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Volumn 58, Issue 8, 2009, Pages 1826-1834

Deletion of PKCε selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse β-cells

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CALCIUM ION; GLUCOSE; INSULIN; PALMITIC ACID; PROTEIN KINASE C EPSILON; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE;

EID: 68049137606     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-0132     Document Type: Article
Times cited : (40)

References (49)
  • 1
    • 0035856943 scopus 로고    scopus 로고
    • Diabetes mellitus and genetically programmed defects in β-cell function
    • Bell GI, Polonsky KS. Diabetes mellitus and genetically programmed defects in β-cell function. Nature 2001;414:788-791
    • (2001) Nature , vol.414 , pp. 788-791
    • Bell, G.I.1    Polonsky, K.S.2
  • 2
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • Kahn SE, Hull RL, Utzschneider KM: Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006;444:840-846
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 3
    • 39749147110 scopus 로고    scopus 로고
    • Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
    • Muoio DM, Newgard CB. Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol 2008;9:193-205
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 193-205
    • Muoio, D.M.1    Newgard, C.B.2
  • 4
    • 33745863033 scopus 로고    scopus 로고
    • Islet β cell failure in type 2 diabetes
    • Prentki M, Nolan CJ. Islet β cell failure in type 2 diabetes. J Clin Invest 2006;116:1802-1812
    • (2006) J Clin Invest , vol.116 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.J.2
  • 5
    • 43549108142 scopus 로고    scopus 로고
    • Glucolipotoxicity: Fuel excess and β-cell dysfunction
    • Poitout V, Robertson RP. Glucolipotoxicity: fuel excess and β-cell dysfunction. Endocr Rev 2008;29:351-366
    • (2008) Endocr Rev , vol.29 , pp. 351-366
    • Poitout, V.1    Robertson, R.P.2
  • 7
    • 0032478314 scopus 로고    scopus 로고
    • Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
    • Shimabukuro M, Zhou Y-T, Levi M, Unger RH. Fatty acid-induced β cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A 1998;95:2498-2502
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 2498-2502
    • Shimabukuro, M.1    Zhou, Y.-T.2    Levi, M.3    Unger, R.H.4
  • 8
    • 0028268936 scopus 로고
    • Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
    • Zhou YP, Grill VE. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 1994;93:870-876
    • (1994) J Clin Invest , vol.93 , pp. 870-876
    • Zhou, Y.P.1    Grill, V.E.2
  • 12
    • 0142093526 scopus 로고    scopus 로고
    • Fatty acid metabolism and insulin secretion in pancreatic beta cells
    • Yaney GC, Corkey BE. Fatty acid metabolism and insulin secretion in pancreatic beta cells. Diabetologia 2003;46:1297-1312
    • (2003) Diabetologia , vol.46 , pp. 1297-1312
    • Yaney, G.C.1    Corkey, B.E.2
  • 13
    • 48249089367 scopus 로고    scopus 로고
    • Protein kinase C function in muscle, liver, and β-cells and its therapeutic implications for type 2 diabetes
    • Schmitz-Peiffer C, Biden TJ. Protein kinase C function in muscle, liver, and β-cells and its therapeutic implications for type 2 diabetes. Diabetes 2008;57:1774-1783
    • (2008) Diabetes , vol.57 , pp. 1774-1783
    • Schmitz-Peiffer, C.1    Biden, T.J.2
  • 14
    • 0030914330 scopus 로고    scopus 로고
    • Alterations in the expression and cellular localization of protein kinase C isozymes ε and θ are associated with insulin resistance in skeletal muscle of the high-fat-fed rat
    • Schmitz-Peiffer C, Browne CL, Oakes ND, Watkinson A, Chisholm DJ, Kraegen EW, Biden TJ. Alterations in the expression and cellular localization of protein kinase C isozymes ε and θ are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. Diabetes 1997;46:169-178
    • (1997) Diabetes , vol.46 , pp. 169-178
