Exercise and the aging endothelium

Journal of Diabetes Research

Volumn 2013, Issue , 2013, Pages

  Golbidi, Saeid ^a   Laher, Ismail ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CYCLOOXYGENASE 2; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIUM DERIVED CONSTRICTING FACTOR; EPITHELIAL CELL ADHESION MOLECULE; INOSINATE DEHYDROGENASE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOXYGENASE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN SYNTHASE; RHO KINASE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; NITRIC OXIDE;

AGING; CARDIOVASCULAR RISK; ENDOTHELIAL DYSFUNCTION; EXERCISE; HOMEOSTASIS; HUMAN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; VASCULAR ENDOTHELIUM; VASCULITIS; INFLAMMATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; VASODILATATION;

AGING; ENDOTHELIUM, VASCULAR; EXERCISE; HUMANS; INFLAMMATION; NITRIC OXIDE; OXIDATIVE STRESS; VASODILATION;

EID: 84883200210     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2013/789607     Document Type: Review

References (145)

1. Yusuf S., Reddy S., Ôunpuu S., Anand S., Global burden of cardiovascular diseases-part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation 2001 104 22 2746 2753 2-s2.0-0035960630
2. National Centre for Health Statistics (US),. http://www.cdc.gov./nchs/ hus.htm
3. Yu B. P., Aging and oxidative stress: modulation by dietary restriction. Free Radical Biology and Medicine 1996 21 5 651 668 2-s2.0-0029759443 10.1016/0891-5849(96)00162-1
4. Beckman K. B., Ames B. N., The free radical theory of aging matures. Physiological Reviews 1998 78 2 547 581 2-s2.0-0031916984
5. Vita J. A., Nitric oxide-dependent vasodilation in human subjects. Methods in Enzymology 2002 359 186 200 2-s2.0-0036441365 10.1016/S0076-6879(02) 59183-7
6. Bonetti P. O., Lerman L. O., Lerman A., Endothelial dysfunction: a marker of atherosclerotic risk. Arteriosclerosis, Thrombosis, and Vascular Biology 2003 23 2 168 175 2-s2.0-0037324283 10.1161/01.ATV.0000051384.43104.FC
7. Anderson T. J., Assessment and treatment of endothelial dysfunction in humans. Journal of the American College of Cardiology 1999 34 3 631 638 2-s2.0-0032869042 10.1016/S0735-1097(99)00259-4
8. Chung H. Y., Kim H. J., Kim J. W., Yu B. P., The inflammation hypothesis of aging: molecular modulation by calorie restriction. Annals of the New York Academy of Sciences 2001 928 327 335 2-s2.0-0035040549
9. Clarkson P., Montgomery H. E., Mullen M. J., Donald A. E., Powe A. J., Bull T., Jubb M., World M., Deanfield J. E., Exercise training enhances endothelial function in young men. Journal of the American College of Cardiology 1999 33 5 1379 1385 2-s2.0-0033117209 10.1016/S0735-1097(99)00036-4
10. Benjamin E. J., Larson M. G., Keyes M. J., Mitchell G. F., Vasan R. S., Keaney J. F. Jr., Lehman B. T., Fan S., Osypiuk E., Vita J. A., Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study. Circulation 2004 109 5 613 619 2-s2.0-10744221815 10.1161/01.CIR.0000112565.60887.1E
11. Hambrecht R., Fiehn E., Weigl C., Gielen S., Hamann C., Kaiser R., Yu J., Adams V., Niebauer J., Schuler G., Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 1998 98 24 2709 2715 2-s2.0-0032534496
12. Maiorana A., O'Driscoll G., Cheetham C., Dembo L., Stanton K., Goodman C., Taylor R., Green D., The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes. Journal of the American College of Cardiology 2001 38 3 860 866 2-s2.0-0034845819 10.1016/S0735-1097(01) 01439-5
13. Maiorana A., O'Driscoll G., Dembo L., Goodman C., Taylor R., Green D., Exercise training, vascular function, and functional capacity in middle-aged subjects. Medicine and Science in Sports and Exercise 2001 33 12 2022 2028 2-s2.0-0035212749
14. Verma S., Anderson T. J., Fundamentals of endothelial function for the clinical cardiologist. Circulation 2002 105 5 546 549 2-s2.0-0037022256 10.1161/hc0502.104540
15. Cosentino F., Osto E., Aging and endothelial dysfunction. Clinical Hemorheology and Microcirculation 2007 37 143 147
16. Deanfield J., Donald A., Ferri C., Giannattasio C., Halcox J., Halligan S., Lerman A., Mancia G., Oliver J. J., Pessina A. C., Rizzoni D., Rossi G. P., Salvetti A., Schiffrin E. L., Taddei S., Webb D. J., Endothelial function and dysfunction-part I: methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension. Journal of Hypertension 2005 23 1 7 17 2-s2.0-19944430327 10.1097/00004872-200501000-00004
