Endogenous reactive oxygen species is an important mediator of miconazole antifungal effect

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 10, 2002, Pages 3113-3117

  Kobayashi, Daisuke ^a   Kondo, Kei ^a   Uehara, Nobuyuki ^a   Otokozawa, Seiko ^a   Tsuji, Naoki ^a   Yagihashi, Atsuhito ^a   Watanabe, Naoki ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; ANTIOXIDANT; DITHIOCARBAMIC ACID DERIVATIVE; FLUCONAZOLE; MICONAZOLE; REACTIVE OXYGEN METABOLITE;

ANTIFUNGAL ACTIVITY; ARTICLE; BIOSYNTHESIS; CANDIDA ALBICANS; COLONY FORMATION; CONCENTRATION RESPONSE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

ANTIFUNGAL AGENTS; ANTIOXIDANTS; CANDIDA ALBICANS; CANDIDA GLABRATA; HUMANS; MICONAZOLE; MICROBIAL SENSITIVITY TESTS; PROLINE; REACTIVE OXYGEN SPECIES; THIOCARBAMATES;

EID: 0036784060     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.10.3113-3117.2002     Document Type: Article

References (31)

1. AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily
2. Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance
3. Direct membrane-damaging effect of ketoconazole and tioconazole on Candida albicans demonstrated by bioluminescent assay of ATP
4. + from Candida species
5. Enhanced ROS production in oncogenically transformed cells potentiates c-jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress
6. Mode of insertion of miconazole, ketoconazole and deacylated ketoconazole in lipid layers. A conformational analysis
7. + release
8. Antioxidant therapy: A new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury
9. Stimulation of oxidative metabolism in murine polymorphonuclear leukocytes by unopsonized fungal cells: Evidence for a mannose-specific mechanism
10. Reductive detoxification as a mechanism of fungal resistance to singlet oxygen-generating photosensitizers
11. Azole resistance in Candida
12. Plasma membrane ATPase of yeast. Comparative inhibition studies of the purified and membranebound enzymes
13. Copper- and zinc-containing superoxide dismutase and its gene from Candida albicans
14. Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta5,6-desaturation
15. Caspase-3 activation downstream from reactive oxygen species in heat-induced apoptosis of pancreatic carcinoma cells carrying a mutant p53 gene
16. Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance
17. Candida albicans expresses an unusual cytoplasmic manganese-containing superoxide dismutase (SOD3 gene product) upon the entry and during the stationary phase
18. Protective role of superoxide dismutases against ionizing radiation in yeast
19. Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p Cyp51p) to azole resistance in Candida albicans
20. Molecular biological characterization of an azole-resistant Candida glabrata isolate
21. Antifungal effects of fluconazole (UK 49858), a new triazole antifungal, in vitro
22. In vitro susceptibility testing of Candida isolates from clinical specimens to four antifungal agents
23. Clinical evaluation of the ASTY colorimetric microdilution panel for antifungal susceptibility testing
24. Manganese-containing superoxide dismutase and its gene from Candida albicans
25. Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents
26. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
27. Augmented adriamycin sensitivity in cells transduced with an antisense tumor necrosis factor gene is mediated by caspase-3 downstream from reactive oxygen species
28. Molecular mechanisms of drug resistance in fungi
29. Biochemical effects of miconazole on fungi. II. Inhibition of ergosterol biosynthesis in Candida albicans
30. Hypothesis on the molecular basis of the antifungal activity of N-substituted imidazoles and triazoles
31. Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans