 scopus 로고    scopus 로고
    • Nef does not inhibit F-actin remodelling and HIV-1 cell-cell transmission at the T lymphocyte virological synapse
    • doi: 10.1016/j.ejcb.2010.09.010
    • Haller C, Tibroni N, Rudolph JM, et al. Nef does not inhibit F-actin remodelling and HIV-1 cell-cell transmission at the T lymphocyte virological synapse. Eur J Cell Biol 2010. doi: 10.1016/j.ejcb.2010.09.010
    • (2010) Eur J Cell Biol
    • Haller, C.1    Tibroni, N.2    Rudolph, J.M.3
  • 27
    • 77649228424 scopus 로고    scopus 로고
    • HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes
    • Nobile C, Rudnicka D, Hasan M, et al. HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes. J Virol 2010; 84: 2282-93.
    • (2010) J Virol , vol.84 , pp. 2282-2293
    • Nobile, C.1    Rudnicka, D.2    Hasan, M.3
  • 28
    • 0036169006 scopus 로고    scopus 로고
    • HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread
    • Sol-Foulon N, Moris A, Nobile C, et al. HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread. Immunity 2002; 16: 145-55.
    • (2002) Immunity , vol.16 , pp. 145-155
    • Sol-Foulon, N.1    Moris, A.2    Nobile, C.3
  • 29
    • 0026562720 scopus 로고
    • Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated betagalactosidase gene
    • Kimpton J and Emerman M. Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated betagalactosidase gene. J Virol 1992; 66: 2232-39.
    • (1992) J Virol , vol.66 , pp. 2232-2239
    • Kimpton, J.1    Emerman, M.2
  • 30
    • 0028936207 scopus 로고
    • Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry
    • Miller MD, Warmerdam MT, Page KA, et al. Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry. J Virol 1995; 69: 579-84.
    • (1995) J Virol , vol.69 , pp. 579-584
    • Miller, M.D.1    Warmerdam, M.T.2    Page, K.A.3
  • 31
    • 37049029214 scopus 로고    scopus 로고
    • Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses
    • Munch J, Rajan D, Schindler M, et al. Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses. J Virol 2007; 81: 13852-64.
    • (2007) J Virol , vol.81 , pp. 13852-13864
    • Munch, J.1    Rajan, D.2    Schindler, M.3
  • 32
    • 0028180868 scopus 로고
    • Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
    • Aiken C, Konner J, Landau NR, et al. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 1994; 76: 853-64.
    • (1994) Cell , vol.76 , pp. 853-864
    • Aiken, C.1    Konner, J.2    Landau, N.R.3
  • 33
    • 0034795885 scopus 로고    scopus 로고
    • CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo
    • Glushakova S, Munch J, Carl S, et al. CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo. J Virol 2001; 75: 10113-7.
    • (2001) J Virol , vol.75 , pp. 10113-10117
    • Glushakova, S.1    Munch, J.2    Carl, S.3
  • 34
    • 36349022028 scopus 로고    scopus 로고
    • Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue
    • Schindler M, Rajan D, Specht A, et al. Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue. J Virol 2007; 81: 13005-14.
    • (2007) J Virol , vol.81 , pp. 13005-13014
    • Schindler, M.1    Rajan, D.2    Specht, A.3
  • 35
    • 78651244198 scopus 로고    scopus 로고
    • CD4 downregulation by the human immunodeficiency virus type 1 Nef protein is dispensable for optimal output and functionality of viral particles in primary T cells
    • Neri F, Giolo G, Potesta M, et al. CD4 downregulation by the human immunodeficiency virus type 1 Nef protein is dispensable for optimal output and functionality of viral particles in primary T cells. J Gen Virol. 2011; 92: 141-50.
    • (2011) J Gen Virol. , vol.92 , pp. 141-150
    • Neri, F.1    Giolo, G.2    Potesta, M.3
  • 36
    • 0031716336 scopus 로고    scopus 로고
    • Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: Analysis of its role in enhancement of viral infectivity
    • Welker R, Harris M, Cardel B and Krausslich HG. Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity. J Virol 1998; 72: 8833-40.
    • (1998) J Virol , vol.72 , pp. 8833-8840
    • Welker, R.1    Harris, M.2    Cardel, B.3    Krausslich, H.G.4
  • 37
    • 34249847836 scopus 로고    scopus 로고
    • Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef
    • Pizzato M, Helander A, Popova E, et al. Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef. Proc Natl Acad Sci USA 2007; 104: 6812-17.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6812-6817
    • Pizzato, M.1    Helander, A.2    Popova, E.3
  • 38
    • 0030816597 scopus 로고    scopus 로고
    • Intravirion generation of the C-terminal core domain of HIV-1 Nef by the HIV-1 protease is insufficient to enhance viral infectivity
    • Miller MD, Warmerdam MT, Ferrell SS, et al. Intravirion generation of the C-terminal core domain of HIV-1 Nef by the HIV-1 protease is insufficient to enhance viral infectivity. Virology 1997; 234: 215-25.
    • (1997) Virology , vol.234 , pp. 215-225
    • Miller, M.D.1    Warmerdam, M.T.2    Ferrell, S.S.3
  • 39
    • 0031901558 scopus 로고    scopus 로고
    • The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity
    • Chen YL, Trono D and Camaur D. The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity. J Virol 1998; 72: 3178-84.