    • Schmitz-Peiffer, C.1    Browne, C.L.2    Oakes, N.D.3    Watkinson, A.4    Chisholm, D.J.5    Kraegen, E.W.6    Biden, T.J.7
  • 16
    • 0033399406 scopus 로고    scopus 로고
    • Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat
    • Laybutt DR, Schmitz-Peiffer C, Saha AK, Ruderman NB, Biden TJ, Kraegen EW. Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat. Am J Physiol 1999;277:E1070-E1076
    • (1999) Am J Physiol , vol.277
    • Laybutt, D.R.1    Schmitz-Peiffer, C.2    Saha, A.K.3    Ruderman, N.B.4    Biden, T.J.5    Kraegen, E.W.6
  • 19
    • 58149145488 scopus 로고    scopus 로고
    • Prevention of insulin resistance and beta-cell loss by abrogating PKCε-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus
    • Mack E, Ziv E, Reuveni H, Kalman R, Niv MY, Jorns A, Lenzen S, Shafrir E. Prevention of insulin resistance and beta-cell loss by abrogating PKCε-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus. Diabetes Metab Res Rev 2008;24:577-584
    • (2008) Diabetes Metab Res Rev , vol.24 , pp. 577-584
    • Mack, E.1    Ziv, E.2    Reuveni, H.3    Kalman, R.4    Niv, M.Y.5    Jorns, A.6    Lenzen, S.7    Shafrir, E.8
  • 24
    • 25844454854 scopus 로고    scopus 로고
    • Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic β-cells from lipoapoptosis
    • Busch AK, Gurisik E, Cordery DV, Sudlow M, Denyer GS, Laybutt DR, Hughes WE, Biden TJ. Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic β-cells from lipoapoptosis. Diabetes 2005;54:2917-2924
    • (2005) Diabetes , vol.54 , pp. 2917-2924
    • Busch, A.K.1    Gurisik, E.2    Cordery, D.V.3    Sudlow, M.4    Denyer, G.S.5    Laybutt, D.R.6    Hughes, W.E.7    Biden, T.J.8
  • 25
    • 0032608438 scopus 로고    scopus 로고
    • Hormone-sensitive lipase and neutral cholesteryl ester lipase
    • Holm C, Osterlund T. Hormone-sensitive lipase and neutral cholesteryl ester lipase. Methods Mol Biol 1999;109:109-121
    • (1999) Methods Mol Biol , vol.109 , pp. 109-121
    • Holm, C.1    Osterlund, T.2
  • 28
    • 0037286364 scopus 로고    scopus 로고
    • Imaging mitochondrial function in intact cells
    • Duchen MR, Surin A, Jacobson J. Imaging mitochondrial function in intact cells. Methods Enzymol 2003;361:353-389
    • (2003) Methods Enzymol , vol.361 , pp. 353-389
    • Duchen, M.R.1    Surin, A.2    Jacobson, J.3
  • 29
    • 3843061592 scopus 로고    scopus 로고
    • AMP kinase and malonyl-CoA: Targets for therapy of the metabolic syndrome
    • Ruderman N, Prentki M. AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nat Rev Drug Discov 2004;3:340-351
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 340-351
    • Ruderman, N.1    Prentki, M.2
  • 31
    • 0347360366 scopus 로고    scopus 로고
    • Inhibition of lipase activity and lipolysis in rat islets reduces insulin secretion
    • Mulder H, Yang S, Winzell MS, Holm C, Ahren B. Inhibition of lipase activity and lipolysis in rat islets reduces insulin secretion. Diabetes 2004;53:122-128
    • (2004) Diabetes , vol.53 , pp. 122-128
    • Mulder, H.1    Yang, S.2    Winzell, M.S.3    Holm, C.4    Ahren, B.5
  • 33
    • 3042781392 scopus 로고    scopus 로고
    • Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1
    • Peyot ML, Nolan CJ, Soni K, Joly E, Lussier R, Corkey BE, Wang SP, Mitchell GA, Prentki M. Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1. Diabetes 2004;53:1733-1742
    • (2004) Diabetes , vol.53 , pp. 1733-1742
    • Peyot, M.L.1    Nolan, C.J.2    Soni, K.3    Joly, E.4    Lussier, R.5    Corkey, B.E.6    Wang, S.P.7    Mitchell, G.A.8    Prentki, M.9
  • 34
    • 33645458999 scopus 로고    scopus 로고
    • Glucose-stimulated insulin secretion correlates with β-cell lipolysis
    • Winzell MS, Ström K, Holm C, Ahrén B. Glucose-stimulated insulin secretion correlates with β-cell lipolysis. Nutr Metab Cardiovasc Dis 2006;16(Suppl.1):S11-S16
    • (2006) Nutr Metab Cardiovasc Dis , vol.16 , Issue.SUPPL.1
