Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging

BioEssays

Volumn 30, Issue 2, 2008, Pages 102-106

  DeCarolis, Nathan A ^a   Wharton Jr , Keith A ^b   Eisch, Amelia J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; WNT PROTEIN;

CELL AGING; CELL FATE; CELL FUNCTION; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; STEM CELL;

ANIMALS; CELL AGING; HUMANS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 38849092190     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.20709     Document Type: Review

References (43)

1. Ye X, Zerlanko B, Kennedy A, Banumathy G, Zhang R, et al. 2007. Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol Cell 27:183-196.
2. Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, et al. 2007. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 317:807-810.
3. Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, et al. 2007. Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317: 803-806.
4. Clevers H. 2006. Wnt/beta-catenin signaling in development and disease. Cell 127:469-480.
5. Reya T, Clevers H. 2005. Wnt signalling in stem cells and cancer. Nature 434:843-850.
6. Manolagas SC, Almeida M. 2007. Gone with the Wnts: {beta}-Catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Mol Endocrinol 21: 2605-2614.
7. Sharpless NE, DePinho RA. 2007. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8:703-713.
8. Campisi J. 2005. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120:513-522.
9. Hoffman J, Kuhnert F, Davis CR, Kuo CJ. 2004. Wnts as essential growth factors for the adult small intestine and colon. Cell Cycle 3:554-557.
10. Kuhnert F, Davis CR, Wang HT, Chu P, Lee M, et al. 2004. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci USA 101:266-271.
11. Zhou CJ, Zhao C, Pleasure SJ. 2004. Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities. J Neurosci 24:121-126.
12. Chen Y, Whetstone HC, Lin AC, Nadesan P, Wei Q, et al. 2007. Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. PLoS Med 4:e249.
13. Ito M, Yang Z, Andl T, Cui C, Kim N, et al. 2007. Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature 447:316-320.
14. Kortlever RM, Higgins PJ, Bernards R. 2006. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol 8:877-884.
15. Zmijewski JW, Jope RS. 2004. Nuclear accumulation of glycogen synthase kinase-3 during replicative senescence of human fibroblasts. Aging Cell 3:309-317.
16. Rowe WB, Blalock EM, Chen KC, Kadish I, Wang D, et al. 2007. Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats. J Neurosci 27:3098-3110.
17. Lee SJ, Chung YH, Joo KM, Lim HC, Jeon GS, et al. 2006. Age-related changes in glycogen synthase kinase 3beta (GSK3beta) immunoreactivity in the central nervous system of rats. Neurosci Lett 409:134-139.
18. Inestrosa NC, Varela-Nallar L, Grabowski CP, Colombres M. 2007. Synaptotoxicity in Alzheimer's disease: the Wnt signaling pathway as a molecular target. IUBMB Life 59:316-321.
19. Alvarez AR, Godoy JA, Mullendorff K, Olivares GH, Bronfman M, et al. 2004. Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons. Exp Cell Res 297:186-196.
20. Asuni AA, Hooper C, Reynolds CH, Lovestone S, Anderton BH, et al. 2006. GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt. Eur J Neurosci 24:3387-3392.
21. Engel T, Goni-Oliver P, Lucas JJ, Avila J, Hernandez F. 2006. Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert. J Neurochem 99:1445-1455.
22. Rockenstein E, Torrance M, Adame A, Mante M, Bar-on P, et al. 2007. Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. J Neurosci 27:1981-1991.
23. Liang J, Slingerland JM. 2003. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2:339-345.
24. Scali C, Caraci F, Gianfriddo M, Diodato E, Roncarati R, et al. 2006. Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by D KK1. Neurobiol Dis 24:254-265.
25. Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, et al. 2005. Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell 8:19-30.
26. Kirstetter P, Anderson K, Porse BT, Jacobsen SE, Nerlov C. 2006. Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol 7:1048-1056.
27. Scheller M, Huelsken J, Rosenbauer F, Taketo MM, Birchmeier W, et al. 2006. Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation. Nat Immunol 7:1037-1047.
28. Mao CD, Hoang P, DiCorleto PE. 2001. Lithium inhibits cell cycle progression and induces stabilization of p53 in bovine aortic endothelial cells. J Biol Chem 276:26180-26188.
29. Damalas A, Kahan S, Shtutman M, Ben-Ze'ev A, Oren M. 2001. Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation. Embo J 20:4912-4922.
30. Ashton KJ, Willems L, Holmgren K, Ferreira L, Headrick JP. 2006. Age-associated shifts in cardiac gene transcription and transcriptional responses to ischemic stress. Exp Gerontol 41:189-204.
31. Chilosi M, Poletti V, Zamo A, Lestani M, Montagna L, et al. 2003. Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol 162:1495-1502.
32. Jiang F, Parsons CJ, Stefanovic B. 2006. Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol 45:401-409.
33. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, et al. 1997. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45-51.
34. Lanske B, Razzaque MS. 2007. Premature aging in klotho mutant mice: cause or consequence? Ageing Res Rev 6:73-79.
35. Miller R. 2007. Of aging mice and men. Science 318:390; author reply 390.
36. Beausejour CM, Campisi J. 2006. Ageing: balancing regeneration and cancer. Nature 443:404-405.
37. Sommer L. 2004. Multiple rales of canonical Wnt signaling in cell cycle progression and cell lineage specification in neural development. Cell Cycle 3:701-703.
38. Polesskaya A, Seale P, Rudnicki MA. 2003. Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration. Cell 113:841-852.
39. Essers MA, de Vries-Smits LM, Barker N, Polderman PE, Burgering BM, et al. 2005. Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308:1181-1184.
40. Almeida M, Han L, Martin-Millan M, O'Brien CA, Manolagas SC. 2007. Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription. J Biol Chem 282:27298-27305.
41. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, et al. 2004. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303:2011-2015.
42. Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, et al. 1997. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389:994-999.
43. Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, et al. 1999. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398:630-634.