-
2
-
-
0014188893
-
Plasma insulin responses to oral and intravenous glucose: Studies in normal and diabetic subjects
-
Perley M, Kipnis DM (1967) Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects. J Clin Invest 46:1954-1962
-
(1967)
J Clin Invest
, vol.46
, pp. 1954-1962
-
-
Perley, M.1
Kipnis, D.M.2
-
3
-
-
0022461548
-
Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
-
Nauck MA, Homberger E, Siegel, Allen RC, Eaton RP, Ebert R et al. (1986) Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab 63:492-498
-
(1986)
J Clin Endocrinol Metab
, vol.63
, pp. 492-498
-
-
Nauck, M.A.1
Homberger, E.2
Siegel3
Allen, R.C.4
Eaton, R.P.5
Ebert, R.6
-
4
-
-
0020549057
-
Discrepancy between plasma C-peptide and insulin response to oral and intravenous glucose
-
Madsbad S, Kehlet H, Hilsted J, Tronier B (1983) Discrepancy between plasma C-peptide and insulin response to oral and intravenous glucose. Diabetes 32:436-438
-
(1983)
Diabetes
, vol.32
, pp. 436-438
-
-
Madsbad, S.1
Kehlet, H.2
Hilsted, J.3
Tronier, B.4
-
5
-
-
0034740428
-
Incretin hormones - An update
-
Holst JJ, Orskov C. Incretin hormones - an update (2001) Scand J Clin Lab Invest 234 [Suppl]:75-85
-
(2001)
Scand J Clin Lab Invest
, vol.234
, Issue.SUPPL.
, pp. 75-85
-
-
Holst, J.J.1
Orskov, C.2
-
6
-
-
0022617246
-
Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
-
Nauck M, Stockmann F, Ebert R, Creutzfeldt W (1986) Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 29:46-52
-
(1986)
Diabetologia
, vol.29
, pp. 46-52
-
-
Nauck, M.1
Stockmann, F.2
Ebert, R.3
Creutzfeldt, W.4
-
7
-
-
0002278973
-
Absence of incretin efect in obese type 2 and diminished effect in lean type 2 and obese subjects
-
abstract
-
Tronier B, Dejgaard A, Andersen T, Madsbad S (1985) Absence of incretin efect in obese type 2 and diminished effect in lean type 2 and obese subjects. Diab Res Clin Pract [Suppl 1]:S568 (abstract)
-
(1985)
Diab Res Clin Pract
, Issue.1 SUPPL.
-
-
Tronier, B.1
Dejgaard, A.2
Andersen, T.3
Madsbad, S.4
-
8
-
-
0029043139
-
Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide
-
Fehmann HC, Goke R, Goke B (1995) Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide. Endocr Rev 16:390-410
-
(1995)
Endocr Rev
, vol.16
, pp. 390-410
-
-
Fehmann, H.C.1
Goke, R.2
Goke, B.3
-
9
-
-
0023434193
-
Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor
-
Takeda J, Seino Y, Tanaka K, Fukumoto H, Kayano T, Takahashi H et al. (1987) Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor. Proc Natl Acad Sci USA 84:7005-7008
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 7005-7008
-
-
Takeda, J.1
Seino, Y.2
Tanaka, K.3
Fukumoto, H.4
Kayano, T.5
Takahashi, H.6
-
10
-
-
0023955686
-
Immunoreactive gastric inhibitory polypeptide
-
Krarup T (1988) Immunoreactive gastric inhibitory polypeptide. Endocr Rev 9:122-134
-
(1988)
Endocr Rev
, vol.9
, pp. 122-134
-
-
Krarup, T.1
-
11
-
-
0027136670
-
Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain
-
Usdin TB, Mezey E, Button DC, Brownstein MJ, Bonner TI (1993) Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. Endocrinology 133:2861-2870
-
(1993)
Endocrinology
, vol.133
, pp. 2861-2870
-
-
Usdin, T.B.1
Mezey, E.2
Button, D.C.3
Brownstein, M.J.4
Bonner, T.I.5
-
12
-
-
0034489385
-
Colocalization of GLP-1 and GIP in human and porcine intestine
-
Mortensen K, Petersen LL, Orskov C (2000) Colocalization of GLP-1 and GIP in human and porcine intestine. Ann NY Acad Sci 921:469-472
-
(2000)
Ann NY Acad Sci
, vol.921
, pp. 469-472
-
-
Mortensen, K.1
Petersen, L.L.2
Orskov, C.3
-
13
-
-
0002632811
-
Gastric inhibitory polypeptide
-
Walsh JH, Dockray GJ (eds). Raven Press, New York
-
Pederson RA (1994) Gastric inhibitory polypeptide. In: Walsh JH, Dockray GJ (eds) Gut peptides: biochemistry and physiology. Raven Press, New York, pp 217-260
-
(1994)
Gut Peptides: Biochemistry and Physiology
, pp. 217-260
-
-
Pederson, R.A.1
-
15
-
-
0037373183
-
International Union of Pharmacology. XXXV. The glucagon receptor family
-
Mayo KE, Miller LJ, Bataille D, Dalle S, Goke B, Thorens B et al. (2003) International Union of Pharmacology. XXXV. The glucagon receptor family. Pharmacol Rev 55:167-194
-
(2003)
Pharmacol Rev
, vol.55
, pp. 167-194
-
-
Mayo, K.E.1
Miller, L.J.2
Bataille, D.3
Dalle, S.4
Goke, B.5
Thorens, B.6
-
16
-
-
0037020242
-
Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway
-
Ehses JA, Pelech SL, Pederson RA, McIntosh CH (2002) Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway. J Biol Chem 277:37088-37097
-
(2002)
J Biol Chem
, vol.277
, pp. 37088-37097
-
-
Ehses, J.A.1
Pelech, S.L.2
Pederson, R.A.3
McIntosh, C.H.4
-
17
-
-
0035968291
-
A new pathway fpr glucose-dependent insulinotropic poly peptiude (GIP) receptor signaling: Evidence for the involvement of phospholipase A2 in the GIP stimulated insulin secretion
-
Ehses JA, Lee SS, Pederson RA, McIntosh CH (2003) A new pathway fpr glucose-dependent insulinotropic poly peptiude (GIP) receptor signaling: evidence for the involvement of phospholipase A2 in the GIP stimulated insulin secretion. J Biol Chem 276:23667-23673
-
(2003)
J Biol Chem
, vol.276
, pp. 23667-23673
-
-
Ehses, J.A.1
Lee, S.S.2
Pederson, R.A.3
McIntosh, C.H.4
-
18
-
-
0034838323
-
Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling
-
Trumper A, Trumper K, Trusheim H, Arnold R, Goke B, Horsch D (2001) Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling. Mol Endocrinol 15:1559-1570
-
(2001)
Mol Endocrinol
, vol.15
, pp. 1559-1570
-
-
Trumper, A.1
Trumper, K.2
Trusheim, H.3
Arnold, R.4
Goke, B.5
Horsch, D.6
-
19
-
-
0015791989
-
Stimulation of insulin secretion by gastric inhibitory polypeptide in man
-
Dupre J, Ross SA, Watson D, Brown JC (1973) Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab 37:826-828
-
(1973)
J Clin Endocrinol Metab
, vol.37
, pp. 826-828
-
-
Dupre, J.1
Ross, S.A.2
Watson, D.3
Brown, J.C.4
-
20
-
-
0018185347
-
Oral glucose augmentation of insulin secretion: Interactions of gastric inhibitory polypeptide with ambient glucose and insuln levels
-
Andersen DK, Elahi D, Brown JC, Tobin JD, Andres R (1978) Oral glucose augmentation of insulin secretion: interactions of gastric inhibitory polypeptide with ambient glucose and insuln levels. J Clin Invest 49:152-161
-
(1978)
J Clin Invest
, vol.49
, pp. 152-161
-
-
Andersen, D.K.1
Elahi, D.2
Brown, J.C.3
Tobin, J.D.4
Andres, R.5
-
21
-
-
0020214380
-
Influence of gastric inhibitory polypeptide antiserum on glucose-induced insulin secretion in rats
-
Ebert R, Creutzfeldt W (1982) Influence of gastric inhibitory polypeptide antiserum on glucose-induced insulin secretion in rats. Endocrinology 111:1601-1606
-
(1982)
Endocrinology
, vol.111
, pp. 1601-1606
-
-
Ebert, R.1
Creutzfeldt, W.2
-
22
-
-
0019501075
-
Depression of insulin release by anti-GIP serum after oral glucose in rats
-
Lauritsen KB, Holst JJ, Moody AJ (1981) Depression of insulin release by anti-GIP serum after oral glucose in rats. Scand J Gastroenterol 16:417-420
-
(1981)
Scand J Gastroenterol
, vol.16
, pp. 417-420
-
-
Lauritsen, K.B.1
Holst, J.J.2
Moody, A.J.3
-
23
-
-
0029834106
-
Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat
-
Tseng CC, Kieffer TJ, Jarboe LA, Usdin TB, Wolfe MM (1996) Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat. J Clin Invest 98:2440-2445
-
(1996)
J Clin Invest
, vol.98
, pp. 2440-2445
-
-
Tseng, C.C.1
Kieffer, T.J.2
Jarboe, L.A.3
Usdin, T.B.4
Wolfe, M.M.5
-
24
-
-
0033744913
-
Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: Demonstration by a receptor antagonist
-
Lewis JT, Dayanandan B, Habener JF, Kieffer TJ (2000) Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist. Endocrinology 141:3710-3716
-
(2000)
Endocrinology
, vol.141
, pp. 3710-3716
-
-
Lewis, J.T.1
Dayanandan, B.2
Habener, J.F.3
Kieffer, T.J.4
-
25
-
-
0007866067
-
Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide receptor knockout mice
-
Miyawaki K, Yamada Y, Yano H, Niwa H, Ban N, Ihara Y et al. (1999) Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc Natl Acad Sci USA 96:14843-14847
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 14843-14847
-
-
Miyawaki, K.1
Yamada, Y.2
Yano, H.3
Niwa, H.4
Ban, N.5
Ihara, Y.6
-
26
-
-
1442321740
-
Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo
-
Gault VA, Parker JC, Harriott P, Flatt PR, O'Harte FP (2002) Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo. J Endocrinol 175:525-533
-
(2002)
J Endocrinol
, vol.175
, pp. 525-533
-
-
Gault, V.A.1
Parker, J.C.2
Harriott, P.3
Flatt, P.R.4
O'Harte, F.P.5
-
27
-
-
0024424884
-
Insulinotropic properties of synthetic human gastric inhibitory polypeptide in man: Interactions with glucose, phenylalanine, and cholecystokinin-8
-
Nauck M, Schmidt WE, Ebert R, Strietzel J, Cantor P, Hoffmann G et al. (1989) Insulinotropic properties of synthetic human gastric inhibitory polypeptide in man: interactions with glucose, phenylalanine, and cholecystokinin-8. J Clin Endocrinol Metab 69:654-662
-
(1989)
J Clin Endocrinol Metab
, vol.69
, pp. 654-662
-
-
Nauck, M.1
Schmidt, W.E.2
Ebert, R.3
Strietzel, J.4
Cantor, P.5
Hoffmann, G.6
-
28
-
-
0020520108
-
Preservation of incretin activity after removal of gastric inhibitory polypeptide (GIP) from rat gut extracts by immunoadsorption
-
Ebert R, Unger H, Creutzfeldt W (1983) Preservation of incretin activity after removal of gastric inhibitory polypeptide (GIP) from rat gut extracts by immunoadsorption. Diabetologia 24:449-454
-
(1983)
Diabetologia
, vol.24
, pp. 449-454
-
-
Ebert, R.1
Unger, H.2
Creutzfeldt, W.3
-
30
-
-
0020077877
-
Gastric inhibitory polypeptide and insulin release in response to oral and intravenous glucose in coeliac disease
-
Lauritsen KB, Lauritzen JB, Christensen KC (1982) Gastric inhibitory polypeptide and insulin release in response to oral and intravenous glucose in coeliac disease. Scand J Gastroenterol 17:241-245
-
(1982)
Scand J Gastroenterol
, vol.17
