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Volumn 33, Issue 7, 2009, Pages 716-726

The accelerator hypothesis: A review of the evidence for insulin resistance as the basis for type i as well as type II diabetes

Author keywords

Accelerator hypothesis; Diabetes; Insulin resistance; Overweight; Tempo

Indexed keywords

INSULIN;

EID: 67650450153     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2009.97     Document Type: Review
Times cited : (120)

References (91)
  • 1
    • 0027990934 scopus 로고
    • Incidence of insulin-dependent diabetes in age groups over 30 years in Denmark
    • Molbak AG, Christau B, Marner B, Borch-Johnsen K, Nerup J. Incidence of insulin-dependent diabetes in age groups over 30 years in Denmark. Diabet Med 1994; 11: 650-655.
    • (1994) Diabet Med , vol.11 , pp. 650-655
    • Molbak, A.G.1    Christau, B.2    Marner, B.3    Borch-Johnsen, K.4    Nerup, J.5
  • 3
    • 0030778746 scopus 로고    scopus 로고
    • Ketosis-onset diabetes in young adults with subsequent non-insulin-dependency, a link between IDDM and NIDDM?
    • Aizawa T, Funase Y, Katakura M, Asanuma N, Yamauchi K, Yoshizawa K et al. Ketosis-onset diabetes in young adults with subsequent non-insulin-dependency, a link between IDDM and NIDDM? Diabet Med 1997; 14: 989-991.
    • (1997) Diabet Med , vol.14 , pp. 989-991
    • Aizawa, T.1    Funase, Y.2    Katakura, M.3    Asanuma, N.4    Yamauchi, K.5    Yoshizawa, K.6
  • 4
    • 33746692515 scopus 로고    scopus 로고
    • Declassifying diabetes
    • Gale EA. Declassifying diabetes. Diabetologia 2006; 49: 1989- 1995.
    • (2006) Diabetologia , vol.49 , pp. 1989-1995
    • Gale, E.A.1
  • 5
    • 34447129009 scopus 로고    scopus 로고
    • Changing perspectives in diabetes: Their impact on its classification
    • Wilkin TJ. Changing perspectives in diabetes: their impact on its classification. Diabetologia 2007; 50: 1587-1592.
    • (2007) Diabetologia , vol.50 , pp. 1587-1592
    • Wilkin, T.J.1
  • 6
    • 0034932098 scopus 로고    scopus 로고
    • The accelerator hypothesis: Weight gain as the missing link between type I and type II diabetes
    • Wilkin TJ. The accelerator hypothesis: weight gain as the missing link between type I and type II diabetes. Diabetologia 2001; 44: 914-922.
    • (2001) Diabetologia , vol.44 , pp. 914-922
    • Wilkin, T.J.1
  • 7
    • 0141446269 scopus 로고    scopus 로고
    • Testing the accelerator hypothesis: The relationship between body mass and age at diagnosis of type 1 diabetes
    • Kibirige M,Metcalf B, Renuka R,Wilkin TJ. Testing the accelerator hypothesis: the relationship between body mass and age at diagnosis of type 1 diabetes. Diabetes Care 2003; 26: 2865-2870.
    • (2003) Diabetes Care , vol.26 , pp. 2865-2870
    • Kibirige, M.1    Metcalf, B.2    Renuka, R.3    Wilkin, T.J.4
  • 8
    • 13444304163 scopus 로고    scopus 로고
    • Increasing body weight predicts the earlier onset of insulin-dependant diabetes in childhood: Testing the 'accelerator hypothesis' (2)
    • Betts P, Mulligan J, Ward P, Smith B, Wilkin TJ. Increasing body weight predicts the earlier onset of insulin-dependant diabetes in childhood: testing the 'accelerator hypothesis' (2). Diabet Med2005; 22: 144-151.
    • (2005) Diabet Med , vol.22 , pp. 144-151
    • Betts, P.1    Mulligan, J.2    Ward, P.3    Smith, B.4    Wilkin, T.J.5
  • 9
    • 28444458516 scopus 로고    scopus 로고
    • DPV Scientific Initiative of Germany and Austria. The 'accelerator hypothesis': Relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9248 German and Austrian children with type 1 diabetes mellitus
    • Knerr I, Wolf J, Reinehr T, Stachow R, Grabert M, Schober E et al.DPV Scientific Initiative of Germany and Austria. The 'accelerator hypothesis': relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9248 German and Austrian children with type 1 diabetes mellitus. Diabetologia2005; 48: 2501-2504.
