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Volumn 47, Issue 3, 2004, Pages 357-366

Incretins, insulin secretion and Type 2 diabetes mellitus

Author keywords

Gastric inhibitory polypeptide; Glucagon like peptide 1; Glucose dependent insulinotropic polypeptide; Incretin effect; Insulin secretion; Type 2 diabetes

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; PEPTIDE HORMONE;

EID: 1842855423     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1342-6     Document Type: Review
Times cited : (381)

References (107)
  • 2
    • 0014188893 scopus 로고
    • Plasma insulin responses to oral and intravenous glucose: Studies in normal and diabetic subjects
    • Perley M, Kipnis DM (1967) Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects. J Clin Invest 46:1954-1962
    • (1967) J Clin Invest , vol.46 , pp. 1954-1962
    • Perley, M.1    Kipnis, D.M.2
  • 3
    • 0022461548 scopus 로고
    • Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
    • Nauck MA, Homberger E, Siegel, Allen RC, Eaton RP, Ebert R et al. (1986) Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab 63:492-498
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 492-498
    • Nauck, M.A.1    Homberger, E.2    Siegel3    Allen, R.C.4    Eaton, R.P.5    Ebert, R.6
  • 4
    • 0020549057 scopus 로고
    • Discrepancy between plasma C-peptide and insulin response to oral and intravenous glucose
    • Madsbad S, Kehlet H, Hilsted J, Tronier B (1983) Discrepancy between plasma C-peptide and insulin response to oral and intravenous glucose. Diabetes 32:436-438
    • (1983) Diabetes , vol.32 , pp. 436-438
    • Madsbad, S.1    Kehlet, H.2    Hilsted, J.3    Tronier, B.4
  • 5
    • 0034740428 scopus 로고    scopus 로고
    • Incretin hormones - An update
    • Holst JJ, Orskov C. Incretin hormones - an update (2001) Scand J Clin Lab Invest 234 [Suppl]:75-85
    • (2001) Scand J Clin Lab Invest , vol.234 , Issue.SUPPL. , pp. 75-85
    • Holst, J.J.1    Orskov, C.2
  • 6
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
    • Nauck M, Stockmann F, Ebert R, Creutzfeldt W (1986) Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 29:46-52
    • (1986) Diabetologia , vol.29 , pp. 46-52
    • Nauck, M.1    Stockmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 7
    • 0002278973 scopus 로고
    • Absence of incretin efect in obese type 2 and diminished effect in lean type 2 and obese subjects
    • abstract
    • Tronier B, Dejgaard A, Andersen T, Madsbad S (1985) Absence of incretin efect in obese type 2 and diminished effect in lean type 2 and obese subjects. Diab Res Clin Pract [Suppl 1]:S568 (abstract)
    • (1985) Diab Res Clin Pract , Issue.1 SUPPL.
    • Tronier, B.1    Dejgaard, A.2    Andersen, T.3    Madsbad, S.4
  • 8
    • 0029043139 scopus 로고
    • Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide
    • Fehmann HC, Goke R, Goke B (1995) Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide. Endocr Rev 16:390-410
    • (1995) Endocr Rev , vol.16 , pp. 390-410
    • Fehmann, H.C.1    Goke, R.2    Goke, B.3
  • 10
    • 0023955686 scopus 로고
    • Immunoreactive gastric inhibitory polypeptide
    • Krarup T (1988) Immunoreactive gastric inhibitory polypeptide. Endocr Rev 9:122-134
    • (1988) Endocr Rev , vol.9 , pp. 122-134
    • Krarup, T.1
  • 11
    • 0027136670 scopus 로고
    • Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain
    • Usdin TB, Mezey E, Button DC, Brownstein MJ, Bonner TI (1993) Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. Endocrinology 133:2861-2870
    • (1993) Endocrinology , vol.133 , pp. 2861-2870
    • Usdin, T.B.1    Mezey, E.2    Button, D.C.3    Brownstein, M.J.4    Bonner, T.I.5
  • 12
    • 0034489385 scopus 로고    scopus 로고
    • Colocalization of GLP-1 and GIP in human and porcine intestine
    • Mortensen K, Petersen LL, Orskov C (2000) Colocalization of GLP-1 and GIP in human and porcine intestine. Ann NY Acad Sci 921:469-472
    • (2000) Ann NY Acad Sci , vol.921 , pp. 469-472
    • Mortensen, K.1    Petersen, L.L.2    Orskov, C.3
  • 13
    • 0002632811 scopus 로고
    • Gastric inhibitory polypeptide
    • Walsh JH, Dockray GJ (eds). Raven Press, New York
    • Pederson RA (1994) Gastric inhibitory polypeptide. In: Walsh JH, Dockray GJ (eds) Gut peptides: biochemistry and physiology. Raven Press, New York, pp 217-260
    • (1994) Gut Peptides: Biochemistry and Physiology , pp. 217-260
    • Pederson, R.A.1
  • 16
    • 0037020242 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway
    • Ehses JA, Pelech SL, Pederson RA, McIntosh CH (2002) Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway. J Biol Chem 277:37088-37097
    • (2002) J Biol Chem , vol.277 , pp. 37088-37097
    • Ehses, J.A.1    Pelech, S.L.2    Pederson, R.A.3    McIntosh, C.H.4
  • 17
    • 0035968291 scopus 로고    scopus 로고
