Novel regulatory mechanisms of pathogenicity and virulence to combat MDR in Candida albicans

International Journal of Microbiology

Volumn 2013, Issue , 2013, Pages

  Hameed, Saif ^a   Fatima, Zeeshan ^a  

^a AMITY UNIVERSITY HARYANA   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84885627084     PISSN: 1687918X     EISSN: 16879198     Source Type: Journal    
DOI: 10.1155/2013/240209     Document Type: Article

References (127)

1. Pfaller M. A., Diekema D. J., Epidemiology of invasive candidiasis: a persistent 873 public health problem. Clinical Microbiology Reviews 2007 20 1 133 163 2-s2.0-33846466508 10.1128/CMR.00029-06 (Pubitemid 46167771)
2. Calderone R. A., Candida and Candidiasis 2002 Washington, DC, USA American Society for Microbiology Press
3. Odds F. C., Candida and Candidosis: A Review and Bibliography 1988 London, UK
4. White T. C., Marr K. A., Bowden R. A., Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clinical Microbiology Reviews 1998 11 2 382 402 2-s2.0-0031969879 (Pubitemid 28197359)
5. White T. C., Holleman S., Dy F., Mirels L. F., Stevens D. A., Resistance mechanisms in clinical isolates of Candida albicans. Antimicrobial Agents and Chemotherapy 2002 46 6 1704 1713 2-s2.0-0036093372 10.1128/AAC.46.6.1704-1713. 2002 (Pubitemid 34535186)
6. Franz R., Kelly S. L., Lamb D. C., Kelly D. E., Ruhnke M., Morschhäuser J., Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains. Antimicrobial Agents and Chemotherapy 1998 42 12 3065 3072 2-s2.0-0031759244 (Pubitemid 28553719)
7. Anderson J. B., Evolution of antifungal-drug resistance: mechanisms and pathogen fitness. Nature Reviews Microbiology 2005 3 7 547 556 2-s2.0-21344451158 10.1038/nrmicro1179 (Pubitemid 40903878)
8. Cowen L. E., Steinbach W. J., Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance. Eukaryotic Cell 2008 7 5 747 764 2-s2.0-47049090269 10.1128/EC.00041-08 (Pubitemid 351968819)
9. Lamb D. C., Kelly D. E., Schunck W.-H., Shyadehi A. Z., Akhtar M., Lowe D. J., Baldwin B. C., Kelly S. L., The mutation T315A in Candida albicans sterol 14 α -demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity. Journal of Biological Chemistry 1997 272 9 5682 5688 2-s2.0-0031054924 10.1074/jbc.272.9.5682 (Pubitemid 27102395)
10. Prasad R., Gupta N., Gaur M., San-Blas G., Calderone R. A., Molecular basis of antifungal resistance in pathogenic fungi. Pathogenic Fungi-Host Interactions and Emerging Strategies For Control 2004 Norfolk, UK Caister Academic Press 357 414
11. Albertson G. D., Niimi M., Cannon R. D., Jenkinson H. F., Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance. Antimicrobial Agents and Chemotherapy 1996 40 12 2835 2841 2-s2.0-0029853191 (Pubitemid 26404354)
12. Kohli A., Smriti S., Mukhopadhyay K., Rattan A., Prasad R., In vitro low-level resistance to azoles in Candida albicans is associated with changes in membrane lipid fluidity and asymmetry. Antimicrobial Agents and Chemotherapy 2002 46 4 1046 1052 2-s2.0-0036208102 10.1128/AAC.46.4.1046-1052.2002 (Pubitemid 34260349)
13. Sanglard D., Ischer F., Monod M., Bille J., Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 1997 143 2 405 416 2-s2.0-0031047670 (Pubitemid 27092176)
14. Ben-Yaacov R., Knoller S., Caldwell G. A., Becker J. M., Koltin Y., Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene. Antimicrobial Agents and Chemotherapy 1994 38 4 648 652 2-s2.0-0028293750 (Pubitemid 24113995)
15. Gupta V., Kohli A., Krishnamurthy S., Puri N., Aalamgeer S. A., Panwar S., Prasad R., Identification of polymorphic mutant alleles of CaMDR1, a major facilitator of Candida albicans which confers multidrug resistance, and its in vitro transcriptional activation. Current Genetics 1998 34 3 192 199 2-s2.0-0031692037 10.1007/s002940050385 (Pubitemid 28458486)
16. Pao S. S., Paulsen I. T., Saier M.H. Jr., Major facilitator superfamily. Microbiology and Molecular Biology Reviews 1998 62 1 34 (Pubitemid 28130794)