, pp. 241-245
-
-
Lauritsen, K.B.1
Lauritzen, J.B.2
Christensen, K.C.3
-
32
-
-
0023008693
-
Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing
-
Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L, Habener JF (1986). Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 261:11880-11889
-
(1986)
J Biol Chem
, vol.261
, pp. 11880-11889
-
-
Mojsov, S.1
Heinrich, G.2
Wilson, I.B.3
Ravazzola, M.4
Orci, L.5
Habener, J.F.6
-
33
-
-
0022971804
-
Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas
-
Orskov C, Holst JJ, Knuhtsen S, Baldissera FG, Poulsen SS, Nielsen OV (1986) Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas. Endocrinology 119:1467-1475
-
(1986)
Endocrinology
, vol.119
, pp. 1467-1475
-
-
Orskov, C.1
Holst, J.J.2
Knuhtsen, S.3
Baldissera, F.G.4
Poulsen, S.S.5
Nielsen, O.V.6
-
34
-
-
0023910424
-
Oxyntomodulin (glicentin-(33-69)): Pharmacokinetics, binding to liver cell membranes, effects on isolated perfused pig pancreas, and secretion from isolated perfused lower small intestine of pigs
-
Baldissera FG, Holst JJ, Knuhtsen S, Hilsted L, Nielsen OV (1988) Oxyntomodulin (glicentin-(33-69)): pharmacokinetics, binding to liver cell membranes, effects on isolated perfused pig pancreas, and secretion from isolated perfused lower small intestine of pigs. Regul Pept 21:151-166
-
(1988)
Regul Pept
, vol.21
, pp. 151-166
-
-
Baldissera, F.G.1
Holst, J.J.2
Knuhtsen, S.3
Hilsted, L.4
Nielsen, O.V.5
-
35
-
-
0020585333
-
Molecular heterogeneity of glucagon in normal subjects and in patients with glucagon-producing tumours
-
Holst JJ (1983) Molecular heterogeneity of glucagon in normal subjects and in patients with glucagon-producing tumours. Diabetologia 24:359-365
-
(1983)
Diabetologia
, vol.24
, pp. 359-365
-
-
Holst, J.J.1
-
36
-
-
0033175006
-
Glucagon-like Peptide 1 (GLP-1): An intestinal hormone signalling nutritional abundance, with an unusual therapeutic potential
-
Holst JJ (1999) Glucagon-like Peptide 1 (GLP-1): an intestinal hormone signalling nutritional abundance, with an unusual therapeutic potential. Trends Endocrinol Metab 10:229-234
-
(1999)
Trends Endocrinol Metab
, vol.10
, pp. 229-234
-
-
Holst, J.J.1
-
37
-
-
0029765475
-
Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day
-
Orskov C, Wettergren A, Holst JJ (1996) Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day. Scand J Gastroenterol 31:665-670
-
(1996)
Scand J Gastroenterol
, vol.31
, pp. 665-670
-
-
Orskov, C.1
Wettergren, A.2
Holst, J.J.3
-
38
-
-
0023638829
-
Glucagon-like peptide-1 7-36: A physiological incretin in man
-
Kreymann B, Williams G, Ghatei MA, Bloom SR (1987) Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 2:1300-1304
-
(1987)
Lancet
, vol.2
, pp. 1300-1304
-
-
Kreymann, B.1
Williams, G.2
Ghatei, M.A.3
Bloom, S.R.4
-
39
-
-
0028883257
-
Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amide
-
Kolligs F, Fehmann HC, Goke R, Goke B (1995) Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amide. Diabetes 44:16-19
-
(1995)
Diabetes
, vol.44
, pp. 16-19
-
-
Kolligs, F.1
Fehmann, H.C.2
Goke, R.3
Goke, B.4
-
40
-
-
0028821658
-
Glucagon-like peptide-1 is a physiological incretin in rat
-
Wang Z, Wang RM, Owji AA, Smith DM, Ghatei MA, Bloom SR (1995) Glucagon-like peptide-1 is a physiological incretin in rat. J Clin Invest 95:417-421
-
(1995)
J Clin Invest
, vol.95
, pp. 417-421
-
-
Wang, Z.1
Wang, R.M.2
Owji, A.A.3
Smith, D.M.4
Ghatei, M.A.5
Bloom, S.R.6
-
41
-
-
0032960834
-
Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: Studies with the antagonist exendin 9-39
-
Edwards CM, Todd JF, Mahmoudi M, Wang Z, Wang RM, Ghatei MA et al. (1999) Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39. Diabetes 48:86-93
-
(1999)
Diabetes
, vol.48
, pp. 86-93
-
-
Edwards, C.M.1
Todd, J.F.2
Mahmoudi, M.3
Wang, Z.4
Wang, R.M.5
Ghatei, M.A.6
-
42
-
-
0029958404
-
Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
-
Scrocchi LA, Brown TJ, MaClusky N, Brubaker PL, Auerbach AB, Joyner AL et al. (1996) Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med 2:1254-1258
-
(1996)
Nat Med
, vol.2
, pp. 1254-1258
-
-
Scrocchi, L.A.1
Brown, T.J.2
Maclusky, N.3
Brubaker, P.L.4
Auerbach, A.B.5
Joyner, A.L.6
-
43
-
-
0031747107
-
Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- Mice
-
Pederson RA, Satkunarajah M, McIntosh CH, Scrocchi LA, Flamez D, Schuit F et al. (1998) Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/-mice. Diabetes 47:1046-1052
-
(1998)
Diabetes
, vol.47
, pp. 1046-1052
-
-
Pederson, R.A.1
Satkunarajah, M.2
McIntosh, C.H.3
Scrocchi, L.A.4
Flamez, D.5
Schuit, F.6
-
44
-
-
0029147672
-
Glucagon-like peptide 1 (7-36 amide) secretion in response to luminal sucrose from the upper and lower gut. A study using alpha-glucosidase inhibition (acarbose)
-
Qualmann C, Nauck MA, Holst JJ, Orskov C, Creutzfeldt W (1995) Glucagon-like peptide 1 (7-36 amide) secretion in response to luminal sucrose from the upper and lower gut. A study using alpha-glucosidase inhibition (acarbose). Scand J Gastroenterol 30:892-896
-
(1995)
Scand J Gastroenterol
, vol.30
, pp. 892-896
-
-
Qualmann, C.1
Nauck, M.A.2
Holst, J.J.3
Orskov, C.4
Creutzfeldt, W.5
-
45
-
-
0037784011
-
GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine
-
Mortensen K, Christensen LL, Holst JJ, Orskov C (2003) GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine. Regul Pept 114:189-196
-
(2003)
Regul Pept
, vol.114
, pp. 189-196
-
-
Mortensen, K.1
Christensen, L.L.2
Holst, J.J.3
Orskov, C.4
-
46
-
-
0028953577
-
Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
-
Deacon CF, Johnsen AH, Holst JJ (1995) Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J Clin Endocrinol Metab 80:952-957
-
(1995)
J Clin Endocrinol Metab
, vol.80
, pp. 952-957
-
-
Deacon, C.F.1
Johnsen, A.H.2
Holst, J.J.3
-
47
-
-
0029118049
-
Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
-
Kieffer TJ, McIntosh CH, Pederson RA (1995) Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 136:3585-3596
-
(1995)
Endocrinology
, vol.136
, pp. 3585-3596
-
-
Kieffer, T.J.1
McIntosh, C.H.2
Pederson, R.A.3
-
48
-
-
0033766716
-
Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide
-
Deacon CF, Nauck MA, Meier J, Hucking K, Holst JJ (2000) Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide. J Clin Endocrinol Metab 85:3575-3581
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 3575-3581
-
-
Deacon, C.F.1
Nauck, M.A.2
Meier, J.3
Hucking, K.4
Holst, J.J.5
-
49
-
-
0030607672
-
Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor
-
Knudsen LB, Pridal L (1996) Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur J Pharmacol 318:429-435
-
(1996)
Eur J Pharmacol
, vol.318
, pp. 429-435
-
-
Knudsen, L.B.1
Pridal, L.2
-
50
-
-
0033619675
-
Dipeptidyl-peptidase IV (CD26) - Role in the inactivation of regulatory peptides
-
Mentlein R (1999) Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides. Regul Pept 85:9-24
-
(1999)
Regul Pept
, vol.85
, pp. 9-24
-
-
Mentlein, R.1
-
51
-
-
0028803336
-
Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects
-
Deacon CF, Nauck MA, Toft-Nielsen M, Pridal L, Willms B, Holst JJ (1995) Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects. Diabetes 44:1126-1131
-
(1995)
Diabetes
, vol.44
, pp. 1126-1131
-
-
Deacon, C.F.1
Nauck, M.A.2
Toft-Nielsen, M.3
Pridal, L.4
Willms, B.5
Holst, J.J.6
-
52
-
-
0037241085
-
Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
-
Vilsboll T, Agerso H, Krarup T, Holst JJ (2003) Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab 88:220-224
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 220-224
-
-
Vilsboll, T.1
Agerso, H.2
Krarup, T.3
Holst, J.J.4
-
53
-
-
0029797540
-
Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig
-
Deacon CF, Pridal L, Klarskov L, Olesen M, Holst JJ (1996) Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig. Am J Physiol 271:E458-E464
-
(1996)
Am J Physiol
, vol.271
-
-
Deacon, C.F.1
Pridal, L.2
Klarskov, L.3
Olesen, M.4
Holst, J.J.5
-
54
-
-
0001095690
-
Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
-
Vilsboll T, Krarup T, Deacon CF, Madsbad S, Holst JJ (2001) Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 50:609-613
-
(2001)
Diabetes
, vol.50
, pp. 609-613
-
-
Vilsboll, T.1
Krarup, T.2
Deacon, C.F.3
Madsbad, S.4
Holst, J.J.5
-
55
-
-
0037902984
-
Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus
-
Vilsboll T, Krarup T, Sonne J, Madsbad S, Volund A, Juul AG et al. (2003) Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus. J Clin Endocrinol Metab 88:2706-2713
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 2706-2713
-
-
Vilsboll, T.1
Krarup, T.2
Sonne, J.3
Madsbad, S.4
Volund, A.5
Juul, A.G.6
-
56
-
-
0037241085
-
Similar elimination rates of GLP-1 in obese type diabetic patients and healthy subjects
-
Vilsboll T, Agersoe H, Krarup T, Holst JJ (2003) Similar elimination rates of GLP-1 in obese type diabetic patients and healthy subjects. J Clin Endocrinol Metab 88:220-224
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 220-224
-
-
Vilsboll, T.1
Agersoe, H.2
Krarup, T.3
Holst, J.J.4
-
57
-
-
0035403058
-
Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs
-
Deacon CF, Danielsen P, Klarskov L, Olesen M, Holst JJ (2001) Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs. Diabetes 50:1588-1597
-
(2001)
Diabetes
, vol.50
, pp. 1588-1597
-
-
Deacon, C.F.1
Danielsen, P.2
Klarskov, L.3
Olesen, M.4
Holst, J.J.5
-
58
-
-
0028945815
-
Effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-I-(7-36) on insulin secretion
-
Jia X, Brown JC, Ma P, Pederson RA, McIntosh CH (1995) Effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-I-(7-36) on insulin secretion. Am J Physiol 268:E645-E651
-
(1995)
Am J Physiol
, vol.268
-
-
Jia, X.1
Brown, J.C.2
Ma, P.3
Pederson, R.A.4
McIntosh, C.H.5
-
59
-
-
0028224617
-
The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects
-