    • (1998) J Virol , vol.72 , pp. 3178-3184
    • Chen, Y.L.1    Trono, D.2    Camaur, D.3
  • 40
    • 33750614324 scopus 로고    scopus 로고
    • Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef
    • Giese SI, Woerz I, Homann S, et al. Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef. Virology 2006; 355: 175-91.
    • (2006) Virology , vol.355 , pp. 175-191
    • Giese, S.I.1    Woerz, I.2    Homann, S.3
  • 41
    • 19244382596 scopus 로고    scopus 로고
    • Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions
    • Liu LX, Heveker N, Fackler OT, et al. Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions. J Virol 2000; 74: 5310-9.
    • (2000) J Virol , vol.74 , pp. 5310-5319
    • Liu, L.X.1    Heveker, N.2    Fackler, O.T.3
  • 42
    • 0032530773 scopus 로고    scopus 로고
    • Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
    • Craig HM, Pandori MW and Guatelli JC. Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity. Proc Natl Acad Sci USA 1998; 95: 11229-34.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11229-11234
    • Craig, H.M.1    Pandori, M.W.2    Guatelli, J.C.3
  • 43
    • 31144476786 scopus 로고    scopus 로고
    • Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef
    • O'Neill E, Kuo LS, Krisko JF, et al. Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef. J Virol 2006; 80: 1311-20.
    • (2006) J Virol , vol.80 , pp. 1311-1320
    • O'Neill, E.1    Kuo, L.S.2    Krisko, J.F.3
  • 44
    • 0037302331 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis
    • Stoddart CA, Geleziunas R, Ferrell S, et al. Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis. J Virol 2003; 77: 2124-33.
    • (2003) J Virol , vol.77 , pp. 2124-2133
    • Stoddart, C.A.1    Geleziunas, R.2    Ferrell, S.3
  • 45
    • 0030273317 scopus 로고    scopus 로고
    • HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis
    • Wiskerchen M and Cheng-Mayer C. HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis. Virology 1996; 224: 292-301.
    • (1996) Virology , vol.224 , pp. 292-301
    • Wiskerchen, M.1    Cheng-Mayer, C.2
  • 46
    • 0029046227 scopus 로고
    • Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef
    • Goldsmith MA, Warmerdam MT, Atchison RE, et al. Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef. J Virol 1995; 69: 4112-21.
    • (1995) J Virol , vol.69 , pp. 4112-4121
    • Goldsmith, M.A.1    Warmerdam, M.T.2    Atchison, R.E.3
  • 47
    • 20044362379 scopus 로고    scopus 로고
    • Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity
    • Madrid R, Janvier K, Hitchin D, et al. Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity. J Biol Chem 2005; 280: 5032-44.
    • (2005) J Biol Chem , vol.280 , pp. 5032-5044
    • Madrid, R.1    Janvier, K.2    Hitchin, D.3
  • 48
    • 0034001233 scopus 로고    scopus 로고
    • Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation
    • Akari H, Arold S, Fukumori T, et al. Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation. J Virol 2000; 74: 2907-12.
    • (2000) J Virol , vol.74 , pp. 2907-2912
    • Akari, H.1    Arold, S.2    Fukumori, T.3
  • 49
    • 52649095981 scopus 로고    scopus 로고
    • Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain
    • Baugh LL, Garcia JV and Foster JL. Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain. J Virol 2008; 82: 9657-67.
    • (2008) J Virol , vol.82 , pp. 9657-9667
    • Baugh, L.L.1    Garcia, J.V.2    Foster, J.L.3
  • 50
    • 33746322762 scopus 로고    scopus 로고
    • Functional characterization of HIV-1 Nef mutants in the context of viral infection
    • Fackler OT, Moris A, Tibroni N, et al. Functional characterization of HIV-1 Nef mutants in the context of viral infection. Virology 2006; 351: 322-39.
    • (2006) Virology , vol.351 , pp. 322-339
    • Fackler, O.T.1    Moris, A.2    Tibroni, N.3
  • 51
    • 72949114062 scopus 로고    scopus 로고
    • Role of HIV-1 Nef protein for virus replication in vitro
    • Jere A, Fujita M, Adachi A and Nomaguchi M. Role of HIV-1 Nef protein for virus replication in vitro. Microbes Infect 2010; 12: 65-70.
    • (2010) Microbes Infect , vol.12 , pp. 65-70
    • Jere, A.1    Fujita, M.2    Adachi, A.3    Nomaguchi, M.4
  • 52
    • 0036231461 scopus 로고    scopus 로고
    • Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes
    • Lundquist CA, Tobiume M, Zhou J, et al. Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. J Virol 2002; 76: 4625-33.
    • (2002) J Virol , vol.76 , pp. 4625-4633
    • Lundquist, C.A.1    Tobiume, M.2    Zhou, J.3
  • 53
    • 0031872106 scopus 로고    scopus 로고
    • Regions of human immunodeficiency virus type 1 nef required for function in vivo
    • Aldrovandi GM, Gao L, Bristol G and Zack JA. Regions of human immunodeficiency virus type 1 nef required for function in vivo. J Virol 1998; 72: 7032-39.
    • (1998) J Virol , vol.72 , pp. 7032-7039
    • Aldrovandi, G.M.1    Gao, L.2    Bristol, G.3    Zack, J.A.4
  • 54
    • 79952088584 scopus 로고    scopus 로고
    • The Role of Lipids in Retrovirus Replication
    • Waheed AA and Freed EO. The Role of Lipids in Retrovirus Replication. Viruses 2010; 2: 1146-80.
