Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: A radically different outcome

Clinical Science

Volumn 116, Issue 5, 2009, Pages 433-441

  Wray, D Walter ^a,b,c   Uberoi, Abhimanyu ^a   Lawrenson, Lesley ^a   Bailey, Damian M ^d   Richardson, Russell S ^a,b,c,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c and Clinical Center   (United States)

^d UNIVERSITY OF GLAMORGAN   (United Kingdom)

^e UNIVERSITY OF UTAH   (United States)

Author keywords

Antioxidant; Blood pressure; Elderly population; Exercise; Free radical; Nitric oxide

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; PLACEBO; THIOCTIC ACID; ANTIOXIDANT; FREE RADICAL;

AEROBIC EXERCISE; AGED; ANTIHYPERTENSIVE ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR RESPONSE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DIET SUPPLEMENTATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; ELDERLY CARE; ELECTRON SPIN RESONANCE; EVALUATION RESEARCH; EXTENSOR MUSCLE; HUMAN; HYPERTENSION; KNEE; MALE; MEAN ARTERIAL PRESSURE; MUSCLE MASS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; VASCULAR ENDOTHELIUM; VASODILATATION; BLOOD; BLOOD PRESSURE; DRUG ADMINISTRATION; DRUG EFFECT; EXERCISE; MULTIMODALITY CANCER THERAPY; PATHOPHYSIOLOGY; PHYSIOLOGY; TREATMENT OUTCOME;

AGED; ANTIOXIDANTS; BLOOD PRESSURE; COMBINED MODALITY THERAPY; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; ENDOTHELIUM, VASCULAR; EXERCISE; FREE RADICALS; HUMANS; HYPERTENSION; MALE; TREATMENT OUTCOME; VASODILATION;

EID: 63449106961     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20080337     Document Type: Article

References (59)