Elahi D, McAloon Dyke M, Fukagawa NK, Meneilly GS, Sclater AL, Minaker KL et al. (1994) The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects. Regul Pept 51:63-74
-
(1994)
Regul Pept
, vol.51
, pp. 63-74
-
-
Elahi, D.1
McAloon Dyke, M.2
Fukagawa, N.K.3
Meneilly, G.S.4
Sclater, A.L.5
Minaker, K.L.6
-
60
-
-
0027391607
-
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
-
Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W (1993) Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 91:301-307
-
(1993)
J Clin Invest
, vol.91
, pp. 301-307
-
-
Nauck, M.A.1
Heimesaat, M.M.2
Orskov, C.3
Holst, J.J.4
Ebert, R.5
Creutzfeldt, W.6
-
61
-
-
0027419106
-
Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations
-
Nauck MA, Bartels E, Orskov C, Ebert R, Creutzfeldt W (1993) Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations. J Clin Endocrinol Metab 76:912-917
-
(1993)
J Clin Endocrinol Metab
, vol.76
, pp. 912-917
-
-
Nauck, M.A.1
Bartels, E.2
Orskov, C.3
Ebert, R.4
Creutzfeldt, W.5
-
62
-
-
0031721391
-
Exaggerated secretion of glucagon-like peptide-1 (GLP-1) could cause reactive hypoglycaemia
-
Toft-Nielsen M, Madsbad S, Holst JJ (1998) Exaggerated secretion of glucagon-like peptide-1 (GLP-1) could cause reactive hypoglycaemia. Diabetologia 41:1180-1186
-
(1998)
Diabetologia
, vol.41
, pp. 1180-1186
-
-
Toft-Nielsen, M.1
Madsbad, S.2
Holst, J.J.3
-
63
-
-
0023179206
-
Effect of porcine gastric inhibitory polypeptide on beta-cell function in type I and type II diabetes mellitus
-
Krarup T, Saurbrey N, Moody AJ, Kuhl C, Madsbad S (1987) Effect of porcine gastric inhibitory polypeptide on beta-cell function in type I and type II diabetes mellitus. Metabolism 36:677-682
-
(1987)
Metabolism
, vol.36
, pp. 677-682
-
-
Krarup, T.1
Saurbrey, N.2
Moody, A.J.3
Kuhl, C.4
Madsbad, S.5
-
64
-
-
0038121744
-
Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects
-
Vilsboll T, Krarup T, Madsbad S, Holst JJ (2003) Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects. Regul Pept 114:115-121
-
(2003)
Regul Pept
, vol.114
, pp. 115-121
-
-
Vilsboll, T.1
Krarup, T.2
Madsbad, S.3
Holst, J.J.4
-
65
-
-
1842857888
-
Disruption of both GLP-1 and GIP signalling pathways in the mouse leads to glucose intolerance
-
abstract
-
Preitner F, Burcelin R, Ibberson M, Hansotia T, Drucker D, Thorens B (2002) Disruption of both GLP-1 and GIP signalling pathways in the mouse leads to glucose intolerance. Diabetes 51 [Suppl 2]:A66 (abstract)
-
(2002)
Diabetes
, vol.51
, Issue.2 SUPPL.
-
-
Preitner, F.1
Burcelin, R.2
Ibberson, M.3
Hansotia, T.4
Drucker, D.5
Thorens, B.6
-
66
-
-
0034880655
-
Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients
-
Toft-Nielsen MB, Damholt MB, Madsbad S, Hilsted LM, Hughes TE, Michelsen BK et al. (2001) Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. J Clin Endocrinol Metab 86:3717-3723
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 3717-3723
-
-
Toft-Nielsen, M.B.1
Damholt, M.B.2
Madsbad, S.3
Hilsted, L.M.4
Hughes, T.E.5
Michelsen, B.K.6
-
67
-
-
0029856880
-
Gut incretin hormones in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM) - Evidence for decreased glucagon-like peptide 1 secretion during oral glucose ingestion in NIDDM twins
-
Vaag AA, Holst JJ, Volund A, Beck-Nielsen HB (1996) Gut incretin hormones in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM) - evidence for decreased glucagon-like peptide 1 secretion during oral glucose ingestion in NIDDM twins. Eur J Endocrinol 135:425-432
-
(1996)
Eur J Endocrinol
, vol.135
, pp. 425-432
-
-
Vaag, A.A.1
Holst, J.J.2
Volund, A.3
Beck-Nielsen, H.B.4
-
68
-
-
0032757178
-
Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of Type II (non-insulin-dependent) diabetic parents: Evidence of several aberrations
-
Nyholm B, Walker M, Gravholt CH, Shearing PA, Sturis J, Alberti KG et al. (1999) Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of Type II (non-insulin-dependent) diabetic parents: evidence of several aberrations. Diabetologia 42:1314-1323
-
(1999)
Diabetologia
, vol.42
, pp. 1314-1323
-
-
Nyholm, B.1
Walker, M.2
Gravholt, C.H.3
Shearing, P.A.4
Sturis, J.5
Alberti, K.G.6
-
69
-
-
0034054153
-
Lack of germline mutations in the proglucagon gene region coding for glucagon-like peptide 1 in type 2 diabetic (NIDDM) patients
-
Nauck M, Hahn S, Sauerwald A, Schmeigel W (2000) Lack of germline mutations in the proglucagon gene region coding for glucagon-like peptide 1 in type 2 diabetic (NIDDM) patients. Exp Clin Endocrinol Diabetes 108:72-75
-
(2000)
Exp Clin Endocrinol Diabetes
, vol.108
, pp. 72-75
-
-
Nauck, M.1
Hahn, S.2
Sauerwald, A.3
Schmeigel, W.4
-
70
-
-
0001292237
-
Lack of germ-line mutations in the GIP-coding region of the pro-GIP in type II diabetic patients
-
abstract
-
Orskov C, Vilsboll T, Krarup T, Inagaki N, Hjorth SA (1999) Lack of germ-line mutations in the GIP-coding region of the pro-GIP in type II diabetic patients. Diabetes 48 [Suppl 1]:A427 (abstract)
-
(1999)
Diabetes
, vol.48
, Issue.1 SUPPL.