    • A new pathway fpr glucose-dependent insulinotropic poly peptiude (GIP) receptor signaling: Evidence for the involvement of phospholipase A2 in the GIP stimulated insulin secretion
    • Ehses JA, Lee SS, Pederson RA, McIntosh CH (2003) A new pathway fpr glucose-dependent insulinotropic poly peptiude (GIP) receptor signaling: evidence for the involvement of phospholipase A2 in the GIP stimulated insulin secretion. J Biol Chem 276:23667-23673
    • (2003) J Biol Chem , vol.276 , pp. 23667-23673
    • Ehses, J.A.1    Lee, S.S.2    Pederson, R.A.3    McIntosh, C.H.4
  • 18
    • 0034838323 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling
    • Trumper A, Trumper K, Trusheim H, Arnold R, Goke B, Horsch D (2001) Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling. Mol Endocrinol 15:1559-1570
    • (2001) Mol Endocrinol , vol.15 , pp. 1559-1570
    • Trumper, A.1    Trumper, K.2    Trusheim, H.3    Arnold, R.4    Goke, B.5    Horsch, D.6
  • 19
    • 0015791989 scopus 로고
    • Stimulation of insulin secretion by gastric inhibitory polypeptide in man
    • Dupre J, Ross SA, Watson D, Brown JC (1973) Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab 37:826-828
    • (1973) J Clin Endocrinol Metab , vol.37 , pp. 826-828
    • Dupre, J.1    Ross, S.A.2    Watson, D.3    Brown, J.C.4
  • 20
    • 0018185347 scopus 로고
    • Oral glucose augmentation of insulin secretion: Interactions of gastric inhibitory polypeptide with ambient glucose and insuln levels
    • Andersen DK, Elahi D, Brown JC, Tobin JD, Andres R (1978) Oral glucose augmentation of insulin secretion: interactions of gastric inhibitory polypeptide with ambient glucose and insuln levels. J Clin Invest 49:152-161
    • (1978) J Clin Invest , vol.49 , pp. 152-161
    • Andersen, D.K.1    Elahi, D.2    Brown, J.C.3    Tobin, J.D.4    Andres, R.5
  • 21
    • 0020214380 scopus 로고
    • Influence of gastric inhibitory polypeptide antiserum on glucose-induced insulin secretion in rats
    • Ebert R, Creutzfeldt W (1982) Influence of gastric inhibitory polypeptide antiserum on glucose-induced insulin secretion in rats. Endocrinology 111:1601-1606
    • (1982) Endocrinology , vol.111 , pp. 1601-1606
    • Ebert, R.1    Creutzfeldt, W.2
  • 22
    • 0019501075 scopus 로고
    • Depression of insulin release by anti-GIP serum after oral glucose in rats
    • Lauritsen KB, Holst JJ, Moody AJ (1981) Depression of insulin release by anti-GIP serum after oral glucose in rats. Scand J Gastroenterol 16:417-420
    • (1981) Scand J Gastroenterol , vol.16 , pp. 417-420
    • Lauritsen, K.B.1    Holst, J.J.2    Moody, A.J.3
  • 23
    • 0029834106 scopus 로고    scopus 로고
    • Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat
    • Tseng CC, Kieffer TJ, Jarboe LA, Usdin TB, Wolfe MM (1996) Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat. J Clin Invest 98:2440-2445
    • (1996) J Clin Invest , vol.98 , pp. 2440-2445
    • Tseng, C.C.1    Kieffer, T.J.2    Jarboe, L.A.3    Usdin, T.B.4    Wolfe, M.M.5
  • 24
    • 0033744913 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: Demonstration by a receptor antagonist
    • Lewis JT, Dayanandan B, Habener JF, Kieffer TJ (2000) Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist. Endocrinology 141:3710-3716
    • (2000) Endocrinology , vol.141 , pp. 3710-3716
    • Lewis, J.T.1    Dayanandan, B.2    Habener, J.F.3    Kieffer, T.J.4
  • 25
    • 0007866067 scopus 로고    scopus 로고
    • Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide receptor knockout mice
    • Miyawaki K, Yamada Y, Yano H, Niwa H, Ban N, Ihara Y et al. (1999) Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc Natl Acad Sci USA 96:14843-14847
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14843-14847
    • Miyawaki, K.1    Yamada, Y.2    Yano, H.3    Niwa, H.4    Ban, N.5    Ihara, Y.6
  • 26
    • 1442321740 scopus 로고    scopus 로고
    • Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo
    • Gault VA, Parker JC, Harriott P, Flatt PR, O'Harte FP (2002) Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo. J Endocrinol 175:525-533
    • (2002) J Endocrinol , vol.175 , pp. 525-533
    • Gault, V.A.1    Parker, J.C.2    Harriott, P.3    Flatt, P.R.4    O'Harte, F.P.5
  • 27
    • 0024424884 scopus 로고
    • Insulinotropic properties of synthetic human gastric inhibitory polypeptide in man: Interactions with glucose, phenylalanine, and cholecystokinin-8
    • Nauck M, Schmidt WE, Ebert R, Strietzel J, Cantor P, Hoffmann G et al. (1989) Insulinotropic properties of synthetic human gastric inhibitory polypeptide in man: interactions with glucose, phenylalanine, and cholecystokinin-8. J Clin Endocrinol Metab 69:654-662
    • (1989) J Clin Endocrinol Metab , vol.69 , pp. 654-662