    • (2005) Diabetologia , vol.48 , pp. 2501-2504
    • Knerr, I.1    Wolf, J.2    Reinehr, T.3    Stachow, R.4    Grabert, M.5    Schober, E.6
  • 10
    • 30044444444 scopus 로고    scopus 로고
    • Higher body weight is associated with earlier onset of type 1 diabetes in children: Confirming the 'Accelerator Hypothesis'
    • Kordonouri O, Hartmann R. Higher body weight is associated with earlier onset of type 1 diabetes in children: confirming the 'Accelerator Hypothesis'. Diabet Med 2005; 22: 1783-1784.
    • (2005) Diabet Med , vol.22 , pp. 1783-1784
    • Kordonouri, O.1    Hartmann, R.2
  • 11
  • 12
    • 33646376936 scopus 로고    scopus 로고
    • SEARCH for Diabetes in Youth Study Group. Testing the accelerator hypothesis: Body size, betacell function, and age at onset of type 1(autoimmune) diabetes
    • Dabelea D, D'Agostino Jr RB, Mayer-Davis EJ, Pettitt DJ, Imperatore G, Dolan LM et al. SEARCH for Diabetes in Youth Study Group. Testing the accelerator hypothesis: body size, betacell function, and age at onset of type 1(autoimmune) diabetes. Diabetes Care 2006; 29: 290-294.
    • (2006) Diabetes Care , vol.29 , pp. 290-294
    • Dabelea, D.1    D'Agostino Jr, R.B.2    Mayer-Davis, E.J.3    Pettitt, D.J.4    Imperatore, G.5    Dolan, L.M.6
  • 13
    • 0141446220 scopus 로고    scopus 로고
    • Obesity, insulin resistance, beta-cell autoimmunity, and the changing clinical epidemiology of childhood diabetes
    • Rosenbloom AL. Obesity, insulin resistance, beta-cell autoimmunity, and the changing clinical epidemiology of childhood diabetes. Diabetes Care 2003; 26: 2954-2956.
    • (2003) Diabetes Care , vol.26 , pp. 2954-2956
    • Rosenbloom, A.L.1
  • 14
    • 13444256314 scopus 로고    scopus 로고
    • Is the 'accelerator hypothesis' worthy of our attention?
    • Daneman D. Is the 'accelerator hypothesis' worthy of our attention? Diabet Med 2005; 22: 115-117.
    • (2005) Diabet Med , vol.22 , pp. 115-117
    • Daneman, D.1
  • 15
    • 34447120854 scopus 로고    scopus 로고
    • To boldly goFor to go too boldly? The accelerator hypothesis revisited
    • Gale EA. To boldly goFor to go too boldly? The accelerator hypothesis revisited. Diabetologia 2007; 50: 1571-1575.
    • (2007) Diabetologia , vol.50 , pp. 1571-1575
    • Gale, E.A.1
  • 16
    • 1642443489 scopus 로고    scopus 로고
    • Type 1 diabetes: Recent developments
    • Devendra D, Liu E, Eisenbarth GS. Type 1 diabetes: recent developments. BMJ 2004; 27: 750-754.
    • (2004) BMJ , vol.27 , pp. 750-754
    • Devendra, D.1    Liu, E.2    Eisenbarth, G.S.3
  • 17
    • 76549198972 scopus 로고
    • Pathologic anatomy of the pancreas in juvenile diabetes mellitus
    • GeptsW. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 1965; 14: 619-633.
    • (1965) Diabetes , vol.14 , pp. 619-633
    • GeptsW1
  • 18
    • 0016177620 scopus 로고
    • HLA antigens and diabetes mellitus
    • Nerup J, Platz P, Anderssen OO. HLA antigens and diabetes mellitus. Lancet 1974; 2: 864-866.
    • (1974) Lancet , vol.2 , pp. 864-866
    • Nerup, J.1    Platz, P.2    Anderssen, O.O.3
  • 19
    • 0016261369 scopus 로고
    • Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
    • Bottazzo GF, Florin-Christensen A, Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 1974; 2: 1279-1283.
    • (1974) Lancet , vol.2 , pp. 1279-1283
    • Bottazzo, G.F.1    Florin-Christensen, A.2    Doniach, D.3
  • 20
    • 0033429304 scopus 로고    scopus 로고
    • Worldwide increase of type 1 diabetesFanalysis of the data on published incidence trends
    • Onkamo P, Vaananen S, Karvonen M, Tuomilehto J. Worldwide increase of type 1 diabetesFanalysis of the data on published incidence trends. Diabetologia 1999; 42: 1395-1403.
