σ-1 receptors (σ1 binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: Roles in endoplasmic reticulum lipid compartmentalization and export

Journal of Pharmacology and Experimental Therapeutics

Volumn 306, Issue 2, 2003, Pages 718-725

  Hayashi, Teruo ^a   Su, Tsung Ping ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOPHILIN; CAVEOLIN 1; CHOLESTEROL; COCAINE; ENDOPLASMIC RETICULUM PROTEIN; LIPID; NEUROLEPTIC AGENT; NEUROSTEROID; OLEIC ACID; PENTAZOCINE; PROTEIN; PSYCHOTROPIC AGENT; SIGMA 1 OPIATE RECEPTOR; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL COMPARTMENTALIZATION; COMPARTMENT MODEL; CONTROLLED STUDY; DEPRESSION; DRUG DEPENDENCE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED LIPID DROPLET; LIPID COMPARTMENTALIZATION; LIPID MICRODOMAIN; LIPID RAFT; LIPID STORAGE; LIPID STORAGE SITE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SCHIZOPHRENIA;

ANIMALS; BACTERIAL PROTEINS; BINDING SITES; ENDOPLASMIC RETICULUM; GUINEA PIGS; HYBRIDOMAS; INTRACELLULAR MEMBRANES; LUMINESCENT PROTEINS; MICE; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, SIGMA; TUMOR CELLS, CULTURED;

EID: 0037924355     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.051284     Document Type: Article

References (40)