17. Perrone G. G., Tan S.-X., Dawes I. W., Reactive oxygen species and yeast apoptosis. Biochimica et Biophysica Acta 2008 1783 7 1354 1368 2-s2.0-46549088173 10.1016/j.bbamcr.2008.01.023
18. Vázquez N., Walsh T. J., Friedman D., Chanock S. J., Lyman C. A., Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans. Infection and Immunity 1998 66 1 145 150 2-s2.0-2642631748 (Pubitemid 28018813)
19. Hwang C.-S., Rhie G.-E., Kim S.-T., Kim Y.-R., Huh W.-K., Baek Y.-U., Kang S.-O., Copper- and zinc-containing superoxide dismutase and its gene from Candida albicans. Biochimica et Biophysica Acta 1999 1427 2 245 255 2-s2.0-0032940248 10.1016/S0304-4165(99)00020-3 (Pubitemid 29182776)
20. Kobayashi D., Kondo K., Uehara N., Otokozawa S., Tsuji N., Yagihashi A., Watanabe N., Endogenous reactive oxygen species is an important mediator of miconazole antifungal effect. Antimicrobial Agents and Chemotherapy 2002 46 10 3113 3117 2-s2.0-0036784060 10.1128/AAC.46.10.3113-3117.2002
21. Wu X.-Z., Cheng A.-X., Sun L.-M., Sun S.-J., Lou H.-X., Plagiochin E, an antifungal bis(bibenzyl), exerts its antifungal activity through mitochondrial dysfunction-induced reactive oxygen species accumulation in Candida albicans. Biochimica et Biophysica Acta 2009 1790 8 770 777 2-s2.0-67649311425 10.1016/j.bbagen.2009.05.002
22. Xu Y., Wang Y., Yan L., Liang R.-M., Dai B.-D., Tang R.-J., Gao P.-H., Jiang Y.-Y., Proteomic analysis reveals a synergistic mechanism of fluconazole and berberine against fluconazole-resistant Candida albicans: endogenous ROS augmentation. Journal of Proteome Research 2009 8 11 5296 5304 2-s2.0-70449412365 10.1021/pr9005074
23. Da Rosa J. L., Boyartchuk V. L., Zhu L. J., Kaufman P. D., Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 2010 107 4 1594 1599 2-s2.0-76549103447 10.1073/pnas.0912427107
24. Shirai A., Ueta S., Maseda H., Kourai H., Omasa T., Action of reactive oxygen species in the antifungal mechanism of gemini-pyridinium salts against yeast. Biocontrol Science and Technology 2012 17 2 77 82
25. Miao H., Zhao L., Li C., Shang Q., Lu H., Fu Z., Inhibitory effect of shikonin on Candida albicans growth. Biological & Pharmaceutical Bulletin 2012 35 11 1956 1963
26. Almeida R. S., Wilson D., Hube B., Candida albicans iron acquisition within the host. FEMS Yeast Research 2009 9 7 1000 1012 2-s2.0-70350020264 10.1111/j.1567-1364.2009.00570.x
27. Bullen J. J., Rogers H. J., Spalding P. B., Ward C. G., Natural resistance, iron and infection: a challenge for clinical medicine. Journal of Medical Microbiology 2006 55 3 251 258 2-s2.0-33645111877 10.1099/jmm.0.46386-0
28. Fischbach M. A., Lin H., Liu D. R., Walsh C. T., How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nature Chemical Biology 2006 2 3 132 138 2-s2.0-33646593180 10.1038/nchembio771 (Pubitemid 44323863)
29. Nyilasi I., Papp T., Takó M., Nagy E., Vágvölgyi C., Iron gathering of opportunistic pathogenic fungi: a mini review. Acta Microbiologica et Immunologica Hungarica 2005 52 2 185 197 2-s2.0-20444441115 10.1556/AMicr.52.2005.2.4 (Pubitemid 40825520)
30. Spacek J., Jilek P., Buchta V., Forstl M., Hronek M., Holeckova M., The serum levels of calcium, magnesium, iron and zinc in patients with recurrent vulvovaginal candidosis during attack, remission and in healthy controls. Mycoses 2005 48 6 391 395 2-s2.0-33644691662 10.1111/j.1439-0507.2005.01164.x (Pubitemid 43942683)
31. Weinberg E. D., The role of iron in protozoan and fungal infectious diseases. Journal of Eukaryotic Microbiology 1999 46 3 231 238 2-s2.0-0033137082 (Pubitemid 29284923)
32. Radisky D., Kaplan J., Regulation of transition metal transport across the yeast plasma membrane. Journal of Biological Chemistry 1999 274 8 4481 4484 2-s2.0-0033582433 10.1074/jbc.274.8.4481 (Pubitemid 29113336)
