Parallel evolution of tumour subclones mimics diversity between tumours

Journal of Pathology

Volumn 230, Issue 4, 2013, Pages 356-364

  Martinez, Pierre ^a   Birkbak, Nicolai Juul ^b   Gerlinger, Marco ^a,c   McGranahan, Nicholas ^a,d   Burrell, Rebecca A ^a   Rowan, Andrew J ^a   Joshi, Tejal ^b   Fisher, Rosalie ^e   Larkin, James ^e   Szallasi, Zoltan ^b,f   Swanton, Charles ^a,g  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e ROYAL MARSDEN HOSPITAL   (United Kingdom)

^f HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

biomarker; chromosomal instability; copy number; intratumour heterogeneity; personalized medicine; tumour evolution

Indexed keywords

EVEROLIMUS;

ARTICLE; CANCER STAGING; COPY NUMBER VARIATION; GENE DOSAGE; GENETIC HETEROGENEITY; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; INTRATUMOUR HETEROGENEITY; KIDNEY BIOPSY; KIDNEY CARCINOMA; MOLECULAR CLONING; MOLECULAR MIMICRY; NUCLEOTIDE SEQUENCE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SAMPLING ERROR; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; TUMOR BIOPSY; TUMOR GROWTH;

BIOMARKER; CHROMOSOMAL INSTABILITY; COPY NUMBER; INTRATUMOUR HETEROGENEITY; PERSONALIZED MEDICINE; TUMOUR EVOLUTION;

BIOPSY; CARCINOMA, RENAL CELL; CHROMOSOMAL INSTABILITY; CLONE CELLS; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; DNA COPY NUMBER VARIATIONS; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORKS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KIDNEY NEOPLASMS; MUTATION; NEOPLASM STAGING; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84880117116     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4214     Document Type: Article

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