    • Nauck, M.1    Schmidt, W.E.2    Ebert, R.3    Strietzel, J.4    Cantor, P.5    Hoffmann, G.6
  • 28
    • 0020520108 scopus 로고
    • Preservation of incretin activity after removal of gastric inhibitory polypeptide (GIP) from rat gut extracts by immunoadsorption
    • Ebert R, Unger H, Creutzfeldt W (1983) Preservation of incretin activity after removal of gastric inhibitory polypeptide (GIP) from rat gut extracts by immunoadsorption. Diabetologia 24:449-454
    • (1983) Diabetologia , vol.24 , pp. 449-454
    • Ebert, R.1    Unger, H.2    Creutzfeldt, W.3
  • 29
    • 0019124304 scopus 로고
    • Gastric inhibitory polypeptide (GIP) and insulin release after small-bowel resection in man
    • Lauritsen KB, Moody AJ, Christensen KC, Lindkaer JS (1980) Gastric inhibitory polypeptide (GIP) and insulin release after small-bowel resection in man. Scand J Gastroenterol 15:833-840
    • (1980) Scand J Gastroenterol , vol.15 , pp. 833-840
    • Lauritsen, K.B.1    Moody, A.J.2    Christensen, K.C.3    Lindkaer, J.S.4
  • 30
    • 0020077877 scopus 로고
    • Gastric inhibitory polypeptide and insulin release in response to oral and intravenous glucose in coeliac disease
    • Lauritsen KB, Lauritzen JB, Christensen KC (1982) Gastric inhibitory polypeptide and insulin release in response to oral and intravenous glucose in coeliac disease. Scand J Gastroenterol 17:241-245
    • (1982) Scand J Gastroenterol , vol.17 , pp. 241-245
    • Lauritsen, K.B.1    Lauritzen, J.B.2    Christensen, K.C.3
  • 31
  • 32
    • 0023008693 scopus 로고
    • Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing
    • Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L, Habener JF (1986). Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 261:11880-11889
    • (1986) J Biol Chem , vol.261 , pp. 11880-11889
    • Mojsov, S.1    Heinrich, G.2    Wilson, I.B.3    Ravazzola, M.4    Orci, L.5    Habener, J.F.6
  • 33
    • 0022971804 scopus 로고
    • Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas
    • Orskov C, Holst JJ, Knuhtsen S, Baldissera FG, Poulsen SS, Nielsen OV (1986) Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas. Endocrinology 119:1467-1475
    • (1986) Endocrinology , vol.119 , pp. 1467-1475
    • Orskov, C.1    Holst, J.J.2    Knuhtsen, S.3    Baldissera, F.G.4    Poulsen, S.S.5    Nielsen, O.V.6
  • 34
    • 0023910424 scopus 로고
    • Oxyntomodulin (glicentin-(33-69)): Pharmacokinetics, binding to liver cell membranes, effects on isolated perfused pig pancreas, and secretion from isolated perfused lower small intestine of pigs
    • Baldissera FG, Holst JJ, Knuhtsen S, Hilsted L, Nielsen OV (1988) Oxyntomodulin (glicentin-(33-69)): pharmacokinetics, binding to liver cell membranes, effects on isolated perfused pig pancreas, and secretion from isolated perfused lower small intestine of pigs. Regul Pept 21:151-166
    • (1988) Regul Pept , vol.21 , pp. 151-166
    • Baldissera, F.G.1    Holst, J.J.2    Knuhtsen, S.3    Hilsted, L.4    Nielsen, O.V.5
  • 35
    • 0020585333 scopus 로고
    • Molecular heterogeneity of glucagon in normal subjects and in patients with glucagon-producing tumours
    • Holst JJ (1983) Molecular heterogeneity of glucagon in normal subjects and in patients with glucagon-producing tumours. Diabetologia 24:359-365
    • (1983) Diabetologia , vol.24 , pp. 359-365
    • Holst, J.J.1
  • 36
    • 0033175006 scopus 로고    scopus 로고
    • Glucagon-like Peptide 1 (GLP-1): An intestinal hormone signalling nutritional abundance, with an unusual therapeutic potential
    • Holst JJ (1999) Glucagon-like Peptide 1 (GLP-1): an intestinal hormone signalling nutritional abundance, with an unusual therapeutic potential. Trends Endocrinol Metab 10:229-234
    • (1999) Trends Endocrinol Metab , vol.10 , pp. 229-234
    • Holst, J.J.1
  • 37
    • 0029765475 scopus 로고    scopus 로고
    • Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day
    • Orskov C, Wettergren A, Holst JJ (1996) Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day. Scand J Gastroenterol 31:665-670
    • (1996) Scand J Gastroenterol , vol.31 , pp. 665-670
    • Orskov, C.1    Wettergren, A.2    Holst, J.J.3
  • 38
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • Kreymann B, Williams G, Ghatei MA, Bloom SR (1987) Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 2:1300-1304
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 39
    • 0028883257 scopus 로고
    • Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amide
    • Kolligs F, Fehmann HC, Goke R, Goke B (1995) Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amide. Diabetes 44:16-19
    • (1995) Diabetes , vol.44 , pp. 16-19
    • Kolligs, F.1    Fehmann, H.C.2    Goke, R.3    Goke, B.4
  • 41
    • 0032960834 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: Studies with the antagonist exendin 9-39