    • (1999) Diabetologia , vol.42 , pp. 1395-1403
    • Onkamo, P.1    Vaananen, S.2    Karvonen, M.3    Tuomilehto, J.4
  • 21
    • 0036897063 scopus 로고    scopus 로고
    • The rise of childhood type 1 diabetes in the 20th century
    • Gale EAM. The rise of childhood type 1 diabetes in the 20th century. Diabetes 2002; 51: 3353-3361.
    • (2002) Diabetes , vol.51 , pp. 3353-3361
    • Gale, E.A.M.1
  • 22
    • 0035522298 scopus 로고    scopus 로고
    • Resistin, obesity and insulin resistanceFthe emerging role of the adipocyte as an endocrine organ
    • Shuldiner AR, Yang R, Gong DW. Resistin, obesity and insulin resistanceFthe emerging role of the adipocyte as an endocrine organ. N Engl J Med 2001; 345: 1345-1346.
    • (2001) N Engl J Med , vol.345 , pp. 1345-1346
    • Shuldiner, A.R.1    Yang, R.2    Gong, D.W.3
  • 23
    • 0025945012 scopus 로고
    • Insulin resistanceFmechanisms, syndromes, and implications
    • Moller DE, Flier JS. Insulin resistanceFmechanisms, syndromes, and implications. N Engl J Med 1991; 325: 938-948.
    • (1991) N Engl J Med , vol.325 , pp. 938-948
    • Moller, D.E.1    Flier, J.S.2
  • 25
    • 55849114349 scopus 로고    scopus 로고
    • Adipocytokines and the metabolic complications of obesity
    • Rastouli N, Kern PA. Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab 2008; 93 (11 Suppl 1): S64-S73.
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.11 SUPPL. 1
    • Rastouli, N.1    Kern, P.A.2
  • 26
    • 0041828484 scopus 로고    scopus 로고
    • Inflammatory mediators and islet beta-cell failure: A link between type 1 and type 2 diabetes
    • Donath MY, Størling J, Maedler K, Mandrup-Poulsen T. Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J Mol Med 2003; 81: 455-470.
    • (2003) J Mol Med , vol.81 , pp. 455-470
    • Donath, M.Y.1    Størling, J.2    Maedler, K.3    Mandrup-Poulsen, T.4
  • 27
    • 21344460247 scopus 로고    scopus 로고
    • An immune origin of type 2 diabetes?
    • Kolb H, Mandrup-Poulsen T. An immune origin of type 2 diabetes? Diabetologia 2005; 48: 1038-1050.
    • (2005) Diabetologia , vol.48 , pp. 1038-1050
    • Kolb, H.1    Mandrup-Poulsen, T.2
  • 28
    • 1442275317 scopus 로고    scopus 로고
    • Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes
    • Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 2004; 27: 813-823.
    • (2004) Diabetes Care , vol.27 , pp. 813-823
    • Pickup, J.C.1
  • 29
    • 0030891555 scopus 로고    scopus 로고
    • Maturity-onset diabetes of the young (MODY), MODY genes and non-insulin-dependent diabetes mellitus
    • Velho C, Froguel P. Maturity-onset diabetes of the young (MODY), MODY genes and non-insulin-dependent diabetes mellitus. Diabetes Metab 1997; 23 (Suppl 2): 34-37.
    • (1997) Diabetes Metab , vol.23 , Issue.SUPPL. 2 , pp. 34-37
    • Velho, C.1    Froguel, P.2
  • 31
    • 61349188907 scopus 로고    scopus 로고
    • Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity
    • Sun Q, Yue P, Jeffrey A, Lumeng CN, Kampfrath T, Mikolaj MB et al. Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation 2009; 119: 538-546.
    • (2009) Circulation , vol.119 , pp. 538-546
    • Sun, Q.1    Yue, P.2    Jeffrey, A.3    Lumeng, C.N.4    Kampfrath, T.5    Mikolaj, M.B.6
  • 32
    • 33750892139 scopus 로고    scopus 로고
    • Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals
    • Saxena R, Gianniny L, Burtt NP, Lyssenko V, Giuducci C, Sjögren M et al. Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes2006; 55: 2890-2895.
