The role of adipokines in β-cell failure of type 2 diabetes

Journal of Endocrinology

Volumn 216, Issue 1, 2013, Pages

  Dunmore, Simon J ^a   Brown, James E P ^b  

^a UNIVERSITY OF WOLVERHAMPTON   (United Kingdom)

^b ASTON UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; ADIPOCYTOKINE; ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; APELIN; CLOFIBRATE; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE 2; LEPTIN; LEPTIN RECEPTOR; LIPOPROTEIN LIPASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; RESISTIN; TRANSCRIPTION FACTOR PDX 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCOUPLING PROTEIN 2; UNINDEXED DRUG; APLN PROTEIN, HUMAN; CYTOKINE; DIPEPTIDYL PEPTIDASE IV; DPP4 PROTEIN, HUMAN; SIGNAL PEPTIDE;

AMINO TERMINAL SEQUENCE; APOPTOSIS; BETA CELL FAILURE; BINDING AFFINITY; CELL DEATH; CELL FUNCTION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INTRACELLULAR SIGNALING; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PANCREAS ISLET DISEASE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REVIEW; ADIPOSE TISSUE; ANIMAL; BLOOD; IMMUNOLOGY; METABOLISM; PANCREAS; PATHOPHYSIOLOGY; SECRETION (PROCESS);

ADIPOKINES; ADIPOSE TISSUE; ANIMALS; CYTOKINES; DIABETES MELLITUS, TYPE 2; DIPEPTIDYL PEPTIDASE 4; HUMANS; INSULIN-SECRETING CELLS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; OBESITY; PANCREAS;

MLCS; MLOWN;

EID: 84874406712     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-12-0278     Document Type: Review

References (74)