17. Golbidi S., Mesdaghinia A., Laher I., Exercise in the metabolic syndrome. Oxidative Medicine and Cellular Longevity 2012 2012 13 349710 10.1155/2012/349710
18. 2+-calmodulin and caveolin. Journal of Biological Chemistry 1997 272 25 15583 15586 2-s2.0-0030953208 10.1074/jbc.272.25.15583
19. Dessy C., Feron O., Balligand J.-L., The regulation of endothelial nitric oxide synthase by caveolin: a paradigm validated in vivo and shared by the 'endothelium-derived hyperpolarizing factor'. Pflugers Archiv-European Journal of Physiology 2010 459 6 817 827 2-s2.0-77952891002 10.1007/s00424-010-0815-3
20. Bobeuf F., Labonte M., Dionne I. J., Khalil A., Combined effect of antioxidant supplementation and resistance training on oxidative stress markers, muscle and body composition in an elderly population. Journal of Nutrition, Health and Aging 2011 15 10 883 889 2-s2.0-84856270125 10.1007/s12603-011-0097-2
21. Anton S. D., Manini T. M., Milsom V. A., Dubyak P., Cesari M., Cheng J., Daniels M. J., Marsiske M., Pahor M., Leeuwenburgh C., Perri M. G., Effects of a weight loss plus exercise program on physical function in overweight, older women: a randomized controlled trial. Clinical Interventions in Aging 2011 6 1 141 149 2-s2.0-80755167676
22. Gano L. B., Donato A. J., Pierce G. L., Pasha H. M., Magerko K. A., Roeca C., Seals D. R., Increased proinflammatory and oxidant gene expression in circulating mononuclear cells in older adults: amelioration by habitual exercise. Physiological Genomics 2011 43 14 895 902 2-s2.0-79960998647 10.1152/physiolgenomics.00204.2010
23. Campbell P. T., Gross M. D., Potter J. D., Schmitz K. H., Duggan C., McTiernan A., Ulrich C. M., Effect of exercise on oxidative stress: a 12-month randomized, controlled trial. Medicine and Science in Sports and Exercise 2010 42 8 1448 1453 2-s2.0-77954889413 10.1249/MSS.0b013e3181cfc908
24. Wray D. W., Uberoi A., Lawrenson L., Bailey D. M., Richardson R. S., Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome. Clinical Science 2009 116 5 433 441 2-s2.0-63449106961 10.1042/CS20080337
25. Sixt S., Rastan A., Desch S., Sonnabend M., Schmidt A., Schuler G., Niebauer J., Exercise training but not rosiglitazone improves endothelial function in prediabetic patients with coronary disease. European Journal of Cardiovascular Prevention and Rehabilitation 2008 15 4 473 478 2-s2.0-55249095583 10.1097/HJR.0b013e3283002733
26. Gonzales J. U., Thistlethwaite J. R., Thompson B. C., Scheuermann B. W., Exercise-induced shear stress is associated with changes in plasma von Willebrand factor in older humans. European Journal of Applied Physiology 2009 106 5 779 784 2-s2.0-67650315420 10.1007/s00421-009-1074-x
27. Xia W.-H., Li J., Su C., Yang Z., Chen L., Wu F., Zhang Y.-Y., Yu B.-B., Qiu Y.-X., Wang S.-M., Tao J., Physical exercise attenuates age-associated reduction in endothelium-reparative capacity of endothelial progenitor cells by increasing CXCR4/JAK-2 signaling in healthy men. Aging Cell 2012 11 1 111 119 2-s2.0-84855836122 10.1111/j.1474-9726.2011.00758.x
28. Pierce G. L., Eskurza I., Walker A. E., Fay T. N., Seals D. R., Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults. Clinical Science 2011 120 1 13 23 2-s2.0-78650918287 10.1042/CS20100174
29. van Guilder G. P., Westby C. M., Greiner J. J., Stauffer B. L., DeSouza C. A., Endothelin-1 vasoconstrictor tone increases with age in healthy men but can be reduced by regular aerobic exercise. Hypertension 2007 50 2 403 409 2-s2.0-34547647233 10.1161/HYPERTENSIONAHA.107.088294
30. da Silva C. A., Ribeiro J. P., Canto J. C. A. U., da Silva R. E., Silva Junior G. B., Botura E., Malschitzky M. A., High-intensity aerobic training improves endothelium-dependent vasodilation in patients with metabolic syndrome and type 2 diabetes mellitus. Diabetes Research and Clinical Practice 2012 95 2 237 245 2-s2.0-84856341590 10.1016/j.diabres.2011.09.034
31. Okada S., Hiuge A., Makino H., Nagumo A., Takaki H., Goto H. K., Yoshimasa Y., Miyamoto Y., Effect of exercise intervention on endothelial function and incidence of cardiovascular disease in patients with type 2 diabetes. Journal of Atherosclerosis and Thrombosis 2010 17 8 828 833 2-s2.0-77957140607
