WISE 2005: Chronic bed rest impairs microcirculatory endothelium in women

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 293, Issue 5, 2007, Pages

  Demiot, Claire ^a   Dignat George, Françoise ^b   Fortrat, Jacques Olivier ^c   Sabatier, Florence ^b   Gharib, Claude ^d   Larina, Irina ^e   Gauquelin Koch, Guillemette ^f   Hughson, Richard ^g   Custaud, Marc Antoine ^a,c  

^a ANGERS UNIVERSITY HOSPITAL   (France)

^b INSERM   (France)

^c Universite d'Angers   (France)

^d UNIVERSITÉ LYON 1   (France)

^e INSTITUTE OF BIOMEDICAL PROBLEMS   (Russian Federation)

^f CNES   (France)

^g UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Bed rest studies; Cardiovascular deconditioning; Circulating endothelial cells; Iontophoresis

Indexed keywords

ACETYLCHOLINE; NITROPRUSSIDE SODIUM;

ADULT; ARTICLE; BED REST; CELL DAMAGE; CONTROLLED STUDY; EXERCISE; FEMALE; HUMAN; IONTOPHORESIS; LASER DOPPLER FLOWMETRY; MICROCIRCULATION; NORMAL HUMAN; PRIORITY JOURNAL; TREADMILL EXERCISE; VASODILATATION;

ADULT; BED REST; BLOOD FLOW VELOCITY; BLOOD PRESSURE; ENDOTHELIUM, VASCULAR; EXERCISE; FEMALE; HUMANS; LOWER BODY NEGATIVE PRESSURE; MICROCIRCULATION; PERIPHERAL VASCULAR DISEASES; WOMEN;

EID: 36148954272     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00591.2007     Document Type: Article

References (39)

