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Volumn 68, Issue 10, 2013, Pages 1197-1208

Basic biology of skeletal aging: Role of stress response pathways

Author keywords

Autophagy; Bone; Mesenchymal stem cells; Osteocytes; Oxidative stress.

Indexed keywords

GLUCOCORTICOID; GROWTH PROMOTOR; SEX HORMONE;

EID: 84885015478     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glt079     Document Type: Article
Times cited : (168)

References (168)
  • 3
    • 77952111123 scopus 로고    scopus 로고
    • Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: A cross-sectional study
    • Zebaze RM, Ghasem-Zadeh A, Bohte A, et al. Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study. Lancet. 2010;375:1729-1736.
    • (2010) Lancet , vol.375 , pp. 1729-1736
    • Zebaze, R.M.1    Ghasem-Zadeh, A.2    Bohte, A.3
  • 4
    • 0021222303 scopus 로고
    • Age-related structural changes in trabecular and cortical bone: Cellular mechanisms and biomechanical consequences
    • Parfitt AM. Age-related structural changes in trabecular and cortical bone: cellular mechanisms and biomechanical consequences. Calcif Tissue Int. 1984;36(suppl 1):S123-S128. (Pubitemid 14043326)
    • (1984) Calcified Tissue International , vol.36 , Issue.SUPPL. 1
    • Parfitt, A.M.1
  • 5
    • 77953520506 scopus 로고    scopus 로고
    • Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia
    • Burghardt AJ, Kazakia GJ, Ramachandran S, Link TM, Majumdar S. Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia. J Bone Miner Res. 2010;25:983-993.
    • (2010) J Bone Miner Res , vol.25 , pp. 983-993
    • Burghardt, A.J.1    Kazakia, G.J.2    Ramachandran, S.3    Link, T.M.4    Majumdar, S.5
  • 6
    • 0027170485 scopus 로고
    • Age-related changes in the tensile properties of cortical bone. The relative importance of changes in porosity, mineralization and microstructure
    • McCalden RW, McGeough JA, Barker MB, Court-Brown CM. Agerelated changes in the tensile properties of cortical bone. The relative importance of changes in porosity, mineralization, and microstructure. J Bone Joint Surg Am. 1993;75:1193-1205. (Pubitemid 23267911)
    • (1993) Journal of Bone and Joint Surgery - Series A , vol.75 , Issue.8 , pp. 1193-1205
    • McCalden, R.W.1    McGlough, J.A.2    Barker, M.B.3    Court-Brown, C.M.4
  • 8
    • 27944480412 scopus 로고    scopus 로고
    • Pathophysiology of age-related bone loss and osteoporosis
    • DOI 10.1016/j.ecl.2005.07.009, PII S0889852905000903, Endocrinology of Aging
    • Khosla S, Riggs BL. Pathophysiology of age-related bone loss and osteoporosis. Endocrinol Metab Clin North Am. 2005;34:1015- 1030, x. i. (Pubitemid 41677410)
    • (2005) Endocrinology and Metabolism Clinics of North America , vol.34 , Issue.4 , pp. 1015-1030
    • Khosla, S.1    Riggs, B.L.2
  • 9
    • 0142211359 scopus 로고    scopus 로고
    • Invited review: Pathogenesis of osteoporosis
    • Seeman E. Invited review: pathogenesis of osteoporosis. J Appl Physiol. 2003;95:2142-2151. (Pubitemid 37310402)
    • (2003) Journal of Applied Physiology , vol.95 , Issue.5 , pp. 2142-2151
    • Seeman, E.1
  • 12
    • 0036372060 scopus 로고    scopus 로고
    • Age-related changes in bone mineral density, cross-sectional area and strength at different skeletal sites in male rats
    • Iida H, Fukuda S. Age-related changes in bone mineral density, cross-sectional area and strength at different skeletal sites in male rats. J Vet Med Sci. 2002;64:29-34.
    • (2002) J Vet Med Sci , vol.64 , pp. 29-34
    • Iida, H.1    Fukuda, S.2
  • 14
    • 0025813305 scopus 로고
    • Structural changes in aging bone: Osteopenia in the proximal femurs of female mice
    • Weiss A, Arbell I, Steinhagen-Thiessen E, Silbermann M. Structural changes in aging bone: osteopenia in the proximal femurs of female mice. Bone. 1991;12:165-172.
    • (1991) Bone , vol.12 , pp. 165-172
    • Weiss, A.1    Arbell, I.2    Steinhagen-Thiessen, E.3    Silbermann, M.4
  • 16
    • 0041762493 scopus 로고    scopus 로고
    • Bone development and age-related bone loss in male C57BL/6J mice
    • DOI 10.1016/S8756-3282(03)00199-6
    • Ferguson VL, Ayers RA, Bateman TA, Simske SJ. Bone development and age-related bone loss in male C57BL/6J mice. Bone. 2003;33:387-398. (Pubitemid 37107464)
    • (2003) Bone , vol.33 , Issue.3 , pp. 387-398
    • Ferguson, V.L.1    Ayers, R.A.2    Bateman, T.A.3    Simske, S.J.4
  • 17
    • 78349266526 scopus 로고    scopus 로고
    • Decreased oxidative stress and greater bone anabolism in the aged, as compared to the young, murine skeleton by parathyroid hormone
    • Jilka RL, Almeida M, Ambrogini E, et al. Decreased oxidative stress and greater bone anabolism in the aged, as compared to the young, murine skeleton by parathyroid hormone. Aging Cell. 2010;9:851-867.
    • (2010) Aging Cell , vol.9 , pp. 851-867
    • Jilka, R.L.1    Almeida, M.2    Ambrogini, E.3
  • 18
    • 0018222773 scopus 로고
    • Mean wall thickness of trabecular bone packets in the human iliac crest: Changes with age
    • Lips P, Courpron P, Meunier PJ. Mean wall thickness of trabecular bone packets in the human iliac crest: changes with age. Calcif Tissue Res. 1978;26:13-17. (Pubitemid 9088823)
    • (1978) Calcified Tissue International , vol.26 , Issue.1 , pp. 13-17
    • Lips, P.1    Courpron, P.2    Meunier, P.J.3
  • 19
    • 0001366345 scopus 로고
    • Bone-forming cells in clinical conditions
    • In: Hall BK, ed.Boca Raton, FL: Telford Press and CRC Press;
    • Parfitt AM. Bone-forming cells in clinical conditions. In: Hall BK, ed. Bone. Volume 1 The Osteoblast and Osteocyte. Boca Raton, FL: Telford Press and CRC Press; 1990:351-429.
    • (1990) Bone. Volume 1 the Osteoblast and Osteocyte , pp. 351-429
    • Parfitt, A.M.1
  • 20
    • 0028919301 scopus 로고
    • Relations between histologic indices of bone formation: Implications for the pathogenesis of spinal osteoporosis
    • Parfitt AM, Villanueva AR, Foldes J, Rao DS. Relations between histologic indices of bone formation: implications for the pathogenesis of spinal osteoporosis. J Bone Miner Res. 1995;10:466-473.