    • (2006) Diabetes , vol.55 , pp. 2890-2895
    • Saxena, R.1    Gianniny, L.2    Burtt, N.P.3    Lyssenko, V.4    Giuducci, C.5    Sjögren, M.6
  • 33
    • 20444363538 scopus 로고    scopus 로고
    • Beta-cells in type 2 diabetes: A loss of function and mass
    • Maedler K, Donath MY. Beta-cells in type 2 diabetes: a loss of function and mass. Horm Res 2004; 62 (Suppl 3): 67-73.
    • (2004) Horm Res , vol.62 , Issue.SUPPL. 3 , pp. 67-73
    • Maedler, K.1    Donath, M.Y.2
  • 34
    • 0842284799 scopus 로고    scopus 로고
    • glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
    • Robertson RP, Harmon J, Tran PO, Poitout V. glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 2004; 53 (Suppl 1): S119-S124.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Poitout, V.4
  • 35
    • 0036895456 scopus 로고    scopus 로고
    • The relative contributions of birth weight, catch-up weight and current weight to the development of insulin resistance in contemporary children (EarlyBird 2)
    • Wilkin TJ, Metcalf B, Jeffery A, Howdle S, Kirkby J, Voss LD. The relative contributions of birth weight, catch-up weight and current weight to the development of insulin resistance in contemporary children (EarlyBird 2). Diabetes 2002; 51: 3468-3472.
    • (2002) Diabetes , vol.51 , pp. 3468-3472
    • Wilkin, T.J.1    Metcalf, B.2    Jeffery, A.3    Howdle, S.4    Kirkby, J.5    Voss, L.D.6
  • 36
    • 44649090118 scopus 로고    scopus 로고
    • Trends, associations and predictions of insulin resistance in prepubertal children (EarlyBird 29)
    • Gardner DS, Metcalf BS, Hosking J, Jeffery AN, Voss LD,Wilkin TJ. Trends, associations and predictions of insulin resistance in prepubertal children (EarlyBird 29). Pediatr Diabetes 2008; 9 (3 Part 1): 214-220.
    • (2008) Pediatr Diabetes , vol.9 , Issue.3 PART 1 , pp. 214-220
    • Gardner, D.S.1    Metcalf, B.S.2    Hosking, J.3    Jeffery, A.N.4    Voss, L.D.5    Wilkin, T.J.6
  • 37
    • 0032586655 scopus 로고    scopus 로고
    • Type 1 1/2 diabetes: Myth or reality?
    • Juneja R, Palmer JP. Type 1 1/2 diabetes: myth or reality? Autoimmunity 1999; 29: 65-83.
    • (1999) Autoimmunity , vol.29 , pp. 65-83
    • Juneja, R.1    Palmer, J.P.2
  • 38
    • 0036897063 scopus 로고    scopus 로고
    • The rise of childhood type 1 diabetes in the 20th century
    • Gale EA. The rise of childhood type 1 diabetes in the 20th century. Diabetes 2002; 51: 3353-3361.
    • (2002) Diabetes , vol.51 , pp. 3353-3361
    • Gale, E.A.1
  • 39
    • 0034031561 scopus 로고    scopus 로고
    • Globalization, coca-colonization and the chronic disease epidemic: Can the Doomsday scenario be averted?
    • Zimmet P. Globalization, coca-colonization and the chronic disease epidemic: can the Doomsday scenario be averted? J Intern Med 2000; 247: 301-310.
    • (2000) J Intern Med , vol.247 , pp. 301-310
    • Zimmet, P.1
  • 40
    • 0027510106 scopus 로고
    • Early nutrition and diabetes mellitus (Editorial)
    • Wilkin TJ. Early nutrition and diabetes mellitus (Editorial). BMJ1992; 306: 283-284.
    • (1992) BMJ , vol.306 , pp. 283-284
    • Wilkin, T.J.1
  • 41
    • 0024455574 scopus 로고
    • Autoimmunity: Attack or defence?
    • Wilkin TJ. Autoimmunity: attack or defence? Autoimmunity 1989; 3: 57-73.
    • (1989) Autoimmunity , vol.3 , pp. 57-73
    • Wilkin, T.J.1
  • 42
    • 0003430697 scopus 로고
    • Autoantibodies and the physiological role of immunoglobulins
    • Grabar P. Autoantibodies and the physiological role of immunoglobulins. Immunol Today 1983; 4: 337-340.
    • (1983) Immunol Today , vol.4 , pp. 337-340
    • Grabar, P.1
  • 45
  • 49
    • 19944361859 scopus 로고    scopus 로고
    • No evidence for genetically determined alteration in insulin secretion or sensitivity predisposing to type 1 diabetes: A study of identical twins
    • Hawa MI, Bonfanti R, Valeri C, Delli Castelli M, Beyan H, Leslie RD. No evidence for genetically determined alteration in insulin secretion or sensitivity predisposing to type 1 diabetes: a study of identical twins. Diabetes Care 2005; 28: 1415-1418.
