메뉴 건너뛰기




Volumn 178, Issue 6, 2011, Pages 2632-2640

β-Cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PROTEIN; INSULIN; THIOFLAVINE;

EID: 79954543511     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.02.036     Document Type: Article
Times cited : (270)

References (33)
  • 1
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    • Kahn SE: The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 2003, 46:3-19 (Pubitemid 36237741)
    • (2003) Diabetologia , vol.46 , Issue.1 , pp. 3-19
    • Kahn, S.E.1
  • 3
    • 0036306096 scopus 로고    scopus 로고
    • β-Cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S.
    • Jensen CC, Cnop M, Hull RL, Fujimoto WY, Kahn SE; American Diabetes Association GENNID Study Group: Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S. Diabetes 2002, 51:2170-2178 (Pubitemid 34729022)
    • (2002) Diabetes , vol.51 , Issue.7 , pp. 2170-2178
    • Jensen, C.C.1    Cnop, M.2    Hull, R.L.3    Fujimoto, W.Y.4    Kahn, S.E.5
  • 4
    • 0021777067 scopus 로고
    • Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited
    • Klöppel G, Löhr M, Habich K, Oberholzer M, Heitz PU: Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Pathol Res 1985, 4:110-125
    • (1985) Surv Synth Pathol Res , vol.4 , pp. 110-125
    • Klöppel, G.1    Löhr, M.2    Habich, K.3    Oberholzer, M.4    Heitz, P.U.5
  • 5
    • 0037219411 scopus 로고    scopus 로고
    • β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
    • DOI 10.2337/diabetes.52.1.102
    • Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC: Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003, 52:102-110 (Pubitemid 36042113)
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 7
    • 0015277207 scopus 로고
    • Quantitative studies on amyloid in the islets of Langerhans
    • Westermark P: Quantitative studies on amyloid in the islets of Langerhans. Ups J Med Sci 1972, 77:91-94
    • (1972) Ups J Med Sci , vol.77 , pp. 91-94
    • Westermark, P.1
  • 9
    • 0036163156 scopus 로고    scopus 로고
    • Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients
    • DOI 10.1007/s125-002-8248-z
    • Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S: Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia 2002, 45:85-96 (Pubitemid 34118546)
    • (2002) Diabetologia , vol.45 , Issue.1 , pp. 85-96
    • Sakuraba, H.1    Mizukami, H.2    Yagihashi, N.3    Wada, R.4    Hanyu, C.5    Yagihashi, S.6
  • 10
    • 0242332129 scopus 로고    scopus 로고
    • Prevalence and Clinicopathological Characteristics of Islet Amyloid in Chinese Patients with Type 2 Diabetes
    • DOI 10.2337/diabetes.52.11.2759
    • Zhao HL, Lai FM, Tong PC, Zhong DR, Yang D, Tomlinson B, Chan JC: Prevalence and clinicopathological characteristics of islet amyloid in Chinese patients with type 2 diabetes. Diabetes 2003, 52: 2759-2766 (Pubitemid 37339705)
    • (2003) Diabetes , vol.52 , Issue.11 , pp. 2759-2766
    • Zhao, H.-L.1    Lai, F.M.M.2    Tong, P.C.Y.3    Zhong, D.-R.4    Yang, D.5    Tomlinson, B.6    Chan, J.C.N.7
  • 11
    • 0000611472 scopus 로고
    • Hyalinization of the islets of Langerhans in nondiabetic individuals
    • Bell ET: Hyalinization of the islets of Langerhans in nondiabetic individuals. Am J Pathol 1959, 35:801-805
    • (1959) Am J Pathol , vol.35 , pp. 801-805
    • Bell, E.T.1
  • 12
    • 0023192941 scopus 로고
    • Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells
    • DOI 10.1073/pnas.84.11.3881
    • Westermark P, Wernstedt C, Wilander E, Hayden DW, O'Brien TD, Johnson KH: Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Proc Natl Acad Sci USA 1987, 84:3881-3885 (Pubitemid 17088383)
    • (1987) Proceedings of the National Academy of Sciences of the United States of America , vol.84 , Issue.11 , pp. 3881-3885
    • Westermark, P.1    Wernstedt, C.2    Wilander, E.3
  • 15
    • 0028303844 scopus 로고
    • Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus
    • DOI 10.1038/368756a0
    • Lorenzo A, Razzaboni B, Weir GC, Yankner BA: Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 1994, 368:756-760 (Pubitemid 24153418)
    • (1994) Nature , vol.368 , Issue.6473 , pp. 756-760
    • Lorenzo, A.1    Razzaboni, B.2    Weir, G.C.3    Yankner, B.A.4
  • 16
    • 0033048453 scopus 로고    scopus 로고
    • The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles
    • Janson J, Ashley RH, Harrison D, McIntyre S, Butler PC: The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles. Diabetes 1999, 48:491-498 (Pubitemid 29106861)
    • (1999) Diabetes , vol.48 , Issue.3 , pp. 491-498
    • Janson, J.1    Ashley, R.H.2    Harrison, D.3    McIntyre, S.4    Butler, P.C.5
  • 17
    • 0022496637 scopus 로고
    • Longitudinal studies on the development of diabetes in individual Macaca nigra
    • Howard CF Jr: Longitudinal studies on the development of diabetes in individual Macaca nigra. Diabetologia 1986, 29:301-306 (Pubitemid 16080927)
    • (1986) Diabetologia , vol.29 , Issue.5 , pp. 301-306
    • Howard Jr., C.F.1
  • 18
    • 0027151935 scopus 로고
    • Diabetes mellitus in Macaca mulatta monkeys is characterised by islet amyloidosis and reduction in beta-cell population
    • de Koning EJ, Bodkin NL, Hansen BC, Clark A: Diabetes mellitus in Macaca mulatta monkeys is characterised by islet amyloidosis and reduction in beta-cell population. Diabetologia 1993, 36:378-384 (Pubitemid 23124039)
    • (1993) Diabetologia , vol.36 , Issue.5 , pp. 378-384
    • De Koning, E.J.P.1    Bodkin, N.L.2    Hansen, B.C.3    Clark, A.4
  • 20
    • 0032243186 scopus 로고    scopus 로고
    • Quantitative immunohistochemical analysis of islet amyloid polypeptide (IAPP) in normal, impaired glucose tolerant, and diabetic cats
    • Ma Z, Westermark GT, Johnson KH, O'Brien TD, Westermark P: Quantitative immunohistochemical analysis of islet amyloid polypeptide (IAPP) in normal, impaired glucose tolerant, and diabetic cats. Amyloid 1998, 5:255-261 (Pubitemid 128690764)
    • (1998) Amyloid , vol.5 , Issue.4 , pp. 255-261
    • Ma, Z.1    Westermark, G.T.2    Johnson, K.H.3    O'Brien, T.D.4    Westermark, P.5
  • 21
    • 0035514444 scopus 로고    scopus 로고
    • Islet Amyloid Develops Diffusely Throughout the Pancreas before Becoming Severe and Replacing Endocrine Cells
    • Wang F, Hull RL, Vidal J, Cnop M, Kahn SE: Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells. Diabetes 2001, 50:2514-2520 (Pubitemid 33642769)
    • (2001) Diabetes , vol.50 , Issue.7-12 , pp. 2514-2520
    • Wang, F.1    Hull, R.L.2    Vidal, J.3    Cnop, M.4    Kahn, S.E.5
  • 22
    • 0037315790 scopus 로고    scopus 로고
    • Increased dietary fat promotes islet amyloid formation and β-cell secretory dysfunction in a transgenic mouse model of islet amyloid
    • DOI 10.2337/diabetes.52.2.372
    • Hull RL, Andrikopoulos S, Verchere CB, Vidal J, Wang F, Cnop M, Prigeon RL, Kahn SE: Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid. Diabetes 2003, 52:372-379 (Pubitemid 36173192)
    • (2003) Diabetes , vol.52 , Issue.2 , pp. 372-379
    • Hull, R.L.1    Andrikopoulos, S.2    Verchere, C.B.3    Vidal, J.4    Wang, F.5    Cnop, M.6    Prigeon, R.L.7    Kahn, S.E.8
  • 24
    • 0015884138 scopus 로고
    • The pancreatic islet cells in insular amyloidosis in human diabetic and non-diabetic adults
    • Westermark P, Grimelius L: The pancreatic islet cells in insular amyloidosis in human diabetic and non-diabetic adults. Acta Pathol Microbiol Scand A 1973, 81:291-300
    • (1973) Acta Pathol Microbiol Scand A , vol.81 , pp. 291-300
    • Westermark, P.1    Grimelius, L.2
  • 26
    • 23944525524 scopus 로고    scopus 로고
    • Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: Evidence for specificity of impaired beta cell adaptation
    • DOI 10.1007/s00125-005-1772-9
    • Hull RL, Kodama K, Utzschneider KM, Carr DB, Prigeon RL, Kahn SE: Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation. Diabetologia 2005, 48:1350-1358 (Pubitemid 41186101)
    • (2005) Diabetologia , vol.48 , Issue.7 , pp. 1350-1358
    • Hull, R.L.1    Kodama, K.2    Utzschneider, K.M.3    Carr, D.B.4    Prigeon, R.L.5    Kahn, S.E.6
  • 27
    • 0042822112 scopus 로고    scopus 로고
    • Increased β-cell apoptosis prevents adaptive increase in β-cell mass in mouse model of type 2 diabetes: Evidence for role of islet amyloid formation rather than direct action of amyloid
    • DOI 10.2337/diabetes.52.9.2304
    • Butler AE, Janson J, Soeller WC, Butler PC: Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes 2003, 52:2304-2314 (Pubitemid 37059501)
    • (2003) Diabetes , vol.52 , Issue.9 , pp. 2304-2314
    • Butler, A.E.1    Janson, J.2    Soeller, W.C.3    Butler, P.C.4
  • 28
    • 58149343826 scopus 로고    scopus 로고
    • Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture
    • Marzban L, Tomas A, Becker TC, Rosenberg L, Oberholzer J, Fraser PE, Halban PA, Verchere CB: Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture. Diabetes 2008, 57:3045-3055
    • (2008) Diabetes , vol.57 , pp. 3045-3055
    • Marzban, L.1    Tomas, A.2    Becker, T.C.3    Rosenberg, L.4    Oberholzer, J.5    Fraser, P.E.6    Halban, P.A.7    Verchere, C.B.8
  • 32
    • 76149102617 scopus 로고    scopus 로고
    • Evidence for proteotoxicity in beta cells in type 2 diabetes: Toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway
    • Gurlo T, Ryazantsev S, Huang CJ, Yeh MW, Reber HA, Hines OJ, O'Brien TD, Glabe CG, Butler PC: Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway. Am J Pathol 2010, 176: 861-869
    • (2010) Am J Pathol , vol.176 , pp. 861-869
    • Gurlo, T.1    Ryazantsev, S.2    Huang, C.J.3    Yeh, M.W.4    Reber, H.A.5    Hines, O.J.6    O'brien, T.D.7    Glabe, C.G.8    Butler, P.C.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.