    • (2010) Viruses , vol.2 , pp. 1146-1180
    • Waheed, A.A.1    Freed, E.O.2
  • 55
    • 3843114507 scopus 로고    scopus 로고
    • The effects of HIV-1 Nef on CD4 surface expression and viral infectivity in lymphoid cells are independent of rafts
    • Sol-Foulon N, Esnault C, Percherancier Y, et al. The effects of HIV-1 Nef on CD4 surface expression and viral infectivity in lymphoid cells are independent of rafts. J Biol Chem 2004; 279: 31398-408.
    • (2004) J Biol Chem , vol.279 , pp. 31398-31408
    • Sol-Foulon, N.1    Esnault, C.2    Percherancier, Y.3
  • 56
    • 35948969818 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains
    • Brugger B, Krautkramer E, Tibroni N, et al. Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains. Retrovirology 2007; 4: 70.
    • (2007) Retrovirology , vol.4 , pp. 70
    • Brugger, B.1    Krautkramer, E.2    Tibroni, N.3
  • 57
    • 0033776709 scopus 로고    scopus 로고
    • HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes
    • Piguet V, Wan L, Borel C, et al. HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. Nat Cell Biol 2000; 2: 163-7.
    • (2000) Nat Cell Biol , vol.2 , pp. 163-167
    • Piguet, V.1    Wan, L.2    Borel, C.3
  • 58
    • 0033153464 scopus 로고    scopus 로고
    • Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions
    • Fackler OT, Luo W, Geyer M, et al. Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions. Mol Cell 1999; 3: 729-39.
    • (1999) Mol Cell , vol.3 , pp. 729-739
    • Fackler, O.T.1    Luo, W.2    Geyer, M.3
  • 59
    • 0034064726 scopus 로고    scopus 로고
    • p21-activated kinase 1 plays a critical role in cellular activation by Nef
    • Fackler OT, Lu X, Frost JA, et al. p21-activated kinase 1 plays a critical role in cellular activation by Nef. Mol Cell Biol 2000; 20: 2619-27.
    • (2000) Mol Cell Biol , vol.20 , pp. 2619-2627
    • Fackler, O.T.1    Lu, X.2    Frost, J.A.3
  • 60
    • 34247129671 scopus 로고    scopus 로고
    • Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor
    • Chaudhuri R, Lindwasser OW, Smith WJ, et al. Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. J Virol 2007; 81: 3877-90.
    • (2007) J Virol , vol.81 , pp. 3877-3890
    • Chaudhuri, R.1    Lindwasser, O.W.2    Smith, W.J.3
  • 61
    • 0033917035 scopus 로고    scopus 로고
    • Characterization and molecular basis of the oligomeric structure of HIV-1 nef protein
    • Arold S, Hoh F, Domergue S, et al. Characterization and molecular basis of the oligomeric structure of HIV-1 nef protein. Protein Sci 2000; 9: 1137-48.
    • (2000) Protein Sci , vol.9 , pp. 1137-1148
    • Arold, S.1    Hoh, F.2    Domergue, S.3
  • 62
    • 70350547756 scopus 로고    scopus 로고
    • HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication
    • Poe JA and Smithgall TE. HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication. J Mol Biol 2009; 394: 329-42.
    • (2009) J Mol Biol , vol.394 , pp. 329-342
    • Poe, J.A.1    Smithgall, T.E.2
  • 63
    • 77956885987 scopus 로고    scopus 로고
    • Self-association of the Lentivirus protein, Nef
    • Kwak YT, Raney A, Kuo LS, et al. Self-association of the Lentivirus protein, Nef. Retrovirology 2010; 7: 77.
    • (2010) Retrovirology , vol.7 , pp. 77
    • Kwak, Y.T.1    Raney, A.2    Kuo, L.S.3
  • 64
    • 0029015330 scopus 로고
    • Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis
    • Aiken C and Trono D. Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J Virol 1995; 69: 5048-56.
    • (1995) J Virol , vol.69 , pp. 5048-5056
    • Aiken, C.1    Trono, D.2
  • 65
    • 0029975546 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase
    • Welker R, Kottler H, Kalbitzer HR and Krausslich HG. Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase. Virology 1996; 219: 228-36.
    • (1996) Virology , vol.219 , pp. 228-236
    • Welker, R.1    Kottler, H.2    Kalbitzer, H.R.3    Krausslich, H.G.4
  • 66
    • 0030014162 scopus 로고    scopus 로고
    • Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein
    • Pandori MW, Fitch NJ, Craig HM, et al. Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein. J Virol 1996; 70: 4283-90.
    • (1996) J Virol , vol.70 , pp. 4283-4290
    • Pandori, M.W.1    Fitch, N.J.2    Craig, H.M.3
  • 67
    • 79953848334 scopus 로고    scopus 로고
    • HIV-1 accessory protein Vpr: Relevance in the pathogenesis of HIV and potential for therapeutic intervention
    • Kogan M and Rappaport J. HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention. Retrovirology 2011; 8: 25.
    • (2011) Retrovirology , vol.8 , pp. 25
    • Kogan, M.1    Rappaport, J.2
  • 68
    • 0031015224 scopus 로고    scopus 로고
    • Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease
    • Bukovsky AA, Dorfman T, Weimann A and Gottlinger HG. Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease. J Virol 1997; 71: 1013-8.