    • (1995) J Bone Miner Res , vol.10 , pp. 466-473
    • Parfitt, A.M.1    Villanueva, A.R.2    Foldes, J.3    Rao, D.S.4
  • 21
    • 84856962930 scopus 로고    scopus 로고
    • Bone turnover markers in peripheral blood and marrow plasma reflect trabecular bone loss but not endocortical expansion in aging mice
    • Shahnazari M, Dwyer D, Chu V, et al. Bone turnover markers in peripheral blood and marrow plasma reflect trabecular bone loss but not endocortical expansion in aging mice. Bone. 2012;50:628-637.
    • (2012) Bone , vol.50 , pp. 628-637
    • Shahnazari, M.1    Dwyer, D.2    Chu, V.3
  • 22
    • 84875860646 scopus 로고    scopus 로고
    • Dysfunctional osteocytes increase RANKL and promote cortical pore formation in their vicinity: A mechanistic explanation for the development of cortical porosity with age
    • Jilka R, Deloose A, Climer L, et al. Dysfunctional osteocytes increase RANKL and promote cortical pore formation in their vicinity: a mechanistic explanation for the development of cortical porosity with age. J Bone Miner Res. 2012;27:S348 (abstract).
    • (2012) J Bone Miner Res , vol.27
    • Jilka, R.1    Deloose, A.2    Climer, L.3
  • 23
    • 78249262917 scopus 로고    scopus 로고
    • Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone
    • Busse B, Djonic D, Milovanovic P, et al. Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone. Aging Cell. 2010;9:1065-1075.
    • (2010) Aging Cell , vol.9 , pp. 1065-1075
    • Busse, B.1    Djonic, D.2    Milovanovic, P.3
  • 24
    • 0036020416 scopus 로고    scopus 로고
    • Age and distance from the surface but not menopause reduce osteocyte density in human cancellous bone
    • DOI 10.1016/S8756-3282(02)00819-0, PII S8756328202008190
    • Qiu S, Rao DS, Palnitkar S, Parfitt AM. Age and distance from the surface but not menopause reduce osteocyte density in human cancellous bone. Bone. 2002;31:313-318. (Pubitemid 34822826)
    • (2002) Bone , vol.31 , Issue.2 , pp. 313-318
    • Qiu, S.1    Rao, D.S.2    Palnitkar, S.3    Parfitt, A.M.4
  • 25
    • 0036948178 scopus 로고    scopus 로고
    • Relationships between osteocyte density and bone formation rate in human cancellous bone
    • DOI 10.1016/S8756-3282(02)00907-9, PII S8756328202009079
    • Qiu S, Rao DS, Palnitkar S, Parfitt AM. Relationships between osteocyte density and bone formation rate in human cancellous bone. Bone. 2002;31:709-711. (Pubitemid 36092095)
    • (2002) Bone , vol.31 , Issue.6 , pp. 709-711
    • Qiu, S.1    Rao, D.S.2    Palnitkar, S.3    Parfitt, A.M.4
  • 27
    • 0015137446 scopus 로고
    • Osteoporosis and the replacement of cell populations of the marrow by adipose tissue A quantitative study of 84 iliac bone biopsies
    • Meunier P, Aaron J, Edouard C, Vignon G. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clin Orthop Relat Res. 1971;80:147-154.
    • (1971) Clin Orthop Relat Res , vol.80 , pp. 147-154
    • Meunier, P.1    Aaron, J.2    Edouard, C.3    Vignon, G.4
  • 28
    • 0036724870 scopus 로고    scopus 로고
    • Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis
    • DOI 10.1136/jcp.55.9.693
    • Verma S, Rajaratnam JH, Denton J, Hoyland JA, Byers RJ. Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol. 2002;55:693-698. (Pubitemid 34970093)
    • (2002) Journal of Clinical Pathology , vol.55 , Issue.9 , pp. 693-698
    • Verma, S.1    Rajaratnam, J.H.2    Denton, J.3    Hoyland, J.A.4    Byers, R.J.5
  • 29
  • 30
    • 70350451479 scopus 로고    scopus 로고
    • Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton
    • Almeida M, Ambrogini E, Han L, Manolagas SC, Jilka RL. Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton. J Biol Chem. 2009;284:27438-27448.
    • (2009) J Biol Chem , vol.284 , pp. 27438-27448
    • Almeida, M.1    Ambrogini, E.2    Han, L.3    Manolagas, S.C.4    Jilka, R.L.5
  • 31
    • 0347627149 scopus 로고    scopus 로고
    • Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells
    • DOI 10.1016/j.bone.2003.07.005
    • Stenderup K, Justesen J, Clausen C, Kassem M. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone. 2003;33:919-926. (Pubitemid 37543568)
    • (2003) Bone , vol.33 , Issue.6 , pp. 919-926
    • Stenderup, K.1    Justesen, J.2    Clausen, C.3    Kassem, M.4
  • 32
    • 31344473379 scopus 로고    scopus 로고
    • Aging of mesenchymal stem cells
    • DOI 10.1016/j.arr.2005.10.001, PII S1568163705000498
    • Sethe S, Scutt A, Stolzing A. Aging of mesenchymal stem cells. Ageing Res Rev. 2006;5:91-116. (Pubitemid 43139669)
    • (2006) Ageing Research Reviews , vol.5 , Issue.1 , pp. 91-116
    • Sethe, S.1    Scutt, A.2    Stolzing, A.3
  • 33
    • 67649628226 scopus 로고    scopus 로고
    • Insights into mesenchymal stem cell aging: Involvement of antioxidant defense and actin cytoskeleton
    • Kasper G, Mao L, Geissler S, et al. Insights into mesenchymal stem cell aging: involvement of antioxidant defense and actin cytoskeleton. Stem Cells. 2009;27:1288-1297.
    • (2009) Stem Cells , vol.27 , pp. 1288-1297
    • Kasper, G.1    Mao, L.2    Geissler, S.3
  • 34
    • 34848814178 scopus 로고    scopus 로고
    • Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting -catenin from T cell factor- to forkhead box O-mediated transcription
    • DOI 10.1074/jbc.M702811200
    • Almeida M, Han L, Martin-Millan M, O'Brien CA, Manolagas SC. Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription. J Biol Chem. 2007;282:27298-27305. (Pubitemid 47501978)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.37 , pp. 27298-27305
    • Almeida, M.1    Han, L.2    Martin-Millan, M.3    O'Brien, C.A.4    Manolagas, S.C.5
  • 35
    • 77956985003 scopus 로고    scopus 로고
    • Skeletal aging and the adipocyte program: New insights from an "old" molecule
    • Lecka-Czernik B, Rosen CJ, Kawai M. Skeletal aging and the adipocyte program: new insights from an "old" molecule. Cell Cycle. 2010;9:3648-3654.