32. Vona M., Codeluppi G. M., Iannino T., Ferrari E., Bogousslavsky J., von Segesser L. K., Effects of different types of exercise training followed by detraining on endothelium-dependent dilation in patients with recent myocardial infarction. Circulation 2009 119 12 1601 1608 2-s2.0-65249088442 10.1161/CIRCULATIONAHA.108.821736
33. Yamamoto K., Ando J., New molecular mechanisms for cardiovascular disease: blood flow sensing mechanism in vascular endothelial cells. Journal of Pharmacological Sciences 2011 116 4 323 331 2-s2.0-84860390350 10.1254/jphs.10R29FM
34. Gielen S., Schuler G., Adams V., Cardiovascular effects of exercise training: molecular mechanisms. Circulation 2010 122 12 1221 1238 2-s2.0-77957268188 10.1161/CIRCULATIONAHA.110.939959
35. Stuart C. A., Shangraw R. E., Prince M. J., Peters E. J., Wolfe R. R., Bed-rest-induced insulin resistance occurs primarily in muscle. Metabolism 1988 37 8 802 806 2-s2.0-0023686865
36. Arciero P. J., Smith D. L., Calles-Escandon J., Effects of short-term inactivity on glucose tolerance, energy expenditure, and blood flow in trained subjects. Journal of Applied Physiology 1998 84 4 1365 1373 2-s2.0-0031921720
37. Smorawiński J., Kaciuba-Uściłko H., Nazar K., Kubala P., Kamińska E., Ziemba A. W., Adrian J., Greenleaf J. E., Effects of three-day bed rest on metabolic, hormonal and circulatory responses to an oral glucose load in endurance or strength trained athletes and untrained subjects. Journal of Physiology and Pharmacology 2000 51 2 279 289 2-s2.0-0033934553
38. Thosar S. S., Johnson B. D., Johnston J. D., Wallace J. P., Sitting and endothelial dysfunction: the role of shear stress. Medical Science Monitor 2012 18 RA173 RA180 10.12659/MSM.883589
39. Demiot C., Dignat-George F., Fortrat J.-O., Sabatier F., Gharib C., Larina I., Gauquelin-Koch G., Hughson R., Custaud M.-A., WISE 2005: chronic bed rest impairs microcirculatory endothelium in women. American Journal of Physiology-Heart and Circulatory Physiology 2007 293 5 H3159 H3164 2-s2.0-36148954272 10.1152/ajpheart.00591.2007
40. di Francescomarino S., Sciartilli A., di Valerio V., di Baldassarre A., Gallina S., The effect of physical exercise on endothelial function. Sports Medicine 2009 39 10 797 812 2-s2.0-70349194901 10.2165/11317750-000000000-00000
41. Luscher T. F., Noll G., The endothelium in coronary vascular control. Heart Disease 1995 3 1 10
42. Vanhoutte P. W., Ageing and endothelial dysfunction. European Heart Journal 2002 4 A8 A17 10.1016/S1520-765X(02)90068-4
43. Lakatta E. G., Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises-part III: cellular and molecular clues to heart and arterial aging. Circulation 2003 107 3 490 497 2-s2.0-0037469206 10.1161/01.CIR.0000048894.99865.02
44. Brandes R. P., Fleming I., Busse R., Endothelial aging. Cardiovascular Research 2005 66 2 286 294 2-s2.0-16344372461 10.1016/j.cardiores.2004.12.027
45. Rahman K., Studies on free radicals, antioxidants, and co-factors. Clinical Interventions in Aging 2007 2 2 219 236 2-s2.0-38449121513
46. Cai H., Harrison D. G., Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circulation Research 2000 87 10 840 844 2-s2.0-0034634281
47. Taddei S., Virdis A., Ghiadoni L., Salvetti G., Bernini G., Magagna A., Salvetti A., Age-related reduction of NO availability and oxidative stress in humans. Hypertension 2001 38 2 274 279 2-s2.0-0035570723
48. Sun D., Huang A., Yan E. H., Wu Z., Yan C., Kaminski P. M., Oury T. D., Wolin M. S., Kaley G., Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats. American Journal of Physiology-Heart and Circulatory Physiology 2004 286 6 H2249 H2256 2-s2.0-2542467787 10.1152/ajpheart.00854.2003
49. Minamino T., Miyauchi H., Yoshida T., Ishida Y., Yoshida H., Komuro I., Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 2002 105 13 1541 1544 2-s2.0-0037007075 10.1161/01.CIR.0000013836.85741.17
50. Durrant J. R., Seals D. R., Connell M. L., Russell M. J., Lawson B. R., Folian B. J., Donato A. J., Lesniewski L. A., Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase. Journal of Physiology 2009 587 13 3271 3285 2-s2.0-67650354412 10.1113/jphysiol.2009.169771
51. van der Loo B., Labugger R., Skepper J. N., Bachschmid M., Kilo J., Powell J. M., Palacios-Callender M., Erusalimsky J. D., Quaschning T., Malinski T., Gygi D., Ullrich V., Lüscher T. F., Enhanced peroxynitrite formation is associated with vascular aging. Journal of Experimental Medicine 2000 192 12 1731 1743 2-s2.0-0034684652 10.1084/jem.192.12.1731