1. Belin de Chantemele E, Pascaud L, Custaud MA, Capri A, Louisy F, Ferretti G, Gharib C, Arbeille P. Calf venous volume during stand-test after a 90-day bed rest study with or without exercise countermeasure. J Physiol 561: 611-622, 2004.
2. Bleeker MW, De Groot PC, Poelkens F, Rongen GA, Smits P, Hopman MT. Vascular adaptation to 4 wk of deconditioning by unilateral lower limb suspension. Am J Physiol Heart Circ Physiol 288: H1747-H1755, 2005.
3. Bleeker MW, De Groot PC, Rongen GA, Rittweger J, Felsenberg D, Smits P, Hopman MT. Vascular adaptation to deconditioning and the effect of an exercise countermeasure: results of the Berlin bed rest study. J Appl Physiol 99: 1293-1300, 2005.
4. Boisseau MR. Roles of mechanical blood forces in vascular diseases. A clinical overview. Clin Hemorheol 33: 201-207, 2005.
5. Bonnin P, Ben Driss A, Benessiano J, Maillet A, Pavy LT, Levy BI. Enhanced flow-dependent vasodilation after bed rest, a possible mechanism for orthostatic intolerance in humans. Eur J Appl Physiol 85: 420-426, 2001.
6. Cao P, Kimura S, Macias BR, Ueno T, Watenpaugh DE, Hargens AR. Exercise within lower body negative pressure partially counteracts lumbar spine deconditioning associated with 28-day bed rest. J Appl Physiol 99: 39-44, 2005.
7. Carlsson S, Midthjell K, Tesfamarian MY, Grill V. Age, overweight and physical inactivity increase the risk of latent autoimmune diabetes in adults: results from the Nord-Trondelag health study. Diabetologia 50: 55-58, 2007.
8. Chong AY, Blann AD, Patel J, Freestone B, Hughes E, Lip GY. Endothelial dysfunction and damage in congestive heart failure: relation of flow-mediated dilation to circulating endothelial cells, plasma indexes of endothelial damage, and brain natriuretic peptide. Circulation 110: 1794-1798, 2004.
9. Cifton VL, Crompton R, Read MA, Gibson PG, Smith R, Wright IM. Microvascular effects of corticotropin-releasing hormone in human skin vary in relation to estrogen concentration during the menstrual cycle. J Endocrinol 186: 69-76, 2005.
10. Cracowski JL, Minson CT, Salvat-Melis M, Halliwill JR. Methodological issues in the assessment of skin microvascular endothelial function in humans. Trends Pharmacol Sci 27: 503-508, 2006.
11. Crandall CG, Shibasaki M, Wilson TE, Cui J, Levine BD. Prolonged head-down tilt exposure reduces maximal cutaneous vasodilator and sweating capacity in humans. J Appl Physiol 94: 2330-2336, 2003.
12. Custaud MA, Belin de Chantemele E, Blanc S, Gauquelin-Koch G, Gharib C. Regulation of blood volume during weightlessness simulation of long duration. Can J Physiol Pharmacol 83: 1147-1153, 2005.
13. De Groot PC, Bleeker MW, Hopman MT. Magnitude and time course of arterial vascular adaptations to inactivity in humans. Exerc Sport Sci Rev 34: 65-71, 2006.
14. Dimmeler S, Hermann C, Galle J, Zeiher AM. Upregulation of superoxide dismutase and nitric oxide synthase mediates the apoptosis- suppressive effects of shear stress on endothelial cells. Arterioscler Thromb Vasc Biol 19: 656-664, 1999.
15. Durand S, Fromy B, Bouye P, Saumet JL, Abraham P. Vasodilatation in response to repeated anodal current application in the human skin relies on aspirin-sensitive mechanisms. J Physiol 540: 261-269, 2002.
16. Durand S, Tartas M, Bouye P, Koitka A, Saumet JL, Abraham P. Prostaglandins participate in the late phase of the vascular response to acetylcholine iontophoresis in humans. J Physiol 561: 811-819, 2004.
17. 2 consumption in man after prolonged bed rest. J Physiol 501: 677-686, 1997.
18. George F, Brisson C, Poncelet P, Laurent JC, Massot O, Arnoux D, Ambrosi P, Klein-Soyer C, Cazenave JP, Sampol J. Rapid isolation of human endothelial cells from whole blood using S-Endo1 monoclonal antibody coupled to immuno-magnetic beads: demonstration of endothelial injury after angioplasty. Thromb Haemost 67: 147-153, 1992.
19. Hesse C, Siedler H, Luntz SP, Arendt BM, Goerlich R, Fricker R, Heer M, Haefeli WE. Modulation of endothelial and smooth muscle function by bed rest and hypoenergetic, low-fat nutrition. J Appl Physiol 99: 2196-2203, 2005.
20. Higashi Y, Sasaki S, Kurisu S, Yoshimizu A, Sasaki N, Matsuura H, Kajiyama G, Oshima T. Regular aerobic exercise augments endothelium- dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide. Circulation 100: 1194-1202, 1999.
21. Ignarro LJ, Balestrieri ML, Napoli C. Nutrition, physical activity, and cardiovascular disease: an update. Cardiovasc Res 73: 326-340, 2007.
22. Kannel WB, Sorlie P. Some health benefits of physical activity. The Framingham Study. Arch Intern Med 139: 857-861, 1979.
23. Kellogg DL Jr, Liu Y, Kosiba IF, O'Donnell D. Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol 86: 1185-1190, 1999.
24. Koitka A, Legrand-Fernandez MS, Abraham P, Fizanne L, Fromy B, Sigaudo Roussel D, Saumet JL. Low skin temperature impairs the cutaneous vasodilator response to local progressive pressure strain. Microvasc Res 67: 203-206, 2004.
25. Koitka A, Abraham P, Bouhanick B, Sigaudo-Roussel D, Demiot C, Saumet JL. Impaired pressure-induced vasodilation at the foot in young adults with type 1 diabetes. Diabetes 53: 721-725, 2004.
26. Lenashi H, Strucl M. Effect of regular physical training on cutaneous microvascular reactivity. Med Sci Sports Exerc 36: 606-612, 2004.
27. Makin AJ, Blann AD, Chung NA, Silverman SH, Lip GY. Assessment of endothelial damage in atherosclerotic vascular disease by quantification of circulating endothelial cells. Relationship with von Willebrand factor and tissue factor. Eur Heart J 25: 371-376, 2004.
28. McGuire DK, Levine BD, Williamson JW, Snell PG, Blomqvist CG, Saltin B, Mitchell JH. A 30-year follow-up of the Dallas bed rest and training study: II. Effect of age on cardiovascular adaptation to exercise training. Circulation 104: 1358-1366, 2001.
29. Millet C, Custaud MA, Allevard AM, Gharib C, Gauquelin-Koch G, Fortrat JO. Adaptations to a 7-day head-down bed rest with thigh cuffs. Med Sci Sports Exerc 32: 1748-1756, 2000.
30. Minson CT, Berry LT, Joyner MJ. Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J Appl Physiol 91: 1619-1626, 2001.
31. Mora S, Lee IM, Buring JE, Ridker PM. Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women. JAMA 295: 1412-1419, 2006.
32. Mutin M, Canavy I, Blann A, Bory M, Sampol J, Dignat-George F. Direct evidence of endothelial injury in acute myocardial infarction and unstable angina by demonstration of circulating endothelial cells. Blood 93: 2951-2958, 1999.
33. Nordstrom CK, Dwyer KM, Merz CN, Shircore A, Dwyer JH. Leisure time physical activity and early atherosclerosis: the Los Angeles Atherosclerosis Study. Am J Med 115: 19-25, 2003.
34. Savage MV, Brengelmann GL. Reproducibility of the vascular response to heating in human skin. J Appl Physiol 76: 1759-1763, 1994.
35. Tartas M, Bouye P, Koitka A, Jaquinandi V, Tan L, Saumet JL, Abraham P. Cathodal current-induced vasodilation to single application and the amplified response to repeated application in humans rely on aspirin-sensitive mechanisms. J Appl Physiol 99: 1538-1544, 2005.
36. Trappe S, Trappe T, Gallagher P, Harber M, Alkner B, Tesch P. Human single muscle fibre function with 84 day bed rest and resistance exercise. J Physiol 557: 501-513, 2004.
37. Villar IC, Francis S, Webba A, Hobbs AJ, Ahluwalia A. Novel aspects of endothelium-dependent regulation of vascular tone. Kidney Int 70: 840-853, 2006.
38. Wang JS. Effects of exercise training and detraining on cutaneous microvascular function in man: the regulatory role of endothelium-dependent dilation in skin vasculature. Eur J Appl Physiol 93: 429-434, 2005.
39. Watenpaugh DE, Breit GA, Buckley TM, Ballard RE, Murthy G, Hargens AR. Human cutaneous vascular responses to whole-body tilting, Gz centrifugation, and LBNP. J Appl Physiol 96: 2153-2160, 2004.