    • Edwards CM, Todd JF, Mahmoudi M, Wang Z, Wang RM, Ghatei MA et al. (1999) Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39. Diabetes 48:86-93
    • (1999) Diabetes , vol.48 , pp. 86-93
    • Edwards, C.M.1    Todd, J.F.2    Mahmoudi, M.3    Wang, Z.4    Wang, R.M.5    Ghatei, M.A.6
  • 42
    • 0029958404 scopus 로고    scopus 로고
    • Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
    • Scrocchi LA, Brown TJ, MaClusky N, Brubaker PL, Auerbach AB, Joyner AL et al. (1996) Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med 2:1254-1258
    • (1996) Nat Med , vol.2 , pp. 1254-1258
    • Scrocchi, L.A.1    Brown, T.J.2    Maclusky, N.3    Brubaker, P.L.4    Auerbach, A.B.5    Joyner, A.L.6
  • 43
    • 0031747107 scopus 로고    scopus 로고
    • Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- Mice
    • Pederson RA, Satkunarajah M, McIntosh CH, Scrocchi LA, Flamez D, Schuit F et al. (1998) Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/-mice. Diabetes 47:1046-1052
    • (1998) Diabetes , vol.47 , pp. 1046-1052
    • Pederson, R.A.1    Satkunarajah, M.2    McIntosh, C.H.3    Scrocchi, L.A.4    Flamez, D.5    Schuit, F.6
  • 44
    • 0029147672 scopus 로고
    • Glucagon-like peptide 1 (7-36 amide) secretion in response to luminal sucrose from the upper and lower gut. A study using alpha-glucosidase inhibition (acarbose)
    • Qualmann C, Nauck MA, Holst JJ, Orskov C, Creutzfeldt W (1995) Glucagon-like peptide 1 (7-36 amide) secretion in response to luminal sucrose from the upper and lower gut. A study using alpha-glucosidase inhibition (acarbose). Scand J Gastroenterol 30:892-896
    • (1995) Scand J Gastroenterol , vol.30 , pp. 892-896
    • Qualmann, C.1    Nauck, M.A.2    Holst, J.J.3    Orskov, C.4    Creutzfeldt, W.5
  • 45
    • 0037784011 scopus 로고    scopus 로고
    • GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine
    • Mortensen K, Christensen LL, Holst JJ, Orskov C (2003) GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine. Regul Pept 114:189-196
    • (2003) Regul Pept , vol.114 , pp. 189-196
    • Mortensen, K.1    Christensen, L.L.2    Holst, J.J.3    Orskov, C.4
  • 46
    • 0028953577 scopus 로고
    • Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
    • Deacon CF, Johnsen AH, Holst JJ (1995) Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J Clin Endocrinol Metab 80:952-957
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 952-957
    • Deacon, C.F.1    Johnsen, A.H.2    Holst, J.J.3
  • 47
    • 0029118049 scopus 로고
    • Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • Kieffer TJ, McIntosh CH, Pederson RA (1995) Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 136:3585-3596
    • (1995) Endocrinology , vol.136 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.2    Pederson, R.A.3
  • 48
    • 0033766716 scopus 로고    scopus 로고
    • Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide
    • Deacon CF, Nauck MA, Meier J, Hucking K, Holst JJ (2000) Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide. J Clin Endocrinol Metab 85:3575-3581
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3575-3581
    • Deacon, C.F.1    Nauck, M.A.2    Meier, J.3    Hucking, K.4    Holst, J.J.5
  • 49
    • 0030607672 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor
    • Knudsen LB, Pridal L (1996) Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur J Pharmacol 318:429-435
    • (1996) Eur J Pharmacol , vol.318 , pp. 429-435
    • Knudsen, L.B.1    Pridal, L.2
  • 50
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26) - Role in the inactivation of regulatory peptides
    • Mentlein R (1999) Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides. Regul Pept 85:9-24
    • (1999) Regul Pept , vol.85 , pp. 9-24
    • Mentlein, R.1
  • 51
    • 0028803336 scopus 로고
    • Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects
    • Deacon CF, Nauck MA, Toft-Nielsen M, Pridal L, Willms B, Holst JJ (1995) Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects. Diabetes 44:1126-1131
    • (1995) Diabetes , vol.44 , pp. 1126-1131
    • Deacon, C.F.1    Nauck, M.A.2    Toft-Nielsen, M.3    Pridal, L.4    Willms, B.5    Holst, J.J.6
  • 52
    • 0037241085 scopus 로고    scopus 로고
    • Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
    • Vilsboll T, Agerso H, Krarup T, Holst JJ (2003) Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab 88:220-224
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 220-224
    • Vilsboll, T.1    Agerso, H.2    Krarup, T.3    Holst, J.J.4
  • 53
    • 0029797540 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig
    • Deacon CF, Pridal L, Klarskov L, Olesen M, Holst JJ (1996) Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig. Am J Physiol 271:E458-E464
    • (1996) Am J Physiol , vol.271