52. Cernadas M. R., Sánchez de Miguel L., García-Durán M., González-Fernández F., Millás I., Montón M., Rodrigo J., Rico L., Fernández P., de Frutos T., Rodríguez-Feo J. A., Guerra J., Caramelo C., Casado S., López-Farré Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats. Circulation Research 1998 83 3 279 286
53. Pennathur S., Heinecke J. W., Oxidative stress and endothelial dysfunction in vascular disease. Current Diabetes Reports 2007 7 4 257 264 2-s2.0-34547875025 10.1007/s11892-007-0041-3
54. Versari D., Daghini E., Virdis A., Ghiadoni L., Taddei S., The ageing endothelium, cardiovascular risk and disease in man. Experimental Physiology 2009 94 3 317 321 2-s2.0-60349117394 10.1113/expphysiol.2008.043356
55. Hamilton C. A., Brosnan M. J., McIntyre M., Graham D., Dominiczak A. F., Superoxide excess in hypertension and aging a common cause of endothelial dysfunction. Hypertension 2001 37 2 529 534 2-s2.0-0035097953
56. Görlach A., Brandes R. P., Nguyen K., Amidi M., Dehghani F., Busse R., A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall. Circulation Research 2000 87 1 26 32 2-s2.0-0034617071
57. Jung O., Schreiber J. G., Geiger H., Pedrazzini T., Busse R., Brandes R. P., gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension. Circulation 2004 109 14 1795 1801 2-s2.0-3342983728 10.1161/01.CIR.0000124223.00113.A4
58. Donato A. J., Eskurza I., Silver A. E., Levy A. S., Pierce G. L., Gates P. E., Seals D. R., Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor- B. Circulation Research 2007 100 11 1659 1666 2-s2.0-34250216014 10.1161/01.RES.0000269183.13937.e8
59. Turko I. V., Marcondes S., Murad F., Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA:3-oxoacid CoA-transferase. American Journal of Physiology-Heart and Circulatory Physiology 2001 281 6 H2289 H2294 2-s2.0-0035668056
60. + channel-mediated vasodilation. Vascular Pharmacology 2002 38 1 43 49 2-s2.0-0036461688 10.1016/S1537-1891(02) 00125-8
61. + channel activity in smooth muscle of human coronary arterioles. Circulation Research 2002 91 11 1070 1076 2-s2.0-0037195428 10.1161/01.RES.0000046003.14031.98
62. Soriano F., Virág L., Szabó C., Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly(ADP-ribose) polymerase activation. Journal of Molecular Medicine 2001 79 8 437 448 2-s2.0-0034890040 10.1007/s001090100236
63. Eskurza I., Myerburgh L. A., Kahn Z. D., Seals D. R., Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults. Journal of Physiology 2005 568 3 1057 1065 2-s2.0-27844587829 10.1113/jphysiol.2005.092734
64. Lee S., Park Y., Zuidema M. Y., Hannink M., Zhang C., Effects of interventions on oxidative stress and inflammation of cardiovascular diseases. World Journal of Cardiology 2011 3 18 24
65. Barton M., Cosentino F., Brandes R. P., Moreau P., Shaw S., Lüscher T. F., Anatomic heterogeneity of vascular aging: role of nitric oxide and endothelin. Hypertension 1997 30 4 817 824 2-s2.0-0030774840
66. He T., Joyner M. J., Katusic Z. S., Aging decreases expression and activity of glutathione peroxidase-1 in human endothelial progenitor cells. Microvascular Research 2009 78 3 447 452 2-s2.0-71549137764 10.1016/j.mvr.2009. 08.009
67. Leung F. P., Yung L. M., Laher I., Yao X., Chen Z. Y., Huang Y., Exercise, vascular wall and cardiovascular diseases: an update (part 1). Sports Medicine 2008 38 12 1009 1024 2-s2.0-56749174410
68. Balducci S., Zanuso S., Nicolucci A., Fernando F., Cavallo S., Cardelli P., Fallucca S., Alessi E., Letizia C., Jimenez A., Fallucca F., Pugliese G., Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutrition, Metabolism and Cardiovascular Diseases 2010 20 8 608 617 2-s2.0-77956738771 10.1016/j.numecd.2009.04.015
69. Sprague A. H., Khalil R. A., Inflammatory cytokines in vascular dysfunction and vascular disease. Biochemical Pharmacology 2009 78 6 539 552 2-s2.0-67651146363 10.1016/j.bcp.2009.04.029
70. Tiwari S., Zhang Y., Heller J., Abernethy D. R., Soldatov N. M., Artherosclerosis-related molecular alteration of the human Ca V1.2 calcium channel α 1C subunit. Proceedings of the National Academy of Sciences of the United States of America 2006 103 45 17024 17029 2-s2.0-33750957976 10.1073/pnas.0606539103
71. Hiroki J., Shimokawa H., Higashi M., Morikawa K., Kandabashi T., Kawamura N., Kubota T., Ichiki T., Amano M., Kaibuchi K., Takeshita A., Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells. Journal of Molecular and Cellular Cardiology 2004 37 2 537 546 2-s2.0-3242730347 10.1016/j.yjmcc.2004.05.008
