In vitro low-level resistance to azoles in Candida albicans is associated with changes in membrane lipid fluidity and asymmetry

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 4, 2002, Pages 1046-1052

  Kohli, Avmeet ^a   Smriti, ^a   Mukhopadhyay, Kasturi ^a   Rattan, Ashok ^a   Prasad, Rajendra ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

1,6 DIPHENYL 1,3,5 HEXATRIENE; ABC TRANSPORTER; FLUCONAZOLE; ITRACONAZOLE; KETOCONAZOLE; MEMBRANE LIPID; NYSTATIN; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; PYRROLE DERIVATIVE; TERBINAFINE;

ANTIBIOTIC RESISTANCE; ARTICLE; CANDIDA ALBICANS; CELL MEMBRANE; CONTROLLED STUDY; CROSS RESISTANCE; DOSE RESPONSE; FLUORESCENCE POLARIZATION; FUNGAL GENE; GENE OVEREXPRESSION; MEMBRANE FLUIDITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

ANTIFUNGAL AGENTS; AZOLES; CANDIDA ALBICANS; COLORING AGENTS; DRUG RESISTANCE, MICROBIAL; FLUCONAZOLE; FLUORESCENCE POLARIZATION IMMUNOASSAY; GLUCOSE; MEMBRANE FLUIDITY; MEMBRANE LIPIDS; PHOSPHOLIPIDS; RHODAMINES; RNA, FUNGAL; RNA, MESSENGER; STEROIDS;

EID: 0036208102     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.4.1046-1052.2002     Document Type: Article

References (35)

1. Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance
2. The uptake of amino acids by erg mutants of Candida albicans
3. Quantitation of ergosterol content: Novel method for determination of fluconazole susceptibility of Candida albicans
4. In vitro resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein is associated with alterations in cytoplasmic membrane fluidity
5. Interaction of anti-Candida amphotericin B (and other polyene antibiotics) with lipids
6. Functional study of multidrug resistance with fluorescent dyes. Limits of the assay for low levels of resistance and application in clinical samples
7. Correlation between Rhodamine 123 accumulation and azole sensitivity in Candida species: Possible role for drug efflux in drug resistance
8. Evolution of drug resistance in experimental populations of Candida albicans
9. Role of translocases in the generation of phosphatidylserine asymmetry
10. Asymmetric distribution of phosphatidylethanolamine in C. albicans: Possible mediation by CDR1, a multidrug transporter belonging to ATP binding cassette (ABC) superfamily
11. Standardization of antifungal susceptibility testing and clinical relevance
12. Analysis of the tangled relationships between P-glycoprotein-mediated multidrug resistance and the lipid phase of the cell membrane
13. Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains
14. Resistance of Candida albicans biofilms to antifungal agents in vitro
15. The lipid composition of azole-sensitive and azole-resistant strains of Candida albicans
16. The lipid composition and permeability to azole of an azole- and polyene-resistant mutant of Candida albicans
17. Chromatographic analysis of lipids
18. The yeast multidrug resistance pump, Pdr5p, confers reduced drug resistance in erg mutants of Saccharomyces cerevisiae
19. Expression of CDR1, a multidrug resistance gene of Candida albicans: In vitro transcriptional activation by heat shock, drugs and human steroid hormones
20. Isolation, characterisation, and sequencing of Candida albicans repetitive element 2
21. Multiple resistant phenotypes of Candida albicans coexist during episodes of oropharyngeal candidiasis in human immunodeficiency virus-infected patients
22. Rhodamine 6G efflux for the detection of CDR1-overexpressing azole-resistant Candida albicans strains
23. Mechanisms of resistance to azole antifungal compounds
24. Emerging role of lipids of Candida albicans, a pathogenic dimorphic yeast
25. Stress factors acting at the level of plasma membrane induce transcription via the stress response element (STRE) of the yeast Saccharomyces cerevisiae
26. Drug resistance mechanisms of human pathogenic fungi
27. Membrane fluidization by ether, other anesthetics, and certain agents abolishes P-glycoprotein ATPase activity and modulates efflux from multidrug-resistant cells
28. Development of interpretive breakpoints for antifungal susceptibility testing: Conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole and Candida infections
29. Stress signaling in yeast
30. Expression of human P-glycoprotein in yeast cells: Effects of membrane component sterols on the activity of P-glycoprotein
31. The P-glycoprotein multidrug transporter: Interactions with membrane lipids, and their modulation of activity
32. Membrane fluidity affects functions of Cdr1p, a multidrug ABC transporter of Candida albicans
33. Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein
34. Cholesterol interaction with the daunorubicin binding site of P-glycoprotein
35. Clinical, cellular, and molecular factors that contribute to antifungal drug resistance