33. Kuipers M. E., De Vries H. G., Eikelboom M. C., Meijer D. K. F., Swart P. J., Synergistic fungistatic effects of lactoferrin in combination with antifungal drugs against clinical Candida isolates. Antimicrobial Agents and Chemotherapy 1999 43 11 2635 2641 2-s2.0-0032707616 (Pubitemid 29519541)
34. Kuipers M. E., Beljaars L., Van Beek N., De Vries H. G., Heegsma J., Van Den Berg J. J. M., Meijer D. K. F., Swart P. J., Conditions influencing the in vitro antifungal activity of lactoferrin combined with antimycotics against clinical isolates of Candida: impact on the development of buccal preparations of lactoferrin. APMIS 2002 110 4 290 298 2-s2.0-0036251099 10.1034/j.1600-0463. 2002.100403.x (Pubitemid 34478391)
35. Kuipers M. E., Heegsma J., Bakker H. I., Meijer D. K. F., Swart P. J., Frijlink E. W., Eissens A. C., De Vries-Hospers H. G., Van Den Berg J. J. M., Design and fungicidal activity of mucoadhesive lactoferrin tablets for the treatment of oropharyngeal candidosis. Drug Delivery 2002 9 1 31 38 2-s2.0-0036177626 10.1080/107175402753413154 (Pubitemid 34171332)
36. Prasad T., Chandra A., Mukhopadhyay C. K., Prasad R., Unexpected link between iron and drug resistance of Candida spp.: iron depletion enhances membrane fluidity and drug diffusion, leading to drug-susceptible cells. Antimicrobial Agents and Chemotherapy 2006 50 11 3597 3606 2-s2.0-33750601648 10.1128/AAC.00653-06 (Pubitemid 44684870)
37. Hameed S., Dhamgaye S., Singh A., Goswami S. K., Prasad R., Calcineurin signaling and membrane lipid homeostasis regulates iron mediated multidrug resistance mechanisms in Candida albicans. PLoS ONE 2011 6 4 2-s2.0-79954526400 10.1371/journal.pone.0018684 e18684
38. Dhamgaye S., Devaux F., Manoharlal R., Vandeputte P., Shah A. H., Singh A., Blugeon C., Sanglard D., Prasad R., In vitro effect of malachite green on Candida albicans involves multiple pathways and transcriptional regulators UPC2 and STP2. Antimicrobial Agents and Chemotherapy 2012 56 1 495 506 2-s2.0-84455192724 10.1128/AAC.00574-11
39. Kobayashi T., Kakeya H., Miyazaki T., Izumikawa K., Yanagihara K., Ohno H., Yamamoto Y., Tashiro T., Kohno S., Synergistic antifungal effect of lactoferrin with azole antifungals against Candida albicans and a proposal for a new treatment method for invasive candidiasis. Japanese Journal of Infectious Diseases 2011 64 4 292 296 2-s2.0-79960975803
40. Singh R. P., Prasad H. K., Sinha I., Agarwal N., Natarajan K., Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans. Journal of Biological Chemistry 2011 286 28 25154 25170 2-s2.0-79960125707 10.1074/jbc.M111.233569
41. Brena S., Cabezas-Olcoz J., Moragues M. D., Fernández De Larrinoa I., Domínguez A., Quindós G., Pontón J., Fungicidal monoclonal antibody C7 interferes with iron acquisition in Candida albicans. Antimicrobial Agents and Chemotherapy 2011 55 7 3156 3163 2-s2.0-79959242949 10.1128/AAC.00892-10
42. Kaba H. E., Nimtz M., Müller P. P., Bilitewski U., Involvement of the mitogen activated protein kinase Hog1p in the response of Candida albicans to iron availability. BMC Microbiology 2013 13, article 16 10.1186/1471-2180
43. Hosogaya N., Miyazaki T., Nagi M., Tanabe K., Minematsu A., Nagayoshi Y., The heme-binding protein Dap1 links iron homeostasis to azole resistance via the P450 protein Erg11 in candida glabrata. FEMS Yeast Research 2013 13 4 411 421
44. Srikantha T., Daniels K. J., Pujol C., Kim E., Soll D. R., Identification of genes upregulated by the transcription factor Bcr1 that are involved in impermeability, impenetrability and drug-resistance of Candida albicans a/ α biofilms. Eukaryot Cell 2013 10.1128/EC.0007
45. Comerford K. M., Wallace T. J., Karhausen J., Louis N. A., Montalto M. C., Colgan S. P., Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Research 2002 62 12 3387 3394 2-s2.0-0037096732 (Pubitemid 34651384)
46. Comerford K. M., Colgan S. P., Assessing oxygen sensitivity of the multidrug resistance (MDR) gene. Methods in Enzymology 2004 381 376 387 2-s2.0-1642484267 10.1016/S0076-6879(04)81025-5 (Pubitemid 38401520)