1. Ahren B & Larsson H 1997 Leptin - a regulator of islet function?: its plasma levels correlate with glucagon and insulin secretion in healthy women Metabolism: Clinical and Experimental 46 1477-1481. (doi:10.1016/ S0026-0495(97)90152-9)
2. Al-Salam S, Rashed H & Adeghate E 2011 Diabetes mellitus is associated with an increased expression of resistin in human pancreatic islet cells. Islets 3 246-249. (doi:10.4161/isl.3.5.16427)
3. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K et al. 1999 Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communications 257 79-83. (doi:10.1006/bbrc.1999.0255)
4. Brown JEP & Dunmore SJ 2007 Leptin decreases apoptosis and alters BCL-2:Bax ratio in clonal rodent pancreatic b-cells. Diabetes/Metabolism Research and Reviews 23 497-502. (doi:10.1002/dmrr.726)
5. Brown JE, Thomas S, Digby JE & Dunmore SJ 2002 Glucose induces and leptin decreases expression of uncoupling protein-2 mRNA in human islets. FEBS Letters 513 189-192. (doi:10.1016/S0014-5793 (02)02296-2)
6. Brown JE, Onyango DJ & Dunmore SJ 2007 Resistin down-regulates insulin receptor expression, and modulates cell viability in rodent pancreatic b-cells. FEBS Letters 581 3273-3276. (doi:10.1016/j.febslet.2007.06. 031)
7. Brown JE, Conner AC, Digby JE, Ward KL, Ramanjaneya M, Randeva HS & Dunmore SJ 2010a Regulation of b-cell viability and gene expression by distinct agonist fragments of adiponectin. Peptides 31 944-949. (doi:10.1016/j.peptides.2010.02.004)
8. Brown JE, Onyango DJ, RamanjaneyaM, Conner AC, Patel ST, Dunmore SJ & Randeva HS 2010b Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic b-cells. Journal of Molecular Endocrinology 44 171-178. (doi:10.1677/JME-09-0071)
9. Buteau J 2008 GLP-1 receptor signaling: effects on pancreatic b-cell proliferation and survival. Diabetes & Metabolism 34 S73-S77. (doi:10.1016/S1262-3636(08)73398-6)
10. Cai K, Qi D, Hou X, Wang O, Chen J, Deng B, Qian L, Liu X & Le Y 2011a MCP-1 upregulates amylin expression in murine pancreatic b cells through ERK/JNK-AP1 and NF-kB related signaling pathways independent of CCR2. PLoS ONE 6 e19559. (doi:10.1371/journal.pone. 0019559)
11. Cai K, Qi D, Wang O, Chen J, Liu X, Deng B, Qian L, Liu X & Le Y 2011b TNF-a acutely upregulates amylin expression in murine pancreatic b cells. Diabetologia 54 617-626. (doi:10.1007/s00125-010-1972-9)
12. Chai F, Wang Y, Zhou Y, Liu Y, Geng D & Liu J 2011 Adiponectin downregulates hyperglycemia and reduces pancreatic islet apoptosis after roux-en-y gastric bypass surgery. Obesity Surgery 21 768-773. (doi:10.1007/s11695-011-0357-6)
13. Chang-Chen KJ, Mullur R & Bernal-Mizrachi E 2008 b-Cell failure as a complication of diabetes. Reviews in Endocrine & Metabolic Disorders 9 329-343. (doi:10.1007/s11154-008-9101-5)
14. Cheng Q, DongW, Qian L, Wu J & Peng Y 2011 Visfatin inhibits apoptosis of pancreatic b-cell line, MIN6, via the mitogen-activated protein kinase/phosphoinositide 3-kinase pathway. Journal of Molecular Endocrinology 47 13-21. (doi:10.1530/JME-10-0106)
15. Chetboun M, Abitbol G, Rozenberg K, Rozenfeld H, Deutsch A, Sampson SR & Rosenzweig T 2012 Maintenance of redox state and pancreatic b-cell function: role of leptin and adiponectin. Journal of Cellular Biochemistry 113 1966-1976. (doi:10.1002/jcb.24065)
16. Corbett JA, Wang JL, Sweetland MA, Lancaster JR Jr & McDaniel ML 1992 Interleukin 1b induces the formation of nitric oxide by b-cells purified from rodent islets of Langerhans. Evidence for the b-cell as a source and site of action of nitric oxide. Journal of Clinical Investigation 90 2384-2391. (doi:10.1172/JCI116129)
17. Deng Y & Scherer PE 2010 Adipokines as novel biomarkers and regulators of the metabolic syndrome. Annals of the New York Academy of Sciences 1212 E1-E19. (doi:10.1111/j.1749-6632.2010.05875.x)
18. Dickson LM, Lingohr MK, McCuaig J, Hugl SR, Snow L, Kahn BB, MyersMG Jr & Rhodes CJ 2001 Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic b-cells (INS-1). Journal of Biological Chemistry 276 21110-21120. (doi:10.1074/ jbc.M101257200)
19. Drucker DJ 1998 Glucagon-like peptides. Diabetes 47 159-169. (doi:10.2337/diabetes.47.2.159)
20. Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, Matsuki Y, Murakami M, Ichisaka T, Murakami H et al. 2005 Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 307 426-430. (doi:10.1126/science.1097243)
21. Gu W, Li X, Liu C, Yang J, Ye L, Tang J, Gu Y, Yang Y, Hong J, Zhang Y et al. 2006 Globular adiponectin augments insulin secretion from pancreatic islet b cells at high glucose concentrations. Endocrine 30 217-221. (doi:10.1385/ENDO:30:2:217)
22. Guo L, Li Q, Wang W, Yu P, Pan H, Li P, Sun Y & Zhang J 2009 Apelin inhibits insulin secretion in pancreatic b-cells by activation of PI3-kinase-phosphodiesterase 3B. Endocrine Research 34 142-154. (doi:10.3109/07435800903287079)
23. Holland WL, Miller RA, Wang ZV, Sun K, Barth BM, Bui HH, Davis KE, Bikman BT, Halberg N, Rutkowski JM et al. 2011 Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nature Medicine 17 55-63. (doi:10.1038/nm.2277)
24. Hotamisligil GS 1999 Mechanisms of TNF-a-induced insulin resistance. Experimental and Clinical Endocrinology & Diabetes 107 119-125. (doi:10.1055/s-0029-1212086)
25. Jacqueminet S, Briaud I, Rouault C, Reach G & Poitout V 2000 Inhibition of insulin gene expression by long-term exposure of pancreatic b cells to palmitate is dependent on the presence of a stimulatory glucose concentration. Metabolism 49 532-536. (doi:10.1016/S0026-0495(00) 80021-9)
26. Jonas JC, Bensellam M, Duprez J, Elouil H, Guiot Y & Pascal SM 2009 Glucose regulation of islet stress responses and b-cell failure in type 2 diabetes. Diabetes, Obesity & Metabolism 11(Suppl 4) 65-81. (doi:10.1111/j.1463-1326.2009.01112.x)
27. Jung TW, Lee MW, Lee YJ, Kim SM, Lee KT, Whang WK, Cheon HJ, Jeong YT, Chung KW, Cho JM et al. 2009 Regulation of adiponectin receptor 2 expression via PPAR-a in NIT-1 cells. Endocrine Journal 56 377-382. (doi:10.1507/endocrj.K08E-354)
28. Kadowaki T & Yamauchi T 2005 Adiponectin and adiponectin receptors. Endocrine Reviews 26 439-451. (doi:10.1210/er.2005-0005)
29. Kazafeos K 2011 Incretin effect: GLP-1, GIP, DPP4. Diabetes Research and Clinical Practice 93(Suppl 1) S32-S36.
30. Kharroubi I, Rasschaert J, Eizirik DL & Cnop M 2003 Expression of adiponectin receptors in pancreatic b cells. Biochemical and Biophysical Research Communications 312 1118-1122. (doi:10.1016/ j.bbrc.2003.11.042)
31. Kharroubi I, Ladrie're L, Cardozo AK, Dogusan Z, Cnop M& Eizirik DL 2004 Free fatty acids and cytokines induce pancreatic b-cell apoptosis by different mechanisms: role of nuclear factor-kB and endoplasmic reticulum stress. Endocrinology 145 5087-5096. (doi:10.1210/ en.2004-0478)
32. Kieffer TJ, Heller RS & Habener JF 1996 Leptin receptors expressed on pancreatic b-cells. Biochemical and Biophysical Research Communications 224 522-527. (doi:10.1006/bbrc.1996.1059)
33. Kilkenny DM & Rocheleau JV 2008 Fibroblast growth factor receptor-1 signaling in pancreatic islet b-cells is modulated by the extracellular matrix. Molecular Endocrinology 22 196-205. (doi:10.1210/me. 2007-0241)
34. Kim HE, Choi SE, Lee SJ, Lee JH, Lee YJ, Kang SS, Chun J & Kang Y 2008 Tumour necrosis factor-a-induced glucose-stimulated insulin secretion inhibition in INS-1 cells is ascribed to a reduction of the glucosestimulated Ca2C influx. Journal of Endocrinology 198 549-560. (doi:10.1677/JOE-08-0131)
35. Kulkarni RN, Wang ZL, Wang RM, Hurley JD, Smith DM, Ghatei MA, Withers DJ, Gardiner JV, Bailey CJ & Bloom SR 1997 Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. Journal of Clinical Investigation 100 2729-2736. (doi:10.1172/JCI119818)
36. Lamers D, Famulla S, Wronkowitz N, Hartwig S, Lehr S, Ouwens DM, Eckardt K, Kaufman JM, Ryden M, Müller S et al. 2011 Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome. Diabetes 60 1917-1925. (doi:10.2337/db10-1707)
37. Laubner K, Kieffer TJ, Lam NT, Niu X, Jakob F & Seufert J 2005 Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic b-cells. Diabetes 54 3410-3417. (doi:10.2337/diabetes.54.12.3410)
38. Leahy JL, Hirsch IB, Peterson KA & Schneider D 2010 Targeting b-cell function early in the course of therapy for type 2 diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 95 4206-4216. (doi:10.1210/jc.2010-0668)