    • Winzell, M.S.1    Ström, K.2    Holm, C.3    Ahrén, B.4
  • 35
    • 0030753653 scopus 로고    scopus 로고
    • Engineering of glycerol-stimulated insulin secretion in islet beta cells: Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling
    • Noel RJ, Antinozzi PA, McGarry JD, Newgard CB. Engineering of glycerol-stimulated insulin secretion in islet beta cells: differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling. J Biol Chem 1997;272:18621-18627
    • (1997) J Biol Chem , vol.272 , pp. 18621-18627
    • Noel, R.J.1    Antinozzi, P.A.2    McGarry, J.D.3    Newgard, C.B.4
  • 37
    • 57049093333 scopus 로고    scopus 로고
    • Phorbol-12-myristate 13-acetate acting through protein kinase Cε induces translocator protein (18-kDa) TSPO gene expression
    • Batarseh A, Giatzakis C, Papadopoulos V: Phorbol-12-myristate 13-acetate acting through protein kinase Cε induces translocator protein (18-kDa) TSPO gene expression. Biochemistry 2008;47:12886-12899
    • (2008) Biochemistry , vol.47 , pp. 12886-12899
    • Batarseh, A.1    Giatzakis, C.2    Papadopoulos, V.3
  • 39
    • 0346729966 scopus 로고    scopus 로고
    • PKCα is activated but not required during glucose-induced insulin secretion from rat pancreatic islets
    • Carpenter L, Mitchell CJ, Xu ZZ, Poronnik P, Both GW, Biden TJ. PKCα is activated but not required during glucose-induced insulin secretion from rat pancreatic islets. Diabetes 2004;53:53-60
    • (2004) Diabetes , vol.53 , pp. 53-60
    • Carpenter, L.1    Mitchell, C.J.2    Xu, Z.Z.3    Poronnik, P.4    Both, G.W.5    Biden, T.J.6
  • 41
    • 0024791536 scopus 로고
    • A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic β-cells
    • Corkey BE, Glennon MC, Chen KS, Deeney JT, Matschinsky FM, Prentki M. A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic β-cells. J Biol Chem 1989;264:21608-21612
    • (1989) J Biol Chem , vol.264 , pp. 21608-21612
    • Corkey, B.E.1    Glennon, M.C.2    Chen, K.S.3    Deeney, J.T.4    Matschinsky, F.M.5    Prentki, M.6
  • 43
    • 52249114681 scopus 로고    scopus 로고
    • The islet beta-cell: Fuel responsive and vulnerable
    • Nolan CJ, Prentki M. The islet beta-cell: fuel responsive and vulnerable. Trends Endocrinol Metab 2008;19:285-291
    • (2008) Trends Endocrinol Metab , vol.19 , pp. 285-291
    • Nolan, C.J.1    Prentki, M.2
  • 44
    • 53049094467 scopus 로고    scopus 로고
    • Glycerolipid metabolism and signaling in health and disease
    • Prentki M, Madiraju SR: Glycerolipid metabolism and signaling in health and disease. Endocr Rev 2008;29:647-676
    • (2008) Endocr Rev , vol.29 , pp. 647-676
    • Prentki, M.1    Madiraju, S.R.2
  • 45
    • 53849110273 scopus 로고    scopus 로고
    • Lipases in the pancreatic β-cell: Implications for insulin secretion
    • Fex M, Mulder H. Lipases in the pancreatic β-cell: implications for insulin secretion. Biochem Soc Trans 2008;36:885-890
    • (2008) Biochem Soc Trans , vol.36 , pp. 885-890
    • Fex, M.1    Mulder, H.2
  • 47
    • 3843052408 scopus 로고    scopus 로고
    • Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact
    • Fex M, Olofsson CS, Fransson U, Bacos K, Lindvall H, Sorhede-Winzell M, Rorsman P, Holm C, Mulder H. Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact. Endocrinology 2004;145:3746-3753
    • (2004) Endocrinology , vol.145 , pp. 3746-3753
    • Fex, M.1    Olofsson, C.S.2    Fransson, U.3    Bacos, K.4    Lindvall, H.5    Sorhede-Winzell, M.6    Rorsman, P.7    Holm, C.8    Mulder, H.9
  • 49
    • 0033826850 scopus 로고    scopus 로고
    • Molecular mechanisms regulating hormone-sensitive lipase and lipolysis
    • Holm C, Osterlund T, Laurell H, Contreras JA. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Annu Rev Nutr 2000;20:365-393
    • (2000) Annu Rev Nutr , vol.20 , pp. 365-393
    • Holm, C.1    Osterlund, T.2    Laurell, H.3    Contreras, J.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.