Impaired differentiation potential of human trabecular bone mesenchymal stromal cells from elderly patients

Cytotherapy

Volumn 11, Issue 5, 2009, Pages 584-594

  Coipeau, Patrick ^a,b   Rosset, Philippe ^a,b   Langonn, Alain ^b,c   Gaillard, Julien ^b,c   Delorme, Bruno ^b   Rico, Anglique ^b,c   Domenech, Jorge ^a,b   Charbord, Pierre ^b   Senseb, Luc ^b,c  

^a UNIVERSITY HOSPITAL OF TOURS   (France)

^b UNIVERSITÉ DE TOURS   (France)

^c ETABLISSEMENT FRANÇAIS DU SANG   (France)

Author keywords

Colony forming unit fi broblasts; Differentiation potential; Fi broblast growth factor 2; Human mesenchymal stromal cells; Trabecular bone

Indexed keywords

5' NUCLEOTIDASE; ALCIAN BLUE; ALPHA1 INTEGRIN; CD146 ANTIGEN; ENDOGLIN; FIBROBLAST GROWTH FACTOR 2; RNA; THY 1 ANTIGEN;

ADIPOCYTE; ADULT; AGED; ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CHONDROGENESIS; CLINICAL ARTICLE; COLONY FORMING UNIT F; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; FEMUR HEAD; HIP OSTEOARTHRITIS; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; MALE; MESENCHYMAL STEM CELL; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOTAL HIP PROSTHESIS; TRABECULAR BONE;

ADIPOGENESIS; AGED; BIOPSY; BONE AND BONES; BONE MARROW; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; HUMANS; MALE; MESENCHYMAL STEM CELLS; MIDDLE AGED; PHENOTYPE; STEM CELLS; STROMAL CELLS;

EID: 70849133991     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1080/14653240903079385     Document Type: Article

References (28)

1. Pountos I, Jones E, Tzioupis C, McGonagle D, Giannoudis PV. Growing bone and cartilage: The role of mesenchymal stem cells. J Bone Joint Surg (Br) 2006; 88: 421-426
2. Muschler GF, Nakamoto C, Griffith LG. E ngineering principles of clinical cell-based tissue engineering. J Bone Joint Surg (Am) 2004; 86: 1541-1558
3. Goldberg VM. Selection of bone grafts for revision total hip arthroplasty. Clin Orthop Relat Res 2000; 381: 68-76.
4. Stevenson S. E nhancement of fracture healing with autogenous and allogeneic bone grafts. Clin Orthop Relat Res 1998; 355: S239-46.
5. Bruder SP, F ox BS. Tissue engineering of bone. Cell based strategies. Clin Orthop Relat Res 1999; 367: S68-83.
6. Hernigou P, Poignard A, Beaujean F, Rouard H. Percutaneous autologous bone-marrow grafting for nonunions. Infl uence of the number and concentration of progenitor cells. J Bone Joint Surg (Am) 2005; 87: 1430-1437
7. Caplan AI. Mesenchymal stem cells. J Orthop Res 1991; 9: 641-650
8. Horwitz EM, Prockop DJ, Fitzpatrick LA, Koo WW, Gordon PL, Neel M, et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 1999; 5: 309-313
9. Quarto R, Mastrogiacomo M, Cancedda R, Kutepov SM, Mukhachev V, Lavroukov A, et al. Repair of large bone defects with the use of autologous bone marrow stromal cells. N Eng J Med 2001; 344: 385-386 (Pubitemid 32107654)
10. Cancedda R, Bianchi G, Derubeis A, Quarto R. Cell therapy for bone disease: A review of current status. Stem Cells 2003; 21: 610-619
11. Sakaguchi Y, Sekiya I, Yagishita K, Ichinose S, Shinomyia K, Muneta T. Suspended cells from trabecular bone by collagenase digestion become virtually identical to mesenchymal stem cells obtained from marrow aspirates. Blood 2004; 104: 2728-2735
12. Tuli R, Seghatoleslami MR, Tuli S, Wang ML, Hozack WJ, Manner PA, et al. A simple, high-yield method for obtaining multipotential mesenchymal progenitor cells from trabecular bone. Mol Biotechnol 2003; 23: 37-49. (Pubitemid 36106222)
13. Banfi A, Muraglia A, Dozin B, Mastrogiacomo M, Cancedda R, Quarto R. Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy. Exp Hematol 2000; 28: 707-715
14. Risbud MV, Shapiro IM, Guttapalli A, Seghatoleslami R, Denaro V, Vaccaro AR, et al. Osteogenic potential of adult human stem cells of the lumbar vertebral body and the iliac crest. Spine 2006; 31: 83-89.
15. Stenderup K, Justensen J, Clausen C, Kassem M. A ging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone 2003; 33: 919-926
16. Baxter MA, Wynn RF, Jowitt SN, Wraith JE, Fairbairn LJ, Bellantuono I. Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion. Stem Cells 2004; 22: 675-682
17. Sensebe L, Li J, Lilly M, Crittenden C, Herve P, Charbord P, et al. Non transformed colony-derived stromal cell lines from normal human marrows. I. Growth requirement and myelopoiesis supportive ability. Exp Hematol 1995; 23: 507-513
18. Bianchi G, Banfi A, Mastrogiacomo M, Notaro R, Luzzatto L, Cancedda R, et al. Ex vivo enrichment of mesenchymal cell progenitors by fi broblast growth factor 2. Exp Cell Res 2003; 287: 98-105.
19. Martin I, Muraglia A, Campanile G, Cancedda R, Quarto R. Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. Endocrinology 1997; 138: 4456-4462
20. Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, et al. Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment. Cell 2007; 131: 324-336
21. Horwitz EM, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, Marchi FC, et al. Clarifi cation of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy 2005; 7: 393-399
22. Gronthos S, Zannettino AC, Hay SJ, Shi S, Graves SE, Kortesidis A, et al. Molecular and cellular characterization of highly purified stromal stem cells derived from human bone marrow. J Cell Science 2003; 116: 1827-1835
23. Tuli R, Tuli S, Nandi S, Wang ML, Alexander PG, Haleem-Smith H, et al. Characterization of multipotential mesenchymal progenitor cells derived from human trabecular bone. Stem Cells 2003; 21: 681-693 (Pubitemid 37329161)
24. Gundle R, Beresford JN. The isolation and culture of cells from explants of human trabecular bone. Calcif Tissue Int 1995; 56: S8-10.
25. Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specifi cation. Cell 2006; 126: 677-689
26. Rodriguez JP, Rios S, Fernandez M, Santibanez JF. Differential activation of ERK1,2 MAP kinase signaling pathway in mesenchymal stem cell from control and osteoporotic postmenopausal women. J Cell Biochem 2004; 92: 745-754
27. Ge C, Xiao G, Jiang D, Franceschi RT. Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biology 2007; 176: 709-718
28. Sensebe L. Clinical grade production of mesenchymal stem cells. Bio-Med Mater Eng 2008; 18: S3-10.