    • (1997) J Virol , vol.71 , pp. 1013-1018
    • Bukovsky, A.A.1    Dorfman, T.2    Weimann, A.3    Gottlinger, H.G.4
  • 69
    • 0038153856 scopus 로고    scopus 로고
    • Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions
    • Zheng YH, Plemenitas A, Fielding CJ and Peterlin BM. Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. Proc Natl Acad Sci USA 2003; 100: 8460-5.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8460-8465
    • Zheng, Y.H.1    Plemenitas, A.2    Fielding, C.J.3    Peterlin, B.M.4
  • 70
    • 40849083511 scopus 로고    scopus 로고
    • Nef enhances HIV-1 infectivity via association with the virus assembly complex
    • Qi M and Aiken C. Nef enhances HIV-1 infectivity via association with the virus assembly complex. Virology 2008; 373: 287-97.
    • (2008) Virology , vol.373 , pp. 287-297
    • Qi, M.1    Aiken, C.2
  • 71
    • 58149526792 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef incorporation into virions does not increase infectivity
    • Laguette N, Benichou S and Basmaciogullari S. Human immunodeficiency virus type 1 Nef incorporation into virions does not increase infectivity. J Virol 2009; 83: 1093-104.
    • (2009) J Virol , vol.83 , pp. 1093-1104
    • Laguette, N.1    Benichou, S.2    Basmaciogullari, S.3
  • 72
    • 0035204796 scopus 로고    scopus 로고
    • Restoration of wildtype infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription
    • Khan M, Garcia-Barrio M and Powell MD. Restoration of wildtype infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription. J Virol 2001; 75: 12081-7.
    • (2001) J Virol , vol.75 , pp. 12081-12087
    • Khan, M.1    Garcia-Barrio, M.2    Powell, M.D.3
  • 73
    • 0029045360 scopus 로고
    • Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell
    • Schwartz O, Marechal V, Danos O and Heard JM. Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell. J Virol 1995; 69: 4053-9.
    • (1995) J Virol , vol.69 , pp. 4053-4059
    • Schwartz, O.1    Marechal, V.2    Danos, O.3    Heard, J.M.4
  • 74
    • 0141780822 scopus 로고    scopus 로고
    • Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication
    • Arganaraz ER, Schindler M, Kirchhoff F, et al. Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication. J Biol Chem. 2003; 278: 33912-9.
    • (2003) J Biol Chem. , vol.278 , pp. 33912-33919
    • Arganaraz, E.R.1    Schindler, M.2    Kirchhoff, F.3
  • 75
    • 0033578072 scopus 로고    scopus 로고
    • Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef-and Vpu-inhibitable manner
    • Lama J, Mangasarian A and Trono D. Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef-and Vpu-inhibitable manner. Curr Biol 1999; 9: 622-31.
    • (1999) Curr Biol , vol.9 , pp. 622-631
    • Lama, J.1    Mangasarian, A.2    Trono, D.3
  • 76
    • 2642545601 scopus 로고    scopus 로고
    • Nef stimulates human immunodeficiency virus type 1 replication in primary T cells by enhancing virion-associated gp120 levels: Coreceptor-dependent requirement for Nef in viral replication
    • Lundquist CA, Zhou J and Aiken C. Nef stimulates human immunodeficiency virus type 1 replication in primary T cells by enhancing virion-associated gp120 levels: coreceptor-dependent requirement for Nef in viral replication. J Virol 2004; 78: 6287-96.
    • (2004) J Virol , vol.78 , pp. 6287-6296
    • Lundquist, C.A.1    Zhou, J.2    Aiken, C.3
  • 77
    • 0037127303 scopus 로고    scopus 로고
    • Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells
    • Cortes MJ, Wong-Staal F and Lama J. Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells. The Journal of biological chemistry 2002; 277: 1770-9.
    • (2002) The Journal of biological chemistry , vol.277 , pp. 1770-1779
    • Cortes, M.J.1    Wong-Staal, F.2    Lama, J.3
  • 78
    • 2542492063 scopus 로고    scopus 로고
    • HIV-1 Nef enhances both membrane expression and virion incorporation of Env products. A model for the Nef-dependent increase of HIV-1 infectivity
    • Schiavoni I, Trapp S, Santarcangelo AC, et al. HIV-1 Nef enhances both membrane expression and virion incorporation of Env products. A model for the Nef-dependent increase of HIV-1 infectivity. J Biol Chem 2004; 279: 22996-006.
    • (2004) J Biol Chem , vol.279 , pp. 6-996
    • Schiavoni, I.1    Trapp, S.2    Santarcangelo, A.C.3
  • 79
    • 0030947406 scopus 로고    scopus 로고
    • The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix
    • Swingler S, Gallay P, Camaur D, et al. The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix. J Virol 1997; 71: 4372-7.
    • (1997) J Virol , vol.71 , pp. 4372-4377
    • Swingler, S.1    Gallay, P.2    Camaur, D.3
  • 80
    • 58549092971 scopus 로고    scopus 로고
    • Mutation of critical serine residues in HIV-1 matrix result in an envelope incorporation defect which can be rescued by truncation of the gp41 cytoplasmic tail
    • Bhatia AK, Kaushik R, Campbell NA, et al. Mutation of critical serine residues in HIV-1 matrix result in an envelope incorporation defect which can be rescued by truncation of the gp41 cytoplasmic tail. Virology 2009; 384: 233-41.
    • (2009) Virology , vol.384 , pp. 233-241
    • Bhatia, A.K.1    Kaushik, R.2    Campbell, N.A.3
  • 81
    • 1242296983 scopus 로고    scopus 로고
    • Role of human immunodeficiency virus type 1 matrix phosphorylation in an early postentry step of virus replication
    • Kaushik R and Ratner L. Role of human immunodeficiency virus type 1 matrix phosphorylation in an early postentry step of virus replication. J Virol 2004; 78: 2319-26.