47. Comerford K. M., Cummins E. P., Taylor C. T., c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1 α -dependent P-glycoprotein expression in hypoxia. Cancer Research 2004 64 24 9057 9061 2-s2.0-10844278331 10.1158/0008-5472.CAN-04-1919 (Pubitemid 39665517)
48. Mukhopadhyay C. K., Mazumder B., Fox P. L., Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency. Journal of Biological Chemistry 2000 275 28 21048 21054 2-s2.0-0034647742 10.1074/jbc.M000636200 (Pubitemid 30481794)
49. Setiadi E. R., Doedt T., Cottier F., Noffz C., Ernst J. F., Transcriptional response of Candida albicans to hypoxia: linkage of oxygen sensing and Efg1p-regulatory networks. Journal of Molecular Biology 2006 361 3 399 411 2-s2.0-33746363517 10.1016/j.jmb.2006.06.040 (Pubitemid 44118339)
50. Sosinska G. J., de Groot P. W. J., de Mattos M. J. T., Dekker H. L., de Koster C. G., Hellingwerf K. J., Klis F. M., Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions. Microbiology 2008 154 2 510 520 2-s2.0-39749119354 10.1099/mic.0.2007/012617-0 (Pubitemid 351292305)
51. Brown A. J. P., Gow N. A. R., Regulatory networks controlling Candida albicans morphogenesis. Trends in Microbiology 1999 7 8 333 338 2-s2.0-0032775156 10.1016/S0966-842X(99)01556-5 (Pubitemid 29342306)
52. Sonneborn A., Bockmühl D. P., Ernst J. F., Chlamydospore formation in Candida albicans requires the Efg1p morphogenetic regulator. Infection and Immunity 1999 67 10 5514 5517 2-s2.0-0344199896 (Pubitemid 29455337)
53. Stichternoth C., Ernst J. F., Hypoxic adaptation by Efg1 regulates biofilm formation by Candida albicans. Applied and Environmental Microbiology 2009 75 11 3663 3672 2-s2.0-66249127199 10.1128/AEM.00098-09
54. Bonhomme J., Chauvel M., Goyard S., Roux P., Rossignol T., D'Enfert C., Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans. Molecular Microbiology 2011 80 4 995 1013 2-s2.0-79955744051 10.1111/j.1365-2958.2011.07626.x
55. Carvalho A. P., Gursky L. C., Rosa R. T., Rymovicz A. U. M., Campelo P. M. S., Grégio A. M. T., Koga-Ito C. Y., Samaranayake L. P., Rosa E. A. R., Non-steroidal anti-inflammatory drugs may modulate the protease activity of Candida albicans. Microbial Pathogenesis 2010 49 6 315 322 2-s2.0-77957767618 10.1016/j.micpath.2010.07.007
56. Synnott J. M., Guida A., Mulhern-Haughey S., Higgins D. G., Butler G., Regulation of the hypoxic response in Candida albicans. Eukaryotic Cell 2010 9 11 1734 1746 2-s2.0-78149240475 10.1128/EC.00159-10
57. 2 sensing to suppress hyphal morphogenesis in Candida albicans. Eukaryotic Cell 2011 10 4 502 511 2-s2.0-79955376490 10.1128/EC.00289-10
58. Ernst J. F., Tielker D., Responses to hypoxia in fungal pathogens. Cellular Microbiology 2009 11 2 183 190 2-s2.0-58349092088 10.1111/j.1462-5822. 2008.01259.x
59. Grahl N., Shepardson K. M., Chung D., Cramer R. A., Hypoxia and fungal pathogenesis: to air or not to air? Eukaryotic Cell 2012 11 5 560 570 2-s2.0-84860317915 10.1128/EC.00031-12
60. Romani L., Bistoni F., Puccetti P., Adaptation of Candida albicans to the host environment: the role of morphogenesis in virulence and survival in mammalian hosts. Current Opinion in Microbiology 2003 6 4 338 343 2-s2.0-0043197392 10.1016/S1369-5274(03)00081-X (Pubitemid 37075349)
61. Gujjar P. R., Finucane M., Larsen B., The effect of estradiol on Candida albicans growth. Annals of Clinical and Laboratory Science 1997 27 2 151 156 2-s2.0-0030961828 (Pubitemid 27157439)
62. Zhang X., Essmann M., Burt E. T., Larsen B., Estrogen effects on Candida albicans: a potential virulence-regulating mechanism. Journal of Infectious Diseases 2000 181 4 1441 1446 2-s2.0-0034109144 10.1086/315406 (Pubitemid 30252551)
63. Madani N. D., Malloy P. J., Rodriguez-Pombo P., Krishnan A. V., Feldman D., Candida albicans estrogen-binding protein gene encodes an oxidoreductase that is inhibited by estradiol. Proceedings of the National Academy of Sciences of the United States of America 1994 91 3 922 926 2-s2.0-0028063939 (Pubitemid 24048480)