    • (2005) Diabetes Care , vol.28 , pp. 1415-1418
    • Hawa, M.I.1    Bonfanti, R.2    Valeri, C.3    Delli Castelli, M.4    Beyan, H.5    Leslie, R.D.6
  • 50
    • 0037711693 scopus 로고    scopus 로고
    • Coexistence of type 1 and type 2 diabetes mellitus: 'double' diabetes?
    • Libman IM, Becker DJ. Coexistence of type 1 and type 2 diabetes mellitus: 'double' diabetes? Pediatr Diabetes 2003; 4: 110-113.
    • (2003) Pediatr Diabetes , vol.4 , pp. 110-113
    • Libman, I.M.1    Becker, D.J.2
  • 51
    • 0027500697 scopus 로고
    • Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulindependent onset of disease
    • Tuomi T, Groop LC, Zimmet PZ, Rowley MJ, Knowles W, Mackay IR. Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulindependent onset of disease. Diabetes 1993; 42: 359-362.
    • (1993) Diabetes , vol.42 , pp. 359-362
    • Tuomi, T.1    Groop, L.C.2    Zimmet, P.Z.3    Rowley, M.J.4    Knowles, W.5    Mackay, I.R.6
  • 52
    • 33744791161 scopus 로고    scopus 로고
    • B-cell autoantibodies in children with type 2 diabetes mellitus: Subgroup or misclassification?
    • Reinehr T, Schober E, Wiegand S, Thon A, Holl R. B-cell autoantibodies in children with type 2 diabetes mellitus: subgroup or misclassification? Arch Dis Child 2006; 91: 473-477.
    • (2006) Arch Dis Child , vol.91 , pp. 473-477
    • Reinehr, T.1    Schober, E.2    Wiegand, S.3    Thon, A.4    Holl, R.5
  • 53
    • 0033429304 scopus 로고    scopus 로고
    • Worldwide increase of type 1 diabetesFanalysis of the data on published incidence trends
    • Onkamo P, Vaananen S, Karvonen M, Tuomilehto J. Worldwide increase of type 1 diabetesFanalysis of the data on published incidence trends. Diabetologia 1999; 42: 1395-1403.
    • (1999) Diabetologia , vol.42 , pp. 1395-1403
    • Onkamo, P.1    Vaananen, S.2    Karvonen, M.3    Tuomilehto, J.4
  • 54
    • 0016578086 scopus 로고
    • Weight gain in infancy and subsequent development of diabetes mellitus in childhood
    • Baum JD, Ounsted M, Smith MA. Weight gain in infancy and subsequent development of diabetes mellitus in childhood. Lancet 1975; ii: 866.
    • (1975) Lancet , vol.2 , pp. 866
    • Baum, J.D.1    Ounsted, M.2    Smith, M.A.3
  • 55
    • 0027976643 scopus 로고
    • A high weight gain in early life is associated with an increased risk of type 1 (insulindependent) diabetes
    • Johansson C, Samuelsson U, Ludvigsson J. A high weight gain in early life is associated with an increased risk of type 1 (insulindependent) diabetes. Diabetologia 1994; 37: 91-94.
    • (1994) Diabetologia , vol.37 , pp. 91-94
    • Johansson, C.1    Samuelsson, U.2    Ludvigsson, J.3
  • 57
    • 0034686954 scopus 로고    scopus 로고
    • Association between infant growth before onset of juvenile type-1 diabetes and autoantibodies to IA-2. Netherlands Kolibrie study group of childhood diabetes
    • Bruining GJ. Association between infant growth before onset of juvenile type-1 diabetes and autoantibodies to IA-2. Netherlands Kolibrie study group of childhood diabetes. Lancet 2000; 356: 655-656.
    • (2000) Lancet , vol.356 , pp. 655-656
    • Bruining, G.J.1
  • 58
    • 0033660085 scopus 로고    scopus 로고
    • Childhood Diabetes in Finland Study Group. Obesity, increased linear growth, and risk of type 1 diabetes in children
    • Hypponen E, Virtanen SM, Kenward MG, Knip M, Akerblom HK, Childhood Diabetes in Finland Study Group. Obesity, increased linear growth, and risk of type 1 diabetes in children. Diabetes Care 2000; 23: 1755-1760.