    • (2010) Cell Cycle , vol.9 , pp. 3648-3654
    • Lecka-Czernik, B.1    Rosen, C.J.2    Kawai, M.3
  • 36
    • 0030807631 scopus 로고    scopus 로고
    • Age-associated decline in human femoral neck cortical and trabecular content of insulin-like growth factor I: Potential implications for age- related (type II) osteoporotic fracture occurrence
    • DOI 10.1007/s002239900318
    • Boonen S, Aerssens J, Dequeker J, et al. Age-associated decline in human femoral neck cortical and trabecular content of insulin-like growth factor I: potential implications for age-related (type II) osteoporotic fracture occurrence. Calcif Tissue Int. 1997;61:173-178. (Pubitemid 27360807)
    • (1997) Calcified Tissue International , vol.61 , Issue.3 , pp. 173-178
    • Boonen, S.1    Aerssens, J.2    Dequeker, J.3    Nicholson, P.4    Cheng, X.-G.5    Lowet, G.6    Verbeke, G.7    Bouillon, R.8
  • 38
    • 0032239547 scopus 로고    scopus 로고
    • Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human
    • Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev. 1998;19:717-797. (Pubitemid 128506521)
    • (1998) Endocrine Reviews , vol.19 , Issue.6 , pp. 717-797
    • Giustina, A.1    Veldhuis, J.D.2
  • 39
    • 84863726841 scopus 로고    scopus 로고
    • Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells
    • Xian L, Wu X, Pang L, et al. Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells. Nat Med. 2012;18:1095-1101.
    • (2012) Nat Med , vol.18 , pp. 1095-1101
    • Xian, L.1    Wu, X.2    Pang, L.3
  • 40
    • 84880562766 scopus 로고    scopus 로고
    • Pathogenesis of age-related bone loss in humans
    • doi:10. 1093/gerona/gls163
    • Khosla S. Pathogenesis of age-related bone loss in humans. J Gerontol A Biol Sci Med Sci. 2012. doi:10.1093/gerona/gls163
    • (2012) J Gerontol A Biol Sci Med Sci
    • Khosla, S.1
  • 41
    • 0034455103 scopus 로고    scopus 로고
    • Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
    • DOI 10.1210/er.21.2.115
    • Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. 2000;21:115-137. (Pubitemid 32275592)
    • (2000) Endocrine Reviews , vol.21 , Issue.2 , pp. 115-137
    • Manolagas, S.C.1
  • 42
    • 78349252031 scopus 로고    scopus 로고
    • Effects of chronic estrogen treatment on modulating age-related bone loss in female mice
    • Syed FA, Mödder UI, Roforth M, et al. Effects of chronic estrogen treatment on modulating age-related bone loss in female mice. J Bone Miner Res. 2010;25:2438-2446.
    • (2010) J Bone Miner Res , vol.25 , pp. 2438-2446
    • Syed, F.A.1    Mödder, U.I.2    Roforth, M.3
  • 43
    • 75149129597 scopus 로고    scopus 로고
    • From estrogen-centric to aging and oxidative stress: A revised perspective of the pathogenesis of osteoporosis
    • Manolagas SC. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev. 2010;31:266-300.
    • (2010) Endocr Rev , vol.31 , pp. 266-300
    • Manolagas, S.C.1
  • 44
    • 0032528180 scopus 로고    scopus 로고
    • Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts end osteocytes by glucocorticoids potential mechanisms of their deleterious effects on bone
    • Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids: potential mechanisms of their deleterious effects on bone. J Clin Invest. 1998;102:274-282. (Pubitemid 28335186)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.2 , pp. 274-282
    • Weinstein, R.S.1    Jilka, R.L.2    Michael Parfitt, A.3    Manolagas, S.C.4
  • 45
    • 84863229757 scopus 로고    scopus 로고
    • Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration
    • Park D, Spencer JA, Koh BI, et al. Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. Cell Stem Cell. 2012;10:259-272.
    • (2012) Cell Stem Cell , vol.10 , pp. 259-272
    • Park, D.1    Spencer, J.A.2    Koh, B.I.3
  • 46
    • 34548153747 scopus 로고    scopus 로고
    • How stem cells age and why this makes us grow old
    • DOI 10.1038/nrm2241, PII NRM2241
    • Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol. 2007;8:703-713. (Pubitemid 47312828)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 703-713
    • Sharpless, N.E.1    DePinho, R.A.2
  • 47
    • 39149086121 scopus 로고    scopus 로고
    • Stems cells and the pathways to aging and cancer
    • DOI 10.1016/j.cell.2008.01.036, PII S0092867408001372
    • Rossi DJ, Jamieson CH, Weissman IL. Stems cells and the pathways to aging and cancer. Cell. 2008;132:681-696. (Pubitemid 351253688)
    • (2008) Cell , vol.132 , Issue.4 , pp. 681-696
    • Rossi, D.J.1    Jamieson, C.H.M.2    Weissman, I.L.3
  • 48
    • 0029863342 scopus 로고    scopus 로고
    • Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation
    • Kuhn HG, Dickinson-Anson H, Gage FH. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci. 1996;16:2027-2033. (Pubitemid 26144015)
    • (1996) Journal of Neuroscience , vol.16 , Issue.6 , pp. 2027-2033
    • Kuhn, H.G.1    Dickinson-Anson, H.2    Gage, F.H.3
  • 50
    • 30344476433 scopus 로고    scopus 로고
    • Aging of male germ line stem cells in mice
    • DOI 10.1095/biolreprod.105.045591
    • Zhang X, Ebata KT, Robaire B, Nagano MC. Aging of male germ line stem cells in mice. Biol Reprod. 2006;74:119-124. (Pubitemid 43068798)
    • (2006) Biology of Reproduction , vol.74 , Issue.1 , pp. 119-124
    • Zhang, X.1    Ebata, K.T.2    Robaire, B.3    Nagano, M.C.4
  • 51
    • 33747595402 scopus 로고    scopus 로고
    • Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal
    • DOI 10.1634/stemcells.2005-0580
    • Ryu BY, Orwig KE, Oatley JM, Avarbock MR, Brinster RL. Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal. Stem Cells. 2006;24:1505-1511. (Pubitemid 44464667)
    • (2006) Stem Cells , vol.24 , Issue.6 , pp. 1505-1511
    • Ryu, B.-Y.1    Orwig, K.E.2    Oatley, J.M.3    Avarbock, M.R.4    Brinster, R.L.5
  • 53
    • 0344827208 scopus 로고    scopus 로고
    • Notch-mediated restoration of regenerative potential to aged muscle
    • DOI 10.1126/science.1087573
    • Conboy IM, Conboy MJ, Smythe GM, Rando TA. Notch-mediated restoration of regenerative potential to aged muscle. Science. 2003;302:1575-1577. (Pubitemid 37475703)
    • (2003) Science , vol.302 , Issue.5650 , pp. 1575-1577
    • Conboy, I.H.1    Conboy, M.J.2    Smythe, G.M.3    Rando, T.A.4
  • 54
    • 33646264523 scopus 로고    scopus 로고
    • Satellite-cell pool size does matter: Defining the myogenic potency of aging skeletal muscle
    • Shefer G, Van de Mark DP, Richardson JB, Yablonka-Reuveni Z. Satellite-cell pool size does matter: defining the myogenic potency of aging skeletal muscle. Dev Biol. 2006;294:50-66.