    • Deacon, C.F.1    Pridal, L.2    Klarskov, L.3    Olesen, M.4    Holst, J.J.5
  • 54
    • 0001095690 scopus 로고    scopus 로고
    • Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
    • Vilsboll T, Krarup T, Deacon CF, Madsbad S, Holst JJ (2001) Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 50:609-613
    • (2001) Diabetes , vol.50 , pp. 609-613
    • Vilsboll, T.1    Krarup, T.2    Deacon, C.F.3    Madsbad, S.4    Holst, J.J.5
  • 55
    • 0037902984 scopus 로고    scopus 로고
    • Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus
    • Vilsboll T, Krarup T, Sonne J, Madsbad S, Volund A, Juul AG et al. (2003) Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus. J Clin Endocrinol Metab 88:2706-2713
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2706-2713
    • Vilsboll, T.1    Krarup, T.2    Sonne, J.3    Madsbad, S.4    Volund, A.5    Juul, A.G.6
  • 56
    • 0037241085 scopus 로고    scopus 로고
    • Similar elimination rates of GLP-1 in obese type diabetic patients and healthy subjects
    • Vilsboll T, Agersoe H, Krarup T, Holst JJ (2003) Similar elimination rates of GLP-1 in obese type diabetic patients and healthy subjects. J Clin Endocrinol Metab 88:220-224
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 220-224
    • Vilsboll, T.1    Agersoe, H.2    Krarup, T.3    Holst, J.J.4
  • 57
    • 0035403058 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs
    • Deacon CF, Danielsen P, Klarskov L, Olesen M, Holst JJ (2001) Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs. Diabetes 50:1588-1597
    • (2001) Diabetes , vol.50 , pp. 1588-1597
    • Deacon, C.F.1    Danielsen, P.2    Klarskov, L.3    Olesen, M.4    Holst, J.J.5
  • 58
    • 0028945815 scopus 로고
    • Effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-I-(7-36) on insulin secretion
    • Jia X, Brown JC, Ma P, Pederson RA, McIntosh CH (1995) Effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-I-(7-36) on insulin secretion. Am J Physiol 268:E645-E651
    • (1995) Am J Physiol , vol.268
    • Jia, X.1    Brown, J.C.2    Ma, P.3    Pederson, R.A.4    McIntosh, C.H.5
  • 59
    • 0028224617 scopus 로고
    • The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects
    • Elahi D, McAloon Dyke M, Fukagawa NK, Meneilly GS, Sclater AL, Minaker KL et al. (1994) The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects. Regul Pept 51:63-74
    • (1994) Regul Pept , vol.51 , pp. 63-74
    • Elahi, D.1    McAloon Dyke, M.2    Fukagawa, N.K.3    Meneilly, G.S.4    Sclater, A.L.5    Minaker, K.L.6
  • 60
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W (1993) Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 91:301-307
    • (1993) J Clin Invest , vol.91 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 61
    • 0027419106 scopus 로고
    • Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations
    • Nauck MA, Bartels E, Orskov C, Ebert R, Creutzfeldt W (1993) Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations. J Clin Endocrinol Metab 76:912-917
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 912-917
    • Nauck, M.A.1    Bartels, E.2    Orskov, C.3    Ebert, R.4    Creutzfeldt, W.5
  • 62
    • 0031721391 scopus 로고    scopus 로고
    • Exaggerated secretion of glucagon-like peptide-1 (GLP-1) could cause reactive hypoglycaemia
    • Toft-Nielsen M, Madsbad S, Holst JJ (1998) Exaggerated secretion of glucagon-like peptide-1 (GLP-1) could cause reactive hypoglycaemia. Diabetologia 41:1180-1186
    • (1998) Diabetologia , vol.41 , pp. 1180-1186
    • Toft-Nielsen, M.1    Madsbad, S.2    Holst, J.J.3
  • 63
    • 0023179206 scopus 로고
    • Effect of porcine gastric inhibitory polypeptide on beta-cell function in type I and type II diabetes mellitus
    • Krarup T, Saurbrey N, Moody AJ, Kuhl C, Madsbad S (1987) Effect of porcine gastric inhibitory polypeptide on beta-cell function in type I and type II diabetes mellitus. Metabolism 36:677-682
    • (1987) Metabolism , vol.36 , pp. 677-682
    • Krarup, T.1    Saurbrey, N.2    Moody, A.J.3    Kuhl, C.4    Madsbad, S.5
  • 64
    • 0038121744 scopus 로고    scopus 로고
    • Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects
    • Vilsboll T, Krarup T, Madsbad S, Holst JJ (2003) Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects. Regul Pept 114:115-121
    • (2003) Regul Pept , vol.114 , pp. 115-121
    • Vilsboll, T.1    Krarup, T.2    Madsbad, S.3    Holst, J.J.4
  • 65
    • 1842857888 scopus 로고    scopus 로고
    • Disruption of both GLP-1 and GIP signalling pathways in the mouse leads to glucose intolerance
    • abstract
    • Preitner F, Burcelin R, Ibberson M, Hansotia T, Drucker D, Thorens B (2002) Disruption of both GLP-1 and GIP signalling pathways in the mouse leads to glucose intolerance. Diabetes 51 [Suppl 2]:A66 (abstract)
    • (2002) Diabetes , vol.51 , Issue.2 SUPPL.