    • (2000) Diabetes Care , vol.23 , pp. 1755-1760
    • Hypponen, E.1    Virtanen, S.M.2    Kenward, M.G.3    Knip, M.4    Akerblom, H.K.5
  • 59
    • 18744397916 scopus 로고    scopus 로고
    • Swedish Childhood Diabetes Study Group. The incidence of Type I diabetes has not increased but shifted to a younger age at diagnosis in the 0-34 years group in Sweden 1983-1998
    • Pundziute-Lycka° A, Dahlquist G, Nyström L, Arnquist H, Björke E, Blohme' G et al. Swedish Childhood Diabetes Study Group. The incidence of Type I diabetes has not increased but shifted to a younger age at diagnosis in the 0-34 years group in Sweden 1983-1998. Diabetologia 2002; 45: 783-791.
    • (2002) Diabetologia , vol.45 , pp. 783-791
    • Pundziute-Lycka°, A.1    Dahlquist, G.2    Nyström, L.3    Arnquist, H.4    Björke, E.5    Blohme', G.6
  • 60
    • 0036580691 scopus 로고    scopus 로고
    • Belgian Diabetes Registry. The incidence of type 1 diabetes in the age group 0-39 years has not increased in Antwerp (Belgium) between 1989 and 2000: Evidence for earlier disease manifestation
    • Weets I, De Leeuw IH, Du Caju MV, Rooman R, Keymeulen B, Mathieu C et al. Belgian Diabetes Registry. The incidence of type 1 diabetes in the age group 0-39 years has not increased in Antwerp (Belgium) between 1989 and 2000: evidence for earlier disease manifestation. Diabetes Care 2002; 25: 840-846.
    • (2002) Diabetes Care , vol.25 , pp. 840-846
    • Weets, I.1    De Leeuw, I.H.2    Du Caju, M.V.3    Rooman, R.4    Keymeulen, B.5    Mathieu, C.6
  • 61
    • 0038222568 scopus 로고    scopus 로고
    • Temporal changes in the frequencies of HLA genotypes in patients with type I diabetes- Findication of an increased environmental pressure?
    • Hermann R, Knip M, Veijola R. Temporal changes in the frequencies of HLA genotypes in patients with type I diabetes- Findication of an increased environmental pressure? Diabetologia2003; 46: 420-425.
    • (2003) Diabetologia , vol.46 , pp. 420-425
    • Hermann, R.1    Knip, M.2    Veijola, R.3
  • 62
    • 7644230152 scopus 로고    scopus 로고
    • The rising incidence of type 1 diabetes is associated with a reduced contribution from high-risk HLA haplotypes
    • Gillespie KM, Bain SC, Barnett AH, Bingley PJ, Christie MR, Gill GVet al. The rising incidence of type 1 diabetes is associated with a reduced contribution from high-risk HLA haplotypes. Lancet2004; 364: 1699-1700.
    • (2004) Lancet , vol.364 , pp. 1699-1700
    • Gillespie, K.M.1    Bain, S.C.2    Barnett, A.H.3    Bingley, P.J.4    Christie, M.R.5    Gill, G.V.6
  • 63
    • 0030994711 scopus 로고    scopus 로고
    • The role of insulin resistance in the natural history of type 1 diabetes
    • Leslie RD, Taylor R, Pozzilli P. The role of insulin resistance in the natural history of type 1 diabetes. Diabet Med 1997; 14: 327-331.
    • (1997) Diabet Med , vol.14 , pp. 327-331
    • Leslie, R.D.1    Taylor, R.2    Pozzilli, P.3
  • 64
    • 0035985231 scopus 로고    scopus 로고
    • Insulin resistance and type 1 diabetes
    • Greenbaum CJ. Insulin resistance and type 1 diabetes. Diabetes Metab Res Rev 2002; 18: 192-200.
    • (2002) Diabetes Metab Res Rev , vol.18 , pp. 192-200
    • Greenbaum, C.J.1
  • 65
    • 28444488345 scopus 로고    scopus 로고
    • Spring harvest? Reflections on the rise of type 1 diabetes
    • Gale EA. Spring harvest? Reflections on the rise of type 1 diabetes. Diabetologia 2005; 48: 2445-2450.