39. Leclercq-Meyer V & Malaisse WJ 1998 Failure of human and mouse leptin to affect insulin, glucagon and somatostatin secretion by the perfused rat pancreas at physiological glucose concentration. Molecular and Cellular Endocrinology 141 111-118. (doi:10.1016/S0303-7207(98)00087-2)
40. Lin P, Chen L, Li D, Liu J, Yang N, Sun Y, Xu Y, Fu Y & Hou X 2009a Adiponectin reduces glucotoxicity-induced apoptosis of INS-1 rat insulin-secreting cells on a microfluidic chip. Tohoku Journal of Experimental Medicine 217 59-65. (doi:10.1620/tjem.217.59)
41. Lin HM, Lee JH, Yadav H, Kamaraju AK, Liu E, Zhigang D, Vieira A, Kim SJ, Collins H, Matschinsky F et al. 2009b Transforming growth factorb/ Smad3 signaling regulates insulin gene transcription and pancreatic islet b-cell function. Journal of Biological Chemistry 284 12246-12257. (doi:10.1074/jbc.M805379200)
42. Mandrup-Poulsen T, Bendtzen K, Nerup J, Dinarello CA, Svenson M & Nielsen JH 1986 Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans. Diabetologia 29 63-67. (doi:10.1007/ BF02427283)
43. Minn AH, Patterson NB, Pack S, Hoffmann SC, Gavrilova O, Vinson C, Harlan DM & Shalev A 2003 Resistin is expressed in pancreatic islets. Biochemical and Biophysical Research Communications 310 641-645. (doi:10.1016/j.bbrc.2003.09.061)
44. Nagaev I & Smith U 2001 Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. Biochemical and Biophysical Research Communications 285 561-564. (doi:10.1006/bbrc.2001.5173)
45. Nakata M, Okada T, Ozawa K & Yada T 2007 Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release. Biochemical and Biophysical Research Communications 353 1046-1051. (doi:10.1016/j.bbrc.2006.12.134)
46. Newsholme P, Keane D, Welters HJ & Morgan NG 2007 Life and death decisions of the pancreatic b-cell: the role of fatty acids. Clinical Science 112 27-42. (doi:10.1042/CS20060115)
47. Ning K, Miller LC, Laidlaw HA, Burgess LA, Perera NM, Downes CP, Leslie NR & Ashford ML 2006 A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic b-cells. EMBO Journal 25 2377-2387. (doi:10.1038/sj.emboj.7601118)
48. Ortis F, Pirot P, Naamane N, Kreins AY, Rasschaert J, Moore F, Théâ tre E, Verhaeghe C, Magnusson NE, Chariot A et al. 2008 Induction of nuclear factor-kB and its downstream genes by TNF-a and IL-1b has a pro-apoptotic role in pancreatic b cells. Diabetologia 51 1213-1225. (doi:10.1007/s00125-008-0999-7)
49. Ortis F, Miani M, Colli ML, Cunha DA, Gurzov EN, Allagnat F, Chariot A & Eizirik DL 2012 Differential usage of NF-kB activating signals by IL-1b and TNF-a in pancreatic b cells. FEBS Letters 586 984-989. (doi:10.1016/ j.febslet.2012.02.021)
50. Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y, Hotta K, Nishida M, Takahashi M, Nakamura T et al. 1999 Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100 2473-2476. (doi:10.1161/01.CIR. 100.25.2473)
51. Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M & Scherer PE 2003 Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. Journal of Biological Chemistry 278 9073-9085. (doi:10.1074/jbc.M207198200)
52. Pallett AL, Morton NM, Cawthorne MA & Emilsson V 1997 Leptin inhibits insulin secretion and reduces insulin mRNA levels in rat isolated pancreatic islets. Biochemical and Biophysical Research Communications 238 267-270. (doi:10.1006/bbrc.1997.7274)
53. Revollo JR, Körner A, Mills KF, Satoh A, Wang T, Garten A, Dasgupta B, Sasaki Y, Wolberger C, Townsend RR et al. 2007 Nampt/PBEF/visfatin regulates insulin secretion in b cells as a systemic NAD biosynthetic enzyme. Cell Metabolism 6 363-375. (doi:10.1016/j.cmet.2007.09.003)
54. Ringström C, Nitert MD, Bennet H, Fex M, Valet P, Rehfeld JF, Friis-Hansen L & Wierup N 2010 Apelin is a novel islet peptide. Regulatory Peptides 162 44-51. (doi:10.1016/j.regpep.2010.03.005)
55. Scherer PE, Williams S, Fogliano M, Baldini G & Lodish HF 1995 A novel serum protein similar to C1q, produced exclusively in adipocytes. Journal of Biological Chemistry 270 26746-26749. (doi:10.1074/jbc. 270.45.26746)
56. Seufert J 2004 Leptin effects on pancreatic b-cell gene expression and function. Diabetes 53(Suppl 1) S152-S158. (doi:10.2337/diabetes.53. 2007.S152)
