The heme-binding protein Dap1 links iron homeostasis to azole resistance via the P450 protein Erg11 in Candida glabrata

FEMS Yeast Research

Volumn 13, Issue 4, 2013, Pages 411-421

  Hosogaya, Naoki ^a,b   Miyazaki, Taiga ^a   Nagi, Minoru ^c,d   Tanabe, Koichi ^c   Minematsu, Asuka ^a   Nagayoshi, Yohsuke ^a   Yamauchi, Shunsuke ^a   Nakamura, Shigeki ^a   Imamura, Yoshifumi ^a   Izumikawa, Koichi ^a   Kakeya, Hiroshi ^a   Yanagihara, Katsunori ^e   Miyazaki, Yoshitsugu ^c   Kugiyama, Kiyotaka ^b   Kohno, Shigeru ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF YAMANASHI   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^e NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

Antifungal resistance; Damage resistance protein 1; Ergosterol; Fluconazole; Iron metabolism; Voriconazole

Indexed keywords

CYTOCHROME P450; DAP1 PROTEIN; ERGOSTEROL; HEME; IRON BINDING PROTEIN; LANOSTEROL; PYRROLE; SQUALENE; UNCLASSIFIED DRUG;

ANTIFUNGAL RESISTANCE; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; BIOACCUMULATION; CANDIDA GLABRATA; CONTROLLED STUDY; DRUG TOLERANCE; ENDOSOME; HOMEOSTASIS; LIPOGENESIS; MUTANT; NONHUMAN; PHENOTYPE; PROTEIN BINDING; STEROL ANALYSIS; SUPPLEMENTATION; TONOPLAST; WILD TYPE;

ANTIFUNGAL AGENTS; AZOLES; CANDIDA GLABRATA; CARRIER PROTEINS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG RESISTANCE, FUNGAL; GENE DELETION; GENETIC COMPLEMENTATION TEST; HEMEPROTEINS; HOMEOSTASIS; IRON; LANOSTEROL; SQUALENE;

CANDIDA GLABRATA; FUNGI;

EID: 84877655667     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/1567-1364.12043     Document Type: Article

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