Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets

Diabetologia

Volumn 54, Issue 7, 2011, Pages 1756-1765

  Aston Mourney, K ^a   Hull, R L ^a   Zraika, S ^a   Udayasankar, J ^a   Subramanian, S L ^a   Kahn, S E ^a  

^a VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

Author keywords

Beta cell apoptosis; Beta cell area; Beta cell proliferation; Exendin 4; GLP 1 receptor agonist; IAPP; Insulin secretion; Islet amyloid

Indexed keywords

AMYLOID PROTEIN; DIAZOXIDE; EXENDIN 4; GLIBENCLAMIDE; GLUCOSE; INSULIN; POLYPEPTIDE; POTASSIUM CHLORIDE; PROTEIN KINASE B; SOMATOSTATIN; TOLBUTAMIDE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LOSS; CELL SIZE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TRANSGENIC MOUSE;

AMYLOID; ANIMALS; APOPTOSIS; DIAZOXIDE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN-SECRETING CELLS; ISLET AMYLOID POLYPEPTIDE; ISLETS OF LANGERHANS; MICE; MICE, TRANSGENIC; PEPTIDES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SOMATOSTATIN; VENOMS;

EID: 79959740380     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2143-3     Document Type: Article

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