    • (2005) Diabetologia , vol.48 , pp. 2445-2450
    • Gale, E.A.1
  • 66
    • 19944431272 scopus 로고    scopus 로고
    • DPT-1 study group. High frequency of abnormal glucose tolerance in DQA1*0102/DQB1*0602 relatives identified as part of the Diabetes Prevention Trial
    • Greenbaum CJ, Eisenbarth G, Atkinson M, Yu L, Babu S, Schatz D et al. DPT-1 study group. High frequency of abnormal glucose tolerance in DQA1*0102/DQB1*0602 relatives identified as part of the Diabetes Prevention Trial. Diabetologia 2005; 48: 68-74.
    • (2005) Diabetologia , vol.48 , pp. 68-74
    • Greenbaum, C.J.1    Eisenbarth, G.2    Atkinson, M.3    Yu, L.4    Babu, S.5    Schatz, D.6
  • 67
    • 0017596666 scopus 로고
    • Clinical and pathogenic significance of pancreatic-islet-cell antibodies in diabetics treated with oral hypoglycaemic agents
    • Irvine WJ, McCallum CJ, Gray RS, Duncan LJ. Clinical and pathogenic significance of pancreatic-islet-cell antibodies in diabetics treated with oral hypoglycaemic agents. Lancet 1977; 1: 1025-1027.
    • (1977) Lancet , vol.1 , pp. 1025-1027
    • Irvine, W.J.1    McCallum, C.J.2    Gray, R.S.3    Duncan, L.J.4
  • 68
    • 0035377557 scopus 로고    scopus 로고
    • Diabetic autoimmune markers in children and adolescents with type 2 diabetes
    • Hathout EH, Thomas W, El-Shahawy M, Nahab F, Mace JW. Diabetic autoimmune markers in children and adolescents with type 2 diabetes. Pediatrics 2001; 107: E102.
    • (2001) Pediatrics , vol.107
    • Hathout, E.H.1    Thomas, W.2    El-Shahawy, M.3    Nahab, F.4    Mace, J.W.5
  • 69
    • 0036012949 scopus 로고    scopus 로고
    • Autoantibodies in children with type 2 diabetes mellitus
    • Umpaichitra V, Banerji MA, Castells S. Autoantibodies in children with type 2 diabetes mellitus. J Pediatr Endocrinol Metab 2002; 15(Suppl 1): 525-530.
    • (2002) J Pediatr Endocrinol Metab , vol.15 , Issue.SUPPL. 1 , pp. 525-530
    • Umpaichitra, V.1    Banerji, M.A.2    Castells, S.3
  • 72
    • 0033016840 scopus 로고    scopus 로고
    • Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: The 2-year analysis of the German BABYDIAB Study
    • Ziegler AG, Hummel M, Schenker M, Bonifacio E. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes 1999; 48: 460-468.
    • (1999) Diabetes , vol.48 , pp. 460-468
    • Ziegler, A.G.1    Hummel, M.2    Schenker, M.3    Bonifacio, E.4
  • 73
    • 1542314922 scopus 로고    scopus 로고
    • Braking the accelerator hypothesis?
    • Porter JR, Barrett TJ. Braking the accelerator hypothesis? Diabetologia 2004; 47: 352-353.
    • (2004) Diabetologia , vol.47 , pp. 352-353
    • Porter, J.R.1    Barrett, T.J.2
  • 75
    • 38149011472 scopus 로고    scopus 로고
    • The European Nicotinamide Diabetes Intervention Trial (ENDIT) Group. Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT)
    • Bingley PJ, Mahon JL, Gale EA, The European Nicotinamide Diabetes Intervention Trial (ENDIT) Group. Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT). Diabetes Care 2008; 31: 146-150.
    • (2008) Diabetes Care , vol.31 , pp. 146-150
    • Bingley, P.J.1    Mahon, J.L.2    Gale, E.A.3
  • 76
    • 33746387907 scopus 로고    scopus 로고
    • Wilkin TJ. Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes: response to Dabelea et al. Diabetes Care 2006; 29: 1462-1463.
    • Wilkin TJ. Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes: response to Dabelea et al. Diabetes Care 2006; 29: 1462-1463.
  • 77
    • 48649091528 scopus 로고    scopus 로고
    • Wilkin TJ. Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT): response to Bingley et al. Diabetologia 2008; 31: e290.
    • Wilkin TJ. Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT): response to Bingley et al. Diabetologia 2008; 31: e290.
  • 79
    • 33845931200 scopus 로고    scopus 로고
    • Analysis of the type 2 diabetes gene TCF7L2 in 13 795 type 1 diabetes cases and control subjects
    • Field SF, Howson JMM, Smyth DJ, Walker NM, Dunger DB, Todd JA. Analysis of the type 2 diabetes gene TCF7L2 in 13 795 type 1 diabetes cases and control subjects. Diabetologia 2007; 50: 212-213.