1. Anderson RG (1998) The caveolae membrane system. Annu Rev Biochem 67:199-225.
2. Aydar E, Palmer CP, Klyachko VA, and Jackson MB (2002) The sigma receptor as a ligand-regulated auxiliary potassium channel subunit. Neuron 34:399-410.
3. Bowen WD, Hellewell SW, and McGarry KA (1989) Evidence for a multi-site model of the rat brain sigma receptor. Eur J Pharmacol 163:309-318.
4. Brasaemle DL, Barber T, Wolins NE, Serrero G, Blanchette-Mackie EJ, and Londos C (1997) Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J Lipid Res 38:2249-2263.
5. Braverman N, Lin P, Moebius FF, Obie C, Moser A, Glossmann H, Wilcox WR, Rimoin DL, Smith M, Kratz L, et al. (1999) Mutations in the gene encoding 3 beta-hydroxysteroid-delta 8, delta 7-isomerase cause X-linked dominant Conradi-Hunermann syndrome. Nat Genet 22:291-294.
6. Brown D, Lydon J, McLaughlin M, Stuart-Tilley A, Tyszkowski R, and Alper S (1996) Antigen retrieval in cryostat tissue sections and cultured cells by treatment with sodium dodecyl sulfate (SDS). Histochem Cell Biol 105:261-267.
7. Corvera S, DiBonaventura C, and Shpetner HS (2000) Cell confluence-dependent remodeling of endothelial membranes mediated by cholesterol. J Biol Chem 275:31414-31421.
8. Dietschy JM and Turley SD (2001) Cholesterol metabolism in the brain. Curr Opin Lipidol 12:105-112.
9. Fujimoto T, Kogo H, Ishiguro K, Tauchi K, and Nomura R (2001) Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell. J Cell Biol 152:1079-1085.
10. Gebreselassie D and Bowen WD (2002) Sigma-2 receptors are components of sphingolipid/cholesterol-rich membrane rafts. Soc Neurosci Abstr 235:20.
11. Hanner M, Moebius FF, Flandorfer A, Knaus HG, Striessnig J, Kempner E, and Glossmann H (1996) Purification, molecular cloning and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci USA 93:8072-8077.
12. 2+ concentration. J Pharmacol Exp Ther 293:788-798.
13. Hayashi T and Su TP (2001) Regulating ankyrin dynamics: roles of sigma-1 receptors. Proc Natl Acad Sci USA 98:491-496.
14. Keon JP, James CS, Court S, Baden-Daintree C, Bailey AM, Burden RS, Bard M, and Hargreaves JA (1994) Isolation of the ERG2 gene, encoding sterol Δ8-Δ7 isomerase, from the rice blast fungus Magnaporthe grisea and its expression in the maize smut pathogen Ustilago maydis. Curr Genet 25:531-537.
15. Labit-Le Bouteiller C, Jamme MF, David M, Silve S, Lanau C, Dhers C, Picard C, Rahier A, Taton M, Loison G, et al. (1998) Antiproliferative effects of SR31747A in animal cell lines are mediated by inhibition of cholesterol biosynthesis at the sterol isomerase step. Eur J Biochem 256:342-349.
16. Londos C, Brasaemle DL, Schultz CJ, Adler-Wailes DC, Levin DM, Kimmel AR, and Rondinone CM (1999b) On the control of lipolysis in adipocytes. Ann NY Acad Sci 892:155-168.
17. Martin WR, Eades CG, Thompson JA, Huppler RE, and Gilbert PE (1976) The effects of morphine and nalorphine-like drugs in the non-dependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther 197:517-532.
18. Matsumoto RR, McCracken KA, Pouw B, Miller J, Bowen WD, Williams W, and De Costa BR (2001) N-Alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice. Eur J Pharmacol 411:261-273.
19. Maurice T and Lockhart BP (1997) Neuroprotective and anti-amnesic potentials of sigma (σ) receptor ligands. Prog Neuropsychopharmacol Biol Psychiatry 21:69-102.
20. 3H]SKF-10,047 binding sites (sigma sites) exhibit a unique distribution in rat brain subcellular fractions. Eur J Pharmacol 188:211-218.
21. Monnet FP, Debonnel G, Junien JL, and De Montigny C (1990) N-Methyl-D-aspartate-induced neuronal activation is selectively modulated by sigma receptors. Eur J Pharmacol 179:441-445.
22. Morin-Surun MP, Collin T, Denavit-Saubie M, Baulieu EE, and Monnet FP (1999) Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem. Proc Natl Acad Sci USA 96:8196-8199.
23. Murphy DJ and Vance J (1999) Mechanisms of lipid-body formation. Trends Biochem Sci 24:109-115.
24. Narita N, Hashimoto K, Tomitaka S, and Minoabe Y (1996) Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain. Eur J Pharmacol 307:117-119.
25. 3H]dopamine release is dependent upon protein kinase C. J Pharmacol Exp Ther 304:364-369.
26. Ostermeyer AG, Paci JM, Zeng Y, Lublin DM, Munro S, and Brown DA (2001) Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets. J Cell Biol 152:1071-1078.
27. Pol A, Luetterforst R, Lindsay M, Heino S, Ikonen E, and Parton RG (2001) A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance. J Cell Biol 152:1057-1070.
28. Schutze MP, Peterson PA, and Jackson MR (1994) An N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulum. EMBO J 13:1696-1705.
29. Seth P, Leibach FH, and Ganapathy V (1997) Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor. Biochem Biophys Res Commun 241:535-540.
30. Sharkey J, Glen KA, Wolfe S, and Kuhar MJ (1988) Cocaine binding at sigma receptors. Eur J Pharmacol 149:171-174.
31. Simons K and Toomre D (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1:31-39.
32. Snyder SH and Largent BL (1989) Receptor mechanisms in antipsychotic drug action: focus on sigma receptors. J Neuropsychiatry Clin Neurosci 1:7-15.
33. 3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain. J Pharmacol Exp Ther 223:284-290.
34. Su TP, London ED, and Jaffe JH (1988) Steroid binding at sigma receptors suggests a link between endocrine, nervous and immune systems. Science (Wash DC) 240:219-221.
35. Takebayashi M, Hayashi T, and Su TP (2002) Nerve growth factor-induced neurite sprouting in PC12 cells involves sigma-1 receptors: implications for antidepressants. J Pharmacol Exp Ther 303:1227-1237.
36. Tauchi-Sato K, Ozeki S, Houjou T, Taguchi R, and Fujimoto T (2002) The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition. J Biol Chem 277:44507-44512.
37. Ujike H, Kuroda S, and Otsuki S (1996) Sigma receptor antagonists block the development of sensitization to cocaine. Eur J Pharmacol 296:123-128.
38. Urani A, Roman FJ, Phan VL, Su TP, and Maurice T (2001) The antidepressant-like effect induced by sigma(1)-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test. J Pharmacol Exp Ther 298:1269-1279.
39. van Meer G and Holthuis JC (2000) Sphingolipid transport in eukaryotic cells. Biochim Biophys Acta 1486:145-170.
40. Yamamoto H, Miura R, Yamamoto T, Shinohara K, Watanabe M, Okuyama S, Nakazato A, and Nukada T (1999) Amino acid residues in the transmembrane domain of the type 1 sigma receptor critical for ligand binding. FEBS Lett 445:19-22.