64. Malloy P. J., Zhao X., Madani N. D., Feldman D., Cloning and expression of the gene from Candida albicans that encodes a high-affinity corticosteroid-binding protein. Proceedings of the National Academy of Sciences of the United States of America 1993 90 5 1902 1906 2-s2.0-0027479446 (Pubitemid 23069965)
65. Das M., Datta A., Steroid binding protein(s) in yeasts. Biochemistry International 1985 11 2 171 176 2-s2.0-0021862533 (Pubitemid 15000142)
66. De Micheli M., Bille J., Schueller C., Sanglard D., A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance. Molecular Microbiology 2002 43 5 1197 1214 2-s2.0-0036223414 10.1046/j.1365-2958.2002.02814.x (Pubitemid 34304537)
67. Kamani N., Akhtar Gaur N., Jha S., Puri N., Krishnamurthy S., Goswami S. K., Mukhopadhyay G., Prasad R., SRE1 and SRE2 are two specific steroid-responsive modules of candida drug resistance gene I (CDRI) promoter. Yeast 2004 21 3 219 239 2-s2.0-1342333093 10.1002/yea.1067 (Pubitemid 38256422)
68. Coste A. T., Karababa M., Ischer F., Bille J., Sanglard D., TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2. Eukaryotic Cell 2004 3 6 1639 1652 2-s2.0-11144270183 10.1128/EC.3.6.1639-1652.2004 (Pubitemid 40025121)
69. Banerjee D., Pillai B., Karnani N., Mukhopadhyay G., Prasad R., Genome-wide expression profile of steroid response in saccharomyces cerevisiae. Biochemical and Biophysical Research Communications 2004 317 2 406 413 2-s2.0-1842583690 10.1016/j.bbrc.2004.03.053 (Pubitemid 38452498)
70. Barnes K. M., Dickstein B., Cutler G. B. Jr., Fojo T., Bates S. E., Steroid transport, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells. Biochemistry 1996 35 15 4820 4827 2-s2.0-0030589989 10.1021/bi952380k (Pubitemid 26126700)
71. Sukhai M., Piquette-Miller M., Regulation of the multidrug resistance genes by stress signals. Journal of Pharmacy & Pharmaceutical Sciences 2000 3 2 268 280 2-s2.0-0034185251
72. Labialle S., Gayet L., Marthinet E., Rigal D., Baggetto L. G., Transcriptional regulators of the human multidrug resistance 1 gene: recent views. Biochemical Pharmacology 2002 64 5-6 943 948 2-s2.0-0036710923 10.1016/S0006-2952(02)01156-5 (Pubitemid 35232268)
73. Banerjee D., Lelandais G., Shukla S., Mukhopadhyay G., Jacq C., Devaux F., Prasad R., Responses of pathogenic and nonpathogenic yeast species to steroids reveal the functioning and evolution of multidrug resistance transcriptional networks. Eukaryotic Cell 2008 7 1 68 77 2-s2.0-40649087677 10.1128/EC.00256-07 (Pubitemid 351959595)
74. Gogoi S., Shekarrao K., Duarah A., Bora T. C., Gogoi S., Boruah R. C., A microwave promoted solvent-free approach to steroidal quinolines and their in vitro evaluation for antimicrobial activities. Steroids 2012 77 13 1438 1445
75. Kakati D., Sarma R. K., Saikia R., Barua N. C., Sarma J. C., Rapid microwave assisted synthesis and antimicrobial bioevaluation of novel steroidal chalcones. Steroids 2013 78 3 321 326
76. Ernst J. F., Schmidt A., Dimorphism in Human Pathogenic and Apathogenic Yeasts 2000 Bern, Switzerland Karger
77. Enrst J. F., Transcription factors in Candida albicans -environmental control of morphogenesis. Microbiology 2000 146 8 1763 1774 2-s2.0-0033870274 (Pubitemid 30639255)
78. Lo H.-J., Wang J.-S., Lin C.-Y., Chen C.-G., Hsiao T.-Y., Hsu C.-T., Su C.-L., Fann M.-J., Ching Y.-T., Yang Y.-L., Efg1 involved in drug resistance by regulating the expression of ERG3 in Candida albicans. Antimicrobial Agents and Chemotherapy 2005 49 3 1213 1215 2-s2.0-14744277263 10.1128/AAC.49.3.1213-1215. 2005 (Pubitemid 40327752)
79. Prasad T., Hameed S., Manoharlal R., Biswas S., Mukhopadhyay C. K., Goswami S. K., Prasad R., Morphogenic regulator EFG1 affects the drug susceptibilities of pathogenic Candida albicans. FEMS Yeast Research 2010 10 5 587 596 2-s2.0-77954496866 10.1111/j.1567-1364.2010.00639.x
