Exercise training enhances endothelial function in young men

Journal of the American College of Cardiology

Volumn 33, Issue 5, 1999, Pages 1379-1385

  Clarkson, Peter ^a   Montgomery, Hugh E ^b   Mullen, Michael J ^a   Donald, Ann E ^c   Powe, Amanda J ^d   Bull, Teresa ^e   Jubb, Michael ^a   World, Michael ^b   Deanfield, John E ^a,b  

^a Great Ormond Street Hospital for Children NHS Trust ^*

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^d Royal Army Medical College   (United Kingdom)

^e Army Medical College   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCERYL TRINITRATE;

ADOLESCENT; ADULT; ARMY; ARTICLE; BLOOD VESSEL REACTIVITY; BRACHIAL ARTERY; EXERCISE; FITNESS; HUMAN; HUMAN EXPERIMENT; HYPEREMIA; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SUBLINGUAL DRUG ADMINISTRATION; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0033117209     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(99)00036-4     Document Type: Article

References (39)

1. Leon AS, Cornett J, Jacobs DR, Rauramara R. Leisure time physical activity levels and risk of coronary heart disease and death: the Multiple Risk Factor Intervention Study. J Am Med Assoc 1987;273:2388-95.
2. Blair SN, Kohl HW, Barlow CE, Paffenbarger RS, Gibbons LW, Macera CA. Changes in physical fitness and all cause mortality. A prospective study of healthy and unhealthy men. J Am Med Assoc 1995;273:1093-8.
3. Lakka TA, Venalainen JM, Rauramara R, Salonen R, Tuomilehto J, Salonen JT. Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction in men. N Engl J Med 1994;330:1549-54.
4. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993;362:801-9.
5. Zeiher AM, Drexler H, Wollschlager H, Just H. Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 1991;83:391-401.
6. Vita JA, Treasure CB, Nabel EG, et al. Coronary vasomotor responses to acetyl choline relates to risk factors for coronary disease. J Am Coll Cardiol 1990;81:491-97.
7. Celermajer DS, Sorensen KE, Georgakopoulous D, et al. Cigarette smoking is associated with a dose dependent and potentially reversible impairment of endothelium dependent dilatation in healthy young adults. Circulation 1993;88:2149-55.
8. Sorensen KE, Celermajer DS, Georgakopoulous D, Hatcher G, Betteridge DJ, Deanfield JE. Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level. J Clin Invest 1994;93:50-5.
9. Clarkson P, Celermajer DS, Sampson M, et al. Endothelial dysfunction in insulin dependent diabetes mellitus is related to disease duration and LDL-cholesterol levels. J Am Coll Cardiol 1996;28:573-9.
10. Anderson TJ, Meredith IT, Yeung AC, Frei B, Selwyn AP, Ganz P. The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med 1995;332:488-93.
11. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic adults. J Clin Invest 1996;97:1989-94.
12. Wang J, Wolin MS, Hintze TH. Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs. Circ Res 1993;73:829-38.
13. Hornig B, Maier V, Drexler H. Physical training improves endothelial function in patients with chronic heart failure. Circulation 1996;93:210-4.
14. Celermajer DS, Sorensen KE, Gooch V, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111-5.
15. Ramsey MW, Goodfellow J, Jones CHJ, Luddington LA, Lewis MJ, Henderson AH. Endothelial control of arterial distensibility is impaired in chronic heart failure. Circulation 1995;92:3212-19.
16. Sorensen KE, Celermajer DS, Spiegelhalter DJ, et al. Non-invasive measurement of endothelium dependent arterial response: accuracy and reproducibility. Br Heart J 1995;74:247-53.
17. Mullen MJ, Clarkson P, Donald AE, et al. The effect of enalapril on endothelial function in young insulin dependent diabetics: a randomized double blind study. J Am Coll Cardiol 1998;31:1330-5.
18. Pate RR, Pratt M, Blair SN, et al. Physical activity and public health. A recommendation from the Centres of Disease Control and Prevention and the American College of Sports Medicine. JAMA 1995;273:402-7.
19. Balady GJ, Fletcher BJ, Froelicher ES, et al. Cardiac rehabilitation programs. A statement for healthcare professionals from the American Heart Association. Circulation 1994;90:1602-10.
20. Wood PD, Stefanick ML, Williams PT, Haskell WL. The effects on plasma lipoproteins of prudent weight reducing diet, with or without exercise in overweight men and women. N Engl J Med 1991;325:461-6.
21. Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS. Physical activity and reduced occurance of non-insulin-dependent diabetes mellitus. N Engl J Med 1991;325:147-52.
22. Harries M, Williams C, Stanish WD, Michaeli LJ, eds. Oxford Textbook of Sports Medicine. New York: Oxford University Press, 1994;276-9.
23. Martin JE, Dubbert PM, Cushman WC. Controlled trial of aerobic exercise in hypertension. Circulation 1990;81:1560-7.
24. Schuler G, Hambrecht R, Schlierf G, et al. Regular physical exercise and low fat diet: effects on progression of coronary artery disease. Circulation 1992;86:1-11.
25. Muller JM, Myers PR, Laughlin MH. Vasodilator responses of coronary resistance arteries of exercise-trained pigs. Circulation 1994;89:2308-14.
26. Delp MD, McAllister RM, Laughlin MH. Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta. J Appl Physiol 1993;75:1354-63.
27. Chen HI, Li HT. Physical conditioning can modulate endothelium-dependent vasorelaxation in rabbits. Arterioscler Thromb 1993;13:852-6.
28. Oltman CL, Parker JL, Laughlin MH. Endothelium-dependent vasodilation of proximal coronary arteries from exercise-trained pigs. J Appl Physiol 1995;79:33-40.
29. Koller A, Huang A, Sun D, Kaley G. Exercise training augments flow-dependent dilation in rat skeletal muscle arterioles. Role of endothelial nitric oxide and prostaglandins. Circ Res 1995;76:544-50.
30. Joannides R, Haefeli WE, Linder L, et al. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 1995;91:1314-9.
31. Miller VM, Vanhoutte PM. Enhanced release of endothelium-derived relaxing factor by chronic increases in blood flow. Am J Physiol 1988;255:h446-58.
32. Tsao PS, Lewis NP, Cooke JP. Exposure to shear stress alters endothelial adhesiveness. Role of nitric oxide. Circulation 1995;92:3513-9.
33. Tsao PS, Buitrago R, Chan JR, Cooke JP. Fluid flow inhibits endothelial adhesiveness. Nitric oxide and transcriptional regulation of VCAM-1. Circulation 1996;94:1682-9.
34. Niebauer J, Cooke JP: Cardiovascular effects of exercise: role of endothelial shear stress. J Am Coll Cardiol 1996;28:1652-60.
35. Sessa WC, Harrison JK, Barber CM, et al. Molecular cloning and expressionof cDNA encoding endothelial cell nitric oxide synthase. J Biol Chem 1992;267:15274-6.
36. Sessa WC, Pritchard K, Seyedi N, Wang J, Hintze TH. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res 1994;74:349-53.
37. Resnick N, Gimbrone MA Jr. Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J 1995;9:874-82.
38. Anderson TJ, Uehata A, Gerhard MD, et al. Close relation of endothelialfunction in the human coronary and peripheral circulations. J Am Coll Cardiol 1995;26:1235-41.
39. Cook JP, Tsao PS. Is NO an anti-atherogenic molecule? Arterioscler Thromb 1994;14:653-5.