    • (2004) J Virol , vol.78 , pp. 2319-2326
    • Kaushik, R.1    Ratner, L.2
  • 82
    • 0036282059 scopus 로고    scopus 로고
    • Nef enhances human immunodeficiency virus type 1 infectivity in the absence of matrix
    • Dorfman T, Popova E, Pizzato M and Gottlinger HG. Nef enhances human immunodeficiency virus type 1 infectivity in the absence of matrix. J Virol 2002; 76: 6857-62.
    • (2002) J Virol , vol.76 , pp. 6857-6862
    • Dorfman, T.1    Popova, E.2    Pizzato, M.3    Gottlinger, H.G.4
  • 83
    • 18744391391 scopus 로고    scopus 로고
    • Plunder and stowaways: Incorporation of cellular proteins by enveloped viruses
    • Cantin R, Methot S and Tremblay MJ. Plunder and stowaways: incorporation of cellular proteins by enveloped viruses. J Virol 2005; 79: 6577-87.
    • (2005) J Virol , vol.79 , pp. 6577-6587
    • Cantin, R.1    Methot, S.2    Tremblay, M.J.3
  • 84
    • 33644834758 scopus 로고    scopus 로고
    • Proteomic analysis of human immunodeficiency virus using liquid chromatography/tandem mass spectrometry effectively distinguishes specific incorporated host proteins
    • Saphire AC, Gallay PA and Bark SJ. Proteomic analysis of human immunodeficiency virus using liquid chromatography/tandem mass spectrometry effectively distinguishes specific incorporated host proteins. J Proteome Res 2006; 5: 530-8.
    • (2006) J Proteome Res , vol.5 , pp. 530-538
    • Saphire, A.C.1    Gallay, P.A.2    Bark, S.J.3
  • 86
    • 0030844666 scopus 로고    scopus 로고
    • The acquisition of host-derived major histocompatibility complex class II glycoproteins by human immunodeficiency virus type 1 accelerates the process of virus entry and infection in human Tlymphoid cells
    • Cantin R, Fortin JF, Lamontagne G and Tremblay M. The acquisition of host-derived major histocompatibility complex class II glycoproteins by human immunodeficiency virus type 1 accelerates the process of virus entry and infection in human Tlymphoid cells. Blood 1997; 90: 1091-100.
    • (1997) Blood , vol.90 , pp. 1091-1100
    • Cantin, R.1    Fortin, J.F.2    Lamontagne, G.3    Tremblay, M.4
  • 87
    • 17444401008 scopus 로고    scopus 로고
    • Envelope glycoproteins are dispensable for insertion of host HLA-DR molecules within nascent human immunodeficiency virus type 1 particles
    • Martin G, Beausejour Y, Thibodeau J and Tremblay MJ. Envelope glycoproteins are dispensable for insertion of host HLA-DR molecules within nascent human immunodeficiency virus type 1 particles. Virology 2005; 335: 286-90.
    • (2005) Virology , vol.335 , pp. 286-290
    • Martin, G.1    Beausejour, Y.2    Thibodeau, J.3    Tremblay, M.J.4
  • 88
    • 2642518681 scopus 로고    scopus 로고
    • Insertion of host-derived costimulatory molecules CD80 (B7.1) and CD86 (B7.2) into human immunodeficiency virus type 1 affects the virus life cycle
    • Giguere JF, Bounou S, Paquette JS, et al. Insertion of host-derived costimulatory molecules CD80 (B7.1) and CD86 (B7.2) into human immunodeficiency virus type 1 affects the virus life cycle. J Virol 2004; 78: 6222-32.
    • (2004) J Virol , vol.78 , pp. 6222-6232
    • Giguere, J.F.1    Bounou, S.2    Paquette, J.S.3
  • 89
    • 2942558670 scopus 로고    scopus 로고
    • Envelope glycoproteins are not required for insertion of host ICAM-1 into human immunodeficiency virus type 1 and ICAM-1-bearing viruses are still infectious despite a suboptimal level of trimeric envelope proteins
    • Beausejour Y and Tremblay MJ. Envelope glycoproteins are not required for insertion of host ICAM-1 into human immunodeficiency virus type 1 and ICAM-1-bearing viruses are still infectious despite a suboptimal level of trimeric envelope proteins. Virology 2004; 324: 165-172.
    • (2004) Virology , vol.324 , pp. 165-172
    • Beausejour, Y.1    Tremblay, M.J.2
  • 90
    • 0036147255 scopus 로고    scopus 로고
    • Presence of host ICAM-1 in laboratory and clinical strains of human immunodeficiency virus type 1 increases virus infectivity and CD4(+)-T-cell depletion in human lymphoid tissue, a major site of replication in vivo
    • Bounou S, Leclerc JE and Tremblay MJ. Presence of host ICAM-1 in laboratory and clinical strains of human immunodeficiency virus type 1 increases virus infectivity and CD4(+)-T-cell depletion in human lymphoid tissue, a major site of replication in vivo. J Virol 2002; 76: 1004-14.
    • (2002) J Virol , vol.76 , pp. 1004-1014
    • Bounou, S.1    Leclerc, J.E.2    Tremblay, M.J.3
  • 91
    • 0032488027 scopus 로고    scopus 로고
    • A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor
    • Bresnahan PA, Yonemoto W, Ferrell S, et al. A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor. Curr Biol 1998; 8: 1235-38.