    • Preitner, F.1    Burcelin, R.2    Ibberson, M.3    Hansotia, T.4    Drucker, D.5    Thorens, B.6
  • 67
    • 0029856880 scopus 로고    scopus 로고
    • Gut incretin hormones in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM) - Evidence for decreased glucagon-like peptide 1 secretion during oral glucose ingestion in NIDDM twins
    • Vaag AA, Holst JJ, Volund A, Beck-Nielsen HB (1996) Gut incretin hormones in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM) - evidence for decreased glucagon-like peptide 1 secretion during oral glucose ingestion in NIDDM twins. Eur J Endocrinol 135:425-432
    • (1996) Eur J Endocrinol , vol.135 , pp. 425-432
    • Vaag, A.A.1    Holst, J.J.2    Volund, A.3    Beck-Nielsen, H.B.4
  • 68
    • 0032757178 scopus 로고    scopus 로고
    • Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of Type II (non-insulin-dependent) diabetic parents: Evidence of several aberrations
    • Nyholm B, Walker M, Gravholt CH, Shearing PA, Sturis J, Alberti KG et al. (1999) Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of Type II (non-insulin-dependent) diabetic parents: evidence of several aberrations. Diabetologia 42:1314-1323
    • (1999) Diabetologia , vol.42 , pp. 1314-1323
    • Nyholm, B.1    Walker, M.2    Gravholt, C.H.3    Shearing, P.A.4    Sturis, J.5    Alberti, K.G.6
  • 69
    • 0034054153 scopus 로고    scopus 로고
    • Lack of germline mutations in the proglucagon gene region coding for glucagon-like peptide 1 in type 2 diabetic (NIDDM) patients
    • Nauck M, Hahn S, Sauerwald A, Schmeigel W (2000) Lack of germline mutations in the proglucagon gene region coding for glucagon-like peptide 1 in type 2 diabetic (NIDDM) patients. Exp Clin Endocrinol Diabetes 108:72-75
    • (2000) Exp Clin Endocrinol Diabetes , vol.108 , pp. 72-75
    • Nauck, M.1    Hahn, S.2    Sauerwald, A.3    Schmeigel, W.4
  • 70
    • 0001292237 scopus 로고    scopus 로고
    • Lack of germ-line mutations in the GIP-coding region of the pro-GIP in type II diabetic patients
    • abstract
    • Orskov C, Vilsboll T, Krarup T, Inagaki N, Hjorth SA (1999) Lack of germ-line mutations in the GIP-coding region of the pro-GIP in type II diabetic patients. Diabetes 48 [Suppl 1]:A427 (abstract)
    • (1999) Diabetes , vol.48 , Issue.1 SUPPL.
    • Orskov, C.1    Vilsboll, T.2    Krarup, T.3    Inagaki, N.4    Hjorth, S.A.5
  • 71
    • 0030876081 scopus 로고    scopus 로고
    • The pathogenesis of NIDDM involves a defective expression of the GIP receptor
    • Holst JJ, Gromada J, Nauck MA (1997) The pathogenesis of NIDDM involves a defective expression of the GIP receptor. Diabetologia 40:984-986
    • (1997) Diabetologia , vol.40 , pp. 984-986
    • Holst, J.J.1    Gromada, J.2    Nauck, M.A.3
  • 72
    • 10544249875 scopus 로고    scopus 로고
    • Identification of two missense mutations in the GIP receptor gene: A functional study and association analysis with NIDDM: No evidence of association with Japanese NIDDM subjects
    • Kubota A, Yamada Y, Hayami T, Yasuda K, Someya Y, Ihara Y et al. (1996) Identification of two missense mutations in the GIP receptor gene: a functional study and association analysis with NIDDM: no evidence of association with Japanese NIDDM subjects. Diabetes 45:1701-1705
    • (1996) Diabetes , vol.45 , pp. 1701-1705
    • Kubota, A.1    Yamada, Y.2    Hayami, T.3    Yasuda, K.4    Someya, Y.5    Ihara, Y.6
  • 73
    • 0031781959 scopus 로고    scopus 로고
    • Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: The impact on the pancreatic beta cell responses and functionel expression studies in Chinese hamster fibroblast cells
    • Almind K, Ambye L, Urhammer SA, Hansen T, Echwald SM, Holst JJ et al. (1998) Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functionel expression studies in Chinese hamster fibroblast cells. Diabetologia 41:1194-1198
    • (1998) Diabetologia , vol.41 , pp. 1194-1198
    • Almind, K.1    Ambye, L.2    Urhammer, S.A.3    Hansen, T.4    Echwald, S.M.5    Holst, J.J.6
  • 74
    • 0035041250 scopus 로고    scopus 로고
    • Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
    • Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA (2001) Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes 50:1004-1011
    • (2001) Diabetes , vol.50 , pp. 1004-1011
    • Lynn, F.C.1    Pamir, N.2    Ng, E.H.3    McIntosh, C.H.4    Kieffer, T.J.5    Pederson, R.A.6
  • 75
    • 0035512742 scopus 로고    scopus 로고
    • Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes
    • Meier JJ, Hucking K, Holst JJ, Deacon CF, Schmiegel WH, Nauck MA (2001) Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes. Diabetes 50:2497-2504
    • (2001) Diabetes , vol.50 , pp. 2497-2504
    • Meier, J.J.1    Hucking, K.2    Holst, J.J.3    Deacon, C.F.4    Schmiegel, W.H.5    Nauck, M.A.6
  • 77
    • 0036373430 scopus 로고    scopus 로고
    • Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients
    • Vilsboll T, Krarup T, Madsbad S, Holst JJ (2002) Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients. Diabetologia 45:1111-1119
    • (2002) Diabetologia , vol.45 , pp. 1111-1119
    • Vilsboll, T.1    Krarup, T.2    Madsbad, S.3    Holst, J.J.4
  • 79
    • 0037312821 scopus 로고    scopus 로고
    • The influence of GLP-1 on glucose-stimulated insulin secretion: Effects on beta-cell sensitivity in type 2 and nondiabetic subjects
    • Kjems LL, Holst JJ, Volund A, Madsbad S (2003) The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects. Diabetes 52:380-386
    • (2003) Diabetes , vol.52 , pp. 380-386
    • Kjems, L.L.1    Holst, J.J.2    Volund, A.3    Madsbad, S.4
  • 80
    • 0242383351 scopus 로고    scopus 로고
    • The pathophysiology of diabetes involves a defective amplification of the late phase insulin response to glucose by GIP - Regardless of aetiology and phenotype
    • Vilsboll T, Knop FK, Krarup T, Johansen A, Madsbad S, Larsen S et al. (2003) The pathophysiology of diabetes involves a defective amplification of the late phase insulin response to glucose by GIP - regardless of aetiology and phenotype. J Clin Endocrinol Metab 88:4897-4903
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4897-4903
    • Vilsboll, T.1    Knop, F.K.2    Krarup, T.3    Johansen, A.4    Madsbad, S.5    Larsen, S.6
  • 81
    • 0031910187 scopus 로고    scopus 로고
    • Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1
    • Gromada J, Holst JJ, Rorsman P (1998) Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1. Pflugers Arch 435:583-594
    • (1998) Pflugers Arch , vol.435 , pp. 583-594
    • Gromada, J.1    Holst, J.J.2    Rorsman, P.3
  • 82
    • 0036022670 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide analogues: Do they have a therapeutic role in diabetes mellitus similar to that of glucagon-like Peptide-1?
    • Holst JJ (2002) Gastric inhibitory polypeptide analogues: do they have a therapeutic role in diabetes mellitus similar to that of glucagon-like Peptide-1? BioDrugs 16:175-181
    • (2002) BioDrugs , vol.16 , pp. 175-181
    • Holst, J.J.1
  • 83
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Orskov C, Holst JJ, Willms B, Creutzfeldt W (1993) Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 36:741-744
    • (1993) Diabetologia , vol.36 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3    Holst, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 84
    • 0028904931 scopus 로고
    • Insulinotropic actions of intravenous glucagon-like peptide-1 (GLP-1) [7-36 amide] in the fasting state in healthy subjects
    • Qualmann C, Nauck MA, Holst JJ, Orskov C, Creutzfeldt W (1995) Insulinotropic actions of intravenous glucagon-like peptide-1 (GLP-1) [7-36 amide] in the fasting state in healthy subjects. Acta Diabetol 32:13-16
    • (1995) Acta Diabetol , vol.32 , pp. 13-16
    • Qualmann, C.1    Nauck, M.A.2    Holst, J.J.3    Orskov, C.4    Creutzfeldt, W.5
  • 85
    • 0035081369 scopus 로고    scopus 로고
    • No reactive hypoglycaemia in Type 2 diabetic patients after subcutaneous administration of GLP-1 and intravenous glucose
    • Vilsboll T, Krarup T, Madsbad S, Holst JJ (2001) No reactive hypoglycaemia in Type 2 diabetic patients after subcutaneous administration of GLP-1 and intravenous glucose. Diabet Med 18:144-149
    • (2001) Diabet Med , vol.18 , pp. 144-149
    • Vilsboll, T.1    Krarup, T.2    Madsbad, S.3    Holst, J.J.4
  • 86
    • 0026535588 scopus 로고
    • Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells
    • Fehmann HC, Habener JF (1992) Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. Endocrinology 130:159-166
    • (1992) Endocrinology , vol.130 , pp. 159-166
    • Fehmann, H.C.1    Habener, J.F.2
  • 87
    • 0032768616 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells
    • Buteau J, Roduit R, Susini S, Prentki M (1999) Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells. Diabetologia 42:856-864
    • (1999) Diabetologia , vol.42 , pp. 856-864
    • Buteau, J.1    Roduit, R.2    Susini, S.3    Prentki, M.4
  • 88
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    • Xu G, Stoffers DA, Habener JF, Bonner-Weir S (1999) Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48:2270-2276
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 89
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF et al. (2000) Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49:741-748
    • (2000) Diabetes , vol.49 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3    Drucker, D.J.4    Bonner-Weir, S.5    Habener, J.F.6
  • 90
    • 0033512486 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and exendin-4 convert pancrteatic AR42J cells into glucagon- and insulin-producing cells
    • Zhou J, Wang X, Pineyro MA, Egan JM (1999) Glucagon-like peptide 1 and exendin-4 convert pancrteatic AR42J cells into glucagon-and insulin-producing cells. Diabetes 48:2358-2366
    • (1999) Diabetes , vol.48 , pp. 2358-2366