    • (2006) Dev Biol , vol.294 , pp. 50-66
    • Shefer, G.1    Van De Mark, D.P.2    Richardson, J.B.3    Yablonka-Reuveni, Z.4
  • 55
    • 0016269155 scopus 로고
    • Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues Cloning in vitro and retransplantation in vivo
    • Friedenstein AJ, Chailakhyan RK, Latsinik NV, Panasyuk AF, Keiliss-Borok IV. Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation. 1974;17:331-340.
    • (1974) Transplantation , vol.17 , pp. 331-340
    • Friedenstein, A.J.1    Chailakhyan, R.K.2    Latsinik, N.V.3    Panasyuk, A.F.4    Keiliss-Borok, I.V.5
  • 56
    • 0026228558 scopus 로고
    • Mesenchymal stem cells
    • Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991;9:641-650.
    • (1991) J Orthop Res , vol.9 , pp. 641-650
    • Caplan, A.I.1
  • 57
    • 50849139576 scopus 로고    scopus 로고
    • A perivascular origin for mesenchymal stem cells in multiple human organs
    • Crisan M, Yap S, Casteilla L, et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell. 2008;3:301-313.
    • (2008) Cell Stem Cell , vol.3 , pp. 301-313
    • Crisan, M.1    Yap, S.2    Casteilla, L.3
  • 58
    • 84862933577 scopus 로고    scopus 로고
    • In vivo fate mapping identifies mesenchymal progenitor cells
    • Grcevic D, Pejda S, Matthews BG, et al. In vivo fate mapping identifies mesenchymal progenitor cells. Stem Cells. 2012;30:187-196.
    • (2012) Stem Cells , vol.30 , pp. 187-196
    • Grcevic, D.1    Pejda, S.2    Matthews, B.G.3
  • 59
    • 70849133991 scopus 로고    scopus 로고
    • Impaired differentiation potential of human trabecular bone mesenchymal stromal cells from elderly patients
    • Coipeau P, Rosset P, Langonne A, et al. Impaired differentiation potential of human trabecular bone mesenchymal stromal cells from elderly patients. Cytotherapy. 2009;11:584-594.
    • (2009) Cytotherapy , vol.11 , pp. 584-594
    • Coipeau, P.1    Rosset, P.2    Langonne, A.3
  • 60
    • 77949467945 scopus 로고    scopus 로고
    • Mechanical strain modulates agerelated changes in the proliferation and differentiation of mouse adipose- derived stromal cells
    • Huang SC, Wu TC, Yu HC, et al. Mechanical strain modulates agerelated changes in the proliferation and differentiation of mouse adipose- derived stromal cells. BMC Cell Biol. 2010;11:18.
    • (2010) BMC Cell Biol , vol.11 , pp. 18
    • Huang, S.C.1    Wu, T.C.2    Yu, H.C.3
  • 61
    • 43149124203 scopus 로고    scopus 로고
    • Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
    • Scaffidi P, Misteli T. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat Cell Biol. 2008;10:452-459.
    • (2008) Nat Cell Biol , vol.10 , pp. 452-459
    • Scaffidi, P.1    Misteli, T.2
  • 62
    • 33744513898 scopus 로고    scopus 로고
    • Age-related impairment of mesenchymal progenitor cell function
    • DOI 10.1111/j.1474-9726.2006.00213.x
    • Stolzing A, Scutt A. Age-related impairment of mesenchymal progenitor cell function. Aging Cell. 2006;5:213-224. (Pubitemid 43809939)
    • (2006) Aging Cell , vol.5 , Issue.3 , pp. 213-224
    • Stolzing, A.1    Scutt, A.2
  • 64
    • 70350497348 scopus 로고    scopus 로고
    • FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
    • Paik JH, Ding Z, Narurkar R, et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell. 2009;5:540-553.
    • (2009) Cell Stem Cell , vol.5 , pp. 540-553
    • Paik, J.H.1    Ding, Z.2    Narurkar, R.3
  • 65
    • 84856695688 scopus 로고    scopus 로고
    • Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model
    • Lavasani M, Robinson AR, Lu A, et al. Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nat Commun. 2012;3:608.
    • (2012) Nat Commun , vol.3 , pp. 608
    • Lavasani, M.1    Robinson, A.R.2    Lu, A.3
  • 66
    • 0031709946 scopus 로고    scopus 로고
    • Morphometric investigation on osteocytes in human auditory ossicles
    • Marotti G, Farneti D, Remaggi F, Tartari F. Morphometric investigation on osteocytes in human auditory ossicles. Ann Anat. 1998;180:449-453. (Pubitemid 28466539)
    • (1998) Annals of Anatomy , vol.180 , Issue.5 , pp. 449-453
    • Marotti, G.1    Farneti, D.2    Remaggi, F.3    Tartari, F.4
  • 67
    • 79251493453 scopus 로고    scopus 로고
    • The amazing osteocyte
    • Bonewald LF. The amazing osteocyte. J Bone Miner Res. 2011;26:229-238.
    • (2011) J Bone Miner Res , vol.26 , pp. 229-238
    • Bonewald, L.F.1
  • 70
    • 80053938104 scopus 로고    scopus 로고
    • Evidence for osteocyte regulation of bone homeostasis through RANKL expression
    • Nakashima T, Hayashi M, Fukunaga T, et al. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med. 2011;17:1231-1234.
    • (2011) Nat Med , vol.17 , pp. 1231-1234
    • Nakashima, T.1    Hayashi, M.2    Fukunaga, T.3
  • 75
    • 0016428907 scopus 로고
    • Accumulation of lipofuscin (age pigment) in aging skeletal connective tissues as revealed by electron microscopy
    • Tonna EA. Accumulation of lipofuscin (age pigment) in aging skeletal connective tissues as revealed by electron microscopy. J Gerontol. 1975;30:3-8.
    • (1975) J Gerontol , vol.30 , pp. 3-8
    • Tonna, E.A.1
  • 76
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956;11:298-300.
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 78
    • 45049085873 scopus 로고    scopus 로고
    • Redox-based regulation of signal transduction: Principles, pitfalls, and promises
    • Janssen-Heininger YM, Mossman BT, Heintz NH, et al. Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic Biol Med. 2008;45:1-17.
