Identification of autoantibody-negative autoimmune type 2 diabetic patients

Diabetes Care

Volumn 34, Issue 1, 2011, Pages 168-173

  Brooks Worrell, Barbara M ^a,b,c,d   Reichow, Jessica L ^c   Goel, Amit ^e   Ismail, Heba ^f,g   Palmer, Jerry P ^a,b,c,d  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Puget Sound Health Care System   (United States)

^c Seattle Institute for Biomedical and Clinical Research   (United States)

^d Dept of Obstetrics and Gynecology   (United States)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^f CAIRO UNIVERSITY   (Egypt)

^g TC Thompson Children's Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; AUTOANTIBODY; C PEPTIDE; GLUCAGON; GLUTAMATE DECARBOXYLASE ANTIBODY; INSULIN; INSULIN ANTIBODY; INSULIN AUTOANTIBODY; INSULINOMA ASSOCIATED PROTEIN 2 AUTOANTIBODY; ORAL ANTIDIABETIC AGENT; PANCREAS ISLET CELL ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; ZINC TRANSPORTER; ZINC TRANSPORTER AUTOANTIBODY;

ADULT; AGED; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BODY MASS; CELL FUNCTION; CELLULAR IMMUNITY; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DIABETIC PATIENT; DIAGNOSTIC TEST ACCURACY STUDY; DIET RESTRICTION; DISEASE DURATION; HUMAN; IMMUNOBLOTTING; IMMUNOREACTIVITY; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PHENOTYPE; SCREENING TEST; SENSITIVITY AND SPECIFICITY; T LYMPHOCYTE;

ADULT; AGED; AUTOANTIBODIES; C-PEPTIDE; DIABETES MELLITUS, TYPE 2; HAPLOTYPES; HUMANS; IMMUNOBLOTTING; INSULIN RESISTANCE; MIDDLE AGED; T-LYMPHOCYTES;

EID: 79951689303     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc10-0579     Document Type: Article

References (25)