    • Zhou, J.1    Wang, X.2    Pineyro, M.A.3    Egan, J.M.4
  • 91
    • 0037312818 scopus 로고    scopus 로고
    • Glucagon-like peptides: Regulators of cell proliferation, differentiation, and apoptosis
    • Drucker DJ (2003) Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis. Mol Endocrinol 17:161-171
    • (2003) Mol Endocrinol , vol.17 , pp. 161-171
    • Drucker, D.J.1
  • 92
    • 0034522773 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
    • Perfetti R, Zhou J, Doyle ME, Egan JM (2000) Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 141:4600-4605
    • (2000) Endocrinology , vol.141 , pp. 4600-4605
    • Perfetti, R.1    Zhou, J.2    Doyle, M.E.3    Egan, J.M.4
  • 93
    • 0029954211 scopus 로고    scopus 로고
    • Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients
    • Creutzfeldt WO, Kleine N, Willms B, Orskov C, Holst JJ, Nauck MA (1996) Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients. Diabetes Care 19:580-586
    • (1996) Diabetes Care , vol.19 , pp. 580-586
    • Creutzfeldt, W.O.1    Kleine, N.2    Willms, B.3    Orskov, C.4    Holst, J.J.5    Nauck, M.A.6
  • 94
    • 0029760864 scopus 로고    scopus 로고
    • Evidence for a major role for glucagon in regulation of plasma glucose in conscious, nondiabetic, and alloxan-induced diabetic rabbits
    • Brand CL, Jorgensen PN, Svendsen I, Holst JJ (1996) Evidence for a major role for glucagon in regulation of plasma glucose in conscious, nondiabetic, and alloxan-induced diabetic rabbits. Diabetes 45:1076-1083
    • (1996) Diabetes , vol.45 , pp. 1076-1083
    • Brand, C.L.1    Jorgensen, P.N.2    Svendsen, I.3    Holst, J.J.4
  • 95
    • 0035195977 scopus 로고    scopus 로고
    • Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans
    • Petersen KF, Sullivan JT (2001) Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans. Diabetologia 44:2018-2024
    • (2001) Diabetologia , vol.44 , pp. 2018-2024
    • Petersen, K.F.1    Sullivan, J.T.2
  • 97
    • 0030667056 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans
    • Nauck MA, Niedereichholz U, Ettler R, Holst JJ, Orskov C, Ritzel R et al. (1997) Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol 273:E981-E988
    • (1997) Am J Physiol , vol.273
    • Nauck, M.A.1    Niedereichholz, U.2    Ettler, R.3    Holst, J.J.4    Orskov, C.5    Ritzel, R.6
  • 98
    • 0031779868 scopus 로고    scopus 로고
    • Roles of amylin in diabetes and in regulation of nutrient load
    • Young A, Denaro M (1998) Roles of amylin in diabetes and in regulation of nutrient load Nutrition 14:524-527
    • (1998) Nutrition , vol.14 , pp. 524-527
    • Young, A.1    Denaro, M.2
  • 99
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • Flint A, Raben A, Astrup A, Holst JJ (1998) Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest 101:515-520
    • (1998) J Clin Invest , vol.101 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 101
    • 0032966882 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2
    • Gutzwiller JP, Drewe J, Goke B, Schmidt H, Rohrer B, Lareida J et al. (1999) Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2. Am J Physiol 276:R1541-R1544
    • (1999) Am J Physiol , vol.276
    • Gutzwiller, J.P.1    Drewe, J.2    Goke, B.3    Schmidt, H.4    Rohrer, B.5    Lareida, J.6
  • 102
    • 0031033531 scopus 로고    scopus 로고
    • Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM
    • Rachman J, Barrow BA, Levy JC, Turner RC (1997) Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM. Diabetologia 40:205-211
    • (1997) Diabetologia , vol.40 , pp. 205-211
    • Rachman, J.1    Barrow, B.A.2    Levy, J.C.3    Turner, R.C.4
  • 103
    • 0029907680 scopus 로고    scopus 로고
    • Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM
    • Nauck MA, Wollschlager D, Werner J, Holst JJ, Orskov C, Creutzfeldt W et al. (1996) Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM. Diabetologia 39:1546-1553
    • (1996) Diabetologia , vol.39 , pp. 1546-1553
    • Nauck, M.A.1    Wollschlager, D.2    Werner, J.3    Holst, J.J.4    Orskov, C.5    Creutzfeldt, W.6
  • 104
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
    • Zander M, Madsbad S, Madsen JL, Holst JJ (2002) Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet 359:824-830
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 105
    • 0036869408 scopus 로고    scopus 로고
    • Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1
    • Holst JJ (2002) Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1. Diabetes Metab Res Rev 18:430-441
    • (2002) Diabetes Metab Res Rev , vol.18 , pp. 430-441
    • Holst, J.J.1
  • 107
    • 0031729818 scopus 로고    scopus 로고
    • The U.K. Prospective Diabetes Study. A review
    • Turner RC (1998) The U.K. Prospective Diabetes Study. A review. Diabetes Care 21 [Suppl 3]:C35-8-C35-C38
    • (1998) Diabetes Care , vol.21 , Issue.3 SUPPL.
    • Turner, R.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.