72. Zhang C., Park Y., Picchi A., Potter B. J., Maturation-induces endothelial dysfunction via vascular inflammation in diabetic mice. Basic Research in Cardiology 2008 103 5 407 416 2-s2.0-50249138173 10.1007/s00395-008-0725-0
73. Mitchell J. A., Larkin S., Williams T. J., Cyclooxygenase-2: regulation and relevance in inflammation. Biochemical Pharmacology 1995 50 10 1535 1542 2-s2.0-0028787224 10.1016/0006-2952(95)00212-X
74. 2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in type 2 diabetic mice. American Journal of Physiology-Heart and Circulatory Physiology 2007 292 1 H649 H656 2-s2.0-33846204372 10.1152/ajpheart.00596.2006
75. Matsumoto T., Kakami M., Noguchi E., Kobayashi T., Kamata K., Imbalance between endothelium-derived relaxing and contracting factors in mesenteric arteries from aged OLETF rats, a model of type 2 diabetes. American Journal of Physiology-Heart and Circulatory Physiology 2007 293 3 H1480 H1490 2-s2.0-34548463480 10.1152/ajpheart.00229.2007
76. Tang E. H. C., Leung F. P., Huang Y., Feletou M., So K.-F., Man R. Y. K., Vanhoutte P. M., Calcium and reactive oxygen species increase in endothelial cells in response to releasers of endothelium-derived contracting factor. British Journal of Pharmacology 2007 151 1 15 23 2-s2.0-34247608691 10.1038/sj.bjp.0707190
77. Kim H. J., Jung K. J., Yu B. P., Cho C. G., Choi J. S., Chung H. Y., Modulation of redox-sensitive transcription factors by calorie restriction during aging. Mechanisms of Ageing and Development 2002 123 12 1589 1595 2-s2.0-0036860192 10.1016/S0047-6374(02)00094-5
78. Chung H. Y., Sung B., Jung K. J., Zou Y., Yu B. P., The molecular inflammatory process in aging. Antioxidants and Redox Signaling 2006 8 3-4 572 581 2-s2.0-33646685457 10.1089/ars.2006.8.572
79. Baldwin A. S. Jr., The NF-kappa B and I kappa B proteins: new discoveries and insights. The Annual Review of Immunology 1996 14 649 683 10.1146/annurev.immunol.14.1.649
80. Barnes P. J., Karin M., Nuclear factor- B-a pivotal transcription factor in chronic inflammatory diseases. The New England Journal of Medicine 1997 336 15 1066 1071 2-s2.0-0030615201 10.1056/NEJM199704103361506
81. Ghosh S., May M. J., Kopp E. B., NF- B and rel proteins: evolutionarily conserved mediators of immune responses. Annual Review of Immunology 1998 16 225 260 2-s2.0-0031897632 10.1146/annurev.immunol.16.1.225
82. Kim H. J., Kim K. W., Yu B. P., Chung H. Y., The effect of age on cyclooxygenase-2 gene expression: NF-kappaB activation and IkappaBalpha degradation. Free Radical Biology and Medicine 2000 28 683 692
83. Chung H. Y., Cesari M., Anton S., Marzetti E., Giovannini S., Seo A. Y., Carter C., Yu B. P., Leeuwenburgh C., Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Research Reviews 2009 8 1 18 30 2-s2.0-57949087452 10.1016/j.arr.2008.07.002
84. Kritchevsky S. B., Cesari M., Pahor M., Inflammatory markers and cardiovascular health in older adults. Cardiovascular Research 2005 66 2 265 275 2-s2.0-16344378434 10.1016/j.cardiores.2004.12.026
85. Cartier A., Côté M., Lemieux I., Pérusse L., Tremblay A., Bouchard C., Després J.-P., Age-related differences in inflammatory markers in men: contribution of visceral adiposity. Metabolism 2009 58 10 1452 1458 2-s2.0-70149113946 10.1016/j.metabol.2009.04.025
86. Bruunsgaard H., Andersen-Ranberg K., Jeune B., Pedersen A. N., Skinhøj P., Pedersen B. K., A high plasma concentration of TNF-alpha is associated with dementia in centenarians. The Journal of Gerontology: Series A 1999 54 7 M357 M364 10.1093/gerona/54.7.M357
87. Willette A. A., Bendlin B. B., McLaren D. G., Canu E., Kastman E. K., Kosmatka K. J., Xu G., Field A. S., Alexander A. L., Colman R. J., Weindruch R. H., Coe C. L., Johnson S. C., Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys. NeuroImage 2010 51 3 987 994 2-s2.0-77952419769 10.1016/j.neuroimage.2010.03.015
88. Devaux B., Scholz D., Hirche A., Klovekorn W. P., Schaper J., Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure. European Heart Journal 1997 18 3 470 479 2-s2.0-0031045884
89. Maggio M., Guralnik J. M., Longo D. L., Ferrucci L., Interleukin-6 in aging and chronic disease: a magnificent pathway. Journals of Gerontology: Series A 2006 61 6 575 584 2-s2.0-33745185337