    • (2008) Free Radic Biol Med , vol.45 , pp. 1-17
    • Janssen-Heininger, Y.M.1    Mossman, B.T.2    Heintz, N.H.3
  • 83
    • 0039425278 scopus 로고    scopus 로고
    • Negative regulation of the forkhead transcription factor FKHR by Akt
    • Tang ED, Nuñez G, Barr FG, Guan KL. Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem. 1999;274:16741-16746.
    • (1999) J Biol Chem , vol.274 , pp. 16741-16746
    • Tang, E.D.1    Nuñez, G.2    Barr, F.G.3    Guan, K.L.4
  • 85
    • 41549135942 scopus 로고    scopus 로고
    • FoxO transcription factors in the maintenance of cellular homeostasis during aging
    • Salih DA, Brunet A. FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol. 2008;20:126-136.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 126-136
    • Salih, D.A.1    Brunet, A.2
  • 86
    • 34249281690 scopus 로고    scopus 로고
    • Stressing the role of FoxO proteins in lifespan and disease
    • DOI 10.1038/nrm2190, PII NRM2190
    • van der Horst A, Burgering BM. Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol. 2007;8:440-450. (Pubitemid 46809159)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.6 , pp. 440-450
    • Van Der Horst, A.1    Burgering, B.M.T.2
  • 87
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • DOI 10.1016/j.cell.2005.02.001
    • Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell. 2005;120:483-495. (Pubitemid 40269763)
    • (2005) Cell , vol.120 , Issue.4 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 88
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Dröge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002;82:47-95. (Pubitemid 34654215)
    • (2002) Physiological Reviews , vol.82 , Issue.1 , pp. 47-95
    • Droge, W.1
  • 89
    • 77956185904 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress and mammalian healthspan
    • Wanagat J, Dai DF, Rabinovitch P. Mitochondrial oxidative stress and mammalian healthspan. Mech Ageing Dev. 2010;131:527-535.
    • (2010) Mech Ageing Dev , vol.131 , pp. 527-535
    • Wanagat, J.1    Dai, D.F.2    Rabinovitch, P.3
  • 91
    • 11144248825 scopus 로고    scopus 로고
    • Tumor necrosis factor- mediates osteopenia caused by depletion of antioxidants
    • DOI 10.1210/en.2004-1058
    • Jagger CJ, Lean JM, Davies JT, Chambers TJ. Tumor necrosis factor- alpha mediates osteopenia caused by depletion of antioxidants. Endocrinology. 2005;146:113-118. (Pubitemid 40051730)
    • (2005) Endocrinology , vol.146 , Issue.1 , pp. 113-118
    • Jagger, C.J.1    Lean, J.M.2    Davies, J.T.3    Chambers, T.J.4
  • 94
    • 80055002537 scopus 로고    scopus 로고
    • Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking
    • Nojiri H, Saita Y, Morikawa D, et al. Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking. J Bone Miner Res. 2011;26:2682-2694.
    • (2011) J Bone Miner Res , vol.26 , pp. 2682-2694
    • Nojiri, H.1    Saita, Y.2    Morikawa, D.3
  • 95
    • 75149146587 scopus 로고    scopus 로고
    • FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice
    • Ambrogini E, Almeida M, Martin-Millan M, et al. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab. 2010;11:136-146.
    • (2010) Cell Metab , vol.11 , pp. 136-146
    • Ambrogini, E.1    Almeida, M.2    Martin-Millan, M.3
  • 96
    • 75149115329 scopus 로고    scopus 로고
    • FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts
    • Rached MT, Kode A, Xu L, et al. FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metab. 2010;11:147-160.
    • (2010) Cell Metab , vol.11 , pp. 147-160
    • Rached, M.T.1    Kode, A.2    Xu, L.3
  • 98
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/?-catenin signaling and disease
    • Clevers H, Nusse R. Wnt/?-catenin signaling and disease. Cell. 2012;149:1192-1205.
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 100
    • 79551707018 scopus 로고    scopus 로고
    • Wnt signaling regulates hepatic metabolism
    • Liu H, Fergusson MM, Wu JJ, et al. Wnt signaling regulates hepatic metabolism. Sci Signal. 2011;4:ra6.
    • (2011) Sci Signal , vol.4
    • Liu, H.1    Fergusson, M.M.2    Wu, J.J.3
  • 101
    • 84885008586 scopus 로고    scopus 로고
    • Combined deletion of the transcription factors FoxO1, 3, and 4 from osteoblast progenitors expressing osterix causes bone anabolism and postpones the adverse effects of aging on bone
    • Iyer S, Ambogini E, Han L, et al. Combined deletion of the transcription factors FoxO1, 3, and 4 from osteoblast progenitors expressing osterix causes bone anabolism and postpones the adverse effects of aging on bone. J Bone Miner Res. 2011;26:1168 (abstract).
    • (2011) J Bone Miner Res , vol.26 , pp. 1168
    • Iyer, S.1    Ambogini, E.2    Han, L.3
  • 102
    • 84859350525 scopus 로고    scopus 로고
    • Generation of functional insulin-producing cells in the gut by Foxo1 ablation
    • S1
    • Talchai C, Xuan S, Kitamura T, DePinho RA, Accili D. Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet. 2012;44:406-412, S1.
    • (2012) Nat Genet , vol.44 , pp. 406-412
    • Talchai, C.1    Xuan, S.2    Kitamura, T.3    Depinho, R.A.4    Accili, D.5
  • 103
    • 35648929883 scopus 로고    scopus 로고
    • Gone with the Wnts: Catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism
    • DOI 10.1210/me.2007-0259
    • Manolagas SC, Almeida M. Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Mol Endocrinol. 2007;21:2605-2614. (Pubitemid 350035144)
    • (2007) Molecular Endocrinology , vol.21 , Issue.11 , pp. 2605-2614
    • Manolagas, S.C.1    Almeida, M.2
  • 104
    • 70349172032 scopus 로고    scopus 로고
    • Should i stay or should i go: Betacatenin decides under stress
    • Hoogeboom D, Burgering BM. Should I stay or should I go: betacatenin decides under stress. Biochim Biophys Acta. 2009;1796:63-74.
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 63-74
    • Hoogeboom, D.1    Burgering, B.M.2
  • 105
    • 41849086320 scopus 로고    scopus 로고
    • FOXO-binding partners: It takes two to tango
    • DOI 10.1038/onc.2008.22, PII ONC200822
    • van der Vos KE, Coffer PJ. FOXO-binding partners: it takes two to tango. Oncogene. 2008;27:2289-2299. (Pubitemid 351501780)
    • (2008) Oncogene , vol.27 , Issue.16 , pp. 2289-2299
    • Van Der Vos, K.E.1    Coffer, P.J.2
  • 106
    • 38849092190 scopus 로고    scopus 로고
    • Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging
    • DOI 10.1002/bies.20709
    • DeCarolis NA, Wharton KA Jr, Eisch AJ. Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging. BioEssays. 2008;30:102-106. (Pubitemid 351196944)
    • (2008) BioEssays , vol.30 , Issue.2 , pp. 102-106
    • DeCarolis, N.A.1    Wharton Jr., K.A.2    Eisch, A.J.3
  • 107
    • 51249114496 scopus 로고    scopus 로고
    • The WNT signalling pathway and diabetes mellitus
    • Jin T. The WNT signalling pathway and diabetes mellitus. Diabetologia. 2008;51:1771-1780.