-
-
Orskov, C.1
Vilsboll, T.2
Krarup, T.3
Inagaki, N.4
Hjorth, S.A.5
-
71
-
-
0030876081
-
The pathogenesis of NIDDM involves a defective expression of the GIP receptor
-
Holst JJ, Gromada J, Nauck MA (1997) The pathogenesis of NIDDM involves a defective expression of the GIP receptor. Diabetologia 40:984-986
-
(1997)
Diabetologia
, vol.40
, pp. 984-986
-
-
Holst, J.J.1
Gromada, J.2
Nauck, M.A.3
-
72
-
-
10544249875
-
Identification of two missense mutations in the GIP receptor gene: A functional study and association analysis with NIDDM: No evidence of association with Japanese NIDDM subjects
-
Kubota A, Yamada Y, Hayami T, Yasuda K, Someya Y, Ihara Y et al. (1996) Identification of two missense mutations in the GIP receptor gene: a functional study and association analysis with NIDDM: no evidence of association with Japanese NIDDM subjects. Diabetes 45:1701-1705
-
(1996)
Diabetes
, vol.45
, pp. 1701-1705
-
-
Kubota, A.1
Yamada, Y.2
Hayami, T.3
Yasuda, K.4
Someya, Y.5
Ihara, Y.6
-
73
-
-
0031781959
-
Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: The impact on the pancreatic beta cell responses and functionel expression studies in Chinese hamster fibroblast cells
-
Almind K, Ambye L, Urhammer SA, Hansen T, Echwald SM, Holst JJ et al. (1998) Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functionel expression studies in Chinese hamster fibroblast cells. Diabetologia 41:1194-1198
-
(1998)
Diabetologia
, vol.41
, pp. 1194-1198
-
-
Almind, K.1
Ambye, L.2
Urhammer, S.A.3
Hansen, T.4
Echwald, S.M.5
Holst, J.J.6
-
74
-
-
0035041250
-
Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
-
Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA (2001) Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes 50:1004-1011
-
(2001)
Diabetes
, vol.50
, pp. 1004-1011
-
-
Lynn, F.C.1
Pamir, N.2
Ng, E.H.3
McIntosh, C.H.4
Kieffer, T.J.5
Pederson, R.A.6
-
75
-
-
0035512742
-
Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes
-
Meier JJ, Hucking K, Holst JJ, Deacon CF, Schmiegel WH, Nauck MA (2001) Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes. Diabetes 50:2497-2504
-
(2001)
Diabetes
, vol.50
, pp. 2497-2504
-
-
Meier, J.J.1
Hucking, K.2
Holst, J.J.3
Deacon, C.F.4
Schmiegel, W.H.5
Nauck, M.A.6
-
76
-
-
0343191486
-
Evaluation of beta-cell secretory capacity using glucagon-like peptide 1
-
Vilsboll T, Toft-Nielsen MB, Krarup T, Madsbad S, Dinesen B, Holst JJ (2000) Evaluation of beta-cell secretory capacity using glucagon-like peptide 1. Diabetes Care 23:807-812
-
(2000)
Diabetes Care
, vol.23
, pp. 807-812
-
-
Vilsboll, T.1
Toft-Nielsen, M.B.2
Krarup, T.3
Madsbad, S.4
Dinesen, B.5
Holst, J.J.6
-
77
-
-
0036373430
-
Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients
-
Vilsboll T, Krarup T, Madsbad S, Holst JJ (2002) Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients. Diabetologia 45:1111-1119
-
(2002)
Diabetologia
, vol.45
, pp. 1111-1119
-
-
Vilsboll, T.1
Krarup, T.2
Madsbad, S.3
Holst, J.J.4
-
78
-
-
0037219411
-
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102-110
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
79
-
-
0037312821
-
The influence of GLP-1 on glucose-stimulated insulin secretion: Effects on beta-cell sensitivity in type 2 and nondiabetic subjects
-
Kjems LL, Holst JJ, Volund A, Madsbad S (2003) The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects. Diabetes 52:380-386
-
(2003)
Diabetes
, vol.52
, pp. 380-386
-
-
Kjems, L.L.1
Holst, J.J.2
Volund, A.3
Madsbad, S.4
-
80
-
-
0242383351
-
The pathophysiology of diabetes involves a defective amplification of the late phase insulin response to glucose by GIP - Regardless of aetiology and phenotype
-
Vilsboll T, Knop FK, Krarup T, Johansen A, Madsbad S, Larsen S et al. (2003) The pathophysiology of diabetes involves a defective amplification of the late phase insulin response to glucose by GIP - regardless of aetiology and phenotype. J Clin Endocrinol Metab 88:4897-4903
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4897-4903
-
-
Vilsboll, T.1
Knop, F.K.2
Krarup, T.3
Johansen, A.4
Madsbad, S.5
Larsen, S.6
-
81
-
-
0031910187
-
Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1
-
Gromada J, Holst JJ, Rorsman P (1998) Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1. Pflugers Arch 435:583-594
-
(1998)
Pflugers Arch
, vol.435
, pp. 583-594
-
-
Gromada, J.1
Holst, J.J.2
Rorsman, P.3
-
82
-
-
0036022670
-
Gastric inhibitory polypeptide analogues: Do they have a therapeutic role in diabetes mellitus similar to that of glucagon-like Peptide-1?
