Mitochondrial two-component signaling systems in Candida albicans

Eukaryotic Cell

Volumn 12, Issue 6, 2013, Pages 913-922

  Mavrianos, John ^a   Berkow, Elizabeth L ^c   Desai, Chirayu ^a   Pandey, Alok ^b   Batish, Mona ^a   Rabadi, Marissa J ^a   Barker, Katherine S ^c   Pain, Debkumar ^b   Rogers, P David ^c   Eugenin, Eliseo A ^a   Chauhan, Neeraj ^a,b  

^a PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; FUNGAL PROTEIN; HEAT SHOCK PROTEIN; HYBRID PROTEIN; PROTEIN HISTIDINE KINASE; PROTEIN KINASE; PROTEIN-HISTIDINE KINASE;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CANDIDA ALBICANS; EVOLUTION; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MITOCHONDRION; MOLECULAR GENETICS; PHYLOGENY; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; ULTRASTRUCTURE;

AMINO ACID SEQUENCE; APOPTOSIS; BACTERIAL PROTEINS; BIOLOGICAL EVOLUTION; CANDIDA ALBICANS; FUNGAL PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; HEAT-SHOCK PROTEINS; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; PHYLOGENY; PROTEIN KINASES; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); CANDIDA ALBICANS; CYANOBACTERIA; EUKARYOTA; FUNGI; PROKARYOTA;

EID: 84878407525     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00048-13     Document Type: Article

References (45)