    • (1998) Curr Biol , vol.8 , pp. 1235-1238
    • Bresnahan, P.A.1    Yonemoto, W.2    Ferrell, S.3
  • 92
    • 0032488055 scopus 로고    scopus 로고
    • A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
    • Greenberg M, DeTulleo L, Rapoport I, et al. A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. Curr Biol 1998; 8: 1239-42.
    • (1998) Curr Biol , vol.8 , pp. 1239-1242
    • Greenberg, M.1    DeTulleo, L.2    Rapoport, I.3
  • 93
    • 0032525137 scopus 로고    scopus 로고
    • The SH3 domainbinding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
    • Greenberg ME, Iafrate AJ and Skowronski J. The SH3 domainbinding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. EMBO J 1998; 17: 2777-89.
    • (1998) EMBO J , vol.17 , pp. 2777-2789
    • Greenberg, M.E.1    Iafrate, A.J.2    Skowronski, J.3
  • 94
    • 0037424537 scopus 로고    scopus 로고
    • HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes
    • Janvier K, Craig H, Hitchin D, et al. HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes. J Biol Chem 2003; 278: 8725-32.
    • (2003) J Biol Chem , vol.278 , pp. 8725-8732
    • Janvier, K.1    Craig, H.2    Hitchin, D.3
  • 95
    • 77956464288 scopus 로고    scopus 로고
    • The role of ERK1/2 signaling pathway in Nef protein upregulation of the expression of the intercellular adhesion molecule 1 in endothelial cells
    • Fan Y, Liu C, Qin X, et al. The role of ERK1/2 signaling pathway in Nef protein upregulation of the expression of the intercellular adhesion molecule 1 in endothelial cells. Angiology 2010; 61: 669-78.
    • (2010) Angiology , vol.61 , pp. 669-678
    • Fan, Y.1    Liu, C.2    Qin, X.3
  • 96
    • 0035811040 scopus 로고    scopus 로고
    • Nef increases infectivity of HIV via lipid rafts
    • Zheng YH, Plemenitas A, Linnemann T, et al. Nef increases infectivity of HIV via lipid rafts. Curr Biol 2001; 11: 875-9.
    • (2001) Curr Biol , vol.11 , pp. 875-879
    • Zheng, Y.H.1    Plemenitas, A.2    Linnemann, T.3
  • 97
    • 33644539188 scopus 로고    scopus 로고
    • The HIV lipidome: A raft with an unusual composition
    • Brugger B, Glass B, Haberkant P, et al. The HIV lipidome: a raft with an unusual composition. Proc Natl Acad Sci USA 2006; 103: 2641-6.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2641-2646
    • Brugger, B.1    Glass, B.2    Haberkant, P.3
  • 98
    • 55549118226 scopus 로고    scopus 로고
    • Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides
    • Chan R, Uchil PD, Jin J, et al. Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides. J Virol 2008; 82: 11228-38.
    • (2008) J Virol , vol.82 , pp. 11228-11238
    • Chan, R.1    Uchil, P.D.2    Jin, J.3
  • 99
    • 22544467000 scopus 로고    scopus 로고
    • Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells
    • van't Wout AB, Swain JV, Schindler M, et al. Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells. J Virol 2005; 79: 10053-8.
    • (2005) J Virol , vol.79 , pp. 10053-10058
    • van't Wout, A.B.1    Swain, J.V.2    Schindler, M.3
  • 100
    • 33751062798 scopus 로고    scopus 로고
    • Human immunodeficiency virus impairs reverse cholesterol transport from macrophages
    • Mujawar Z, Rose H, Morrow MP, et al. Human immunodeficiency virus impairs reverse cholesterol transport from macrophages. PLoS Biol 2006; 4: e365.
    • (2006) PLoS Biol , vol.4
    • Mujawar, Z.1    Rose, H.2    Morrow, M.P.3
  • 101
    • 77954944601 scopus 로고    scopus 로고
    • Stimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATPbinding cassette transporter A1
    • Morrow MP, Grant A, Mujawar Z, et al. Stimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATPbinding cassette transporter A1. Mol Pharmacol 2010; 78: 215-25.
    • (2010) Mol Pharmacol , vol.78 , pp. 215-225
    • Morrow, M.P.1    Grant, A.2    Mujawar, Z.3
  • 102
    • 4544312874 scopus 로고    scopus 로고
    • The raft-promoting property of virion-associated cholesterol, but not the presence of virionassociated Brij 98 rafts, is a determinant of human immunodeficiency virus type 1 infectivity
    • Campbell S, Gaus K, Bittman R, et al. The raft-promoting property of virion-associated cholesterol, but not the presence of virionassociated Brij 98 rafts, is a determinant of human immunodeficiency virus type 1 infectivity. J Virol 2004; 78: 10556-65.
    • (2004) J Virol , vol.78 , pp. 10556-10565
    • Campbell, S.1    Gaus, K.2    Bittman, R.3
  • 103
    • 0034814426 scopus 로고    scopus 로고
    • Requirement of nef for HIV-1 infectivity is biased by the expression levels of Env in the virus-producing cells and CD4 in the target cells
    • Tobiume M, Tokunaga K, Kiyokawa E, et al. Requirement of nef for HIV-1 infectivity is biased by the expression levels of Env in the virus-producing cells and CD4 in the target cells. Arch Virol 2001; 146: 1739-51.