    • (2008) Diabetologia , vol.51 , pp. 1771-1780
    • Jin, T.1
  • 108
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132:27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 109
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet. 2009;43:67-93.
    • (2009) Annu Rev Genet , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 110
    • 51049118332 scopus 로고    scopus 로고
    • The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy'Protein modifications: Beyond the usual suspects' review series
    • Geng J, Klionsky DJ. The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep. 2008;9:859-864.
    • (2008) EMBO Rep , vol.9 , pp. 859-864
    • Geng, J.1    Klionsky, D.J.2
  • 112
    • 57049186623 scopus 로고    scopus 로고
    • How to live long and prosper: Autophagy, mitochondria, and aging
    • Yen WL, Klionsky DJ. How to live long and prosper: autophagy, mitochondria, and aging. Physiology (Bethesda). 2008;23:248-262.
    • (2008) Physiology (Bethesda) , vol.23 , pp. 248-262
    • Yen, W.L.1    Klionsky, D.J.2
  • 114
    • 40149105890 scopus 로고    scopus 로고
    • A role for autophagy in the extension of lifespan by dietary restriction in C elegans
    • Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C. A role for autophagy in the extension of lifespan by dietary restriction in C. Elegans. PLoS Genet. 2008;4:e24.
    • (2008) PLoS Genet , vol.4
    • Hansen, M.1    Chandra, A.2    Mitic, L.L.3    Onken, B.4    Driscoll, M.5    Kenyon, C.6
  • 115
    • 77952409809 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy
    • Wu JJ, Quijano C, Chen E, et al. Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy. Aging (Albany NY). 2009;1:425-437.
    • (2009) Aging (Albany NY) , vol.1 , pp. 425-437
    • Wu, J.J.1    Quijano, C.2    Chen, E.3
  • 116
    • 65549139675 scopus 로고    scopus 로고
    • Regulation of the aging process by autophagy
    • Salminen A, Kaarniranta K. Regulation of the aging process by autophagy. Trends Mol Med. 2009;15:217-224.
    • (2009) Trends Mol Med , vol.15 , pp. 217-224
    • Salminen, A.1    Kaarniranta, K.2
  • 117
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon CJ. The genetics of ageing. Nature. 2010;464:504-512.
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 118
    • 77951157657 scopus 로고    scopus 로고
    • Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
    • Kume S, Uzu T, Horiike K, et al. Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. J Clin Invest. 2010;120:1043-1055.
    • (2010) J Clin Invest , vol.120 , pp. 1043-1055
    • Kume, S.1    Uzu, T.2    Horiike, K.3
  • 119
    • 77956274584 scopus 로고    scopus 로고
    • Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
    • Lipinski MM, Zheng B, Lu T, et al. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A. 2010;107:14164-14169.
    • (2010) Proc Natl Acad Sci U S A. , vol.107 , pp. 14164-14169
    • Lipinski, M.M.1    Zheng, B.2    Lu, T.3
  • 120
    • 77649128750 scopus 로고    scopus 로고
    • Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis
    • Caramés B, Taniguchi N, Otsuki S, Blanco FJ, Lotz M. Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum. 2010;62:791-801.
    • (2010) Arthritis Rheum , vol.62 , pp. 791-801
    • Caramés, B.1    Taniguchi, N.2    Otsuki, S.3    Blanco, F.J.4    Lotz, M.5
  • 121
    • 38949099761 scopus 로고    scopus 로고
    • Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
    • Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy. 2008;4:176-184. (Pubitemid 351231181)
    • (2008) Autophagy , vol.4 , Issue.2 , pp. 176-184
    • Simonsen, A.1    Cumming, R.C.2    Brech, A.3    Isakson, P.4    Schubert, D.R.5    Finley, K.D.6
  • 122
    • 52749094770 scopus 로고    scopus 로고
    • Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia
    • Jung HS, Chung KW, Won Kim J, et al. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab. 2008;8:318-324.
    • (2008) Cell Metab , vol.8 , pp. 318-324
    • Jung, H.S.1    Chung, K.W.2    Won Kim, J.3
  • 123
    • 52749093177 scopus 로고    scopus 로고
    • Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet
    • Ebato C, Uchida T, Arakawa M, et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab. 2008;8:325-332.
    • (2008) Cell Metab , vol.8 , pp. 325-332
    • Ebato, C.1    Uchida, T.2    Arakawa, M.3
  • 124
    • 64249123646 scopus 로고    scopus 로고
    • Autophagy is essential for mitochondrial clearance in mature T lymphocytes
    • Pua HH, Guo J, Komatsu M, He YW. Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol. 2009;182:4046-4055.
    • (2009) J Immunol , vol.182 , pp. 4046-4055
    • Pua, H.H.1    Guo, J.2    Komatsu, M.3    He, Y.W.4
  • 125
    • 65949095803 scopus 로고    scopus 로고
    • Autophagy regulates lipid metabolism
    • Singh R, Kaushik S, Wang Y, et al. Autophagy regulates lipid metabolism. Nature. 2009;458:1131-1135.
    • (2009) Nature , vol.458 , pp. 1131-1135
    • Singh, R.1    Kaushik, S.2    Wang, Y.3
  • 126
    • 76249127368 scopus 로고    scopus 로고
    • Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo
    • Mortensen M, Ferguson DJ, Edelmann M, et al. Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci USA. 2010;107:832-837.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 832-837
    • Mortensen, M.1    Ferguson, D.J.2    Edelmann, M.3
  • 127
    • 70449927247 scopus 로고    scopus 로고
    • Autophagy is required to maintain muscle mass
    • Masiero E, Agatea L, Mammucari C, et al. Autophagy is required to maintain muscle mass. Cell Metab. 2009;10:507-515.
    • (2009) Cell Metab , vol.10 , pp. 507-515
    • Masiero, E.1    Agatea, L.2    Mammucari, C.3
  • 128
    • 34249104544 scopus 로고    scopus 로고
    • Oxidative stress and aberrant signaling in aging and cognitive decline
    • DOI 10.1111/j.1474-9726.2007.00294.x
    • Dröge W, Schipper HM. Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell. 2007;6:361-370. (Pubitemid 46785141)
    • (2007) Aging Cell , vol.6 , Issue.3 , pp. 361-370
    • Droge, W.1    Schipper, H.M.2
  • 130
    • 84884995469 scopus 로고    scopus 로고
    • Suppression of autophagy in osteoblasts and osteocytes increases oxidative stress and recapitulates the effects of aging on the murine skeleton
    • Onal M, Xiong J, Ye S, et al. Suppression of autophagy in osteoblasts and osteocytes increases oxidative stress and recapitulates the effects of aging on the murine skeleton. J Bone Miner Res. 2012;27:S349 (abstract).