1. Huang, H. and Manton, K. G. (2004) The role of oxidative damage in mitochondria during aging: a review. Front. Biosci. 9, 1100-1117
2. Touyz, R. M. (2004) Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance? Hypertension 44, 248-252
3. Wassmann, S., Wassmann, K. and Nickenig, G. (2004) Modulation of oxidant and antioxidant enzyme expression and function in vascular cells. Hypertension 44, 381-386
4. Kojda, G. and Hambrecht, R. (2005) Molecular mechanisms of vascular adaptations to exercise. Physical activity as an effective antioxidant therapy? Cardiovasc. Res. 67, 187-197
5. Ji, L. L. (1999) Antioxidants and oxidative stress in exercise. Proc. Soc. Exp. Biol. Med. 222, 283-292
6. Ji, L. L. (2001) Exercise at old age: does it increase or alleviate oxidative stress? Ann. N.Y. Acad. Sci. 928, 236-247
7. Taddei, S., Galetta, F., Virdis, A. et al. (2000) Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. Circulation 101, 2896-2901
8. Green, D. J., Maiorana, A., O'Driscoll, G. and Taylor, R. (2004) Effect of exercise training on endothelium-derived nitric oxide function in humans. J. Physiol. 561, 1-25
9. Knowles, R. G. and Moncada, S. (1994) Nitric oxide synthases in mammals. Biochem. J. 298, 249-258
10. Yetik-Anacak, G. and Catravas, J. D. (2006) Nitric oxide and the endothelium: history and impact on cardiovascular disease. Vasc. Pharmacol. 45, 268-276
11. Bejma, J. and Ji, L. L. (1999) Aging and acute exercise enhance free radical generation in rat skeletal muscle. J. Appl. Physiol. 87, 465-470
12. Bailey, D. M., Young, I. S., McEneny, J. et al. (2004) Regulation of free radical outflow from an isolated muscle bed in exercising humans. Am. J. Physiol. Heart Circ. Physiol. 287, H1689-H1699
13. Higuchi, M., Cartier, L. J., Chen, M. and Holloszy, J. O. (1985) Superoxide dismutase and catalase in skeletal muscle: adaptive response to exercise. J. Gerontol. 40, 281-286
14. Jablonski, K. L., Seals, D. R., Eskurza, I., Monahan, K. D. and Donato, A. J. (2007) High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men. J. Appl. Physiol. 103, 1715-1721
15. Dudgeon, S., Benson, D. P., MacKenzie, A., Paisley-Zyszkiewicz, K. and Martin, W. (1998) Recovery by ascorbate of impaired nitric oxide-dependent relaxation resulting from oxidant stress in rat aorta. Br. J. Pharmacol. 125, 782-786
16. Benkusky, N. A., Lewis, S. J. and Kooy, N. W. (1998) Attenuation of vascular relaxation after development of tachyphylaxis to peroxynitrite in vivo. Am. J. Physiol. 275, H501-H508
17. Lucchesi, P. A., Belmadani, S. and Matrougui, K. (2005) Hydrogen peroxide acts as both vasodilator and vasoconstrictor in the control of perfused mouse mesenteric resistance arteries. J. Hypertens. 23, 571-579
18. Uppu, R. M., Nossaman, B. D., Greco, A. J. et al. (2007) Cardiovascular effects of peroxynitrite. Clin. Exp. Pharmacol. Physiol. 34, 933-937
19. Richardson, R. S., Donato, A. J., Uberoi, A. et al. (2007) Exercise-induced brachial artery vasodilation: role of free radicals. Am. J. Physiol. Heart Circ. Physiol. 292, H1516-H1522
20. European Society of Hypertension-European Society of Cardiology Guideline Committee (2003) 2003 Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J. Hypertens. 21, 1011-1053
21. Reference deleted
22. Wray, D. W., Uberoi, A., Lawrenson, L. and Richardson, R. S. (2005) Heterogeneous limb vascular responsiveness to shear stimuli during dynamic exercise in humans. J. Appl. Physiol. 99, 81-86
23. 2 max.Am. J. Physiol. Heart Circ. Physiol. 286, H1565-H1572
24. McCann, M. E., Hill, D., Thomas, K. C., Zurakowski, D. and Laussen, P. C. (2005) A comparison of radial artery blood pressure determination between the Vasotrac device and invasive arterial blood pressure monitoring in adolescents undergoing scoliosis surgery. Anesth. Analg. 101, 978-985
25. Cua, C. L., Thomas, K., Zurakowski, D. and Laussen, P. C. (2005) A comparison of the Vasotrac with invasive arterial blood pressure monitoring in children after pediatric cardiac surgery. Anesth. Analg. 100, 1289-1294
26. Belani, K., Ozaki, M., Hynson, J. et al. (1999) A new noninvasive method to measure blood pressure: results of a multicenter trial. Anesthesiology 91, 686-692
27. Wray, D.W., Donato, A. J., Nishiyama, S. K. and Richardson, R. S. (2007) Acute sympathetic vasoconstriction at rest and during dynamic exercise in cyclists and sedentary humans. J. Appl. Physiol. 102, 704-712
28. Donato, A. J., Uberoi, A., Wray, D. W., Nishiyama, S., Lawrenson, L. and Richardson, R. S. (2006) Differential effects of aging on limb blood flow in humans. Am. J. Physiol. Heart Circ. Physiol. 290, H272-H278
29. Wray, D.W., Uberoi, A., Lawrenson, L. and Richardson, R. S. (2006) Evidence of preserved endothelial function and vascular plasticity with age. Am. J. Physiol. Heart Circ. Physiol. 290, H1271-H1277
30. Nishiyama, S. K., Wray, D. W., Berkstresser, K., Ramaswamy, M. and Richardson, R. S. (2007) Limb-specific differences in flow-mediated dilation: the role of shear rate. J. Appl. Physiol. 103, 843-851