    • (2001) Arch Virol , vol.146 , pp. 1739-1751
    • Tobiume, M.1    Tokunaga, K.2    Kiyokawa, E.3
  • 104
    • 0028820530 scopus 로고
    • The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation
    • Chowers MY, Pandori MW, Spina CA, et al. The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation. Virology 1995; 212: 451-57.
    • (1995) Virology , vol.212 , pp. 451-457
    • Chowers, M.Y.1    Pandori, M.W.2    Spina, C.A.3
  • 105
    • 2442707757 scopus 로고    scopus 로고
    • Disruption of the actin cytoskeleton can complement the ability of Nef to enhance human immunodeficiency virus type 1 infectivity
    • Campbell EM, Nunez R and Hope TJ. Disruption of the actin cytoskeleton can complement the ability of Nef to enhance human immunodeficiency virus type 1 infectivity. J Virol 2004; 78: 5745-55.
    • (2004) J Virol , vol.78 , pp. 5745-5755
    • Campbell, E.M.1    Nunez, R.2    Hope, T.J.3
  • 106
    • 4544240500 scopus 로고    scopus 로고
    • HIV-1 virion fusion assay: Uncoating not required and no effect of Nef on fusion
    • Cavrois M, Neidleman J, Yonemoto W, et al. HIV-1 virion fusion assay: uncoating not required and no effect of Nef on fusion. Virology 2004; 328: 36-44.
    • (2004) Virology , vol.328 , pp. 36-44
    • Cavrois, M.1    Neidleman, J.2    Yonemoto, W.3
  • 107
    • 0141744628 scopus 로고    scopus 로고
    • Nef does not affect the efficiency of human immunodeficiency virus type 1 fusion with target cells
    • Tobiume M, Lineberger JE, Lundquist CA, et al. Nef does not affect the efficiency of human immunodeficiency virus type 1 fusion with target cells. J Virol 2003; 77: 10645-50.
    • (2003) J Virol , vol.77 , pp. 10645-10650
    • Tobiume, M.1    Lineberger, J.E.2    Lundquist, C.A.3
  • 108
    • 0035120461 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions
    • Schaeffer E, Geleziunas R and Greene WC. Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions. J Virol 2001; 75: 2993-3000.
    • (2001) J Virol , vol.75 , pp. 2993-3000
    • Schaeffer, E.1    Geleziunas, R.2    Greene, W.C.3
  • 109
    • 0030835321 scopus 로고    scopus 로고
    • Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A
    • Aiken C. Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A. J Virol 1997; 71: 5871-7.
    • (1997) J Virol , vol.71 , pp. 5871-5877
    • Aiken, C.1
  • 110
    • 0032520144 scopus 로고    scopus 로고
    • Infectivity enhancement by HIV-1 Nef is dependent on the pathway of virus entry: Implications for HIV-based gene transfer systems
    • Luo T, Douglas JL, Livingston RL and Garcia JV. Infectivity enhancement by HIV-1 Nef is dependent on the pathway of virus entry: implications for HIV-based gene transfer systems. Virology 1998; 241: 224-33.
    • (1998) Virology , vol.241 , pp. 224-233
    • Luo, T.1    Douglas, J.L.2    Livingston, R.L.3    Garcia, J.V.4
  • 111
    • 0035088135 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity
    • Chazal N, Singer G, Aiken C, et al. Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity. J Virol 2001; 75: 4014-8.
    • (2001) J Virol , vol.75 , pp. 4014-4018
    • Chazal, N.1    Singer, G.2    Aiken, C.3
  • 112
    • 55249115173 scopus 로고    scopus 로고
    • Nef can enhance the infectivity of receptor-pseudotyped human immunodeficiency virus type 1 particles
    • Pizzato M, Popova E and Gottlinger HG. Nef can enhance the infectivity of receptor-pseudotyped human immunodeficiency virus type 1 particles. J Virol 2008; 82: 10811-9.
    • (2008) J Virol , vol.82 , pp. 10811-10819
    • Pizzato, M.1    Popova, E.2    Gottlinger, H.G.3
  • 113
    • 50249107532 scopus 로고    scopus 로고
    • HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells
    • Yoder A, Yu D, Dong L, et al. HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell 2008; 134: 782-92.
    • (2008) Cell , vol.134 , pp. 782-792
    • Yoder, A.1    Yu, D.2    Dong, L.3
  • 114
    • 13744252968 scopus 로고    scopus 로고
    • Involvement of clathrin-mediated endocytosis in human immunodeficiency virus type 1 entry
    • Daecke J, Fackler OT, Dittmar MT and Krausslich HG. Involvement of clathrin-mediated endocytosis in human immunodeficiency virus type 1 entry. J Virol 2005; 79: 1581-94.
    • (2005) J Virol , vol.79 , pp. 1581-1594
    • Daecke, J.1    Fackler, O.T.2    Dittmar, M.T.3    Krausslich, H.G.4
  • 115
    • 65249139458 scopus 로고    scopus 로고
    • HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes
    • Miyauchi K, Kim Y, Latinovic O, et al. HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes. Cell 2009; 137: 433-44.
    • (2009) Cell , vol.137 , pp. 433-444
    • Miyauchi, K.1    Kim, Y.2    Latinovic, O.3
  • 117
    • 73449090496 scopus 로고    scopus 로고
    • The HIV envelope but not VSV glycoprotein is capable of mediating HIV latent infection of resting CD4 T cells
    • Yu D, Wang W, Yoder A, et al. The HIV envelope but not VSV glycoprotein is capable of mediating HIV latent infection of resting CD4 T cells. PLoS Pathog 2009; 5: e1000633
    • (2009) PLoS Pathog , vol.5
    • Yu, D.1    Wang, W.2    Yoder, A.3
  • 118
    • 0031775745 scopus 로고    scopus 로고
    • Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton
    • Bukrinskaya A, Brichacek B, Mann A and Stevenson M. Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton. J Exp Med 1998; 188: 2113-25.