-
Holst JJ (2002) Gastric inhibitory polypeptide analogues: do they have a therapeutic role in diabetes mellitus similar to that of glucagon-like Peptide-1? BioDrugs 16:175-181
-
(2002)
BioDrugs
, vol.16
, pp. 175-181
-
-
Holst, J.J.1
-
83
-
-
0027248866
-
Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
-
Nauck MA, Kleine N, Orskov C, Holst JJ, Willms B, Creutzfeldt W (1993) Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 36:741-744
-
(1993)
Diabetologia
, vol.36
, pp. 741-744
-
-
Nauck, M.A.1
Kleine, N.2
Orskov, C.3
Holst, J.J.4
Willms, B.5
Creutzfeldt, W.6
-
84
-
-
0028904931
-
Insulinotropic actions of intravenous glucagon-like peptide-1 (GLP-1) [7-36 amide] in the fasting state in healthy subjects
-
Qualmann C, Nauck MA, Holst JJ, Orskov C, Creutzfeldt W (1995) Insulinotropic actions of intravenous glucagon-like peptide-1 (GLP-1) [7-36 amide] in the fasting state in healthy subjects. Acta Diabetol 32:13-16
-
(1995)
Acta Diabetol
, vol.32
, pp. 13-16
-
-
Qualmann, C.1
Nauck, M.A.2
Holst, J.J.3
Orskov, C.4
Creutzfeldt, W.5
-
85
-
-
0035081369
-
No reactive hypoglycaemia in Type 2 diabetic patients after subcutaneous administration of GLP-1 and intravenous glucose
-
Vilsboll T, Krarup T, Madsbad S, Holst JJ (2001) No reactive hypoglycaemia in Type 2 diabetic patients after subcutaneous administration of GLP-1 and intravenous glucose. Diabet Med 18:144-149
-
(2001)
Diabet Med
, vol.18
, pp. 144-149
-
-
Vilsboll, T.1
Krarup, T.2
Madsbad, S.3
Holst, J.J.4
-
86
-
-
0026535588
-
Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells
-
Fehmann HC, Habener JF (1992) Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. Endocrinology 130:159-166
-
(1992)
Endocrinology
, vol.130
, pp. 159-166
-
-
Fehmann, H.C.1
Habener, J.F.2
-
87
-
-
0032768616
-
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells
-
Buteau J, Roduit R, Susini S, Prentki M (1999) Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells. Diabetologia 42:856-864
-
(1999)
Diabetologia
, vol.42
, pp. 856-864
-
-
Buteau, J.1
Roduit, R.2
Susini, S.3
Prentki, M.4
-
88
-
-
0033513455
-
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
-
Xu G, Stoffers DA, Habener JF, Bonner-Weir S (1999) Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48:2270-2276
-
(1999)
Diabetes
, vol.48
, pp. 2270-2276
-
-
Xu, G.1
Stoffers, D.A.2
Habener, J.F.3
Bonner-Weir, S.4
-
89
-
-
0034032317
-
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
-
Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF et al. (2000) Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49:741-748
-
(2000)
Diabetes
, vol.49
, pp. 741-748
-
-
Stoffers, D.A.1
Kieffer, T.J.2
Hussain, M.A.3
Drucker, D.J.4
Bonner-Weir, S.5
Habener, J.F.6
-
90
-
-
0033512486
-
Glucagon-like peptide 1 and exendin-4 convert pancrteatic AR42J cells into glucagon- and insulin-producing cells
-
Zhou J, Wang X, Pineyro MA, Egan JM (1999) Glucagon-like peptide 1 and exendin-4 convert pancrteatic AR42J cells into glucagon-and insulin-producing cells. Diabetes 48:2358-2366
-
(1999)
Diabetes
, vol.48
, pp. 2358-2366
-
-
Zhou, J.1
Wang, X.2
Pineyro, M.A.3
Egan, J.M.4
-
91
-
-
0037312818
-
Glucagon-like peptides: Regulators of cell proliferation, differentiation, and apoptosis
-
Drucker DJ (2003) Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis. Mol Endocrinol 17:161-171
-
(2003)
Mol Endocrinol
, vol.17
, pp. 161-171
-
-
Drucker, D.J.1
-
92
-
-
0034522773
-
Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
-
Perfetti R, Zhou J, Doyle ME, Egan JM (2000) Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 141:4600-4605
-
(2000)
Endocrinology
, vol.141
, pp. 4600-4605
-
-
Perfetti, R.1
Zhou, J.2
Doyle, M.E.3
Egan, J.M.4
-
93
-
-
0029954211
-
Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients
-
Creutzfeldt WO, Kleine N, Willms B, Orskov C, Holst JJ, Nauck MA (1996) Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients. Diabetes Care 19:580-586
-
(1996)
Diabetes Care
, vol.19
, pp. 580-586
-
-
Creutzfeldt, W.O.1
Kleine, N.2
Willms, B.3
Orskov, C.4
Holst, J.J.5
Nauck, M.A.6
-
94
-
-
0029760864
-
Evidence for a major role for glucagon in regulation of plasma glucose in conscious, nondiabetic, and alloxan-induced diabetic rabbits
-
Brand CL, Jorgensen PN, Svendsen I, Holst JJ (1996) Evidence for a major role for glucagon in regulation of plasma glucose in conscious, nondiabetic, and alloxan-induced diabetic rabbits. Diabetes 45:1076-1083
-
(1996)
Diabetes
, vol.45
, pp. 1076-1083
-
-
Brand, C.L.1
Jorgensen, P.N.2