80. Vandeputte P., Pradervand S., Ischer F., Coste A. T., Ferrari S., Harshman K., Identification and functional characterization of Rca1, a transcription factor involved in both antifungal susceptibility and host response in Candida albicans. Eukaryot Cell 2012 11 7 916 931 0.1128/EC.00134-12
81. Roepe P. D., pH and multidrug resistance. Novartis Foundation Symposium 2001 240 232 247 2-s2.0-0035232386 (Pubitemid 33603790)
82. Davis D., Adaptation to environmental pH in Candida albicans and its relation to pathogenesis. Current Genetics 2003 44 1 1 7 2-s2.0-0142092728 10.1007/s00294-003-0415-2 (Pubitemid 37265825)
83. Davis D., Wilson R. B., Mitchell A. P., RIM101-dependent and-independent pathways govern pH responses in Candida albicans. Molecular and Cellular Biology 2000 20 3 971 978 2-s2.0-0033985662 10.1128/MCB.20.3.971-978.2000 (Pubitemid 30044234)
84. Ghannoum M. A., Spellberg B., Saporito-Irwin S. M., Fonzi W. A., Reduced virulence of Candida albicans PHR1 mutants. Infection and Immunity 1995 63 11 4528 4530 2-s2.0-0028823906
85. Serrano R., Ruiz A., Bernal D., Chambers J. R., Ariño J., The transcriptional response to alkaline pH in saccharomyces cerevisiae: Evidence for calcium-mediated signalling. Molecular Microbiology 2002 46 5 1319 1333 2-s2.0-0036886546 10.1046/j.1365-2958.2002.03246.x (Pubitemid 36961266)
86. Bader T., Bodendorfer B., Schröppel K., Morschhäuser J., Calcineurin is essential for virulence in Candida albicans. Infection and Immunity 2003 71 9 5344 5354 2-s2.0-0041322613 10.1128/IAI.71.9.5344-5354.2003 (Pubitemid 37070782)
87. Mukhopadhyay K., Kohli A., Prasad R., Drug susceptibilities of yeast cells are affected by membrane lipid composition. Antimicrobial Agents and Chemotherapy 2002 46 12 3695 3705 2-s2.0-0036894215 10.1128/AAC.46.12.3695-3705. 2002 (Pubitemid 35403239)
88. Löffler J., Einsele H., Hebart H., Schumacher U., Hrastnik C., Daum G., Phospholipid and sterol analysis of plasma membranes of azole-resistant Candida albicans strains. FEMS Microbiology Letters 2000 185 1 59 63 2-s2.0-0034176596 10.1016/S0378-1097(00)00071-9 (Pubitemid 30145607)
89. Mukhopadhyay K., Prasad T., Saini P., Pucadyil T. J., Chattopadhyay A., Prasad R., Membrane sphingolipid-ergosterol interactions are important determinants of multidrug resistance in Candida albicans. Antimicrobial Agents and Chemotherapy 2004 48 5 1778 1787 2-s2.0-2142645082 10.1128/AAC.48.5.1778- 1787.2004 (Pubitemid 38544389)
90. Shea J. M., Del Poeta M., Lipid signaling in pathogenic fungi. Current Opinion in Microbiology 2006 9 4 352 358 2-s2.0-33746297857 10.1016/j.mib.2006. 06.003 (Pubitemid 44108715)
91. Ejsinga C. S., Sampaioa J. L., Surendranatha V., Duchoslavb E., Ekroosc K., Klemma R. W., Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry. Proceedings of the National Academy of Sciences 2009 106 7 2136 2141
92. Sharma M., Dhamgaye S., Singh A., Prasad R., Lipidome analysis reveals antifungal polyphenol curcumin affects membrane lipid homeostasis. Frontiers in Bioscience 2012 4 1195 1209
93. Singh A., Prasad R., Comparative lipidomics of azole sensitive and resistant clinical isolates of Candida albicans reveals unexpected diversity in molecular lipid imprints. PLoS ONE 2011 6 4 e19266 2-s2.0-79955777587 10.1371/journal.pone.0019266
94. Singh A., Yadav V., Prasad R., Comparative lipidomics in clinical isolates of Candida albicans reveal crosstalk between mitochondria, cell wall integrity and azole resistance. PLoS One 2012 7 6 e39812
95. Singh A., Mahto K. K., Prasad R., Lipidomics and in vitro azole resistance in Candida albicans. OMICS 2013 17 2 84 93
96. Jain P., Akula I., Edlind T., Cyclic AMP signaling pathway modulates susceptibility of candida species and Saccharomyces cerevisiae to antifungal azoles and other sterol biosynthesis inhibitors. Antimicrobial Agents and Chemotherapy 2003 47 10 3195 3201 2-s2.0-0141924879 10.1128/AAC.47.10.3195-3201. 2003 (Pubitemid 37229578)