    • (1998) J Exp Med , vol.188 , pp. 2113-2125
    • Bukrinskaya, A.1    Brichacek, B.2    Mann, A.3    Stevenson, M.4
  • 119
    • 70449336949 scopus 로고    scopus 로고
    • Maturation of the HIV reverse transcription complex: Putting the jigsaw together
    • Warrilow D, Tachedjian G and Harrich D. Maturation of the HIV reverse transcription complex: putting the jigsaw together. Rev Med Virol 2009; 19: 324-37.
    • (2009) Rev Med Virol , vol.19 , pp. 324-337
    • Warrilow, D.1    Tachedjian, G.2    Harrich, D.3
  • 120
    • 0031850309 scopus 로고    scopus 로고
    • Pathogenesis of human immunodeficiency virus (HIV)-associated nephropathy
    • Schwartz EJ and Klotman PE. Pathogenesis of human immunodeficiency virus (HIV)-associated nephropathy. Semin Nephrol 1998; 18: 436-45.
    • (1998) Semin Nephrol , vol.18 , pp. 436-445
    • Schwartz, E.J.1    Klotman, P.E.2
  • 121
    • 17444388017 scopus 로고    scopus 로고
    • Inhibition of lysosome and proteasome function enhances human immunodeficiency virus type 1 infection
    • Wei BL, Denton PW, O'Neill E, et al. Inhibition of lysosome and proteasome function enhances human immunodeficiency virus type 1 infection. J Virol 2005; 79: 5705-12.
    • (2005) J Virol , vol.79 , pp. 5705-5712
    • Wei, B.L.1    Denton, P.W.2    O'Neill, E.3
  • 122
    • 33846474764 scopus 로고    scopus 로고
    • Selective restriction of Nef-defective human immunodeficiency virus type 1 by a proteasome-dependent mechanism
    • Qi M and Aiken C. Selective restriction of Nef-defective human immunodeficiency virus type 1 by a proteasome-dependent mechanism. J Virol 2007; 81: 1534-6.
    • (2007) J Virol , vol.81 , pp. 1534-1536
    • Qi, M.1    Aiken, C.2
  • 123
    • 27544473312 scopus 로고    scopus 로고
    • Membrane hemifusion: Crossing a chasm in two leaps
    • Chernomordik LV and Kozlov MM. Membrane hemifusion: crossing a chasm in two leaps. Cell 2005; 123: 375-82.
    • (2005) Cell , vol.123 , pp. 375-382
    • Chernomordik, L.V.1    Kozlov, M.M.2
  • 124
    • 59849107898 scopus 로고    scopus 로고
    • Common principles and intermediates of viral protein-mediated fusion: The HIV-1 paradigm
    • Melikyan GB. Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm. Retrovirology 2008; 5: 111.
    • (2008) Retrovirology , vol.5 , pp. 111
    • Melikyan, G.B.1
  • 125
    • 20844457308 scopus 로고    scopus 로고
    • Imaging individual retroviral fusion events: From hemifusion to pore formation and growth
    • Melikyan GB, Barnard RJ, Abrahamyan LG, et al. Imaging individual retroviral fusion events: from hemifusion to pore formation and growth. Proc Natl Acad Sci USA 2005; 102: 8728-33.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8728-8733
    • Melikyan, G.B.1    Barnard, R.J.2    Abrahamyan, L.G.3
  • 126
    • 51349141354 scopus 로고    scopus 로고
    • Role of Nef in primate lentiviral immunopathogenesis
    • Kirchhoff F, Schindler M, Specht A, et al. Role of Nef in primate lentiviral immunopathogenesis. Cell Mol Life Sci 2008; 65: 2621-36.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 2621-2636
    • Kirchhoff, F.1    Schindler, M.2    Specht, A.3
  • 127
    • 33646167689 scopus 로고    scopus 로고
    • Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques
    • Brenner M, Munch J, Schindler M, et al. Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques. J Virol 2006; 80: 4469-81.
    • (2006) J Virol , vol.80 , pp. 4469-4481
    • Brenner, M.1    Munch, J.2    Schindler, M.3
  • 128
    • 0033775488 scopus 로고    scopus 로고
    • Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo
    • Iafrate AJ, Carl S, Bronson S, et al. Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo. J Virol 2000; 74: 9836-44.
    • (2000) J Virol , vol.74 , pp. 9836-9844
    • Iafrate, A.J.1    Carl, S.2    Bronson, S.3
  • 129
    • 77952683763 scopus 로고    scopus 로고
    • MLV glycosylated-Gag is an infectivity factor that rescues Nef-deficient HIV-1
    • Pizzato M. MLV glycosylated-Gag is an infectivity factor that rescues Nef-deficient HIV-1. Proc Natl Acad Sci USA 2010; 107: 9364-69.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 9364-9369
    • Pizzato, M.1
  • 130
    • 0033856458 scopus 로고    scopus 로고
    • Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120
    • Derdeyn CA, Decker JM, Sfakianos JN, et al. Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120. J Virol 2000; 74: 8358-67.
    • (2000) J Virol , vol.74 , pp. 8358-8367
    • Derdeyn, C.A.1    Decker, J.M.2    Sfakianos, J.N.3


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