    • (2012) J Bone Miner Res , vol.27
    • Onal, M.1    Xiong, J.2    Ye, S.3
  • 131
    • 79952728102 scopus 로고    scopus 로고
    • The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
    • Mortensen M, Soilleux EJ, Djordjevic G, et al. The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. J Exp Med. 2011;208:455-467.
    • (2011) J Exp Med , vol.208 , pp. 455-467
    • Mortensen, M.1    Soilleux, E.J.2    Djordjevic, G.3
  • 132
    • 84874192375 scopus 로고    scopus 로고
    • FOXO3A directs a protective autophagy program in haematopoietic stem cells
    • Warr MR, Binnewies M, Flach J, et al. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature. 2013;494:323-327.
    • (2013) Nature , vol.494 , pp. 323-327
    • Warr, M.R.1    Binnewies, M.2    Flach, J.3
  • 133
    • 84967614664 scopus 로고    scopus 로고
    • Sex steroids and the construction and conservation of the adult skeleton
    • DOI 10.1210/er.23.3.279
    • Riggs BL, Khosla S, Melton LJ III. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev. 2002;23:279-302. (Pubitemid 34651948)
    • (2002) Endocrine Reviews , vol.23 , Issue.3 , pp. 279-302
    • Riggs, B.L.1    Khosla, S.2    Melton III, L.J.3
  • 135
    • 75149165271 scopus 로고    scopus 로고
    • The estrogen receptor- alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone
    • Martin-Millan M, Almeida M, Ambrogini E, et al. The estrogen receptor- alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol. 2010;24:323-334.
    • (2010) Mol Endocrinol , vol.24 , pp. 323-334
    • Martin-Millan, M.1    Almeida, M.2    Ambrogini, E.3
  • 136
    • 84873824098 scopus 로고    scopus 로고
    • Estrogen receptor-? Signaling in osteoblast progenitors stimulates cortical bone accrual
    • Almeida M, Iyer S, Martin-Millan M, et al. Estrogen receptor-? signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest. 2013;123:394-404.
    • (2013) J Clin Invest , vol.123 , pp. 394-404
    • Almeida, M.1    Iyer, S.2    Martin-Millan, M.3
  • 137
    • 0032145401 scopus 로고    scopus 로고
    • Cytokines, bone remodeling, and estrogen deficiency: A 1998 update
    • DOI 10.1016/S8756-3282(98)00077-5, PII S8756328298000775
    • Jilka RL. Cytokines, bone remodeling, and estrogen deficiency: a 1998 update. Bone. 1998;23:75-81. (Pubitemid 28379866)
    • (1998) Bone , vol.23 , Issue.2 , pp. 75-81
    • Jilka, R.L.1
  • 138
    • 84865446399 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor ?B ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss
    • Onal M, Xiong J, Chen X, et al. Receptor activator of nuclear factor ?B ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem. 2012;287: 29851-29860.
    • (2012) J Biol Chem , vol.287 , pp. 29851-29860
    • Onal, M.1    Xiong, J.2    Chen, X.3
  • 139
    • 79960087488 scopus 로고    scopus 로고
    • Glucocorticoid-induced bone disease
    • Weinstein RS. Glucocorticoid-induced bone disease. N Engl J Med. 2011;365:62-70.
    • (2011) N Engl J Med , vol.365 , pp. 62-70
    • Weinstein, R.S.1
  • 140
    • 84455161897 scopus 로고    scopus 로고
    • Glucocorticoids and tumor necrosis factor ? Increase oxidative stress and suppress Wnt protein signaling in osteoblasts
    • Almeida M, Han L, Ambrogini E, Weinstein RS, Manolagas SC. Glucocorticoids and tumor necrosis factor ? increase oxidative stress and suppress Wnt protein signaling in osteoblasts. J Biol Chem. 2011;286:44326- 44335.
    • (2011) J Biol Chem , vol.286 , pp. 44326-44335
    • Almeida, M.1    Han, L.2    Ambrogini, E.3    Weinstein, R.S.4    Manolagas, S.C.5
  • 141
    • 34548204415 scopus 로고    scopus 로고
    • Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival: Evidence for inside-out signaling leading to anoikis
    • DOI 10.1074/jbc.M611435200
    • Plotkin LI, Manolagas SC, Bellido T. Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis. J Biol Chem. 2007;282:24120-24130. (Pubitemid 47328056)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.33 , pp. 24120-24130
    • Plotkin, L.I.1    Manolagas, S.C.2    Bellido, T.3
  • 142
    • 41549138806 scopus 로고    scopus 로고
    • Modulation of Dickkopf-1 attenuates glucocorticoid induction of osteoblast apoptosis, adipocytic differentiation, and bone mass loss
    • Wang FS, Ko JY, Yeh DW, Ke HC, Wu HL. Modulation of Dickkopf-1 attenuates glucocorticoid induction of osteoblast apoptosis, adipocytic differentiation, and bone mass loss. Endocrinology. 2008;149:1793-1801.
    • (2008) Endocrinology , vol.149 , pp. 1793-1801
    • Wang, F.S.1    Ko, J.Y.2    Yeh, D.W.3    Ke, H.C.4    Wu, H.L.5
  • 143
    • 12544250379 scopus 로고    scopus 로고
    • Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner
    • Smith E, Frenkel B. Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner. J Biol Chem. 2005;280:2388-2394.
    • (2005) J Biol Chem , vol.280 , pp. 2388-2394
    • Smith, E.1    Frenkel, B.2
  • 144
    • 33751501004 scopus 로고    scopus 로고
    • Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density
    • DOI 10.1210/en.2006-0459
    • Jia D, O'Brien CA, Stewart SA, Manolagas SC, Weinstein RS. Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density. Endocrinology. 2006;147:5592-5599. (Pubitemid 44833476)
    • (2006) Endocrinology , vol.147 , Issue.12 , pp. 5592-5599
    • Jia, D.1    O'Brien, C.A.2    Stewart, S.A.3    Manolagas, S.C.4    Weinstein, R.S.5
  • 145
    • 27144526659 scopus 로고    scopus 로고
    • A histomorphometric study of cortical bone of the iliac crest in patients treated with glucocorticoids
    • DOI 10.1007/s00223-004-0205-y
    • Vedi S, Elkin SL, Compston JE. A histomorphometric study of cortical bone of the iliac crest in patients treated with glucocorticoids. Calcif Tissue Int. 2005;77:79-83. (Pubitemid 41507194)
    • (2005) Calcified Tissue International , vol.77 , Issue.2 , pp. 79-83
    • Vedi, S.1    Elkin, S.L.2    Compston, J.E.3
  • 146
    • 58149134854 scopus 로고    scopus 로고
    • 11beta-Hydroxysteroid dehydrogenase: A regulator of glucocorticoid response in osteoporosis
    • Cooper MS. 11beta-Hydroxysteroid dehydrogenase: a regulator of glucocorticoid response in osteoporosis. J Endocrinol Invest. 2008;31:16-21.