31. Woodman, R. J., Playford, D. A., Watts, G. F. et al. (2001) Improved analysis of brachial artery ultrasound using a novel edge-detection software system. J. Appl. Physiol. 91, 929-937
32. Nishiyama, S. K.,Wray, D.W. and Richardson, R. S. (2008) Sex and limb-specific ischemic reperfusion and vascular reactivity. Am. J. Physiol. Heart Circ Physiol. 295, H1100-H1108
33. Bailey, D. M., Ainslie, P. N., Jackson, S. K., Richardson, R. S. and Ghatei, M. (2004) Evidence against redox regulation of energy homoeostasis in humans at high altitude. Clin. Sci. 107, 589-600
34. Pescatello, L. S., Franklin, B. A., Fagard, R., Farquhar, W. B., Kelley, G. A. and Ray, C. A. (2004) American College of Sports Medicine position stand. Exercise and hypertension. Med. Sci. Sports Exercise 36, 533-553
35. Andersen, P. and Saltin, B. (1985) Maximal perfusion of skeletal muscle in man. J. Physiol. 366, 233-249
36. Richardson, R. S. and Saltin, B. (1998) Human muscle blood flow and metabolism studied in the isolated quadriceps muscles. Med. Sci. Sports Exercise 30, 28-33
37. Haram, P. M., Kemi, O. J. and Wisloff, U. (2008) Adaptation of endothelium to exercise training: insights from experimental studies. Front. Biosci. 13, 336-346
38. Green, D. J., Bilsborough, W., Naylor, L. H. et al. (2005) Comparison of forearm blood flow responses to incremental handgrip and cycle ergometer exercise: relative contribution of nitric oxide. J. Physiol. 562, 617-628
39. DeSouza, C. A., Shapiro, L. F., Clevenger, C. M. et al. (2000) Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation 102, 1351-1357
40. Lundberg, J. O., Weitzberg, E. and Gladwin, M. T. (2008) The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat. Rev. Drug Discov. 7, 156-167
41. Perri, M. G., Anton, S. D., Durning, P. E., et al. (2002) Adherence to exercise prescriptions: effects of prescribing moderate versus higher levels of intensity and frequency. Health Psychol. 21, 452-458
42. Shephard, R. J. (1997) Exercise for patients with congestive heart failure. Sports Med. 23, 75-92
43. 2 with small muscle mass exercise. Am. J. Respir. Crit. Care Med. 169, 89-96
44. Schutte, A. E., Huisman, H. W., Oosthuizen, W., van Rooyen, J. M. and Jerling, J. C. (2004) Cardiovascular effects of oral supplementation of vitamin C, E and folic acid in young healthy males. Int. J. Vitam. Nutr. Res. 74, 285-293
45. Miller, III, E. R., Appel, L. J., Levander, O. A. and Levine, D. M. (1997) The effect of antioxidant vitamin supplementation on traditional cardiovascular risk factors. J. Cardiovasc. Risk 4, 19-24
46. Zureik, M., Galan, P., Bertrais, S. et al. (2004) Effects of long-term daily low-dose supplementation with antioxidant vitamins and minerals on structure and function of large arteries. Arterioscler. Thromb. Vasc. Biol. 24, 1485-1491
47. Eskurza, I., Monahan, K. D., Robinson, J. A. and Seals, D. R. (2004) Ascorbic acid does not affect large elastic artery compliance or central blood pressure in young and older men. Am. J. Physiol. Heart Circ. Physiol. 286, H1528-H1534
48. Mottram, P., Shige, H. and Nestel, P. (1999) Vitamin E improves arterial compliance in middle-aged men and women. Atherosclerosis 145, 399-404
49. Eskurza, I., Monahan, K. D., Robinson, J. A. and Seals, D. R. (2004) Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing. J. Physiol. 556, 315-324
50. Taddei, S., Virdis, A., Ghiadoni, L., Magagna, A. and Salvetti, A. (1998) Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 97, 2222-2229
51. Wei, E. P., Kontos, H. A., Christman, C. W., DeWitt, D. S. and Povlishock, J. T. (1985) Superoxide generation and reversal of acetylcholine-induced cerebral arteriolar dilation after acute hypertension. Circ. Res. 57, 781-787
52. Simons, L. A., von Konigsmark, M., Simons, J., Stocker, R. and Celermajer, D. S. (1999) Vitamin E ingestion does not improve arterial endothelial dysfunction in older adults. Atherosclerosis 143, 193-199
53. Beckman, J. A., Goldfine, A. B., Gordon, M. B., Garrett, L. A., Keaney, Jr, J. F. and Creager, M. A. (2003) Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus. Am. J. Physiol. Heart Circ. Physiol. 285, H2392-H2398
54. Taddei, S., Virdis, A., Ghiadoni, L. et al. (2001) Age-related reduction of NO availability and oxidative stress in humans. Hypertension 38, 274-279
55. Cheitlin, M. D. (2003) Cardiovascular physiology: changes with aging. Am. J. Geriatr. Cardiol. 12, 9-13
56. Benetos, A. (2005) Does blood pressure control contribute to a more successful aging? Hypertension 46, 261-262
57. Beckman, J. S. and Koppenol, W. H. (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am. J. Physiol. 271, C1424-C1437
58. Peluso, I., Serafini, M., Campolongo, P. and Palmery, M. (2004) Effect on rat arterial blood pressure of chemically generated peroxyl radicals and protection by antioxidants. J. Nutr. Biochem. 15, 323-327
59. Heitzer, T., Schlinzig, T., Krohn, K., Meinertz, T. and Munzel, T. (2001) Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104, 2673-2678