Fungi sensing environmental stress

Clinical Microbiology and Infection

Volumn 15, Issue SUPPL. 1, 2009, Pages 17-19

  Alonso Monge, R ^a   Roman E ^a   Arana, D M ^a   Pla, J ^a   Nombela, C ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Candida albicans; Fungi; Mitogen activated protein kinase; Signal transduction

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; VIRULENCE FACTOR;

CANDIDA ALBICANS; CELL FUNCTION; DEVELOPED COUNTRY; ENVIRONMENTAL STRESS; ENZYME ACTIVATION; EVOLUTIONARY ADAPTATION; FUNGAL GENETICS; FUNGAL VIRULENCE; FUNGUS ISOLATION; GENETIC CONSERVATION; MYCOLOGY; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; SURVIVAL RATE;

CANDIDA ALBICANS; FUNGI;

EID: 59649099610     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2008.02690.x     Document Type: Review

References (20)

1. Kultz D. Phylogenetic and functional classification of mitogen- and stress-activated protein kinases. J Mol Evol 1998; 46: 571-588.
2. Whiteway M, Bachewich C. Morphogenesis in Candida albicans. Annu Rev Microbiol 2007; 61: 529 -53.
3. Lin X, Heitman J. The biology of the Cryptococcus neoformans species complex. Annu Rev Microbiol 2006; 60: 69-105.
4. Singh N, Paterson DL. Aspergillus infections in transplant recipients. Clin Microbiol Rev 2005; 18: 44-69.
5. Alonso-Monge R, Navarro-García F, Román E et al. The Hog1 mitogen-activated protein kinase is essential in the oxidative stress response and chlamydospore formation in Candida albicans. Eukaryot Cell 2003; 2: 351-361.
6. Smith DA, Nicholls S, Morgan BA, Brown AJ, Quinn J. A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans. Mol Biol Cell 2004; 15: 4179-4190.
7. Alonso-Monge R, Navarro-García F, Molero G et al. Role of the mitogen-activated protein kinase Hog1p in morphogenesis and virulence of Candida albicans. J Bacteriol 1999; 181: 3058-3068.
8. Arana DM, Nombela C, Alonso-Monge R, Pla J. The Pbs2 MAP kinase is essential for the oxidative-stress response in the fungal pathogen Candida albicans. Microbiology 2005; 151: 1033-1049.
9. Whiteway M, Dignard D, Thomas DY. Dominant negative selection of heterologous genes: Isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest. Proc Natl Acad Sci USA 1992; 89: 9410-9414.
10. Roman E, Nombela C, Pla J. The Sho1 adaptor protein links oxidative stress to morphogenesis and cell wall biosynthesis in the fungal pathogen Candida albicans. Mol Cell Biol 2005; 25: 10611-10627.
11. Chauhan N, Inglis D, Román E et al. Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress. Eukaryot Cell 2003; 2: 1018-1024.
12. Du C, Calderone R, Richert J, Li D. Deletion of the SSK1 response regulator gene in Candida albicans contributes to enhanced killing by human polymorphonuclear neutrophils. Infect Immun 2005; 73: 865-871.
13. Arana DM, Alonso-Monge R, Du C, Calderone R, Pla J. Differential susceptibility of mitogen-activated protein kinase pathway mutants to oxidative-mediated killing by phagocytes in the fungal pathogen Candida albicans. Cell Microbiol 2007; 9: 1647 -1659.
14. Navarro-García F, Alonso-Monge R, Rico H, Pla J, Sentandreu R, Nombela C. A role for the MAP kinase gene MKC1 in cell wall construction and morphological transitions in Candida albicans. Microbiology 1998; 144: 411-424.
15. Navarro-García F, Sanchez M, Pla J, Nombela C. Functional characterization of the MKC1 gene of Candida albicans, which encodes a mitogen-activated protein kinase homolog related to cell integrity. Mol Cell Biol 1995; 15: 2197-2206.
16. Navarro-Garcia F, Eisman B, Fiuza SM, Nombela C, Pla J. The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans. Microbiology 2005; 151: 2737-2749.
17. Kumamoto CA. A contact-activated kinase signals Candida albicans invasive growth and biofilm development. Proc Natl Acad Sci USA 2005; 102: 5576-5581.
18. Diez-Orejas R, Molero G, Navarro-García F, Pla J, Nombela C, Sánchez-Pérez M. Reduced virulence of Candida albicans MKC1 mutants: A role for a mitogen-activated protein kinase in pathogenesis. Infect Immun 1997; 65: 833-837.
19. Molero G, Guillen MV, Martinez-Solano L et al. The importance of the phagocytes' innate response in resolution of the infection induced by a low virulent Candida albicans mutant. Scand J Immunol 2005; 62: 224-233.
20. Diez-Orejas R, Molero G, Moro MA, Gil C, Nombela C, Sanchez-Perez M. Two different NO-dependent mechanisms account for the low virulence of a non-mycelial morphological mutant of Candida albicans. Med Microbiol Immunol 2001; 189: 153-160.