1. Lampeter EF, Homberg M, Quabeck K, Schaefer UW, Wernet P, Bertrams J, Grosse-Wilde H, Gries FA, Kolb H. Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation. Lancet 1993;341:1243-1244 (Pubitemid 23146932)
2. Ehses JA, Ellingsgaard H, Böni-Schnetzler M, Donath MY. Pancreatic islet inflammation in type 2 diabetes: from α and β cell compensation to dysfunction. Arch Physiol Biochem 2009;115:240-147
3. Donath MY, Schumann DM, Faulenbach M, Ellingsgaard H, Perren A, Ehses JA. Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Diabetes Care 2008;31:S161-S164
4. Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG. Islet-associated macrophages in type 2 diabetes. Diabetologia 2009;52:1686-1688
5. Juneja R, Hirsch IB, Naik RG, Brooks-Worrell BM, Greenbaum CJ, Palmer JP. Islet cell antibodies and glutamic acid decarboxylase antibodies, but not the clinical phenotype, help to identify type 1(1/2) diabetes in patients presenting with type 2 diabetes. Metabolism 2001;50:1008-1013 (Pubitemid 32904156)
6. Lohmann T, Sessler J, Verlohren HJ, Schröder S, Rötger J, Dãhn K, Morgenthaler N, Scherbaum WA. Distinct genetic and immunological features in patients with onset of IDDM before and after age 40. Diabetes Care 1997;20:524-529 (Pubitemid 27143409)
7. Wang J, Miao D, Babu S, Yu J, Barker J, Klingensmith G, Rewers M, Eisenbarth GS, Yu L. Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesity. J Clin Endocrinol Metab 2007;92:88-92 (Pubitemid 46075008)
8. Nagata M, Moriyama H, Kotani R, Yasuda H, Kishi M, Kurohara M, Hara K, Yokono K. Immunological aspects of 'fulminant type 1 diabetes.' Diabetes Res Clin Pract 2007(Suppl.);77:S99-S103
9. Seyfert-Margolis V, Gisler TD, Asare AL, Wang RS, Dosch HM, Brooks-Worrell B, Eisenbarth GS, Palmer JP, Greenbaum CJ, Gitelman SE, Nepom GT, Bluestone JA, Herold KC. Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study. Diabetes 2006; 55:2588-2594 (Pubitemid 44871160)
10. Herold KC, Brooks-Worrell B, Palmer J, Dosch HM, Peakman M, Gottlieb P, Reijonen H, Arif S, Spain LM, Thompson C, Lachin JM, Type 1 Diabetes Trail Net Research Group. Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes. Diabetes 2009;58:2588-2595
11. Brooks-Worrell BM, Starkebaum GA, Greenbaum C, Palmer JP. Peripheral blood mononuclear cells of insulin-dependent diabetic patients respond to multiple islet cell proteins. J Immunol 1996; 157:5668-5674 (Pubitemid 126448991)
12. Goel A, Chiu H, Felton J, Palmer JP, Brooks-Worrell B. T cell responses to islet antigens improves detection of autoimmune diabetes and identifies patients with more severe β-cell lesions in phenotypic type 2 diabetes. Diabetes 2007;56: 2110-2115 (Pubitemid 47195836)
13. Brooks-Worrell BM, Juneja R, Minokadeh A, Greenbaum CJ, Palmer JP. Cellular immune responses to human islet proteins in antibody-positive type 2 diabetes patients. Diabetes 1999;48:983-988 (Pubitemid 29226343)
14. 3H recombinant human ligands. J Immunol Methods 1995;196:89-99
15. Törn C, Mueller PW, Schlosser M, Bonifacio E, Bingley PJ. Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2. Diabetologia 2008;51:846-852
16. Wenzlau JM, Juhl K, Yu L, Moua O, Sarkar SA, Gottlieb P, Rewers M, Eisenbarth GS, Jensen J, Davidson HW, Hutton JC. Hutton JC. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci USA 2007;104:17040-17045 (Pubitemid 350210987)
17. Rowe RE, Leech NJ, Nepom GT, Mc- Culloch DK. High genetic risk for IDDM in the Pacific northwest: first report from the Washington State Diabetes Prediction Study. Diabetes 1994;43:87-94
18. Schatz D, Krischer J, Horne G, Riley W, Spillar R, Silverstein J, Winter W, Muir A, Derovanesian D, Shah S. Derovanesian D, Shah S, Malone J, MaClaren N. Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerfully as in unaffected relatives. J Clin Invest 1994;93:2403-2407 (Pubitemid 24177152)
19. Yu L, Rewers M, Gianani R, Kawasaki E, Zhang Y, Verge C, Chase P, Klingensmith G, Erlich H, Norris J, Eisenbarth GS. Antiislet autoantibodies usually develop sequentially rather than simultaneously. J Clin Endocrinol Metab 1996;81:4264-4267 (Pubitemid 26412027)
20. Yu L, Robles DT, Abiru N, Kaur P, Rewers M, Kelemen K, Eisenbarth GS. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc Natl Acad Sci USA 2000;97: 1701-1706 (Pubitemid 30118506)
21. Ringquist S, Nichol L, Trucco M. Transplantation genetics. In Principles and Practice of Medical Genetics. 5th ed. Elsevier, Philadelphia PA, 2007, p. 983-1010
22. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419 (Pubitemid 15018832)
23. Brooks-Worrell B, Warsen A, Palmer JP. Improved T cell assay for identification of type 1 diabetes patients. J Immunol Methods 2009;344:79-83
24. Desai M, Clark A. Autoimmune diabetes in adults: lessons from the UKPDS. Diabet Med 2008;25:30-34 (Pubitemid 352020093)
25. Greenbaum CJ, Mandrup-Poulsen T, McGee PF, Battelino T, Haastert B, Ludvigsson J, Pozzilli P, Lachin JM, Kolb H, Type 1 Diabetes Trial Net Research Group, European C-Peptide Trial Study Group. Mixed-mean tolerance test versus glucagons stimulation test for the assessment of β-cell function in therapeutic trials in type 1 diabetes. Diabetes Care 2008; 10:1966-1971