90. Wannamethee S. G., Shaper A. G., Whincup P. H., Modifiable lifestyle factors and the metabolic syndrome in older men: effects of lifestyle changes. Journal of the American Geriatrics Society 2006 54 12 1909 1914 2-s2.0-33845478592 10.1111/j.1532-5415.2006.00974.x
91. Mokdad A. H., Marks J. S., Stroup D. F., Gerberding J. L., Actual causes of death in the United States, 2000. Journal of the American Medical Association 2004 291 10 1238 1245 2-s2.0-1542347858 10.1001/jama.291.10.1238
92. Golbidi S., Laher I., Molecular mechanisms in exercise-induced cardioprotection. Cardiology Research and Practice 2011 2011 15 972807 10.4061/2011/972807
93. Ghosh S., Golbidi S., Werner I., Verchere B. C., Laher I., Selecting exercise regimens and strains to modify obesity and diabetes in rodents: an overview. Clinical Science 2010 119 2 57 74 2-s2.0-77954911083 10.1042/CS20090389
94. Macera C. A., Hootman J. M., Sniezek J. E., Major public health benefits of physical activity. Arthritis Care and Research 2003 49 1 122 128 2-s2.0-0037440874
95. Macera C. A., Powell K. E., Population attributable risk: implications of physical activity dose. Medicine and Science in Sports and Exercise 2001 33 6 S635 S639 2-s2.0-0034994744
96. Myers J., Kaykha A., George S., Abella J., Zaheer N., Lear S., Yamazaki T., Froelicher V., Fitness versus physical activity patterns in predicting mortality in men. American Journal of Medicine 2004 117 12 912 918 2-s2.0-11344275794 10.1016/j.amjmed.2004.06.047
97. Brown W. J., McLaughlin D., Leung J., McCaul K. A., Flicker L., Almeida O. P., Hankey G. J., Lopez D., Dobson A. J., Physical activity and all-cause mortality in older women and men. British Journal of Sports Medicine 2012 46 664 668
98. DeSouza C. A., Shapiro L. F., Clevenger C. M., Dinenno F. A., Monahan K. D., Tanaka H., Seals D. R., Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation 2000 102 12 1351 1357 2-s2.0-0034687139
99. Taddei S., Galetta F., Virdis A., Ghiadoni L., Salvetti G., Franzoni F., Giusti C., Salvetti A., Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. Circulation 2000 101 25 2896 2901 2-s2.0-0034720839
100. Lauer T., Heiss C., Balzer J., Kehmeier E., Mangold S., Leyendecker T., Rottler J., Meyer C., Merx M. W., Kelm M., Rassaf T., Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise. Basic Research in Cardiology 2008 103 3 291 297 2-s2.0-42249114001 10.1007/s00395-008-0714-3
101. Franzoni F., Galetta F., Morizzo C., Lubrano V., Palombo C., Santoro G., Ferrannini E., Quiñones-Galyan A., Effects of age and physical fitness on microcirculatory function. Clinical Science 2004 106 3 329 335 2-s2.0-1642344358 10.1042/CS20030229
102. Karolkiewicz J., Szczêsniak L., Deskur-Smielecka E., Nowak A., Stemplewski R., Szeklicki R., Oxidative stress and antioxidant defense system in healthy, elderly men: relationship to physical activity. Aging Male 2003 6 2 100 105 2-s2.0-0042704802
103. Cheng X., Siow R. C. M., Mann G. E., Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: a role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1 defense pathway. Antioxidants and Redox Signaling 2011 14 3 469 487 2-s2.0-78650913154 10.1089/ars.2010.3283
104. Bao W., Song F., Li X., Rong S., Yang W., Zhang M., Yao P., Hao L., Yang N., Hu F. B., Liu L., Plasma heme oxygenase-1 concentration is elevated in individuals with type 2 diabetes mellitus. PLoS One 2010 5 8 2-s2.0-77957882550 10.1371/journal.pone.0012371 e12371
105. Babusikova E., Jesenak M., Durdik P., Dobrota D., Banovcin P., Exhaled carbon monoxide as a new marker of respiratory diseases in children. Journal of Physiology and Pharmacology 2008 59 supplement 6 9 17 2-s2.0-64549163687
106. Vile G. F., Tyrrell R. M., Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin. Journal of Biological Chemistry 1993 268 20 14678 14681 2-s2.0-0027255106
107. Bélanger S., Lavoie J.-C., Chessex P., Influence of bilirubin on the antioxidant capacity of plasma in newborn infants. Biology of the Neonate 1997 71 4 233 238 2-s2.0-1842404737
108. Ryter S. W., Alam J., Choi A. M. K., Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiological Reviews 2006 86 2 583 650 2-s2.0-33645945014 10.1152/physrev.00011.2005
109. Niess A. M., Passek F., Lorenz I., Schneider E. M., Dickhuth H.-H., Northoff H., Fehrenbach E., Expression of the antioxidant stress protein heme oxygenase-1 (HO-1) in human leukocytes: acute and adaptational responses to endurance exercise. Free Radical Biology and Medicine 1999 26 1-2 184 192 2-s2.0-0345561630 10.1016/S0891-5849(98)00192-0