97. Steinbach W. J., Reedy J. L., Cramer R. A. Jr., Perfect J. R., Heitman J., Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections. Nature Reviews Microbiology 2007 5 6 418 430 2-s2.0-34249069582 10.1038/nrmicro1680 (Pubitemid 46780079)
98. Alonso-Monge R., Román E., Arana D. M., Pla J., Nombela C., Fungi sensing environmental stress. Clinical Microbiology and Infection 2009 15 1 17 19 2-s2.0-59649099610 10.1111/j.1469-0691.2008.02690.x
99. Cowen L. E., Lindquist S., Cell biology: Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science 2005 309 5744 2185 2189 2-s2.0-25844530060 10.1126/science.1118370 (Pubitemid 41396062)
100. Cowen L. E., Singha S. D., Köhlerb J. R., Collinsa C., Zaasc A. K., Schellc W. A., Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. Proceedings of the National Academy of Sciences 2009 106 8 2818 2823
101. Bastidas R. J., Reedy J. L., Morales-Johansson H., Heitman J., Cardenas M. E., Signaling cascades as drug targets in model and pathogenic fungi. Current Opinion in Investigational Drugs 2008 9 8 856 864 2-s2.0-48349141125
102. Thakur J. K., Arthanari H., Yang F., Pan S.-J., Fan X., Breger J., Frueh D. P., Gulshan K., Li D. K., Mylonakis E., Struhl K., Moye-Rowley W. S., Cormack B. P., Wagner G., Näär A. M., A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature 2008 452 7187 604 609 2-s2.0-41649118757 10.1038/nature06836 (Pubitemid 351483364)
103. Robbins N., Collins C., Morhayim J., Cowen L. E., Metabolic control of antifungal drug resistance. Fungal Genetics and Biology 2010 47 2 81 93 2-s2.0-73749084686 10.1016/j.fgb.2009.07.004
104. Lafayette S. L., Collins C., Zaas A. K., Schell W. A., Betancourt-Quiroz M., Leslie Gunatilaka A. A., Perfect J. R., Cowen L. E., PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of mkc1, calcineurin, and hsp90. PLoS Pathogens 2010 6 8 79 80 2-s2.0-77958121046 10.1371/journal.ppat.1001069 e1001069
105. de Dios C. H., Román E., Monge R. A., Pla J., The role of MAPK signal transduction pathways in the response to oxidative stress in the fungal pathogen Candida albicans: implications in virulence. Current Protein and Peptide Science 2010 11 8 693 703 2-s2.0-79951755537 10.2174/138920310794557655
106. Konopka J. B., N-acetylglucosamine (GlcNAc) functions in cell signaling. Scientifica 2012 2012 15 489208 10.6064/2012/489208
107. Desai J. V., Bruno V. M., Ganguly S., Stamper R. J., Mitchell K. F., Solis N., Regulatory role of glycerol in Candida albicans biofilm formation. MBio 2013 4 2 10.1128/mBio.00637-12
108. Lee S. H., Jeon J. E., Ahn C. H., Chung S. C., Shin J., Oh K. B., Inhibition of yeast-to-hypha transition in Candida albicans by phorbasin H isolated from phorbas sp. 2013 97 7 3141 3148 10.1007/s00253-012-4549-3
109. Saito H., Tamura M., Imai K., Ishigami T., Ochiai K., Catechin inhibits Candida albicans dimorphism by disrupting Cek1 phosphorylation and cAMP synthesis. Microbial Pathogenesis 2013 56 16 20
110. Mavrianos J., Berkow E. L., Desai C., Pandey A., Batish M., Rabadi M. J., Mitochondrial two-component signaling systems in Candida albicans. Eukaryot Cell 2013 10.1128/EC.00048-13
111. Gaur N. A., Puri N., Karnani N., Mukhopadhyay G., Goswami S. K., Prasad R., Identification of a negative regulatory element which regulates basal transcription of a multidrug resistance gene CDR1 of Candida albicans. FEMS Yeast Research 2004 4 4-5 389 399 2-s2.0-0742269679 10.1016/S1567-1356(03)00204- 6 (Pubitemid 38156203)
112. Talibi D., Raymond M., Isolation of a putative Candida albicans transcriptional regulator involved in pleiotropic drug resistance by functional complementation of a pdr1 pdr3 mutation in saccharomyces cerevisiae. Journal of Bacteriology 1999 181 1 231 240 2-s2.0-0032902758 (Pubitemid 29013676)
