c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1α-dependent P-glycoprotein expression in hypoxia

Cancer Research

Volumn 64, Issue 24, 2004, Pages 9057-9061

  Comerford, Katrina M ^a   Cummins, Eoin P ^a   Taylor, Cormac T ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; COBALT CHLORIDE; GLYCOPROTEIN P; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MULTIDRUG RESISTANCE PROTEIN 1; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; ANTIOXIDANT; COBALT; HIF1A PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CANCER RESISTANCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR CELL; BIOSYNTHESIS; CELL HYPOXIA; DRUG ANTAGONISM; GENE; GENETIC TRANSFECTION; GENETICS; HELA CELL; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TRANSACTIVATION; UPREGULATION;

ANTIOXIDANTS; CELL HYPOXIA; COBALT; ENZYME ACTIVATION; GENES, MDR; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; JNK MITOGEN-ACTIVATED PROTEIN KINASES; P-GLYCOPROTEIN; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION; UP-REGULATION;

EID: 10844278331     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-1919     Document Type: Article

References (32)

1. Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-32.
2. Schofeild CJ, Ratcliffe PJ. Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 2004;5:343-54.
3. Semenza GL. Hypoxia-inducible factor 1: master regulator of O2 homeostasis. Curr Opin Genet Dev 1998;8:558-94.
4. Koch S, Mayer F, Honecker F, Schittenhelm M, Bokemeyer C. Efficacy of cytotoxic agents used in the treatment of testicular germ cell tumors under normoxic and hypoxic conditions in vitro. Br J Cancer 2003;89:2133-9.
5. Kalr R, Jones AM, Kirk J, Adams GE, Stratford IJ. The effect of hypoxia on acquired drug resistance and response to epidermal growth factor in Chinese hamster lung fibroblasts and human breast cancer cells in vitro. Int J Cancer 1993;54:650-5.
6. Liang BC. Effects of hypoxia on drug resistance phenotype and genotype in human glioma cell lines. J Neurooncol 1996;29:149-55.
7. Comerford KM, Wallace TJ, Karhausen J, Louis NA, Montalto MC, Colgan SP. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res 2002;62:3387-94.
8. Wartenberg M, Ling FC, Muschen M, et al. Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species. FASEB J 2003;17:503-5.
9. Davis RJ. Signal transduction by the c-Jun N-terminal kinase. Biochem Soc Symp 1999;64:1-12.
10. Kunz M, Ibrahim S, Koczan D, et al. Activation of c-jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) is critical for hypoxia-induced apoptosis of human malignant melanoma. Cell Growth Differ 2001;12:137-45.
11. Jin N, Hatton N, Swartz DR, et al. Hypoxia activates jun-N-terminal kinase, extra-cellular signal-regulated protein kinase, and p38 kinase in pulmonary arteries. Am J Respir Cell Mol Biol 2000;23:593-601.
12. Kuan CY, Whitmarsh AJ, Yang DD, et al. A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci USA 2003;100:15184-9.
13. Mishra OP, Zubrow AB, Ashraf QM. Nitric oxide-mediated activation of extracellular signal-regulated kinase (ERK) and c-jun N terminal kinase (JNK) during hypoxia in cerebral cortical nuclei of newborn piglets. Neuroscience 2004;123:179-86.
14. Laderoute KR, Calaoagan JM, Knapp M, Johnson RS. Glucose utilization is essential for hypoxia-inducible factor 1 α-dependent phosphorylation of c-jun. Mol Cell Biol 2004;24:4128-37.
15. Seko Y, Takahashi N, Tobe K, Kadowaki T, Yazaki Y. Hypoxia and hypoxia/reoxygenation activate p65PAK, p38 mitogen activated protein kinase (MAPK) and stress-activated protein kinase (SAPK) in cultured rat cardiac myocytes. Biochem Biophys Res Comm 1997;239:804-44.
16. Le YJ, Corry PM. Hypoxia-inducible bFGF gene expression is mediated through the JNK signal transduction pathway. Mol Cell Biochem 1999;202:1-8.
17. Garay M, Gaarde W, Monia BP, Nero P, Cioffi CL. Inhibition of hypoxia/reoxygenation-induced apoptosis by an antisense oligonucleotide targeted to JNK1 in human kidney cells. Biochem Pharmacol 2000;59:1033-43.
18. Minet E, Michel G, Mottet D, et al. c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells. Exp Cell Res 2001;265:114-24.
19. Osborn MT, Chambers TC. Role of the stress-activated/c-Jun NH2-trminal kinase pathway in the cellular response to adriamycin and other chemotherapeutic drugs. J Biol Chem 1996;271:30950-5.
20. Alfranca A, Gutierrez MD, Vara A, Aragones J, Vidai F, Landazuri MO. c-jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription. Mol Cell Biol 2002;22:12-22.
21. Poulaki V, Mitsiades CS, McMullan C, et al. Regulation of vascular endothelial growth factor expression by insulin-like growth factor I in thyroid carcinomas. J Clin Endocrinol Metab 2003;88:5392-8.
22. Tacchini L, Matteucci E, De Ponti C, Desiderio MA. Hepatocyte growth factor signaling regulates transactivation of genes belonging to the plasminogen activation system via hypoxia inducible factor 1. Exp Cell Res 2003;290:391-401.
23. Tacchini L, Dansi P, Matteucci E, Desiderio MA. Hepatocyte growth factor signaling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells. Carcinogenesis 2001;22:1363-71.
24. Leonard MO, Cottell DC, Godson C, Brady HR, Taylor CT. The role of HIF-1αa in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia. J Biol Chem 2003;278:40296-304.
25. Taylor CT, Furuta GT, Synnestvedt K, Colgan SP. Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia. Proc Natl Acad Sci USA 2000;97:12091-6.
26. Taylor CT, Fueki N, Agah A, Hershberg RM, Colgan SP. Critical role of the cAMP response element binding protein in hypoxia-elicited induction of epithelial tumor necrosis factor-α. J Biol Chem 1999;274:19447-54.
27. Comerford KM, Leonard MO, Karhausen J, Carey R, Colgan SP, Taylor CT. Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. Proc Natl Acad Sci USA 2003;100:986-91.
28. Hagen T, Taylor CT, Lam F, Moncada S. Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF-1αa. Science 2003;302:1975-8.
29. Felix RA. Barrand MA. P-glycoprotein expression in rat brain endothelial cells: evidence for regulation by transient oxidative stress. J Neurochem 2002;80:64-72.
30. Dougherty CJ, Kubasiak LA, Prentice H, et al. Activation of c-jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress. Biochem J 2002;362:561-71.
31. Chandel NS, Schumacker PT. Cellular oxygen sensing by mitochondria: old questions, new insight. J Appl Physiol 2000;88:1880-9.
32. Rolfe DE, Brown GC. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Phys Rev 1997;77:731-58.