110. Asghar M., George L., Lokhandwala M. F., Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats. American Journal of Physiology-Renal Physiology 2007 293 3 F914 F919 2-s2.0-34548618130 10.1152/ajprenal.00272.2007
111. Fleming I., Busse R., Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2003 284 1 R1 R12 2-s2.0-0037216768
112. Fukai T., Siegfried M. R., Ushio-Fukai M., Cheng Y., Kojda G., Harrison D. G., Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training. Journal of Clinical Investigation 2000 105 11 631 1639 2-s2.0-0034201168
113. Kojda G., Cheng Y. C., Burchfield J., Harrison D. G., Dysfunctional regulation of endothelial nitric oxide synthase (eNOS) expression in response to exercise in mice lacking one eNOS gene. Circulation 2001 103 23 2839 2844 2-s2.0-0035849576
114. Hambrecht R., Adams V., Erbs S., Linke A., Kränkel N., Shu Y., Baither Y., Gielen S., Thiele H., Gummert J. F., Mohr F. W., Schuler G., Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 2003 107 25 3152 3158 2-s2.0-0038755650 10.1161/01.CIR.0000074229.93804.5C
115. Hambrecht R., Wolf A., Gielen S., Linke A., Hofer J., Erbs S., Schoene N., Schuler G., Effect of exercise on coronary endothelial function in patients with coronary artery disease. The New England Journal of Medicine 2000 342 7 454 460 2-s2.0-0034677448 10.1056/NEJM200002173420702
116. Hambrecht R., Gielen S., Linke A., Fiehn E., Yu J., Walther C., Schoene N., Schuler G., Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure: a randomized trial. Journal of the American Medical Association 2000 283 23 3095 3101 2-s2.0-0034697756
117. Johnson B. D., Mather K. J., Wallace J. P., Mechanotransduction of shear in the endothelium: basic studies and clinical implications. Vascular Medicine 2011 16 365 377 10.1177/1358863X11422109
118. Laurindo F. R. M., Pedro M. D. A., Barbeiro H. V., Pileggi F., Carvalho M. H. C., Augusto O., Da Luz P. L., Vascular free radical release: ex vivo and in vivo evidence for a flow- dependent endothelial mechanism. Circulation Research 1994 74 4 700 709 2-s2.0-0028294691
119. de Keulenaer G. W., Chappell D. C., Ishizaka N., Nerem R. M., Alexander R. W., Griendling K. K., Oscillatory and steady laminar shear stress differentially affect human endothelial redox state: role of a superoxide-producing NADH oxidase. Circulation Research 1998 82 10 1094 1101 2-s2.0-0032104153
120. Drummond G. R., Cai H., Davis M. E., Ramasamy S., Harrison D. G., Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. Circulation Research 2000 86 3 347 354 2-s2.0-0033952940
121. 2+/calmodulin- dependent protein kinase II/janus kinase 2-dependent pathway. Arteriosclerosis, Thrombosis, and Vascular Biology 2001 21 10 1571 1576 2-s2.0-0035724654
122. Rush J. W. E., Turk J. R., Laughlin M. H., Exercise training regulates SOD-1 and oxidative stress in porcine aortic endothelium. American Journal of Physiology-Heart and Circulatory Physiology 2003 284 4 H1378 H1387 2-s2.0-0037377579
123. Maeda S., Sugawara J., Yoshizawa M., Otsuki T., Shimojo N., Jesmin S., Ajisaka R., Miyauchi T., Tanaka H., Involvement of endothelin-1 in habitual exercise-induced increase in arterial compliance. Acta Physiologica 2009 196 2 223 229 2-s2.0-65449149753 10.1111/j.1748-1716.2008.01909.x
124. Kasapis C., Thompson P. D., The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. Journal of the American College of Cardiology 2005 45 10 1563 1569 2-s2.0-18944393401 10.1016/j.jacc.2004.12.077
125. Plaisance E. P., Grandjean P. W., Physical activity and high-sensitivity C-reactive protein. Sports Medicine 2006 36 5 443 458 2-s2.0-33750944939 10.2165/00007256-200636050-00006
126. Fallon K. E., Fallon S. K., Boston T., The acute phase response and exercise: court and field sports. British Journal of Sports Medicine 2001 35 3 170 173 2-s2.0-0034763480 10.1136/bjsm.35.3.170
127. Nieman D. C., Davis J. M., Henson D. A., Walberg-Rankin J., Shute M., Dumke C. L., Utter A. C., Vinci D. M., Carson J. A., Brown A., Lee W. J., McAnulty S. R., McAnulty L. S., Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run. Journal of Applied Physiology 2003 94 5 1917 1925 2-s2.0-1642461635