1. Chauhan N, Calderone R. 2008. Two-component signal transduction proteins as potential drug targets in medically important fungi. Infect. Immun. 76:4795-4803.
2. Calera JA, Zhao XJ, De Bernardis F, Sheridan M, Calderone R. 1999. Avirulence of Candida albicans CaHK1 mutants in a murine model of hematogenously disseminated candidiasis. Infect. Immun. 67:4280-4284.
3. Calera JA, Zhao XJ, Calderone R. 2000. Defective hyphal development and avirulence caused by a deletion of the SSK1 response regulator gene in Candida albicans. Infect. Immun. 68:518-525.
4. Du C, Calderone R, Richert J, Li D. 2005. Deletion of the SSK1 response regulator gene in Candida albicans contributes to enhanced killing by human polymorphonuclear neutrophils. Infect. Immun. 73:865-871.
5. Torosantucci A, Chiani P, De Bernardis F, Cassone A, Calera JA, Calderone R. 2002. Deletion of the two-component histidine kinase gene (CHK1) of Candida albicans contributes to enhanced growth inhibition and killing by human neutrophils in vitro. Infect. Immun. 70:985-987.
6. Li D, Bernhardt J, Calderone R. 2002. Temporal expression of the Candida albicans genes CHK1 and CSSK1, adherence, and morphogenesis in a model of reconstituted human esophageal epithelial candidiasis. Infect. Immun. 70:1558-1565.
7. Kruppa M, Krom BP, Chauhan N, Bambach AV, Cihlar RL, Calderone RA. 2004. The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans. Eukaryot. Cell 3:1062-1065.
8. Chauhan N, Inglis D, Roman E, Pla J, Li D, Calera JA, Calderone R. 2003. Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress. Eukaryot. Cell 2:1018-1024.
9. Singh P, Chauhan N, Ghosh A, Dixon F, Calderone R. 2004. SKN7 of Candida albicans: mutant construction and phenotype analysis. Infect. Immun. 72:2390-2394.
10. Desai C, Mavrianos J, Chauhan N. 2011. Candida albicans SRR1, a putative two-component response regulator gene, is required for stress adaptation, morphogenesis, and virulence. Eukaryot. Cell 10:1370-1374.
11. Koretke KK, Lupas AN, Warren PV, Rosenberg M, Brown JR. 2000. Evolution of two-component signal transduction. Mol. Biol. Evol. 17: 1956-1970.
12. Stock AM, Robinson VL, Goudreau PN. 2000. Two-component signal transduction. Annu. Rev. Biochem. 69:183-215.
13. Chauhan N, Latge JP, Calderone R. 2006. Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus. Nat. Rev. Microbiol. 4:435-444.
14. Catlett NL, Yoder OC, Turgeon BG. 2003. Whole-genome analysis of two-component signal transduction genes in fungal pathogens. Eukaryot. Cell 2:1151-1161.
15. Butler G, Rasmussen MD, Lin MF, Santos MA, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, Agrafioti I, Arnaud MB, Bates S, Brown AJ, Brunke S, Costanzo MC, Fitzpatrick DA, de Groot PW, Harris D, Hoyer LL, Hube B, Klis FM, Kodira C, Lennard N, Logue ME, Martin R, Neiman AM, Nikolaou E, Quail MA, Quinn J, Santos MC, Schmitzberger FF, Sherlock G, Shah P, Silverstein KA, Skrzypek MS, Soll D, Staggs R, Stansfield I, Stumpf MP, Sudbery PE, Srikantha T, Zeng Q, Berman J, Berriman M, Heitman J, Gow NA, Lorenz MC, Birren BW, Kellis M, Cuomo CA. 2009. Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature 459:657-662.
16. Cheng WC, Leach KM, Hardwick JM. 2008. Mitochondrial death pathways in yeast and mammalian cells. Biochim. Biophys. Acta 1783:1272-1279.
17. Shingu-Vazquez M, Traven A. 2011. Mitochondria and fungal pathogenesis: drug tolerance, virulence, and potential for antifungal therapy. Eukaryot. Cell 10:1376-1383.
18. Cormack BP, Bertram G, Egerton M, Gow NA, Falkow S, Brown AJ. 1997. Yeast-enhanced green fluorescent protein (yEGFP): a reporter of gene expression in Candida albicans. Microbiology 143(Pt 2):303-311.
19. Murad AM, Lee PR, Broadbent ID, Barelle CJ, Brown AJ. 2000. CIp10, an efficient and convenient integrating vector for Candida albicans. Yeast 16:325-327.
20. Barelle CJ, Manson CL, MacCallum DM, Odds FC, Gow NA, Brown AJ. 2004. GFP as a quantitative reporter of gene regulation in Candida albicans. Yeast 21:333-340.
21. Amutha B, Gordon DM, Dancis A, Pain D. 2009. Nucleotide-dependent iron-sulfur cluster biogenesis of endogenous and imported apoproteins in isolated intact mitochondria. Methods Enzymol. 456:247-266.
22. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (ed). 1992. Current protocols in molecular biology. John Wiley and Sons, New York, NY.
23. Dunkel N, Liu TT, Barker KS, Homayouni R, Morschhauser J, Rogers PD. 2008. A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate. Eukaryot. Cell 7:1180-1190.
24. Pfanner N, Geissler A. 2001. Versatility of the mitochondrial protein import machinery. Nat. Rev. Mol. Cell Biol. 2:339-349.
25. Pain J, Balamurali MM, Dancis A, Pain D. 2010. Mitochondrial NADH kinase, Pos5p, is required for efficient iron-sulfur cluster biogenesis in Saccharomyces cerevisiae. J. Biol. Chem. 285:39409-39424.
26. Schulke N, Sepuri NB, Gordon DM, Saxena S, Dancis A, Pain D. 1999. A multisubunit complex of outer and inner mitochondrial membrane protein translocases stabilized in vivo by translocation intermediates. J. Biol. Chem. 274:22847-22854.
27. Bambach A, Fernandes MP, Ghosh A, Kruppa M, Alex D, Li D, Fonzi WA, Chauhan N, Sun N, Agrellos OA, Vercesi AE, Rolfes RJ, Calderone R. 2009. Goa1p of Candida albicans localizes to the mitochondria during stress and is required for mitochondrial function and virulence. Eukaryot. Cell 8:1706-1720.
28. Arnaud MB, Costanzo MC, Skrzypek MS, Binkley G, Lane C, Miyasato SR, Sherlock G. 2005. The Candida Genome Database (CGD), a community resource for Candida albicans gene and protein information. Nucleic Acids Res. 33:D358-D363.
29. Li D, Chen H, Florentino A, Alex D, Sikorski P, Fonzi WA, Calderone R. 2011. Enzymatic dysfunction of mitochondrial complex I of the Candida albicans goa1 mutant is associated with increased reactive oxidants and cell death. Eukaryot. Cell 10:672-682.
30. Andersson SG, Karlberg O, Canback B, Kurland CG. 2003. On the origin of mitochondria: a genomics perspective. Philos. Trans. R. Soc. Lond. B Biol. Sci. 358:165-177, discussion 177-179.
31. Gabaldon T, Huynen MA. 2004. Shaping the mitochondrial proteome. Biochim. Biophys. Acta 1659:212-220.
32. Gray MW. 1993. Origin and evolution of organelle genomes. Curr. Opin. Genet. Dev. 3:884-890.
33. Chan DC. 2006. Mitochondria: dynamic organelles in disease, aging, and development. Cell 125:1241-1252.
34. Westermann B, Neupert W. 2003. 'Omics' of the mitochondrion. Nat. Biotechnol. 21:239-240.
35. Arnaud MB, Costanzo MC, Skrzypek MS, Shah P, Binkley Lane GC, Miyasato SR, Sherlock G. 2007. Sequence resources at the Candida Genome Database. Nucleic Acids Res. 35:D452-D456.
36. Inglis DO, Arnaud MB, Binkley J, Shah P, Skrzypek MS, Wymore F, Binkley G, Miyasato SR, Simison M, Sherlock G. 2012. The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata. Nucleic Acids Res. 40:D667-D674.
37. Burger G, Gray MW, Lang BF. 2003. Mitochondrial genomes: anything goes. Trends Genet. 19:709-716.
38. Puthiyaveetil S, Allen JF. 2009. Chloroplast two-component systems: evolution of the link between photosynthesis and gene expression. Proc. Biol. Sci. 276:2133-2145.
39. Puthiyaveetil S, Ibrahim IM, Jelicic B, Tomasic A, Fulgosi H, Allen JF. 2010. Transcriptional control of photosynthesis genes: the evolutionarily conserved regulatory mechanism in plastid genome function. Genome Biol. Evol. 2:888-896.
40. Puthiyaveetil S, Kavanagh TA, Cain P, Sullivan JA, Newell CA, Gray JC, Robinson C, van der Giezen M, Rogers MB, Allen JF. 2008. The ancestral symbiont sensor kinase CSK links photosynthesis with gene expression in chloroplasts. Proc. Natl. Acad. Sci. U. S. A. 105:10061-10066.
41. Reith M, Munholland J. 1993. A high-resolution gene map of the chloroplast genome of the red alga Porphyra purpurea. Plant Cell 5:465-475.
42. Bruce CR, Smith DA, Rodgers D, da Silva Dantas A, MacCallum DM, Morgan BA, Quinn JA. 2011. Identification of a novel response regulator, Crr1, that is required for hydrogen peroxide resistance in Candida albicans. PLoS One 6:e27979. doi:10.1371/journal.pone.0027979.
43. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. 2011. MEGA5: Molecular Evolutionary Genetics Analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol. Biol. Evol. 28:2731-2739.
44. Saitou N, Nei M. 1987. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol. Biol. Evol. 4:406-425.
45. Zuckerkandl E, Pauling L. 1965. Evolutionary divergence and convergence in proteins, p 97-166. In Bryson V, Vogel HJ (ed), Evolving genes and proteins. Academic Press, New York, NY.