    • (2008) J Endocrinol Invest , vol.31 , pp. 16-21
    • Cooper, M.S.1
  • 147
    • 77953271453 scopus 로고    scopus 로고
    • Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice
    • Weinstein RS, Wan C, Liu Q, et al. Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice. Aging Cell. 2010;9:147-161.
    • (2010) Aging Cell , vol.9 , pp. 147-161
    • Weinstein, R.S.1    Wan, C.2    Liu, Q.3
  • 149
    • 34347235843 scopus 로고    scopus 로고
    • Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein and peroxisome proliferator-activated receptor
    • DOI 10.1074/jbc.M700030200
    • Kang S, Bennett CN, Gerin I, Rapp LA, Hankenson KD, Macdougald OA. Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma. J Biol Chem. 2007;282:14515-14524. (Pubitemid 47100486)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.19 , pp. 14515-14524
    • Kang, S.1    Bennett, C.N.2    Gerin, I.3    Rapp, L.A.4    Hankenson, K.D.5    MacDougald, O.A.6
  • 150
    • 65249138877 scopus 로고    scopus 로고
    • COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis
    • Okamura M, Kudo H, Wakabayashi K, et al. COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis. Proc Natl Acad Sci U S A. 2009;106:5819-5824.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , pp. 5819-5824
    • Okamura, M.1    Kudo, H.2    Wakabayashi, K.3
  • 151
    • 84867505259 scopus 로고    scopus 로고
    • Loss of wnt/?-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes
    • Song L, Liu M, Ono N, Bringhurst FR, Kronenberg HM, Guo J. Loss of wnt/?-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes. J Bone Miner Res. 2012;27:2344-2358.
    • (2012) J Bone Miner Res , vol.27 , pp. 2344-2358
    • Song, L.1    Liu, M.2    Ono, N.3    Bringhurst, F.R.4    Kronenberg, H.M.5    Guo, J.6
  • 152
    • 4143065010 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activation can regulate -catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway
    • DOI 10.1074/jbc.M403143200
    • Sharma C, Pradeep A, Wong L, Rana A, Rana B. Peroxisome proliferator- activated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coliindependent pathway. J Biol Chem. 2004;279:35583-35594. (Pubitemid 39100560)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.34 , pp. 35583-35594
    • Sharma, C.1    Pradeep, A.2    Wong, L.3    Rana, A.4    Rana, B.5
  • 153
    • 47049095632 scopus 로고    scopus 로고
    • Routes to 4-hydroxynonenal: Fundamental issues in the mechanisms of lipid peroxidation
    • Schneider C, Porter NA, Brash AR. Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation. J Biol Chem. 2008;283:15539-15543.
    • (2008) J Biol Chem , vol.283 , pp. 15539-15543
    • Schneider, C.1    Porter, N.A.2    Brash, A.R.3
  • 155
    • 38649110396 scopus 로고    scopus 로고
    • Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells
    • DOI 10.1016/j.freeradbiomed.2007.08.030, PII S0891584907005928
    • Brodeur MR, Brissette L, Falstrault L, Ouellet P, Moreau R. Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells. Free Radic Biol Med. 2008;44:506-517. (Pubitemid 351181262)
    • (2008) Free Radical Biology and Medicine , vol.44 , Issue.4 , pp. 506-517
    • Brodeur, M.R.1    Brissette, L.2    Falstrault, L.3    Ouellet, P.4    Moreau, R.5
  • 158
    • 0023037767 scopus 로고
    • Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose
    • Hauschka PV, Mavrakos AE, Iafrati MD, Doleman SE, Klagsbrun M. Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-sepharose. J Biol Chem. 1986;261:12665-12674. (Pubitemid 17204223)
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.27 , pp. 12665-12674
    • Hauschka, P.V.1    Mavrakos, A.E.2    Iafrati, M.D.3
  • 160
    • 77956988551 scopus 로고    scopus 로고
    • The IGF-I regulatory system and its impact on skeletal and energy homeostasis
    • Kawai M, Rosen CJ. The IGF-I regulatory system and its impact on skeletal and energy homeostasis. J Cell Biochem. 2010;111: 14-19.
    • (2010) J Cell Biochem , vol.111 , pp. 14-19
    • Kawai, M.1    Rosen, C.J.2
  • 161
    • 0029082311 scopus 로고
    • The insulin-like growth factor system and the coupling of formation to resorption
    • Hayden JM, Mohan S, Baylink DJ. The insulin-like growth factor system and the coupling of formation to resorption. Bone. 1995;17 (2 suppl):93S-98S.
    • (1995) Bone , vol.17 , Issue.2 SUPPL.
    • Hayden, J.M.1    Mohan, S.2    Baylink, D.J.3
  • 163
    • 0031196718 scopus 로고    scopus 로고
    • Serum Insulin-Like Growth Factor Binding Protein (IGFBP)-4 and IGFBP-5 Levels in Aging and Age-Associated Diseases
    • Mohan S, Baylink DJ. Serum insulin-like growth factor binding protein (IGFBP)-4 and IGFBP-5 levels in aging and age-associated diseases. Endocrine. 1997;7:87-91. (Pubitemid 127483093)
    • (1997) Endocrine , vol.7 , Issue.1 , pp. 87-91
    • Mohan, S.1    Baylink, D.J.2
  • 165
    • 0034635778 scopus 로고    scopus 로고
    • Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women
    • DOI 10.1016/S0140-6736(99)05463-X
    • Garnero P, Sornay-Rendu E, Delmas PD. Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women. Lancet. 2000;355:898-899. (Pubitemid 30137673)
    • (2000) Lancet , vol.355 , Issue.9207 , pp. 898-899
    • Garnero, P.1    Sornay-Rendu, E.2    Delmas, P.D.3
  • 166
    • 84867647498 scopus 로고    scopus 로고
    • Inflammation in aging: Cause, effect, or both?
    • Jenny NS. Inflammation in aging: cause, effect, or both? Discov Med. 2012;13:451-460.
    • (2012) Discov Med , vol.13 , pp. 451-460
    • Jenny, N.S.1
  • 168
    • 33748091692 scopus 로고    scopus 로고
    • Osteoclast precursors: Cytokine-stimulated immunomodulators of inflammatory bone disease
    • DOI 10.1097/01.bor.0000231913.32364.32, PII 0000228120060700000017
    • Boyce BF, Schwarz EM, Xing L. Osteoclast precursors: cytokinestimulated immunomodulators of inflammatory bone disease. Curr Opin Rheumatol. 2006;18:427-432. (Pubitemid 44297290)
    • (2006) Current Opinion in Rheumatology , vol.18 , Issue.4 , pp. 427-432
    • Boyce, B.F.1    Schwarz, E.M.2    Xing, L.3


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