128. Keller C., Steensberg A., Pilegaard H., Osada T., Saltin B., Pedersen B. K., Neufer P. D., Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content. The FASEB Journal 2001 15 14 2748 2750 2-s2.0-0035651023
129. Febbraio M. A., Pedersen B. K., Contraction-induced myokine production and release: is skeletal muscle an endocrine organ? Exercise and Sport Sciences Reviews 2005 33 3 114 119 2-s2.0-22244477735 10.1097/00003677-200507000-00003
130. Nielsen A. R., Mounier R., Plomgaard P., Mortensen O. H., Penkowa M., Speerschneider T., Pilegaard H., Pedersen B. K., Expression of interleukin-15 in human skeletal muscle effect of exercise and muscle fibre type composition. Journal of Physiology 2007 584 1 305 312 2-s2.0-34848878670 10.1113/jphysiol. 2007.139618
131. Pedersen B. K., Febbraio M. A., Point: interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis. Journal of Applied Physiology 2007 102 2 814 819 2-s2.0-33846883060 10.1152/japplphysiol. 01208.2006
132. Pedersen B. K., Bruunsgaard H., Possible beneficial role of exercise in modulating low-grade inflammation in the elderly. Scandinavian Journal of Medicine and Science in Sports 2003 13 1 56 62 2-s2.0-0038137397 10.1034/j.1600-0838.2003.20218.x
133. Festa A., D'Agostino R. Jr., Howard G., Mykkänen L., Tracy R. P., Haffner S. M., Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 2000 102 1 42 47 2-s2.0-0034604248
134. Starkie R., Ostrowski S. R., Jauffred S., Febbraio M., Pedersen B. K., Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. The FASEB Journal 2003 17 8 884 886 2-s2.0-0038322493
135. Keller C., Keller P., Giralt M., Hidalgo J., Pedersen B. K., Exercise normalises overexpression of TNF- α in knockout mice. Biochemical and Biophysical Research Communications 2004 321 1 179 182 2-s2.0-3543032809 10.1016/j.bbrc.2004.06.129
136. van der Poll T., Coyle S. M., Barbosa K., Braxton C. C., Lowry S. F., Epinephrine inhibits tumor necrosis factor- α and potentiates interleukin 10 production during human endotoxemia. Journal of Clinical Investigation 1996 97 3 713 719 2-s2.0-0030056373
137. Petersen E. W., Carey A. L., Sacchetti M., Steinberg G. R., Macaulay S. L., Febbraio M. A., Pedersen B. K., Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro. American Journal of Physiology-Endocrinology and Metabolism 2005 288 1 E155 E162 2-s2.0-11144325623 10.1152/ajpendo.00257.2004
138. Wallenius V., Wallenius K., Ahrén B., Rudling M., Carlsten H., Dickson S. L., Ohlsson C., Jansson J.-O., Interleukin-6-deficient mice develop mature-onset obesity. Nature Medicine 2002 8 1 75 79 2-s2.0-0036152683 10.1038/nm0102-75
139. van Hall G., Steensberg A., Sacchetti M., Fischer C., Keller C., Schjerling P., Hiscock N., Møller K., Saltin B., Febbraio M. A., Pedersen B. K., Interleukin-6 stimulates lipolysis and fat oxidation in humans. Journal of Clinical Endocrinology and Metabolism 2003 88 7 3005 3010 2-s2.0-0038372035 10.1210/jc.2002-021687
140. Brandt C., Pedersen B. K., The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases. Journal of Biomedicine and Biotechnology 2010 2010 6 2-s2.0-77951685571 10.1155/2010/520258 520258
141. Hopps E., Canino B., Caimi G., Effects of exercise on inflammation markers in type 2 diabetic subjects. Acta Diabetologica 2011 48 3 183 189 2-s2.0-80052388640 10.1007/s00592-011-0278-9
142. Quinn L. S., Anderson B. G., Drivdahl R. H., Alvarez B., Argilés J. M., Overexpression of interleukin-15 induces skeletal muscle hypertrophy in vitro: implications for treatment of muscle wasting disorders. Experimental Cell Research 2002 280 1 55 63 2-s2.0-0036031875 10.1006/excr.2002.5624
143. Figueras M., Busquets S., Carbó N., Barreiro E., Almendro V., Argilés J. M., López-Soriano F. J., Interleukin-15 is able to suppress the increased DNA fragmentation associated with muscle wasting in tumour-bearing rats. FEBS Letters 2004 569 1-3 201 206 2-s2.0-3042593899 10.1016/j.febslet.2004.05.066
144. Marzetti E., Groban L., Wohlgemuth S. E., Lees H. A., Lin M., Jobe H., Giovannini S., Leeuwenburgh C., Carter C. S., Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2008 294 2 R558 R567 2-s2.0-38949120530 10.1152/ajpregu.00620.2007
145. Marzetti E., Lawler J. M., Hiona A., Manini T., Seo A. Y., Leeuwenburgh C., Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle. Free Radical Biology and Medicine 2008 44 2 160 168 2-s2.0-38049058773 10.1016/j.freeradbiomed.2007.05. 028