57. Sheng F, Ren X, Dai X, Xu X, Dong M, Pei Q, Qu J, Zhou Z, Zhou H & Liu Z 2011 Effect of nicotinamide mononucleotide on insulin secretion and gene expressions of PDX-1 and FoxO1 in RIN-m5f cells. Zhong Nan Da Xue Xue Bao. Yi Xue BanZJournal of Central South University. Medical sciences 36 958-963.
58. Shimizu H, Ohtani K, Kato Y & Mori M 2000 Interleukin-6 increases insulin secretion and preproinsulin mRNA expression via Ca2C-dependent mechanism. Journal of Endocrinology 166 121-126. (doi:10.1677/joe.0. 1660121)
59. Sörhede Winzell M, Magnusson C & Ahrén B 2005 The apj receptor is expressed in pancreatic islets and its ligand, apelin, inhibits insulin secretion in mice. Regulatory Peptides 131 12-17. (doi:10.1016/ j.regpep.2005.05.004)
60. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS & Lazar MA 2001 The hormone resistin links obesity to diabetes. Nature 409 307-312. (doi:10.1038/35053000)
61. Suzuki T, Imai J, Yamada T, Ishigaki Y, Kaneko K, Uno K, Hasegawa Y, Ishihara H, Oka Y & Katagiri H 2011 Interleukin-6 enhances glucose-stimulated insulin secretion from pancreatic b-cells: potential involvement of the PLC-IP3-dependent pathway. Diabetes 60 537-547. (doi:10.2337/db10-0796)
62. Tanabe K, Okuya S, Tanizawa Y, Matsutani A & Oka Y 1997 Leptin induces proliferation of pancreatic b cell line MIN6 through activation of mitogen-activated protein kinase. Biochemical and Biophysical Research Communications 241 765-768. (doi:10.1006/bbrc.1997.7894)
63. Tanizawa Y, Okuya S, Ishihara H, Asano T, Yada T & Oka Y 1997 Direct stimulation of basal insulin secretion by physiological concentrations of leptin in pancreatic b cells. Endocrinology 138 4513-4516. (doi:10.1210/en.138.10.4513)
64. Thams P & Capito K 2001 Differential mechanisms of glucose and palmitate in augmentation of insulin secretion in mouse pancreatic islets. Diabetologia 44 738-746. (doi:10.1007/s001250051683)
65. Tsiotra PC, Tsigos C & Raptis SA 2001 TNFa and leptin inhibit basal and glucose-stimulated insulin secretion and gene transcription in the HIT-T15 pancreatic cells. International Journal of Obesity and Related Metabolic Disorders 25 1018-1026. (doi:10.1038/sj.ijo.0801657)
66. Wang L, Liu Y, Yan Lu S, Nguyen KT, Schroer SA, Suzuki A, Mak TW, Gaisano H & Woo M 2010 Deletion of Pten in pancreatic b-cells protects against deficient b-cell mass and function in mouse models of type 2 diabetes. Diabetes 59 3117-3126. (doi:10.2337/db09-1805)
67. Weir GC, Laybutt DR, Kaneto H, Bonner-Weir S & Sharma A 2001 b-Cell adaptation and decompensation during the progression of diabetes. Diabetes 50 S154-S159. (doi:10.2337/diabetes.50.2007.S154)
68. Wellen KE & Hotamisligil GS 2005 Inflammation, stress, and diabetes. Journal of Clinical Investigation 115 1111-1119. (doi:10.1172/JCI25102)
69. WenteW, Efanov AM, BrennerM, Kharitonenkov A, Köster A, Sandusky GE, Sewing S, Treinies I, Zitzer H & Gromada J 2006 Fibroblast growth factor-21 improves pancreatic b-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. Diabetes 55 2470-2478. (doi:10.2337/db05-1435)
70. Westermark P, Andersson A & Westermark GT 2011 Islet amyloid polypeptide, islet amyloid, and diabetes mellitus. Physiological Reviews 91 795-826. (doi:10.1152/physrev.00042.2009)
71. Wijesekara N, Krishnamurthy M, Bhattacharjee A, Suhail A, Sweeney G & Wheeler MB 2010 Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic b cell apoptosis and increases insulin gene expression and secretion. Journal of Biological Chemistry 285 33623-33631. (doi:10.1074/jbc.M109.085084)
72. Zhang S & Kim KH 1995 TNF-a inhibits glucose-induced insulin secretion in a pancreatic b-cell line (INS-1). FEBS Letters 18 237-239. (doi:10.1016/0014-5793(95)01272-9)
73. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L & Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372 425-432. (doi:10.1038/372425a0)
74. Zhao Y-F, Feng DD & Chen C 2006 Contribution of adipocyte-derived factors to β-cell dysfunction in diabetes. International Journal of Biochemistry & Cell Biology 38 804-819. (doi:10.1016/ j.biocel.2005.11.008)