113. Chen C.-G., Yang Y.-L., Shih H.-I., Su C.-L., Lo H.-J., CaNdt80 is involved in drug resistance in Candida albicans by regulating CDR1. Antimicrobial Agents and Chemotherapy 2004 48 12 4505 4512 2-s2.0-9644283078 10.1128/AAC.48.12.4505-4512.2004 (Pubitemid 39577646)
114. Morschhäuser J., Barker K. S., Liu T. T., Blaß-Warmuth J., Homayouni R., Rogers P. D., The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans. PLoS Pathogens 2007 3 11, article e164 2-s2.0-38749122534 10.1371/journal.ppat. 0030164 (Pubitemid 350291598)
115. Chen C.-G., Yang Y.-L., Tseng K.-Y., Shih H.-I., Liou C.-H., Lin C.-C., Lo H.-J., Rep1p negatively regulating MDR1 efflux pump involved in drug resistance in Candida albicans. Fungal Genetics and Biology 2009 46 9 714 720 2-s2.0-67650572854 10.1016/j.fgb.2009.06.003
116. Silver P. M., Oliver B. G., White T. C., Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism. Eukaryotic Cell 2004 3 6 1391 1397 2-s2.0-11144308844 10.1128/EC.3.6.1391-1397.2004 (Pubitemid 40025098)
117. Coste A. T., Turner V., Ischer F., Morschhäuser J., Forche A., Selmecki A., Berman J., Bille J., Sanglard D., A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans. Genetics 2006 172 4 2139 2156 2-s2.0-33646171879 10.1534/genetics.105. 054767
118. Tsai H.-F., Krol A. A., Sarti K. E., Bennett J. E., Candida glabrata PDR1, a transcriptional regulator of a pleiotropic drug resistance network, mediates azole resistance in clinical isolates and petite mutants. Antimicrobial Agents and Chemotherapy 2006 50 4 1384 1392 2-s2.0-33645773419 10.1128/AAC.50.4.1384-1392.2006
119. Vermitsky J.-P., Earhart K. D., Smith W. L., Homayouni R., Edlind T. D., Rogers P. D., Pdr1 regulates multidrug resistance in candida glabrata: gene disruption and genome-wide expression studies. Molecular Microbiology 2006 61 3 704 722 2-s2.0-33748042707 10.1111/j.1365-2958.2006.05235.x (Pubitemid 44324094)
120. Dunkel N., Blaß J., Rogers P. D., Morschhäuser J., Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains. Molecular Microbiology 2008 69 4 827 840 2-s2.0-47749142093 10.1111/j.1365-2958.2008.06309.x (Pubitemid 352033303)
121. Dunkel N., Liu T. T., Barker K. S., Homayouni R., Morschhäuser J., Rogers P. D., A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate. Eukaryotic Cell 2008 7 7 1180 1190 2-s2.0-47049101245 10.1128/EC.00103-08 (Pubitemid 351969332)
122. Ferrari S., Ischer F., Calabrese D., Posteraro B., Sanguinetti M., Fadda G., Rohde B., Bauser C., Bader O., Sanglard D., Gain of function mutations in CgPDR1 of candida glabrata not only mediate antifungal resistance but also enhance virulence. PLoS Pathogens 2009 5 1 2-s2.0-59249085257 10.1371/journal.ppat.1000268 e1000268
123. Pérez J. C., Kumamoto C. A., Johnson A. D., Candida albicans commensalism and pathogenicity are intertwined traits directed by a tightly knit transcriptional regulatory circuit. PLOS Biology 2013 11 3 e1001510 10.1371/journal.pbio.1001510
124. Dhamgaye S., Bernard M., Lelandais G., Sismeiro O., Lemoine S., Coppée J. Y., RNA sequencing revealed novel actors of the acquisition of drug resistance in Candida albicans. BMC Genomics 2012 13, article 396 10.1186/1471-2164-13-396
125. Manoharlal R., Gaur N. A., Panwar S. L., Morschhäuser J., Prasad R., Transcriptional activation and increased mRNA stability contribute to overexpression of CDR1 in azole-resistant Candida albicans. Antimicrobial Agents and Chemotherapy 2008 52 4 1481 1492 2-s2.0-42049094413 10.1128/AAC.01106-07 (Pubitemid 351522015)
126. Manoharlal R., Gorantala J., Sharma M., Sanglard D., Prasad R., PAP1 [poly(A) polymerase 1] homozygosity and hyperadenylation are major determinants of increased mRNA stability of CDR1 in azole-resistant clinical isolates of Candida albicans. Microbiology 2010 156 2 313 326 2-s2.0-76449116487 10.1099/mic.0.035154-0
127. Chen C., Noble S. M., Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host. PLOS Pathogens 2012 8 11 e1002956 10.1371/journal.ppat.1002956