    • (2007) Diabetologia , vol.50 , pp. 212-213
    • Field, S.F.1    Howson, J.M.M.2    Smyth, D.J.3    Walker, N.M.4    Dunger, D.B.5    Todd, J.A.6
  • 80
    • 34447131684 scopus 로고    scopus 로고
    • The accelerator hypothesis cannot be tested using the type 2 diabetes gene, TCF7L2
    • Wilkint TJ. The accelerator hypothesis cannot be tested using the type 2 diabetes gene, TCF7L2. Diabetologia 2007; 50: 1780.
    • (2007) Diabetologia , vol.50 , pp. 1780
    • Wilkint, T.J.1
  • 81
    • 34447116059 scopus 로고    scopus 로고
    • Analysis of the obesity gene FTO in 14 803 type 1 diabetes cases and controls
    • Field SF, Howson JM, Walker NM, Dunger DB, Todd JA. Analysis of the obesity gene FTO in 14 803 type 1 diabetes cases and controls. Diabetologia 2007; 50: 2218-2220.
    • (2007) Diabetologia , vol.50 , pp. 2218-2220
    • Field, S.F.1    Howson, J.M.2    Walker, N.M.3    Dunger, D.B.4    Todd, J.A.5
  • 82
    • 34447646553 scopus 로고    scopus 로고
    • Major increase in type 1 diabetesFno support for the accelerator hypothesis
    • O'connell MA, Donath S, Cameron FJ. Major increase in type 1 diabetesFno support for the accelerator hypothesis. Diabet Med2007; 24: 920-923.
    • (2007) Diabet Med , vol.24 , pp. 920-923
    • O'connell, M.A.1    Donath, S.2    Cameron, F.J.3
  • 83
    • 40049102024 scopus 로고    scopus 로고
    • Wilkin T. Major increase in type 1 diabetes: no support for the accelerator hypothesis (response to O'Connell et al). Diabet Med2008; 25: 376-377.
    • Wilkin T. Major increase in type 1 diabetes: no support for the accelerator hypothesis (response to O'Connell et al). Diabet Med2008; 25: 376-377.
  • 84
    • 0031784244 scopus 로고    scopus 로고
    • The aetiology of type 1 diabetes: An epidemiological perspective
    • Dahlquist G. The aetiology of type 1 diabetes: an epidemiological perspective. Acta Paediatr 1998; 425 (Suppl): 5-10.
    • (1998) Acta Paediatr , vol.425 , Issue.SUPPL. , pp. 5-10
    • Dahlquist, G.1
  • 85
    • 0032727659 scopus 로고    scopus 로고
    • Day C. Thiazolidinediones. Diabetic Med 1999; 16: 179.92.
    • Day C. Thiazolidinediones. Diabetic Med 1999; 16: 179.92.
  • 86
    • 0037034257 scopus 로고    scopus 로고
    • Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA et al. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393-403.
    • (2002) N Engl J Med , vol.346 , pp. 393-403
    • Knowler, W.C.1    Barrett-Connor, E.2    Fowler, S.E.3    Hamman, R.F.4    Lachin, J.M.5    Walker, E.A.6
  • 87
    • 0035799806 scopus 로고    scopus 로고
    • Finnish Diabetes Prevention Study Group. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    • Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P et al. Finnish Diabetes Prevention Study Group. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med2001; 344: 1343-1350.
    • (2001) N Engl J Med , vol.344 , pp. 1343-1350
    • Tuomilehto, J.1    Lindström, J.2    Eriksson, J.G.3    Valle, T.T.4    Hämäläinen, H.5    Ilanne-Parikka, P.6
  • 88
    • 22544478744 scopus 로고    scopus 로고
    • Immune intervention with anti-CD3 in diabetes
    • Harlan DM, von Herrath M. Immune intervention with anti-CD3 in diabetes. Nat Med 2005; 11: 716-718.
    • (2005) Nat Med , vol.11 , pp. 716-718
    • Harlan, D.M.1    von Herrath, M.2
  • 89
    • 20044375937 scopus 로고    scopus 로고
    • Single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
    • Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D et al. Single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 2005; 54: 1763-1769.
    • (2005) Diabetes , vol.54 , pp. 1763-1769
    • Herold, K.C.1    Gitelman, S.E.2    Masharani, U.3    Hagopian, W.4    Bisikirska, B.5    Donaldson, D.6


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