Svendsen, I.3
Holst, J.J.4
-
95
-
-
0035195977
-
Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans
-
Petersen KF, Sullivan JT (2001) Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans. Diabetologia 44:2018-2024
-
(2001)
Diabetologia
, vol.44
, pp. 2018-2024
-
-
Petersen, K.F.1
Sullivan, J.T.2
-
96
-
-
0027533758
-
Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man
-
Wettergren A, Schjoldager B, Mortensen PE, Myhre J, Christiansen J, Holst JJ (1993) Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man. Dig Dis Sci 38:665-673
-
(1993)
Dig Dis Sci
, vol.38
, pp. 665-673
-
-
Wettergren, A.1
Schjoldager, B.2
Mortensen, P.E.3
Myhre, J.4
Christiansen, J.5
Holst, J.J.6
-
97
-
-
0030667056
-
Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans
-
Nauck MA, Niedereichholz U, Ettler R, Holst JJ, Orskov C, Ritzel R et al. (1997) Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol 273:E981-E988
-
(1997)
Am J Physiol
, vol.273
-
-
Nauck, M.A.1
Niedereichholz, U.2
Ettler, R.3
Holst, J.J.4
Orskov, C.5
Ritzel, R.6
-
98
-
-
0031779868
-
Roles of amylin in diabetes and in regulation of nutrient load
-
Young A, Denaro M (1998) Roles of amylin in diabetes and in regulation of nutrient load Nutrition 14:524-527
-
(1998)
Nutrition
, vol.14
, pp. 524-527
-
-
Young, A.1
Denaro, M.2
-
99
-
-
0032005005
-
Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
-
Flint A, Raben A, Astrup A, Holst JJ (1998) Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest 101:515-520
-
(1998)
J Clin Invest
, vol.101
, pp. 515-520
-
-
Flint, A.1
Raben, A.2
Astrup, A.3
Holst, J.J.4
-
100
-
-
0033021677
-
Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men
-
Naslund E, Barkeling B, King N, Gutniak M, Blundell JE, Holst JJ et al. (1999) Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men. Int J Obes Relat Metab Disord 23:304-311
-
(1999)
Int J Obes Relat Metab Disord
, vol.23
, pp. 304-311
-
-
Naslund, E.1
Barkeling, B.2
King, N.3
Gutniak, M.4
Blundell, J.E.5
Holst, J.J.6
-
101
-
-
0032966882
-
Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2
-
Gutzwiller JP, Drewe J, Goke B, Schmidt H, Rohrer B, Lareida J et al. (1999) Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2. Am J Physiol 276:R1541-R1544
-
(1999)
Am J Physiol
, vol.276
-
-
Gutzwiller, J.P.1
Drewe, J.2
Goke, B.3
Schmidt, H.4
Rohrer, B.5
Lareida, J.6
-
102
-
-
0031033531
-
Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM
-
Rachman J, Barrow BA, Levy JC, Turner RC (1997) Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM. Diabetologia 40:205-211
-
(1997)
Diabetologia
, vol.40
, pp. 205-211
-
-
Rachman, J.1
Barrow, B.A.2
Levy, J.C.3
Turner, R.C.4
-
103
-
-
0029907680
-
Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM
-
Nauck MA, Wollschlager D, Werner J, Holst JJ, Orskov C, Creutzfeldt W et al. (1996) Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM. Diabetologia 39:1546-1553
-
(1996)
Diabetologia
, vol.39
, pp. 1546-1553
-
-
Nauck, M.A.1
Wollschlager, D.2
Werner, J.3
Holst, J.J.4
Orskov, C.5
Creutzfeldt, W.6
-
104
-
-
0037045845
-
Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
-
Zander M, Madsbad S, Madsen JL, Holst JJ (2002) Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet 359:824-830
-
(2002)
Lancet
, vol.359
, pp. 824-830
-
-
Zander, M.1
Madsbad, S.2
Madsen, J.L.3
Holst, J.J.4
-
105
-
-
0036869408
-
Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1
-
Holst JJ (2002) Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1. Diabetes Metab Res Rev 18:430-441
-
(2002)
Diabetes Metab Res Rev
, vol.18
, pp. 430-441
-
-
Holst, J.J.1
-
106
-
-
1842846874
-
-
abstract
-
Baron A, Poon T, Taylor K, Nielsen L, Boies S, Zhou J et al. (2003) Exenatide (synthetic exendin-4) showed marked HbA1c decline over 5 months in patients with type 2 diabetes failing oral agents in an open-label study. American Diabetes Association, Late-breaking clinical studies, 3-LB (abstract)
-
(2003)
Exenatide (Synthetic Exendin-4) Showed Marked HbA1c Decline over 5 Months in Patients with Type 2 Diabetes Failing Oral Agents in an Open-label Study. American Diabetes Association, Late-breaking Clinical Studies
, pp. 3-LB
-
-
Baron, A.1
Poon, T.2
Taylor, K.3
Nielsen, L.4
Boies, S.5
Zhou, J.6
-
107
-
-
0031729818
-
The U.K. Prospective Diabetes Study. A review
-
Turner RC (1998) The U.K. Prospective Diabetes Study. A review. Diabetes Care 21 [Suppl 3]:C35-8-C35-C38
-
(1998)
Diabetes Care
, vol.21
, Issue.3 SUPPL.
-
-
Turner, R.C.1
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